Nfu_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL91_LEIBR

TriTrypDb:

LbrM.33.0550 , LBRM2903_330010900

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HL91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL91

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016226	iron-sulfur cluster assembly	4	10
GO:0022607	cellular component assembly	4	10
GO:0031163	metallo-sulfur cluster assembly	5	10
GO:0044237	cellular metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005506	iron ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0051536	iron-sulfur cluster binding	3	10
GO:0051540	metal cluster binding	2	10
GO:0051539	4 iron, 4 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.729
CLV_C14_Caspase3-7	204	208	PF00656	0.425
CLV_C14_Caspase3-7	260	264	PF00656	0.491
CLV_NRD_NRD_1	22	24	PF00675	0.616
CLV_PCSK_KEX2_1	114	116	PF00082	0.279
CLV_PCSK_KEX2_1	22	24	PF00082	0.616
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.347
CLV_PCSK_SKI1_1	316	320	PF00082	0.187
CLV_PCSK_SKI1_1	335	339	PF00082	0.264
CLV_PCSK_SKI1_1	46	50	PF00082	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DOC_CKS1_1	53	58	PF01111	0.338
DOC_MAPK_gen_1	313	322	PF00069	0.527
DOC_MAPK_MEF2A_6	2	10	PF00069	0.586
DOC_MAPK_RevD_3	99	115	PF00069	0.279
DOC_PP1_RVXF_1	288	295	PF00149	0.493
DOC_PP1_RVXF_1	386	392	PF00149	0.486
DOC_PP4_FxxP_1	70	73	PF00568	0.395
DOC_USP7_MATH_1	147	151	PF00917	0.454
DOC_USP7_MATH_1	182	186	PF00917	0.595
DOC_USP7_MATH_1	190	194	PF00917	0.594
DOC_USP7_MATH_1	261	265	PF00917	0.443
DOC_USP7_MATH_1	31	35	PF00917	0.433
DOC_USP7_MATH_1	352	356	PF00917	0.572
DOC_WW_Pin1_4	14	19	PF00397	0.554
DOC_WW_Pin1_4	389	394	PF00397	0.625
DOC_WW_Pin1_4	40	45	PF00397	0.521
DOC_WW_Pin1_4	52	57	PF00397	0.340
DOC_WW_Pin1_4	85	90	PF00397	0.279
LIG_14-3-3_CanoR_1	28	36	PF00244	0.692
LIG_14-3-3_CanoR_1	342	350	PF00244	0.592
LIG_14-3-3_CanoR_1	414	419	PF00244	0.602
LIG_14-3-3_CanoR_1	82	87	PF00244	0.200
LIG_deltaCOP1_diTrp_1	223	229	PF00928	0.353
LIG_EH1_1	228	236	PF00400	0.344
LIG_FHA_1	234	240	PF00498	0.387
LIG_FHA_1	315	321	PF00498	0.540
LIG_FHA_1	369	375	PF00498	0.694
LIG_FHA_1	45	51	PF00498	0.437
LIG_FHA_2	255	261	PF00498	0.591
LIG_FHA_2	53	59	PF00498	0.279
LIG_GBD_Chelix_1	90	98	PF00786	0.279
LIG_LIR_Apic_2	83	89	PF02991	0.303
LIG_LIR_Gen_1	109	118	PF02991	0.335
LIG_LIR_Gen_1	222	231	PF02991	0.377
LIG_LIR_Gen_1	344	352	PF02991	0.539
LIG_LIR_Gen_1	47	56	PF02991	0.310
LIG_LIR_Gen_1	7	18	PF02991	0.446
LIG_LIR_Nem_3	109	113	PF02991	0.335
LIG_LIR_Nem_3	131	135	PF02991	0.330
LIG_LIR_Nem_3	222	227	PF02991	0.357
LIG_LIR_Nem_3	288	294	PF02991	0.444
LIG_LIR_Nem_3	344	350	PF02991	0.536
LIG_LIR_Nem_3	404	410	PF02991	0.658
LIG_LIR_Nem_3	47	52	PF02991	0.419
LIG_LIR_Nem_3	58	64	PF02991	0.328
LIG_LIR_Nem_3	7	13	PF02991	0.448
LIG_Pex14_2	128	132	PF04695	0.463
LIG_SH2_CRK	407	411	PF00017	0.659
LIG_SH2_SRC	64	67	PF00017	0.200
LIG_SH2_STAT5	127	130	PF00017	0.509
LIG_SH2_STAT5	64	67	PF00017	0.381
LIG_SH2_STAT5	86	89	PF00017	0.347
LIG_SH3_3	245	251	PF00018	0.548
LIG_SUMO_SIM_anti_2	263	270	PF11976	0.395
LIG_SUMO_SIM_par_1	263	272	PF11976	0.394
LIG_SUMO_SIM_par_1	317	324	PF11976	0.527
LIG_TRAF2_1	346	349	PF00917	0.392
MOD_CDK_SPxK_1	40	46	PF00069	0.393
MOD_CK1_1	109	115	PF00069	0.410
MOD_CK1_1	17	23	PF00069	0.489
MOD_CK1_1	185	191	PF00069	0.612
MOD_CK1_1	202	208	PF00069	0.638
MOD_CK1_1	27	33	PF00069	0.533
MOD_CK1_1	341	347	PF00069	0.541
MOD_CK1_1	368	374	PF00069	0.624
MOD_CK1_1	85	91	PF00069	0.329
MOD_CK1_1	9	15	PF00069	0.586
MOD_CK2_1	254	260	PF00069	0.542
MOD_CK2_1	342	348	PF00069	0.592
MOD_CK2_1	414	420	PF00069	0.624
MOD_GlcNHglycan	14	17	PF01048	0.525
MOD_GlcNHglycan	166	169	PF01048	0.628
MOD_GlcNHglycan	176	179	PF01048	0.584
MOD_GlcNHglycan	231	234	PF01048	0.351
MOD_GlcNHglycan	240	243	PF01048	0.452
MOD_GlcNHglycan	29	32	PF01048	0.414
MOD_GlcNHglycan	344	347	PF01048	0.479
MOD_GlcNHglycan	367	370	PF01048	0.579
MOD_GlcNHglycan	398	401	PF01048	0.620
MOD_GlcNHglycan	403	406	PF01048	0.565
MOD_GSK3_1	102	109	PF00069	0.422
MOD_GSK3_1	12	19	PF00069	0.552
MOD_GSK3_1	182	189	PF00069	0.526
MOD_GSK3_1	197	204	PF00069	0.524
MOD_GSK3_1	229	236	PF00069	0.475
MOD_GSK3_1	27	34	PF00069	0.594
MOD_GSK3_1	308	315	PF00069	0.451
MOD_GSK3_1	338	345	PF00069	0.573
MOD_GSK3_1	360	367	PF00069	0.567
MOD_GSK3_1	368	375	PF00069	0.752
MOD_GSK3_1	389	396	PF00069	0.636
MOD_GSK3_1	40	47	PF00069	0.519
MOD_N-GLC_1	80	85	PF02516	0.324
MOD_NEK2_1	128	133	PF00069	0.357
MOD_NEK2_1	199	204	PF00069	0.689
MOD_NEK2_1	229	234	PF00069	0.389
MOD_NEK2_1	273	278	PF00069	0.467
MOD_NEK2_1	32	37	PF00069	0.433
MOD_NEK2_1	365	370	PF00069	0.571
MOD_NEK2_1	6	11	PF00069	0.715
MOD_NEK2_1	80	85	PF00069	0.340
MOD_NEK2_2	308	313	PF00069	0.486
MOD_NEK2_2	44	49	PF00069	0.439
MOD_PIKK_1	147	153	PF00454	0.544
MOD_PK_1	414	420	PF00069	0.482
MOD_PKA_2	27	33	PF00069	0.627
MOD_PKA_2	324	330	PF00069	0.488
MOD_PKA_2	341	347	PF00069	0.541
MOD_PKA_2	372	378	PF00069	0.645
MOD_PKA_2	413	419	PF00069	0.608
MOD_Plk_1	102	108	PF00069	0.279
MOD_Plk_1	190	196	PF00069	0.616
MOD_Plk_2-3	372	378	PF00069	0.482
MOD_Plk_4	106	112	PF00069	0.446
MOD_Plk_4	214	220	PF00069	0.492
MOD_Plk_4	32	38	PF00069	0.624
MOD_Plk_4	6	12	PF00069	0.525
MOD_Plk_4	74	80	PF00069	0.395
MOD_Plk_4	82	88	PF00069	0.395
MOD_ProDKin_1	14	20	PF00069	0.554
MOD_ProDKin_1	389	395	PF00069	0.621
MOD_ProDKin_1	40	46	PF00069	0.521
MOD_ProDKin_1	52	58	PF00069	0.340
MOD_ProDKin_1	85	91	PF00069	0.279
MOD_SUMO_rev_2	223	229	PF00179	0.360
TRG_ENDOCYTIC_2	127	130	PF00928	0.419
TRG_ENDOCYTIC_2	407	410	PF00928	0.655
TRG_ER_diArg_1	21	23	PF00400	0.635
TRG_NES_CRM1_1	209	223	PF08389	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M8	Leptomonas seymouri	60%	91%
A0A0S4J2M4	Bodo saltans	42%	95%
A0A3S7X6H5	Leishmania donovani	75%	96%
A4I8R7	Leishmania infantum	75%	96%
D0A4Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B3N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q4F4	Leishmania major	76%	99%
V5B2F6	Trypanosoma cruzi	50%	95%