Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL90_LEIBR

TriTrypDb:

LbrM.33.0540 , LBRM2903_330010700

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.440
CLV_C14_Caspase3-7	26	30	PF00656	0.442
CLV_NRD_NRD_1	195	197	PF00675	0.511
CLV_PCSK_KEX2_1	195	197	PF00082	0.511
CLV_PCSK_SKI1_1	77	81	PF00082	0.446
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DOC_ANK_TNKS_1	173	180	PF00023	0.468
DOC_MAPK_MEF2A_6	61	69	PF00069	0.323
DOC_PP2B_LxvP_1	46	49	PF13499	0.413
DOC_PP4_FxxP_1	106	109	PF00568	0.641
DOC_PP4_FxxP_1	149	152	PF00568	0.525
DOC_WW_Pin1_4	121	126	PF00397	0.456
DOC_WW_Pin1_4	61	66	PF00397	0.483
LIG_14-3-3_CanoR_1	188	192	PF00244	0.584
LIG_14-3-3_CanoR_1	24	32	PF00244	0.490
LIG_14-3-3_CanoR_1	39	47	PF00244	0.265
LIG_14-3-3_CanoR_1	77	85	PF00244	0.403
LIG_14-3-3_CanoR_1	99	108	PF00244	0.510
LIG_Actin_WH2_2	25	41	PF00022	0.538
LIG_BRCT_BRCA1_1	145	149	PF00533	0.513
LIG_EH1_1	128	136	PF00400	0.535
LIG_EH1_1	69	77	PF00400	0.455
LIG_eIF4E_1	129	135	PF01652	0.528
LIG_FHA_1	146	152	PF00498	0.575
LIG_FHA_1	153	159	PF00498	0.421
LIG_FHA_1	35	41	PF00498	0.272
LIG_FHA_2	24	30	PF00498	0.584
LIG_GBD_Chelix_1	157	165	PF00786	0.443
LIG_IRF3_LxIS_1	28	35	PF10401	0.364
LIG_LIR_Apic_2	105	109	PF02991	0.643
LIG_LIR_Apic_2	146	152	PF02991	0.581
LIG_LIR_Gen_1	168	178	PF02991	0.429
LIG_LIR_Nem_3	168	173	PF02991	0.444
LIG_PCNA_yPIPBox_3	77	89	PF02747	0.448
LIG_SH2_NCK_1	129	133	PF00017	0.543
LIG_SH2_NCK_1	139	143	PF00017	0.478
LIG_SH2_SRC	45	48	PF00017	0.457
LIG_SH2_STAP1	139	143	PF00017	0.681
LIG_SH2_STAT5	129	132	PF00017	0.546
LIG_SH2_STAT5	199	202	PF00017	0.557
LIG_SH2_STAT5	45	48	PF00017	0.396
LIG_SH2_STAT5	88	91	PF00017	0.421
LIG_SH3_3	172	178	PF00018	0.335
LIG_SH3_3	41	47	PF00018	0.469
LIG_TRAF2_1	50	53	PF00917	0.303
MOD_CDK_SPxxK_3	121	128	PF00069	0.446
MOD_CK1_1	102	108	PF00069	0.531
MOD_CK2_1	47	53	PF00069	0.283
MOD_GlcNHglycan	101	104	PF01048	0.409
MOD_GlcNHglycan	115	118	PF01048	0.662
MOD_GlcNHglycan	33	37	PF01048	0.543
MOD_GSK3_1	152	159	PF00069	0.398
MOD_GSK3_1	177	184	PF00069	0.481
MOD_GSK3_1	28	35	PF00069	0.504
MOD_GSK3_1	57	64	PF00069	0.455
MOD_GSK3_1	98	105	PF00069	0.472
MOD_N-GLC_1	113	118	PF02516	0.499
MOD_NEK2_1	13	18	PF00069	0.449
MOD_NEK2_1	145	150	PF00069	0.596
MOD_NEK2_1	32	37	PF00069	0.314
MOD_NEK2_1	38	43	PF00069	0.408
MOD_NEK2_2	65	70	PF00069	0.503
MOD_PIKK_1	108	114	PF00454	0.612
MOD_PIKK_1	156	162	PF00454	0.438
MOD_PKA_2	187	193	PF00069	0.487
MOD_PKA_2	23	29	PF00069	0.424
MOD_PKA_2	38	44	PF00069	0.254
MOD_PKA_2	8	14	PF00069	0.484
MOD_PKA_2	98	104	PF00069	0.367
MOD_Plk_1	28	34	PF00069	0.528
MOD_Plk_4	130	136	PF00069	0.560
MOD_Plk_4	145	151	PF00069	0.537
MOD_Plk_4	177	183	PF00069	0.367
MOD_Plk_4	187	193	PF00069	0.419
MOD_Plk_4	8	14	PF00069	0.555
MOD_ProDKin_1	121	127	PF00069	0.452
MOD_ProDKin_1	61	67	PF00069	0.479
TRG_NES_CRM1_1	156	168	PF08389	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI4	Leptomonas seymouri	47%	89%
A0A1X0P1T8	Trypanosomatidae	28%	78%
A0A3S5IQJ3	Trypanosoma rangeli	28%	85%
A0A3S7X6D3	Leishmania donovani	86%	100%
D0A4Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AHN2	Leishmania infantum	86%	100%
E9B3N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q4F5	Leishmania major	87%	100%
V5AM33	Trypanosoma cruzi	30%	82%