Putative d-xylulose reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

d-xylulose reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HL87_LEIBR

TriTrypDb:

LbrM.33.0510 , LBRM2903_330010300

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL87

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0047939	L-glucuronate reductase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.742
CLV_PCSK_SKI1_1	128	132	PF00082	0.667
CLV_PCSK_SKI1_1	74	78	PF00082	0.630
DEG_Nend_UBRbox_3	1	3	PF02207	0.713
DOC_CYCLIN_RxL_1	90	101	PF00134	0.562
DOC_MAPK_gen_1	125	134	PF00069	0.672
DOC_MAPK_gen_1	29	37	PF00069	0.752
DOC_MAPK_gen_1	8	14	PF00069	0.728
DOC_MAPK_MEF2A_6	125	134	PF00069	0.672
DOC_PP1_RVXF_1	72	79	PF00149	0.646
DOC_PP1_RVXF_1	91	98	PF00149	0.314
DOC_USP7_UBL2_3	113	117	PF12436	0.411
DOC_USP7_UBL2_3	99	103	PF12436	0.652
LIG_14-3-3_CanoR_1	8	14	PF00244	0.728
LIG_14-3-3_CanoR_1	93	98	PF00244	0.651
LIG_APCC_ABBA_1	134	139	PF00400	0.625
LIG_APCC_ABBA_1	146	151	PF00400	0.535
LIG_BRCT_BRCA1_1	106	110	PF00533	0.633
LIG_FHA_1	139	145	PF00498	0.686
LIG_FHA_1	160	166	PF00498	0.750
LIG_FHA_1	51	57	PF00498	0.642
LIG_LIR_Gen_1	75	84	PF02991	0.647
LIG_LIR_Nem_3	75	81	PF02991	0.642
LIG_LYPXL_S_1	87	91	PF13949	0.643
LIG_LYPXL_yS_3	88	91	PF13949	0.646
LIG_PDZ_Class_1	163	168	PF00595	0.753
LIG_Pex14_2	78	82	PF04695	0.650
LIG_SH2_CRK	84	88	PF00017	0.652
LIG_SH2_NCK_1	45	49	PF00017	0.666
LIG_SH2_SRC	45	48	PF00017	0.666
LIG_SH2_STAP1	119	123	PF00017	0.679
LIG_SH2_STAP1	45	49	PF00017	0.666
LIG_SH3_3	54	60	PF00018	0.657
LIG_UBA3_1	91	99	PF00899	0.649
LIG_WRC_WIRS_1	94	99	PF05994	0.564
MOD_GlcNHglycan	106	109	PF01048	0.592
MOD_GlcNHglycan	165	168	PF01048	0.755
MOD_GSK3_1	153	160	PF00069	0.736
MOD_LATS_1	157	163	PF00433	0.750
MOD_NEK2_1	112	117	PF00069	0.579
MOD_PK_1	31	37	PF00069	0.762
MOD_PKA_2	153	159	PF00069	0.734
MOD_PKA_2	7	13	PF00069	0.730
MOD_Plk_1	74	80	PF00069	0.638
MOD_Plk_4	77	83	PF00069	0.650
MOD_SUMO_rev_2	120	130	PF00179	0.680
MOD_SUMO_rev_2	3	10	PF00179	0.727
MOD_SUMO_rev_2	96	105	PF00179	0.653
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.455
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.643
TRG_ENDOCYTIC_2	84	87	PF00928	0.652
TRG_ENDOCYTIC_2	88	91	PF00928	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A2QAC0	ASPNC	27%	44%
P07846	SHEEP	33%	47%
P0DMQ6	CHICK	33%	47%
P27867	RAT	34%	47%
P36624	SCHPO	34%	47%
P77280	ECOLI	36%	48%
Q06004	BACSU	31%	48%
Q07993	YEAST	38%	47%
Q1PSI9	VITVI	32%	46%
Q58D31	BOVIN	33%	47%
Q59545	MORMO	69%	50%
Q5R5F3	PONAB	35%	47%
Q64442	MOUSE	36%	47%
Q7SI09	NEUCR	30%	46%
Q8U7Y1	AGRFC	45%	48%
Q92MT4	RHIME	60%	49%
Q96V44	HYPJE	29%	45%
Q98D10	RHILO	48%	48%