SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL86_LEIBR

TriTrypDb:

LbrM.33.0500 , LBRM2903_330010200

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL86

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.393
CLV_NRD_NRD_1	31	33	PF00675	0.596
CLV_NRD_NRD_1	317	319	PF00675	0.636
CLV_NRD_NRD_1	592	594	PF00675	0.320
CLV_NRD_NRD_1	648	650	PF00675	0.550
CLV_NRD_NRD_1	700	702	PF00675	0.290
CLV_NRD_NRD_1	822	824	PF00675	0.353
CLV_PCSK_KEX2_1	31	33	PF00082	0.596
CLV_PCSK_KEX2_1	317	319	PF00082	0.636
CLV_PCSK_KEX2_1	486	488	PF00082	0.288
CLV_PCSK_KEX2_1	647	649	PF00082	0.479
CLV_PCSK_KEX2_1	700	702	PF00082	0.290
CLV_PCSK_KEX2_1	822	824	PF00082	0.353
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.280
CLV_PCSK_SKI1_1	141	145	PF00082	0.634
CLV_PCSK_SKI1_1	161	165	PF00082	0.412
CLV_PCSK_SKI1_1	211	215	PF00082	0.506
CLV_PCSK_SKI1_1	218	222	PF00082	0.556
CLV_PCSK_SKI1_1	479	483	PF00082	0.468
CLV_PCSK_SKI1_1	508	512	PF00082	0.320
CLV_PCSK_SKI1_1	594	598	PF00082	0.373
CLV_PCSK_SKI1_1	69	73	PF00082	0.569
CLV_PCSK_SKI1_1	711	715	PF00082	0.450
DEG_APCC_DBOX_1	217	225	PF00400	0.537
DEG_SCF_FBW7_1	125	132	PF00400	0.480
DEG_SPOP_SBC_1	298	302	PF00917	0.508
DEG_SPOP_SBC_1	91	95	PF00917	0.471
DOC_CDC14_PxL_1	444	452	PF14671	0.644
DOC_CYCLIN_RxL_1	708	716	PF00134	0.448
DOC_MAPK_gen_1	216	224	PF00069	0.491
DOC_MAPK_gen_1	341	351	PF00069	0.515
DOC_MAPK_MEF2A_6	216	224	PF00069	0.482
DOC_MAPK_MEF2A_6	344	351	PF00069	0.514
DOC_MAPK_MEF2A_6	616	625	PF00069	0.475
DOC_MAPK_MEF2A_6	78	86	PF00069	0.580
DOC_PP1_RVXF_1	429	436	PF00149	0.532
DOC_PP2B_LxvP_1	49	52	PF13499	0.612
DOC_USP7_MATH_1	129	133	PF00917	0.629
DOC_USP7_MATH_1	148	152	PF00917	0.386
DOC_USP7_MATH_1	155	159	PF00917	0.473
DOC_USP7_MATH_1	180	184	PF00917	0.389
DOC_USP7_MATH_1	227	231	PF00917	0.487
DOC_USP7_MATH_1	249	253	PF00917	0.638
DOC_USP7_MATH_1	334	338	PF00917	0.520
DOC_USP7_MATH_1	395	399	PF00917	0.593
DOC_USP7_MATH_1	425	429	PF00917	0.545
DOC_USP7_MATH_1	440	444	PF00917	0.523
DOC_USP7_MATH_1	496	500	PF00917	0.500
DOC_USP7_MATH_1	685	689	PF00917	0.509
DOC_USP7_MATH_1	691	695	PF00917	0.392
DOC_USP7_MATH_1	852	856	PF00917	0.367
DOC_USP7_MATH_1	91	95	PF00917	0.682
DOC_USP7_UBL2_3	482	486	PF12436	0.431
DOC_WW_Pin1_4	125	130	PF00397	0.545
DOC_WW_Pin1_4	391	396	PF00397	0.531
DOC_WW_Pin1_4	529	534	PF00397	0.520
DOC_WW_Pin1_4	92	97	PF00397	0.483
LIG_14-3-3_CanoR_1	124	128	PF00244	0.738
LIG_14-3-3_CanoR_1	161	171	PF00244	0.549
LIG_14-3-3_CanoR_1	198	208	PF00244	0.596
LIG_14-3-3_CanoR_1	216	221	PF00244	0.566
LIG_14-3-3_CanoR_1	44	49	PF00244	0.639
LIG_14-3-3_CanoR_1	660	664	PF00244	0.481
LIG_14-3-3_CanoR_1	8	13	PF00244	0.516
LIG_14-3-3_CanoR_1	859	863	PF00244	0.444
LIG_Actin_WH2_2	767	785	PF00022	0.280
LIG_APCC_ABBA_1	144	149	PF00400	0.562
LIG_BIR_III_4	99	103	PF00653	0.635
LIG_BRCT_BRCA1_1	227	231	PF00533	0.405
LIG_Clathr_ClatBox_1	526	530	PF01394	0.415
LIG_Clathr_ClatBox_1	702	706	PF01394	0.354
LIG_CSL_BTD_1	13	16	PF09270	0.502
LIG_deltaCOP1_diTrp_1	633	638	PF00928	0.429
LIG_EVH1_1	49	53	PF00568	0.666
LIG_FHA_1	165	171	PF00498	0.643
LIG_FHA_1	217	223	PF00498	0.665
LIG_FHA_1	248	254	PF00498	0.411
LIG_FHA_1	323	329	PF00498	0.606
LIG_FHA_1	35	41	PF00498	0.661
LIG_FHA_1	357	363	PF00498	0.417
LIG_FHA_1	566	572	PF00498	0.398
LIG_FHA_1	60	66	PF00498	0.600
LIG_FHA_1	714	720	PF00498	0.359
LIG_FHA_2	111	117	PF00498	0.525
LIG_FHA_2	163	169	PF00498	0.424
LIG_FHA_2	276	282	PF00498	0.466
LIG_FHA_2	298	304	PF00498	0.520
LIG_FHA_2	37	43	PF00498	0.515
LIG_FHA_2	750	756	PF00498	0.438
LIG_FHA_2	868	874	PF00498	0.432
LIG_GBD_Chelix_1	663	671	PF00786	0.317
LIG_GBD_Chelix_1	733	741	PF00786	0.329
LIG_Integrin_isoDGR_2	122	124	PF01839	0.441
LIG_LIR_Gen_1	167	177	PF02991	0.397
LIG_LIR_Gen_1	632	638	PF02991	0.432
LIG_LIR_Gen_1	716	725	PF02991	0.414
LIG_LIR_Gen_1	831	841	PF02991	0.397
LIG_LIR_Nem_3	11	17	PF02991	0.749
LIG_LIR_Nem_3	116	121	PF02991	0.502
LIG_LIR_Nem_3	167	172	PF02991	0.545
LIG_LIR_Nem_3	632	637	PF02991	0.436
LIG_LIR_Nem_3	716	721	PF02991	0.418
LIG_LIR_Nem_3	831	836	PF02991	0.377
LIG_LYPXL_SIV_4	729	737	PF13949	0.382
LIG_NRBOX	220	226	PF00104	0.540
LIG_NRBOX	361	367	PF00104	0.568
LIG_PCNA_yPIPBox_3	575	587	PF02747	0.305
LIG_Pex14_1	634	638	PF04695	0.426
LIG_PTAP_UEV_1	444	449	PF05743	0.581
LIG_Rb_LxCxE_1	873	888	PF01857	0.480
LIG_Rb_pABgroove_1	109	117	PF01858	0.426
LIG_SH2_CRK	497	501	PF00017	0.415
LIG_SH2_CRK	730	734	PF00017	0.366
LIG_SH2_NCK_1	147	151	PF00017	0.552
LIG_SH2_NCK_1	730	734	PF00017	0.366
LIG_SH2_PTP2	833	836	PF00017	0.391
LIG_SH2_SRC	147	150	PF00017	0.559
LIG_SH2_SRC	564	567	PF00017	0.408
LIG_SH2_STAP1	730	734	PF00017	0.366
LIG_SH2_STAP1	860	864	PF00017	0.431
LIG_SH2_STAT5	287	290	PF00017	0.627
LIG_SH2_STAT5	469	472	PF00017	0.509
LIG_SH2_STAT5	497	500	PF00017	0.415
LIG_SH2_STAT5	564	567	PF00017	0.408
LIG_SH2_STAT5	773	776	PF00017	0.407
LIG_SH2_STAT5	833	836	PF00017	0.394
LIG_SH3_3	10	16	PF00018	0.591
LIG_SH3_3	130	136	PF00018	0.466
LIG_SH3_3	387	393	PF00018	0.489
LIG_SH3_3	442	448	PF00018	0.649
LIG_SH3_3	47	53	PF00018	0.670
LIG_SH3_3	813	819	PF00018	0.361
LIG_SUMO_SIM_anti_2	873	879	PF11976	0.300
LIG_SUMO_SIM_par_1	109	116	PF11976	0.426
LIG_SUMO_SIM_par_1	345	352	PF11976	0.512
LIG_SUMO_SIM_par_1	36	42	PF11976	0.661
LIG_SUMO_SIM_par_1	525	530	PF11976	0.520
LIG_SUMO_SIM_par_1	701	706	PF11976	0.357
LIG_TRAF2_1	556	559	PF00917	0.471
LIG_TRAF2_1	656	659	PF00917	0.391
LIG_TRAF2_1	752	755	PF00917	0.370
LIG_WRC_WIRS_1	853	858	PF05994	0.363
LIG_WW_3	464	468	PF00397	0.635
MOD_CDK_SPK_2	391	396	PF00069	0.531
MOD_CDK_SPxK_1	529	535	PF00069	0.228
MOD_CK1_1	229	235	PF00069	0.487
MOD_CK1_1	337	343	PF00069	0.538
MOD_CK1_1	36	42	PF00069	0.514
MOD_CK1_1	418	424	PF00069	0.548
MOD_CK1_1	443	449	PF00069	0.586
MOD_CK1_1	503	509	PF00069	0.273
MOD_CK1_1	694	700	PF00069	0.313
MOD_CK1_1	739	745	PF00069	0.374
MOD_CK1_1	87	93	PF00069	0.459
MOD_CK2_1	162	168	PF00069	0.424
MOD_CK2_1	238	244	PF00069	0.288
MOD_CK2_1	297	303	PF00069	0.537
MOD_CK2_1	553	559	PF00069	0.479
MOD_CK2_1	571	577	PF00069	0.293
MOD_CK2_1	652	658	PF00069	0.424
MOD_CK2_1	749	755	PF00069	0.427
MOD_CK2_1	867	873	PF00069	0.360
MOD_CK2_1	876	882	PF00069	0.387
MOD_CMANNOS	377	380	PF00535	0.444
MOD_Cter_Amidation	29	32	PF01082	0.535
MOD_GlcNHglycan	184	187	PF01048	0.403
MOD_GlcNHglycan	2	5	PF01048	0.632
MOD_GlcNHglycan	231	234	PF01048	0.475
MOD_GlcNHglycan	27	31	PF01048	0.528
MOD_GlcNHglycan	314	317	PF01048	0.536
MOD_GlcNHglycan	332	335	PF01048	0.636
MOD_GlcNHglycan	337	340	PF01048	0.611
MOD_GlcNHglycan	355	359	PF01048	0.499
MOD_GlcNHglycan	445	448	PF01048	0.602
MOD_GlcNHglycan	504	508	PF01048	0.334
MOD_GlcNHglycan	555	558	PF01048	0.341
MOD_GlcNHglycan	654	657	PF01048	0.467
MOD_GlcNHglycan	686	690	PF01048	0.450
MOD_GlcNHglycan	741	744	PF01048	0.365
MOD_GlcNHglycan	89	92	PF01048	0.531
MOD_GSK3_1	123	130	PF00069	0.643
MOD_GSK3_1	155	162	PF00069	0.496
MOD_GSK3_1	225	232	PF00069	0.494
MOD_GSK3_1	243	250	PF00069	0.369
MOD_GSK3_1	289	296	PF00069	0.547
MOD_GSK3_1	322	329	PF00069	0.647
MOD_GSK3_1	330	337	PF00069	0.539
MOD_GSK3_1	34	41	PF00069	0.545
MOD_GSK3_1	391	398	PF00069	0.558
MOD_GSK3_1	421	428	PF00069	0.593
MOD_GSK3_1	439	446	PF00069	0.462
MOD_GSK3_1	496	503	PF00069	0.305
MOD_GSK3_1	565	572	PF00069	0.397
MOD_GSK3_1	629	636	PF00069	0.569
MOD_GSK3_1	709	716	PF00069	0.445
MOD_GSK3_1	87	94	PF00069	0.458
MOD_NEK2_1	159	164	PF00069	0.573
MOD_NEK2_1	225	230	PF00069	0.584
MOD_NEK2_1	238	243	PF00069	0.312
MOD_NEK2_1	571	576	PF00069	0.398
MOD_NEK2_1	626	631	PF00069	0.482
MOD_NEK2_1	728	733	PF00069	0.412
MOD_NEK2_1	737	742	PF00069	0.339
MOD_NEK2_1	774	779	PF00069	0.385
MOD_NEK2_2	110	115	PF00069	0.426
MOD_OFUCOSY	644	651	PF10250	0.509
MOD_PIKK_1	425	431	PF00454	0.509
MOD_PIKK_1	571	577	PF00454	0.399
MOD_PK_1	386	392	PF00069	0.487
MOD_PKA_1	330	336	PF00069	0.550
MOD_PKA_1	415	421	PF00069	0.520
MOD_PKA_1	647	653	PF00069	0.491
MOD_PKA_2	123	129	PF00069	0.739
MOD_PKA_2	395	401	PF00069	0.545
MOD_PKA_2	43	49	PF00069	0.762
MOD_PKA_2	647	653	PF00069	0.491
MOD_PKA_2	659	665	PF00069	0.368
MOD_PKA_2	691	697	PF00069	0.372
MOD_PKA_2	7	13	PF00069	0.518
MOD_PKA_2	858	864	PF00069	0.439
MOD_Plk_1	148	154	PF00069	0.554
MOD_Plk_1	243	249	PF00069	0.454
MOD_Plk_1	386	392	PF00069	0.487
MOD_Plk_1	425	431	PF00069	0.502
MOD_Plk_1	558	564	PF00069	0.307
MOD_Plk_2-3	654	660	PF00069	0.402
MOD_Plk_4	110	116	PF00069	0.493
MOD_Plk_4	155	161	PF00069	0.417
MOD_Plk_4	361	367	PF00069	0.578
MOD_Plk_4	386	392	PF00069	0.546
MOD_Plk_4	44	50	PF00069	0.678
MOD_Plk_4	544	550	PF00069	0.307
MOD_Plk_4	560	566	PF00069	0.307
MOD_Plk_4	633	639	PF00069	0.523
MOD_Plk_4	691	697	PF00069	0.372
MOD_Plk_4	852	858	PF00069	0.420
MOD_ProDKin_1	125	131	PF00069	0.548
MOD_ProDKin_1	391	397	PF00069	0.534
MOD_ProDKin_1	529	535	PF00069	0.375
MOD_ProDKin_1	92	98	PF00069	0.488
MOD_SUMO_for_1	679	682	PF00179	0.531
TRG_DiLeu_BaEn_1	605	610	PF01217	0.433
TRG_DiLeu_BaEn_1	755	760	PF01217	0.397
TRG_DiLeu_BaEn_1	806	811	PF01217	0.430
TRG_DiLeu_BaEn_1	873	878	PF01217	0.375
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.571
TRG_DiLeu_BaLyEn_6	762	767	PF01217	0.410
TRG_ENDOCYTIC_2	497	500	PF00928	0.228
TRG_ENDOCYTIC_2	730	733	PF00928	0.369
TRG_ENDOCYTIC_2	773	776	PF00928	0.407
TRG_ENDOCYTIC_2	833	836	PF00928	0.391
TRG_ER_diArg_1	308	311	PF00400	0.582
TRG_ER_diArg_1	31	33	PF00400	0.599
TRG_ER_diArg_1	584	587	PF00400	0.385
TRG_ER_diArg_1	647	649	PF00400	0.530
TRG_ER_diArg_1	699	701	PF00400	0.294
TRG_ER_diArg_1	719	722	PF00400	0.323
TRG_ER_diArg_1	821	823	PF00400	0.349
TRG_NES_CRM1_1	693	706	PF08389	0.311
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEX7	Leptomonas seymouri	37%	91%
A0A3S7X6B7	Leishmania donovani	69%	88%
A4I8R4	Leishmania infantum	69%	88%
E9B3M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q4F8	Leishmania major	70%	100%