HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL85_LEIBR

TriTrypDb:

LbrM.33.0490 , LBRM2903_330010100

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.384
CLV_NRD_NRD_1	126	128	PF00675	0.307
CLV_NRD_NRD_1	32	34	PF00675	0.476
CLV_PCSK_SKI1_1	144	148	PF00082	0.445
CLV_PCSK_SKI1_1	151	155	PF00082	0.412
CLV_PCSK_SKI1_1	33	37	PF00082	0.424
CLV_PCSK_SKI1_1	62	66	PF00082	0.300
DEG_APCC_DBOX_1	150	158	PF00400	0.266
DEG_APCC_DBOX_1	61	69	PF00400	0.299
DEG_Nend_UBRbox_2	1	3	PF02207	0.391
DEG_SPOP_SBC_1	165	169	PF00917	0.338
DOC_MAPK_DCC_7	248	257	PF00069	0.394
DOC_MAPK_gen_1	125	134	PF00069	0.280
DOC_MAPK_MEF2A_6	248	257	PF00069	0.394
DOC_PP2B_LxvP_1	265	268	PF13499	0.380
DOC_PP4_FxxP_1	110	113	PF00568	0.594
DOC_USP7_MATH_1	164	168	PF00917	0.603
DOC_USP7_MATH_1	221	225	PF00917	0.641
DOC_WW_Pin1_4	49	54	PF00397	0.449
LIG_14-3-3_CanoR_1	101	107	PF00244	0.322
LIG_14-3-3_CanoR_1	11	16	PF00244	0.400
LIG_14-3-3_CanoR_1	127	134	PF00244	0.300
LIG_14-3-3_CanoR_1	293	301	PF00244	0.372
LIG_14-3-3_CanoR_1	33	42	PF00244	0.410
LIG_14-3-3_CanoR_1	86	91	PF00244	0.424
LIG_Actin_WH2_2	226	241	PF00022	0.487
LIG_BIR_III_4	78	82	PF00653	0.473
LIG_deltaCOP1_diTrp_1	7	15	PF00928	0.374
LIG_FHA_1	11	17	PF00498	0.419
LIG_FHA_1	272	278	PF00498	0.336
LIG_FHA_2	117	123	PF00498	0.585
LIG_FHA_2	133	139	PF00498	0.364
LIG_FHA_2	50	56	PF00498	0.453
LIG_HCF-1_HBM_1	74	77	PF13415	0.372
LIG_LIR_Apic_2	108	113	PF02991	0.470
LIG_LIR_Gen_1	167	177	PF02991	0.333
LIG_LIR_Nem_3	108	114	PF02991	0.470
LIG_LIR_Nem_3	167	173	PF02991	0.348
LIG_SH2_CRK	61	65	PF00017	0.444
LIG_SH2_NCK_1	197	201	PF00017	0.409
LIG_SH2_PTP2	111	114	PF00017	0.384
LIG_SH2_STAP1	142	146	PF00017	0.451
LIG_SH2_STAP1	6	10	PF00017	0.249
LIG_SH2_STAT5	111	114	PF00017	0.495
LIG_SH2_STAT5	176	179	PF00017	0.443
LIG_SH2_STAT5	197	200	PF00017	0.332
LIG_SH2_STAT5	43	46	PF00017	0.481
LIG_SH3_3	109	115	PF00018	0.521
LIG_Sin3_3	95	102	PF02671	0.414
LIG_TRAF2_1	120	123	PF00917	0.526
LIG_TYR_ITIM	109	114	PF00017	0.475
LIG_WRC_WIRS_1	87	92	PF05994	0.463
MOD_CAAXbox	299	302	PF01239	0.323
MOD_CDK_SPxxK_3	49	56	PF00069	0.296
MOD_CK2_1	116	122	PF00069	0.577
MOD_CK2_1	49	55	PF00069	0.474
MOD_GlcNHglycan	118	122	PF01048	0.629
MOD_GlcNHglycan	17	20	PF01048	0.409
MOD_GlcNHglycan	260	263	PF01048	0.403
MOD_GlcNHglycan	78	82	PF01048	0.399
MOD_GSK3_1	11	18	PF00069	0.392
MOD_GSK3_1	211	218	PF00069	0.540
MOD_GSK3_1	221	228	PF00069	0.396
MOD_LATS_1	31	37	PF00433	0.467
MOD_NEK2_1	132	137	PF00069	0.405
MOD_NEK2_1	15	20	PF00069	0.364
MOD_NEK2_1	256	261	PF00069	0.418
MOD_NEK2_1	44	49	PF00069	0.521
MOD_OFUCOSY	194	199	PF10250	0.439
MOD_PIKK_1	127	133	PF00454	0.299
MOD_PIKK_1	221	227	PF00454	0.606
MOD_PKA_1	127	133	PF00069	0.274
MOD_PKA_1	33	39	PF00069	0.458
MOD_PKA_2	10	16	PF00069	0.432
MOD_PKA_2	215	221	PF00069	0.699
MOD_PKB_1	125	133	PF00069	0.282
MOD_Plk_1	271	277	PF00069	0.398
MOD_Plk_2-3	175	181	PF00069	0.305
MOD_Plk_4	105	111	PF00069	0.446
MOD_Plk_4	11	17	PF00069	0.385
MOD_Plk_4	166	172	PF00069	0.509
MOD_Plk_4	86	92	PF00069	0.298
MOD_ProDKin_1	49	55	PF00069	0.444
MOD_SUMO_rev_2	141	148	PF00179	0.264
TRG_DiLeu_BaEn_1	272	277	PF01217	0.495
TRG_DiLeu_BaEn_1	37	42	PF01217	0.346
TRG_DiLeu_BaEn_1	94	99	PF01217	0.422
TRG_ENDOCYTIC_2	111	114	PF00928	0.495
TRG_ENDOCYTIC_2	61	64	PF00928	0.433
TRG_NES_CRM1_1	232	247	PF08389	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I587	Leptomonas seymouri	59%	98%
A0A0S4KI40	Bodo saltans	42%	100%
A0A1X0P0R2	Trypanosomatidae	43%	100%
A0A3R7LX07	Trypanosoma rangeli	41%	100%
A0A3S7X6G1	Leishmania donovani	78%	99%
A4I8R3	Leishmania infantum	78%	99%
D0A4Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q4F9	Leishmania major	80%	100%
V5BKA1	Trypanosoma cruzi	40%	100%