Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL83_LEIBR

TriTrypDb:

LbrM.33.0470 , LBRM2903_330009900

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.776
CLV_NRD_NRD_1	164	166	PF00675	0.601
CLV_NRD_NRD_1	221	223	PF00675	0.626
CLV_NRD_NRD_1	227	229	PF00675	0.535
CLV_NRD_NRD_1	231	233	PF00675	0.480
CLV_NRD_NRD_1	239	241	PF00675	0.393
CLV_NRD_NRD_1	248	250	PF00675	0.392
CLV_NRD_NRD_1	31	33	PF00675	0.674
CLV_NRD_NRD_1	327	329	PF00675	0.616
CLV_NRD_NRD_1	346	348	PF00675	0.401
CLV_NRD_NRD_1	387	389	PF00675	0.615
CLV_NRD_NRD_1	477	479	PF00675	0.589
CLV_NRD_NRD_1	507	509	PF00675	0.619
CLV_NRD_NRD_1	77	79	PF00675	0.620
CLV_PCSK_FUR_1	155	159	PF00082	0.568
CLV_PCSK_FUR_1	475	479	PF00082	0.461
CLV_PCSK_KEX2_1	157	159	PF00082	0.573
CLV_PCSK_KEX2_1	166	168	PF00082	0.510
CLV_PCSK_KEX2_1	221	223	PF00082	0.626
CLV_PCSK_KEX2_1	226	228	PF00082	0.557
CLV_PCSK_KEX2_1	239	241	PF00082	0.393
CLV_PCSK_KEX2_1	248	250	PF00082	0.567
CLV_PCSK_KEX2_1	31	33	PF00082	0.667
CLV_PCSK_KEX2_1	322	324	PF00082	0.597
CLV_PCSK_KEX2_1	327	329	PF00082	0.557
CLV_PCSK_KEX2_1	348	350	PF00082	0.489
CLV_PCSK_KEX2_1	387	389	PF00082	0.615
CLV_PCSK_KEX2_1	477	479	PF00082	0.589
CLV_PCSK_KEX2_1	76	78	PF00082	0.514
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.573
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.510
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.597
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.624
CLV_PCSK_PC7_1	222	228	PF00082	0.615
CLV_PCSK_PC7_1	323	329	PF00082	0.605
CLV_PCSK_SKI1_1	200	204	PF00082	0.545
CLV_PCSK_SKI1_1	232	236	PF00082	0.577
CLV_PCSK_SKI1_1	287	291	PF00082	0.477
CLV_PCSK_SKI1_1	395	399	PF00082	0.530
CLV_Separin_Metazoa	392	396	PF03568	0.277
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SCF_FBW7_1	305	312	PF00400	0.654
DEG_SPOP_SBC_1	114	118	PF00917	0.686
DOC_CKS1_1	595	600	PF01111	0.798
DOC_CYCLIN_RxL_1	72	85	PF00134	0.650
DOC_MAPK_gen_1	440	449	PF00069	0.454
DOC_MAPK_gen_1	74	84	PF00069	0.642
DOC_MAPK_MEF2A_6	442	451	PF00069	0.448
DOC_MAPK_MEF2A_6	51	60	PF00069	0.801
DOC_MAPK_MEF2A_6	76	84	PF00069	0.659
DOC_MAPK_NFAT4_5	77	85	PF00069	0.663
DOC_MAPK_RevD_3	462	478	PF00069	0.554
DOC_PP2B_LxvP_1	523	526	PF13499	0.788
DOC_USP7_MATH_1	106	110	PF00917	0.666
DOC_USP7_MATH_1	112	116	PF00917	0.630
DOC_USP7_MATH_1	175	179	PF00917	0.686
DOC_USP7_MATH_1	332	336	PF00917	0.797
DOC_USP7_MATH_1	377	381	PF00917	0.636
DOC_USP7_MATH_1	432	436	PF00917	0.506
DOC_USP7_MATH_1	473	477	PF00917	0.662
DOC_USP7_MATH_1	552	556	PF00917	0.815
DOC_USP7_MATH_1	580	584	PF00917	0.800
DOC_USP7_MATH_1	621	625	PF00917	0.277
DOC_USP7_MATH_1	92	96	PF00917	0.788
DOC_USP7_MATH_1	98	102	PF00917	0.743
DOC_USP7_UBL2_3	189	193	PF12436	0.839
DOC_WW_Pin1_4	266	271	PF00397	0.674
DOC_WW_Pin1_4	305	310	PF00397	0.742
DOC_WW_Pin1_4	566	571	PF00397	0.803
DOC_WW_Pin1_4	594	599	PF00397	0.790
LIG_14-3-3_CanoR_1	167	172	PF00244	0.740
LIG_14-3-3_CanoR_1	210	217	PF00244	0.704
LIG_14-3-3_CanoR_1	226	235	PF00244	0.720
LIG_14-3-3_CanoR_1	243	251	PF00244	0.619
LIG_14-3-3_CanoR_1	287	292	PF00244	0.663
LIG_14-3-3_CanoR_1	303	309	PF00244	0.620
LIG_14-3-3_CanoR_1	32	42	PF00244	0.838
LIG_14-3-3_CanoR_1	395	405	PF00244	0.530
LIG_14-3-3_CanoR_1	565	570	PF00244	0.769
LIG_14-3-3_CanoR_1	608	614	PF00244	0.659
LIG_14-3-3_CanoR_1	619	628	PF00244	0.424
LIG_14-3-3_CanoR_1	668	674	PF00244	0.433
LIG_14-3-3_CanoR_1	77	83	PF00244	0.705
LIG_14-3-3_CanoR_1	86	92	PF00244	0.797
LIG_BIR_III_2	657	661	PF00653	0.496
LIG_BRCT_BRCA1_1	582	586	PF00533	0.792
LIG_CtBP_PxDLS_1	448	452	PF00389	0.530
LIG_eIF4E_1	672	678	PF01652	0.603
LIG_FHA_1	114	120	PF00498	0.845
LIG_FHA_1	229	235	PF00498	0.791
LIG_FHA_1	288	294	PF00498	0.676
LIG_FHA_1	306	312	PF00498	0.779
LIG_FHA_1	363	369	PF00498	0.822
LIG_FHA_1	439	445	PF00498	0.429
LIG_FHA_1	517	523	PF00498	0.792
LIG_FHA_1	595	601	PF00498	0.621
LIG_FHA_2	218	224	PF00498	0.792
LIG_FHA_2	280	286	PF00498	0.728
LIG_FHA_2	489	495	PF00498	0.681
LIG_FHA_2	639	645	PF00498	0.556
LIG_FHA_2	85	91	PF00498	0.688
LIG_Integrin_RGD_1	349	351	PF01839	0.602
LIG_IRF3_LxIS_1	598	604	PF10401	0.638
LIG_LIR_Apic_2	494	500	PF02991	0.654
LIG_LIR_Gen_1	148	159	PF02991	0.666
LIG_LIR_Gen_1	583	594	PF02991	0.778
LIG_LIR_Nem_3	148	154	PF02991	0.663
LIG_LIR_Nem_3	583	589	PF02991	0.787
LIG_NRBOX	519	525	PF00104	0.786
LIG_NRBOX	588	594	PF00104	0.761
LIG_NRBOX	6	12	PF00104	0.786
LIG_RPA_C_Fungi	10	22	PF08784	0.522
LIG_SH2_CRK	252	256	PF00017	0.775
LIG_SH2_STAP1	516	520	PF00017	0.755
LIG_SH2_STAT3	341	344	PF00017	0.542
LIG_SH2_STAT5	252	255	PF00017	0.775
LIG_SH3_3	379	385	PF00018	0.581
LIG_SH3_3	570	576	PF00018	0.766
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.465
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.597
LIG_SUMO_SIM_par_1	289	295	PF11976	0.563
LIG_SUMO_SIM_par_1	312	318	PF11976	0.544
LIG_SUMO_SIM_par_1	521	528	PF11976	0.489
LIG_SUMO_SIM_par_1	591	597	PF11976	0.474
LIG_SUMO_SIM_par_1	599	604	PF11976	0.505
LIG_TRAF2_1	282	285	PF00917	0.572
LIG_TRAF2_1	87	90	PF00917	0.604
LIG_UBA3_1	56	64	PF00899	0.533
MOD_CK1_1	101	107	PF00069	0.623
MOD_CK1_1	113	119	PF00069	0.763
MOD_CK1_1	242	248	PF00069	0.726
MOD_CK1_1	35	41	PF00069	0.848
MOD_CK1_1	380	386	PF00069	0.744
MOD_CK1_1	400	406	PF00069	0.231
MOD_CK1_1	476	482	PF00069	0.595
MOD_CK1_1	568	574	PF00069	0.691
MOD_CK1_1	612	618	PF00069	0.747
MOD_CK1_1	85	91	PF00069	0.760
MOD_CK2_1	253	259	PF00069	0.531
MOD_CK2_1	279	285	PF00069	0.576
MOD_CK2_1	332	338	PF00069	0.508
MOD_CK2_1	488	494	PF00069	0.594
MOD_CK2_1	582	588	PF00069	0.745
MOD_CK2_1	638	644	PF00069	0.316
MOD_CK2_1	84	90	PF00069	0.600
MOD_GlcNHglycan	143	146	PF01048	0.741
MOD_GlcNHglycan	244	247	PF01048	0.709
MOD_GlcNHglycan	334	337	PF01048	0.507
MOD_GlcNHglycan	378	382	PF01048	0.736
MOD_GlcNHglycan	400	403	PF01048	0.316
MOD_GlcNHglycan	428	431	PF01048	0.637
MOD_GlcNHglycan	470	473	PF01048	0.580
MOD_GlcNHglycan	488	491	PF01048	0.640
MOD_GlcNHglycan	494	497	PF01048	0.643
MOD_GlcNHglycan	582	585	PF01048	0.590
MOD_GlcNHglycan	611	614	PF01048	0.562
MOD_GlcNHglycan	66	69	PF01048	0.795
MOD_GlcNHglycan	94	97	PF01048	0.644
MOD_GSK3_1	106	113	PF00069	0.659
MOD_GSK3_1	114	121	PF00069	0.606
MOD_GSK3_1	141	148	PF00069	0.744
MOD_GSK3_1	209	216	PF00069	0.823
MOD_GSK3_1	235	242	PF00069	0.503
MOD_GSK3_1	253	260	PF00069	0.464
MOD_GSK3_1	294	301	PF00069	0.783
MOD_GSK3_1	305	312	PF00069	0.596
MOD_GSK3_1	32	39	PF00069	0.622
MOD_GSK3_1	396	403	PF00069	0.299
MOD_GSK3_1	428	435	PF00069	0.740
MOD_GSK3_1	488	495	PF00069	0.569
MOD_GSK3_1	561	568	PF00069	0.531
MOD_GSK3_1	599	606	PF00069	0.756
MOD_GSK3_1	609	616	PF00069	0.613
MOD_GSK3_1	78	85	PF00069	0.782
MOD_GSK3_1	92	99	PF00069	0.648
MOD_LATS_1	30	36	PF00433	0.649
MOD_N-GLC_1	106	111	PF02516	0.818
MOD_N-GLC_1	257	262	PF02516	0.560
MOD_NEK2_1	141	146	PF00069	0.554
MOD_NEK2_1	176	181	PF00069	0.604
MOD_NEK2_1	209	214	PF00069	0.821
MOD_NEK2_1	235	240	PF00069	0.512
MOD_NEK2_1	304	309	PF00069	0.773
MOD_NEK2_1	398	403	PF00069	0.530
MOD_NEK2_1	467	472	PF00069	0.761
MOD_NEK2_1	601	606	PF00069	0.546
MOD_NEK2_1	82	87	PF00069	0.844
MOD_NEK2_2	98	103	PF00069	0.682
MOD_PIKK_1	121	127	PF00454	0.730
MOD_PIKK_1	215	221	PF00454	0.560
MOD_PIKK_1	85	91	PF00454	0.603
MOD_PK_1	110	116	PF00069	0.598
MOD_PKA_1	165	171	PF00069	0.756
MOD_PKA_1	227	233	PF00069	0.760
MOD_PKA_1	239	245	PF00069	0.550
MOD_PKA_2	176	182	PF00069	0.604
MOD_PKA_2	209	215	PF00069	0.617
MOD_PKA_2	227	233	PF00069	0.690
MOD_PKA_2	235	241	PF00069	0.626
MOD_PKA_2	242	248	PF00069	0.478
MOD_PKA_2	264	270	PF00069	0.646
MOD_PKA_2	383	389	PF00069	0.757
MOD_PKA_2	415	421	PF00069	0.465
MOD_PKA_2	476	482	PF00069	0.814
MOD_PKA_2	607	613	PF00069	0.565
MOD_PKA_2	667	673	PF00069	0.533
MOD_PKA_2	85	91	PF00069	0.806
MOD_PKB_1	165	173	PF00069	0.756
MOD_PKB_1	226	234	PF00069	0.761
MOD_PKB_1	76	84	PF00069	0.570
MOD_Plk_1	110	116	PF00069	0.598
MOD_Plk_1	377	383	PF00069	0.530
MOD_Plk_2-3	2	8	PF00069	0.731
MOD_Plk_4	115	121	PF00069	0.846
MOD_Plk_4	2	8	PF00069	0.731
MOD_Plk_4	309	315	PF00069	0.806
MOD_Plk_4	415	421	PF00069	0.541
MOD_Plk_4	432	438	PF00069	0.435
MOD_Plk_4	568	574	PF00069	0.766
MOD_Plk_4	582	588	PF00069	0.514
MOD_Plk_4	596	602	PF00069	0.495
MOD_ProDKin_1	266	272	PF00069	0.582
MOD_ProDKin_1	305	311	PF00069	0.681
MOD_ProDKin_1	566	572	PF00069	0.768
MOD_ProDKin_1	594	600	PF00069	0.750
MOD_SUMO_rev_2	161	168	PF00179	0.720
MOD_SUMO_rev_2	555	561	PF00179	0.530
TRG_DiLeu_BaEn_1	198	203	PF01217	0.594
TRG_DiLeu_BaEn_1	588	593	PF01217	0.466
TRG_DiLeu_BaEn_4	538	544	PF01217	0.480
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.760
TRG_ENDOCYTIC_2	151	154	PF00928	0.564
TRG_ENDOCYTIC_2	252	255	PF00928	0.775
TRG_ER_diArg_1	225	228	PF00400	0.617
TRG_ER_diArg_1	239	241	PF00400	0.482
TRG_ER_diArg_1	247	249	PF00400	0.742
TRG_ER_diArg_1	326	328	PF00400	0.776
TRG_ER_diArg_1	346	349	PF00400	0.468
TRG_ER_diArg_1	387	390	PF00400	0.774
TRG_ER_diArg_1	474	477	PF00400	0.820
TRG_ER_diArg_1	76	78	PF00400	0.543
TRG_NES_CRM1_1	415	426	PF08389	0.721
TRG_NLS_MonoExtC_3	165	171	PF00514	0.756
TRG_NLS_MonoExtN_4	165	170	PF00514	0.740
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.799
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6F7	Leishmania donovani	65%	87%
A4I8R1	Leishmania infantum	65%	87%
E9B3M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q4G1	Leishmania major	65%	100%