Putative deoxyribodipyrimidine photolyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyribodipyrimidine photo-lyase, putative

Species:

Leishmania braziliensis

UniProt:

A4HL82_LEIBR

TriTrypDb:

LbrM.33.0460 , LBRM2903_330009800

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL82

Function

Biological processes
Term	Name	Level	Count
GO:0007623	circadian rhythm	2	1
GO:0009314	response to radiation	3	1
GO:0009416	response to light stimulus	4	1
GO:0009605	response to external stimulus	2	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009648	photoperiodism	5	1
GO:0009649	entrainment of circadian clock	3	1
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0032501	multicellular organismal process	1	1
GO:0032922	circadian regulation of gene expression	2	1
GO:0042752	regulation of circadian rhythm	3	1
GO:0043153	entrainment of circadian clock by photoperiod	4	1
GO:0048511	rhythmic process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050896	response to stimulus	1	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003904	deoxyribodipyrimidine photo-lyase activity	5	7
GO:0003913	DNA photolyase activity	4	7
GO:0016829	lyase activity	2	8
GO:0016830	carbon-carbon lyase activity	3	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0000166	nucleotide binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.280
CLV_NRD_NRD_1	255	257	PF00675	0.283
CLV_NRD_NRD_1	33	35	PF00675	0.233
CLV_PCSK_KEX2_1	114	116	PF00082	0.235
CLV_PCSK_KEX2_1	18	20	PF00082	0.463
CLV_PCSK_KEX2_1	2	4	PF00082	0.616
CLV_PCSK_KEX2_1	246	248	PF00082	0.470
CLV_PCSK_KEX2_1	255	257	PF00082	0.283
CLV_PCSK_KEX2_1	33	35	PF00082	0.204
CLV_PCSK_KEX2_1	500	502	PF00082	0.287
CLV_PCSK_KEX2_1	506	508	PF00082	0.243
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.463
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.616
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.452
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.287
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.243
CLV_PCSK_SKI1_1	380	384	PF00082	0.257
CLV_PCSK_SKI1_1	462	466	PF00082	0.287
CLV_PCSK_SKI1_1	522	526	PF00082	0.344
DEG_APCC_DBOX_1	32	40	PF00400	0.487
DEG_Nend_UBRbox_1	1	4	PF02207	0.636
DEG_SPOP_SBC_1	509	513	PF00917	0.375
DOC_CDC14_PxL_1	465	473	PF14671	0.500
DOC_CKS1_1	179	184	PF01111	0.457
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.450
DOC_MAPK_gen_1	204	211	PF00069	0.341
DOC_MAPK_gen_1	366	374	PF00069	0.500
DOC_MAPK_MEF2A_6	24	31	PF00069	0.354
DOC_PP1_RVXF_1	122	129	PF00149	0.457
DOC_PP1_RVXF_1	300	307	PF00149	0.461
DOC_PP4_FxxP_1	315	318	PF00568	0.500
DOC_PP4_FxxP_1	63	66	PF00568	0.433
DOC_USP7_MATH_1	52	56	PF00917	0.454
DOC_USP7_UBL2_3	332	336	PF12436	0.436
DOC_USP7_UBL2_3	488	492	PF12436	0.375
DOC_USP7_UBL2_3	522	526	PF12436	0.497
DOC_USP7_UBL2_3	533	537	PF12436	0.450
DOC_WW_Pin1_4	130	135	PF00397	0.433
DOC_WW_Pin1_4	178	183	PF00397	0.433
DOC_WW_Pin1_4	270	275	PF00397	0.381
DOC_WW_Pin1_4	5	10	PF00397	0.557
LIG_14-3-3_CanoR_1	227	235	PF00244	0.432
LIG_14-3-3_CanoR_1	380	387	PF00244	0.500
LIG_14-3-3_CanoR_1	413	419	PF00244	0.457
LIG_14-3-3_CanoR_1	452	459	PF00244	0.439
LIG_14-3-3_CanoR_1	507	517	PF00244	0.375
LIG_14-3-3_CanoR_1	54	59	PF00244	0.524
LIG_Actin_WH2_2	98	116	PF00022	0.435
LIG_AP2alpha_1	77	81	PF02296	0.487
LIG_BIR_III_2	440	444	PF00653	0.457
LIG_BRCT_BRCA1_1	453	457	PF00533	0.487
LIG_Clathr_ClatBox_1	89	93	PF01394	0.487
LIG_deltaCOP1_diTrp_1	407	415	PF00928	0.433
LIG_FHA_1	267	273	PF00498	0.381
LIG_FHA_1	281	287	PF00498	0.392
LIG_FHA_1	299	305	PF00498	0.291
LIG_FHA_1	415	421	PF00498	0.433
LIG_FHA_1	523	529	PF00498	0.457
LIG_IBAR_NPY_1	74	76	PF08397	0.479
LIG_LIR_Apic_2	511	517	PF02991	0.433
LIG_LIR_Apic_2	60	66	PF02991	0.375
LIG_LIR_Gen_1	174	184	PF02991	0.483
LIG_LIR_Gen_1	308	318	PF02991	0.433
LIG_LIR_Gen_1	360	367	PF02991	0.492
LIG_LIR_Gen_1	412	422	PF02991	0.433
LIG_LIR_Gen_1	447	455	PF02991	0.500
LIG_LIR_Gen_1	79	90	PF02991	0.500
LIG_LIR_Nem_3	130	135	PF02991	0.484
LIG_LIR_Nem_3	174	180	PF02991	0.483
LIG_LIR_Nem_3	181	187	PF02991	0.392
LIG_LIR_Nem_3	197	203	PF02991	0.517
LIG_LIR_Nem_3	308	313	PF02991	0.433
LIG_LIR_Nem_3	349	353	PF02991	0.427
LIG_LIR_Nem_3	360	365	PF02991	0.461
LIG_LIR_Nem_3	412	418	PF02991	0.433
LIG_LIR_Nem_3	447	451	PF02991	0.457
LIG_LIR_Nem_3	530	535	PF02991	0.500
LIG_LIR_Nem_3	79	85	PF02991	0.500
LIG_PCNA_PIPBox_1	322	331	PF02747	0.375
LIG_PCNA_yPIPBox_3	317	329	PF02747	0.487
LIG_Pex14_1	306	310	PF04695	0.433
LIG_Pex14_2	183	187	PF04695	0.509
LIG_Pex14_2	463	467	PF04695	0.487
LIG_Pex14_2	77	81	PF04695	0.500
LIG_PTB_Apo_2	71	78	PF02174	0.436
LIG_Rb_LxCxE_1	243	263	PF01857	0.438
LIG_SH2_CRK	310	314	PF00017	0.433
LIG_SH2_GRB2like	350	353	PF00017	0.426
LIG_SH2_NCK_1	422	426	PF00017	0.449
LIG_SH2_SRC	257	260	PF00017	0.436
LIG_SH2_STAP1	121	125	PF00017	0.457
LIG_SH2_STAP1	310	314	PF00017	0.433
LIG_SH2_STAP1	353	357	PF00017	0.375
LIG_SH2_STAP1	510	514	PF00017	0.392
LIG_SH2_STAT5	132	135	PF00017	0.534
LIG_SH2_STAT5	229	232	PF00017	0.428
LIG_SH2_STAT5	353	356	PF00017	0.422
LIG_SH2_STAT5	444	447	PF00017	0.456
LIG_SH2_STAT5	485	488	PF00017	0.457
LIG_SH2_STAT5	510	513	PF00017	0.375
LIG_SH2_STAT5	76	79	PF00017	0.433
LIG_SH3_3	152	158	PF00018	0.569
LIG_SH3_3	170	176	PF00018	0.451
LIG_SH3_3	192	198	PF00018	0.474
LIG_SH3_3	208	214	PF00018	0.467
LIG_SH3_3	342	348	PF00018	0.509
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.433
LIG_SUMO_SIM_par_1	416	421	PF11976	0.484
LIG_SUMO_SIM_par_1	87	93	PF11976	0.487
LIG_TRAF2_1	108	111	PF00917	0.375
LIG_TRFH_1	161	165	PF08558	0.457
LIG_WRC_WIRS_1	325	330	PF05994	0.487
LIG_WRC_WIRS_1	445	450	PF05994	0.457
MOD_CDK_SPxxK_3	178	185	PF00069	0.383
MOD_CDK_SPxxK_3	270	277	PF00069	0.374
MOD_CK1_1	178	184	PF00069	0.506
MOD_CK1_1	270	276	PF00069	0.473
MOD_CK1_1	57	63	PF00069	0.429
MOD_CK1_1	8	14	PF00069	0.637
MOD_CK2_1	105	111	PF00069	0.461
MOD_CK2_1	11	17	PF00069	0.614
MOD_CK2_1	116	122	PF00069	0.527
MOD_CK2_1	279	285	PF00069	0.324
MOD_Cter_Amidation	329	332	PF01082	0.175
MOD_Cter_Amidation	504	507	PF01082	0.260
MOD_DYRK1A_RPxSP_1	5	9	PF00069	0.587
MOD_GlcNHglycan	118	121	PF01048	0.251
MOD_GlcNHglycan	13	16	PF01048	0.614
MOD_GlcNHglycan	434	437	PF01048	0.240
MOD_GSK3_1	205	212	PF00069	0.486
MOD_GSK3_1	266	273	PF00069	0.369
MOD_GSK3_1	3	10	PF00069	0.652
MOD_GSK3_1	491	498	PF00069	0.472
MOD_GSK3_1	518	525	PF00069	0.448
MOD_LATS_1	275	281	PF00433	0.367
MOD_N-GLC_1	351	356	PF02516	0.175
MOD_N-GLC_1	495	500	PF02516	0.175
MOD_N-GLC_2	390	392	PF02516	0.233
MOD_NEK2_1	209	214	PF00069	0.369
MOD_NEK2_1	313	318	PF00069	0.487
MOD_NEK2_1	335	340	PF00069	0.547
MOD_NEK2_1	382	387	PF00069	0.457
MOD_NEK2_1	394	399	PF00069	0.457
MOD_NEK2_1	432	437	PF00069	0.433
MOD_NEK2_1	85	90	PF00069	0.457
MOD_NEK2_2	250	255	PF00069	0.275
MOD_PIKK_1	209	215	PF00454	0.438
MOD_PIKK_1	335	341	PF00454	0.527
MOD_PK_1	54	60	PF00069	0.375
MOD_PKA_2	105	111	PF00069	0.457
MOD_PKA_2	116	122	PF00069	0.457
MOD_PKA_2	451	457	PF00069	0.457
MOD_PKB_1	5	13	PF00069	0.561
MOD_Plk_1	159	165	PF00069	0.433
MOD_Plk_1	351	357	PF00069	0.448
MOD_Plk_4	175	181	PF00069	0.485
MOD_Plk_4	205	211	PF00069	0.371
MOD_Plk_4	324	330	PF00069	0.565
MOD_Plk_4	474	480	PF00069	0.487
MOD_Plk_4	85	91	PF00069	0.487
MOD_ProDKin_1	130	136	PF00069	0.433
MOD_ProDKin_1	178	184	PF00069	0.433
MOD_ProDKin_1	270	276	PF00069	0.382
MOD_ProDKin_1	5	11	PF00069	0.557
MOD_SUMO_rev_2	118	126	PF00179	0.457
MOD_SUMO_rev_2	454	464	PF00179	0.487
TRG_AP2beta_CARGO_1	360	369	PF09066	0.487
TRG_DiLeu_BaEn_3	25	31	PF01217	0.401
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.487
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.487
TRG_ENDOCYTIC_2	132	135	PF00928	0.523
TRG_ENDOCYTIC_2	177	180	PF00928	0.433
TRG_ENDOCYTIC_2	184	187	PF00928	0.433
TRG_ENDOCYTIC_2	229	232	PF00928	0.514
TRG_ENDOCYTIC_2	257	260	PF00928	0.376
TRG_ENDOCYTIC_2	310	313	PF00928	0.433
TRG_ER_diArg_1	113	115	PF00400	0.435
TRG_ER_diArg_1	254	256	PF00400	0.381
TRG_ER_diArg_1	317	320	PF00400	0.487
TRG_ER_diArg_1	32	34	PF00400	0.433
TRG_ER_diArg_1	391	394	PF00400	0.433
TRG_ER_diLys_1	537	541	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT2	Leptomonas seymouri	66%	99%
A0A1X0P0R5	Trypanosomatidae	49%	97%
A0A3Q8IEQ0	Leishmania donovani	86%	100%
A4I8R0	Leishmania infantum	85%	100%
A9CJC9	Agrobacterium fabrum (strain C58 / ATCC 33970)	29%	100%
D0A4Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9B3M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O48652	Arabidopsis thaliana	24%	97%
O77059	Drosophila melanogaster	22%	100%
P00914	Escherichia coli (strain K12)	31%	100%
P05066	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	96%
P05327	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	29%	100%
P12768	Streptomyces griseus	31%	100%
P25078	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
P40115	Sinapis alba	27%	100%
P57386	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	28%	100%
P77967	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	100%
P97784	Mus musculus	23%	89%
Q04449	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	29%	100%
Q0E2Y1	Oryza sativa subsp. japonica	25%	98%
Q16526	Homo sapiens	23%	92%
Q17DK5	Aedes aegypti	23%	99%
Q293P8	Drosophila pseudoobscura pseudoobscura	21%	100%
Q32Q86	Rattus norvegicus	23%	92%
Q3IPX9	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	26%	100%
Q43125	Arabidopsis thaliana	27%	79%
Q49AN0	Homo sapiens	24%	91%
Q4I1Q6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	78%
Q4KML2	Danio rerio	26%	100%
Q4Q4G2	Leishmania major	86%	100%
Q55081	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	100%
Q5IFN2	Ostreococcus tauri	23%	99%
Q5IZC5	Erithacus rubecula	23%	87%
Q5QXE0	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	27%	100%
Q651U1	Oryza sativa subsp. japonica	25%	93%
Q6ZZY0	Sylvia borin	24%	87%
Q70AD6	Spalax judaei	23%	92%
Q75WS4	Xenopus laevis	27%	100%
Q7NMD1	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	27%	100%
Q7PYI7	Anopheles gambiae	23%	99%
Q7UJB1	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	25%	100%
Q84KJ5	Arabidopsis thaliana	24%	95%
Q87JP5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	26%	100%
Q8QG60	Gallus gallus	24%	93%
Q8QG61	Gallus gallus	23%	87%
Q8WP19	Macaca fascicularis	23%	92%
Q923I8	Rattus norvegicus	24%	91%
Q96524	Arabidopsis thaliana	27%	88%
Q9HQ46	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	29%	100%
Q9KNA8	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	100%
Q9KR33	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	25%	100%
Q9R194	Mus musculus	24%	91%