Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL81_LEIBR

TriTrypDb:

LbrM.33.0450 , LBRM2903_330009700

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.430
CLV_NRD_NRD_1	136	138	PF00675	0.594
CLV_NRD_NRD_1	248	250	PF00675	0.516
CLV_NRD_NRD_1	261	263	PF00675	0.399
CLV_NRD_NRD_1	52	54	PF00675	0.679
CLV_PCSK_KEX2_1	133	135	PF00082	0.621
CLV_PCSK_KEX2_1	138	140	PF00082	0.570
CLV_PCSK_KEX2_1	248	250	PF00082	0.516
CLV_PCSK_KEX2_1	261	263	PF00082	0.399
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.430
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.466
CLV_PCSK_PC7_1	134	140	PF00082	0.539
CLV_PCSK_SKI1_1	248	252	PF00082	0.373
CLV_PCSK_SKI1_1	5	9	PF00082	0.508
DEG_SPOP_SBC_1	120	124	PF00917	0.456
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.624
DOC_MAPK_MEF2A_6	145	154	PF00069	0.407
DOC_PP2B_LxvP_1	112	115	PF13499	0.557
DOC_PP2B_LxvP_1	207	210	PF13499	0.480
DOC_PP2B_LxvP_1	80	83	PF13499	0.631
DOC_USP7_MATH_1	120	124	PF00917	0.456
DOC_USP7_MATH_1	177	181	PF00917	0.589
DOC_USP7_MATH_1	186	190	PF00917	0.580
DOC_USP7_MATH_1	195	199	PF00917	0.578
DOC_USP7_MATH_1	73	77	PF00917	0.497
DOC_WW_Pin1_4	208	213	PF00397	0.562
LIG_14-3-3_CanoR_1	100	105	PF00244	0.484
LIG_14-3-3_CanoR_1	119	129	PF00244	0.430
LIG_14-3-3_CanoR_1	199	209	PF00244	0.525
LIG_14-3-3_CanoR_1	237	241	PF00244	0.381
LIG_14-3-3_CanoR_1	53	62	PF00244	0.651
LIG_BRCT_BRCA1_1	121	125	PF00533	0.441
LIG_EH1_1	147	155	PF00400	0.386
LIG_FHA_1	186	192	PF00498	0.714
LIG_FHA_1	249	255	PF00498	0.382
LIG_FHA_1	39	45	PF00498	0.595
LIG_FHA_1	69	75	PF00498	0.661
LIG_FHA_1	77	83	PF00498	0.561
LIG_FHA_2	223	229	PF00498	0.394
LIG_GSK3_LRP6_1	208	213	PF00069	0.456
LIG_LIR_Nem_3	6	10	PF02991	0.651
LIG_PCNA_PIPBox_1	238	247	PF02747	0.376
LIG_PCNA_yPIPBox_3	234	245	PF02747	0.500
LIG_PDZ_Class_3	283	288	PF00595	0.642
LIG_SH2_STAT5	222	225	PF00017	0.444
LIG_SH2_STAT5	9	12	PF00017	0.668
LIG_SH3_1	29	35	PF00018	0.634
LIG_SH3_3	206	212	PF00018	0.602
LIG_SH3_3	29	35	PF00018	0.634
LIG_SH3_CIN85_PxpxPR_1	208	213	PF14604	0.456
LIG_TRAF2_1	225	228	PF00917	0.487
LIG_TRAF2_1	35	38	PF00917	0.501
LIG_WRC_WIRS_1	4	9	PF05994	0.648
MOD_CDK_SPK_2	208	213	PF00069	0.598
MOD_CDK_SPxxK_3	208	215	PF00069	0.589
MOD_CK1_1	121	127	PF00069	0.462
MOD_CK1_1	178	184	PF00069	0.522
MOD_CK1_1	198	204	PF00069	0.627
MOD_CK1_1	263	269	PF00069	0.530
MOD_CK1_1	279	285	PF00069	0.455
MOD_CK1_1	76	82	PF00069	0.491
MOD_CK2_1	100	106	PF00069	0.423
MOD_CK2_1	222	228	PF00069	0.394
MOD_CK2_1	53	59	PF00069	0.571
MOD_GlcNHglycan	177	180	PF01048	0.554
MOD_GlcNHglycan	181	184	PF01048	0.584
MOD_GlcNHglycan	193	196	PF01048	0.632
MOD_GlcNHglycan	49	52	PF01048	0.547
MOD_GSK3_1	114	121	PF00069	0.484
MOD_GSK3_1	171	178	PF00069	0.473
MOD_GSK3_1	191	198	PF00069	0.510
MOD_GSK3_1	199	206	PF00069	0.542
MOD_GSK3_1	40	47	PF00069	0.600
MOD_GSK3_1	49	56	PF00069	0.658
MOD_GSK3_1	64	71	PF00069	0.530
MOD_GSK3_1	72	79	PF00069	0.596
MOD_N-GLC_1	191	196	PF02516	0.538
MOD_N-GLC_1	76	81	PF02516	0.492
MOD_NEK2_1	152	157	PF00069	0.466
MOD_NEK2_1	40	45	PF00069	0.519
MOD_PKA_1	248	254	PF00069	0.367
MOD_PKA_1	53	59	PF00069	0.675
MOD_PKA_2	118	124	PF00069	0.492
MOD_PKA_2	198	204	PF00069	0.557
MOD_PKA_2	233	239	PF00069	0.385
MOD_PKA_2	248	254	PF00069	0.391
MOD_PKA_2	260	266	PF00069	0.489
MOD_Plk_1	279	285	PF00069	0.477
MOD_Plk_1	58	64	PF00069	0.657
MOD_Plk_4	236	242	PF00069	0.383
MOD_ProDKin_1	208	214	PF00069	0.556
TRG_ER_diArg_1	137	140	PF00400	0.594
TRG_ER_diArg_1	212	215	PF00400	0.575
TRG_ER_diArg_1	247	249	PF00400	0.511
TRG_ER_diArg_1	260	262	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHC5	Leishmania donovani	66%	100%
A4I8Q9	Leishmania infantum	66%	100%
E9B3M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q4G3	Leishmania major	67%	100%