Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL80_LEIBR

TriTrypDb:

LbrM.33.0440 , LBRM2903_330009600

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HL80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.588
CLV_NRD_NRD_1	26	28	PF00675	0.405
DEG_APCC_DBOX_1	136	144	PF00400	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DOC_MAPK_gen_1	148	154	PF00069	0.549
DOC_USP7_MATH_2	134	140	PF00917	0.393
DOC_WW_Pin1_4	56	61	PF00397	0.592
LIG_14-3-3_CanoR_1	126	134	PF00244	0.596
LIG_14-3-3_CanoR_1	137	141	PF00244	0.624
LIG_14-3-3_CanoR_1	210	216	PF00244	0.567
LIG_14-3-3_CanoR_1	32	38	PF00244	0.326
LIG_14-3-3_CanoR_1	81	90	PF00244	0.672
LIG_FHA_1	155	161	PF00498	0.584
LIG_FHA_1	32	38	PF00498	0.474
LIG_FHA_2	118	124	PF00498	0.518
LIG_FHA_2	128	134	PF00498	0.504
LIG_LIR_Apic_2	212	216	PF02991	0.690
LIG_LIR_Gen_1	179	188	PF02991	0.531
LIG_LIR_Nem_3	179	185	PF02991	0.538
LIG_LIR_Nem_3	194	200	PF02991	0.512
LIG_SH2_STAP1	47	51	PF00017	0.484
LIG_SH2_STAT3	47	50	PF00017	0.603
LIG_SH3_3	165	171	PF00018	0.566
LIG_SH3_3	3	9	PF00018	0.500
MOD_CK1_1	183	189	PF00069	0.602
MOD_CK2_1	129	135	PF00069	0.411
MOD_CK2_1	136	142	PF00069	0.402
MOD_CK2_1	71	77	PF00069	0.597
MOD_CMANNOS	76	79	PF00535	0.650
MOD_GlcNHglycan	14	18	PF01048	0.485
MOD_GlcNHglycan	162	165	PF01048	0.590
MOD_N-GLC_1	154	159	PF02516	0.584
MOD_N-GLC_1	180	185	PF02516	0.553
MOD_NEK2_1	127	132	PF00069	0.583
MOD_NEK2_1	160	165	PF00069	0.600
MOD_NEK2_1	19	24	PF00069	0.433
MOD_PIKK_1	83	89	PF00454	0.624
MOD_PIKK_1	90	96	PF00454	0.627
MOD_PK_1	180	186	PF00069	0.620
MOD_PK_1	32	38	PF00069	0.326
MOD_PKA_2	136	142	PF00069	0.632
MOD_PKA_2	20	26	PF00069	0.450
MOD_PKA_2	209	215	PF00069	0.556
MOD_PKA_2	31	37	PF00069	0.449
MOD_Plk_1	154	160	PF00069	0.593
MOD_Plk_1	180	186	PF00069	0.550
MOD_Plk_1	71	77	PF00069	0.588
MOD_Plk_2-3	136	142	PF00069	0.644
MOD_Plk_4	155	161	PF00069	0.685
MOD_Plk_4	32	38	PF00069	0.462
MOD_Plk_4	41	47	PF00069	0.449
MOD_Plk_4	71	77	PF00069	0.651
MOD_ProDKin_1	56	62	PF00069	0.592
MOD_SUMO_rev_2	142	151	PF00179	0.427
TRG_DiLeu_BaEn_4	135	141	PF01217	0.505
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.623
TRG_ER_diArg_1	54	57	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD0	Leptomonas seymouri	69%	99%
A0A0S4KNW6	Bodo saltans	41%	100%
A0A1X0P0X4	Trypanosomatidae	56%	100%
A0A3Q8IHM0	Leishmania donovani	84%	100%
A0A3R7MM31	Trypanosoma rangeli	55%	100%
A4I8Q8	Leishmania infantum	84%	100%
D0A4P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B3M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q4G4	Leishmania major	81%	100%
V5BKE3	Trypanosoma cruzi	55%	100%