Rab3 GTPase-activating protein catalytic subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL79_LEIBR

TriTrypDb:

LbrM.33.0430 , LBRM2903_330009500

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.430
CLV_NRD_NRD_1	196	198	PF00675	0.473
CLV_PCSK_FUR_1	194	198	PF00082	0.553
CLV_PCSK_KEX2_1	196	198	PF00082	0.499
DEG_MDM2_SWIB_1	94	101	PF02201	0.420
DEG_SCF_FBW7_1	48	54	PF00400	0.469
DEG_SPOP_SBC_1	121	125	PF00917	0.532
DOC_CKS1_1	48	53	PF01111	0.504
DOC_MAPK_MEF2A_6	96	103	PF00069	0.383
DOC_MAPK_NFAT4_5	96	104	PF00069	0.455
DOC_PP2B_LxvP_1	99	102	PF13499	0.481
DOC_USP7_MATH_1	120	124	PF00917	0.609
DOC_USP7_MATH_1	142	146	PF00917	0.569
DOC_USP7_MATH_1	51	55	PF00917	0.476
DOC_WW_Pin1_4	47	52	PF00397	0.537
LIG_14-3-3_CanoR_1	100	110	PF00244	0.426
LIG_Clathr_ClatBox_1	63	67	PF01394	0.457
LIG_deltaCOP1_diTrp_1	202	209	PF00928	0.506
LIG_FHA_1	165	171	PF00498	0.399
LIG_FHA_2	35	41	PF00498	0.396
LIG_FHA_2	48	54	PF00498	0.531
LIG_LIR_Apic_2	20	24	PF02991	0.361
LIG_LIR_Gen_1	37	47	PF02991	0.489
LIG_LIR_Nem_3	37	42	PF02991	0.409
LIG_Pex14_1	90	94	PF04695	0.403
LIG_Pex14_2	94	98	PF04695	0.414
LIG_SH2_STAT3	86	89	PF00017	0.420
LIG_SH2_STAT5	21	24	PF00017	0.338
LIG_SH2_STAT5	86	89	PF00017	0.420
LIG_SH3_3	116	122	PF00018	0.655
LIG_SH3_3	123	129	PF00018	0.557
LIG_SH3_3	136	142	PF00018	0.531
LIG_SH3_3	45	51	PF00018	0.511
LIG_Sin3_3	128	135	PF02671	0.376
MOD_CK1_1	143	149	PF00069	0.597
MOD_CK1_1	214	220	PF00069	0.442
MOD_CK2_1	106	112	PF00069	0.557
MOD_CK2_1	176	182	PF00069	0.376
MOD_CK2_1	34	40	PF00069	0.418
MOD_CK2_1	47	53	PF00069	0.471
MOD_GlcNHglycan	142	145	PF01048	0.478
MOD_GlcNHglycan	216	219	PF01048	0.462
MOD_GlcNHglycan	6	9	PF01048	0.576
MOD_GSK3_1	2	9	PF00069	0.686
MOD_GSK3_1	47	54	PF00069	0.593
MOD_LATS_1	2	8	PF00433	0.596
MOD_NEK2_1	6	11	PF00069	0.698
MOD_NEK2_1	75	80	PF00069	0.406
MOD_NEK2_2	122	127	PF00069	0.402
MOD_PIKK_1	101	107	PF00454	0.438
MOD_PIKK_1	51	57	PF00454	0.423
MOD_Plk_1	176	182	PF00069	0.502
MOD_Plk_1	2	8	PF00069	0.719
MOD_Plk_1	75	81	PF00069	0.368
MOD_Plk_4	34	40	PF00069	0.577
MOD_Plk_4	89	95	PF00069	0.388
MOD_ProDKin_1	47	53	PF00069	0.531
MOD_SUMO_for_1	113	116	PF00179	0.484
TRG_DiLeu_BaEn_1	83	88	PF01217	0.312
TRG_ENDOCYTIC_2	39	42	PF00928	0.474
TRG_ER_diArg_1	193	196	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL76	Leptomonas seymouri	49%	68%
A0A1X0P0M0	Trypanosomatidae	34%	72%
A0A3Q8IDL0	Leishmania donovani	77%	100%
D0A4P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	70%
E9AHN1	Leishmania infantum	77%	100%
E9B3M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q4G5	Leishmania major	75%	100%