Archaic translocase of outer membrane 11 kDa subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Archaic translocase of outer membrane 11 kDa subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HL77_LEIBR

TriTrypDb:

LbrM.33.0410 , LBRM2903_330009300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HL77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL77

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	70	77	PF00400	0.421
DOC_CKS1_1	76	81	PF01111	0.448
DOC_MAPK_DCC_7	36	46	PF00069	0.482
DOC_PP1_RVXF_1	34	40	PF00149	0.545
DOC_PP4_FxxP_1	3	6	PF00568	0.529
DOC_PP4_FxxP_1	81	84	PF00568	0.504
DOC_WW_Pin1_4	70	75	PF00397	0.370
DOC_WW_Pin1_4	80	85	PF00397	0.492
LIG_CAP-Gly_1	94	99	PF01302	0.458
LIG_CSL_BTD_1	39	42	PF09270	0.289
LIG_deltaCOP1_diTrp_1	12	18	PF00928	0.619
LIG_GBD_Chelix_1	44	52	PF00786	0.335
LIG_LIR_Apic_2	38	42	PF02991	0.351
LIG_LIR_Apic_2	78	84	PF02991	0.447
LIG_PDZ_Class_3	94	99	PF00595	0.456
LIG_Pex14_1	13	17	PF04695	0.533
LIG_SH2_STAT5	17	20	PF00017	0.526
MOD_GlcNHglycan	70	73	PF01048	0.656
MOD_GlcNHglycan	88	91	PF01048	0.646
MOD_GSK3_1	70	77	PF00069	0.447
MOD_NEK2_1	32	37	PF00069	0.592
MOD_Plk_4	48	54	PF00069	0.300
MOD_Plk_4	63	69	PF00069	0.353
MOD_ProDKin_1	70	76	PF00069	0.374
MOD_ProDKin_1	80	86	PF00069	0.494
TRG_ENDOCYTIC_2	19	22	PF00928	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI7	Leptomonas seymouri	75%	99%
A0A0S4J2D1	Bodo saltans	42%	100%
A0A1X0P0Q4	Trypanosomatidae	47%	100%
A0A3Q8ITU6	Leishmania donovani	87%	100%
A4I8Q6	Leishmania infantum	86%	100%
D0A4P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9B3M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4G7	Leishmania major	85%	100%
V5BKE8	Trypanosoma cruzi	55%	94%