Putative serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HL75_LEIBR

TriTrypDb:

LbrM.33.0390 , LBRM2903_330008900

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.362
CLV_NRD_NRD_1	265	267	PF00675	0.603
CLV_NRD_NRD_1	28	30	PF00675	0.467
CLV_NRD_NRD_1	306	308	PF00675	0.515
CLV_NRD_NRD_1	317	319	PF00675	0.375
CLV_PCSK_KEX2_1	203	205	PF00082	0.362
CLV_PCSK_KEX2_1	250	252	PF00082	0.473
CLV_PCSK_KEX2_1	265	267	PF00082	0.594
CLV_PCSK_KEX2_1	28	30	PF00082	0.444
CLV_PCSK_KEX2_1	306	308	PF00082	0.515
CLV_PCSK_KEX2_1	317	319	PF00082	0.375
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.498
CLV_PCSK_PC7_1	246	252	PF00082	0.495
CLV_PCSK_SKI1_1	230	234	PF00082	0.327
CLV_PCSK_SKI1_1	246	250	PF00082	0.459
CLV_PCSK_SKI1_1	361	365	PF00082	0.350
CLV_PCSK_SKI1_1	374	378	PF00082	0.481
DEG_APCC_DBOX_1	229	237	PF00400	0.334
DEG_Nend_UBRbox_3	1	3	PF02207	0.362
DOC_CYCLIN_RxL_1	227	235	PF00134	0.301
DOC_MAPK_gen_1	163	173	PF00069	0.302
DOC_MAPK_gen_1	61	71	PF00069	0.415
DOC_MAPK_MEF2A_6	64	71	PF00069	0.364
DOC_PP4_FxxP_1	10	13	PF00568	0.392
DOC_USP7_MATH_1	111	115	PF00917	0.231
DOC_USP7_MATH_1	259	263	PF00917	0.633
DOC_USP7_MATH_1	308	312	PF00917	0.319
DOC_USP7_MATH_1	320	324	PF00917	0.385
DOC_USP7_MATH_1	329	333	PF00917	0.492
DOC_USP7_MATH_1	387	391	PF00917	0.593
LIG_14-3-3_CanoR_1	182	192	PF00244	0.469
LIG_14-3-3_CanoR_1	265	273	PF00244	0.545
LIG_14-3-3_CanoR_1	28	34	PF00244	0.467
LIG_14-3-3_CanoR_1	354	363	PF00244	0.275
LIG_14-3-3_CanoR_1	41	45	PF00244	0.352
LIG_14-3-3_CanoR_1	61	71	PF00244	0.234
LIG_Actin_WH2_2	167	184	PF00022	0.312
LIG_BRCT_BRCA1_1	356	360	PF00533	0.419
LIG_BRCT_BRCA1_1	389	393	PF00533	0.444
LIG_BRCT_BRCA1_1	6	10	PF00533	0.402
LIG_CaM_IQ_9	241	257	PF13499	0.336
LIG_FHA_1	176	182	PF00498	0.391
LIG_FHA_1	239	245	PF00498	0.323
LIG_FHA_1	262	268	PF00498	0.468
LIG_FHA_1	279	285	PF00498	0.487
LIG_FHA_1	288	294	PF00498	0.483
LIG_FHA_2	113	119	PF00498	0.398
LIG_FHA_2	217	223	PF00498	0.301
LIG_FHA_2	325	331	PF00498	0.402
LIG_HCF-1_HBM_1	129	132	PF13415	0.388
LIG_LIR_Apic_2	7	13	PF02991	0.401
LIG_LIR_Gen_1	129	140	PF02991	0.454
LIG_LIR_Gen_1	353	364	PF02991	0.502
LIG_LIR_Nem_3	101	105	PF02991	0.312
LIG_LIR_Nem_3	129	135	PF02991	0.335
LIG_LIR_Nem_3	137	143	PF02991	0.368
LIG_LIR_Nem_3	197	202	PF02991	0.425
LIG_LIR_Nem_3	300	305	PF02991	0.354
LIG_LIR_Nem_3	353	359	PF02991	0.510
LIG_LIR_Nem_3	43	47	PF02991	0.343
LIG_MAD2	182	190	PF02301	0.462
LIG_NRBOX	243	249	PF00104	0.480
LIG_Pex14_2	336	340	PF04695	0.357
LIG_Pex14_2	356	360	PF04695	0.214
LIG_Pex14_2	366	370	PF04695	0.216
LIG_RPA_C_Fungi	235	247	PF08784	0.458
LIG_SH2_CRK	143	147	PF00017	0.334
LIG_SH2_CRK	309	313	PF00017	0.414
LIG_SH2_NCK_1	125	129	PF00017	0.312
LIG_SH2_STAP1	132	136	PF00017	0.466
LIG_SH2_STAP1	85	89	PF00017	0.389
LIG_SH2_STAT5	102	105	PF00017	0.461
LIG_SH2_STAT5	159	162	PF00017	0.312
LIG_SH2_STAT5	191	194	PF00017	0.448
LIG_SH2_STAT5	362	365	PF00017	0.432
LIG_SH3_3	6	12	PF00018	0.409
LIG_SUMO_SIM_par_1	170	176	PF11976	0.312
LIG_TRAF2_1	350	353	PF00917	0.345
LIG_UBA3_1	232	238	PF00899	0.281
LIG_WRC_WIRS_1	174	179	PF05994	0.312
MOD_CK1_1	123	129	PF00069	0.363
MOD_CK1_1	175	181	PF00069	0.334
MOD_CK1_1	32	38	PF00069	0.487
MOD_CK1_1	379	385	PF00069	0.429
MOD_CK2_1	112	118	PF00069	0.327
MOD_CK2_1	216	222	PF00069	0.291
MOD_CK2_1	308	314	PF00069	0.309
MOD_GlcNHglycan	107	110	PF01048	0.351
MOD_GlcNHglycan	268	271	PF01048	0.570
MOD_GlcNHglycan	340	343	PF01048	0.394
MOD_GlcNHglycan	37	40	PF01048	0.511
MOD_GlcNHglycan	381	384	PF01048	0.463
MOD_GlcNHglycan	389	392	PF01048	0.461
MOD_GSK3_1	172	179	PF00069	0.328
MOD_GSK3_1	278	285	PF00069	0.544
MOD_GSK3_1	31	38	PF00069	0.487
MOD_GSK3_1	320	327	PF00069	0.402
MOD_GSK3_1	364	371	PF00069	0.321
MOD_GSK3_1	81	88	PF00069	0.388
MOD_LATS_1	27	33	PF00433	0.338
MOD_NEK2_1	173	178	PF00069	0.348
MOD_NEK2_1	31	36	PF00069	0.471
MOD_NEK2_1	324	329	PF00069	0.604
MOD_NEK2_1	364	369	PF00069	0.325
MOD_NEK2_1	377	382	PF00069	0.366
MOD_NEK2_1	4	9	PF00069	0.426
MOD_NEK2_1	79	84	PF00069	0.231
MOD_OFUCOSY	180	187	PF10250	0.506
MOD_PKA_2	226	232	PF00069	0.384
MOD_PKA_2	387	393	PF00069	0.565
MOD_PKA_2	40	46	PF00069	0.435
MOD_PKA_2	63	69	PF00069	0.426
MOD_Plk_1	120	126	PF00069	0.312
MOD_Plk_1	297	303	PF00069	0.372
MOD_Plk_1	320	326	PF00069	0.351
MOD_Plk_1	329	335	PF00069	0.438
MOD_Plk_2-3	297	303	PF00069	0.393
MOD_Plk_4	120	126	PF00069	0.312
MOD_Plk_4	297	303	PF00069	0.467
MOD_Plk_4	4	10	PF00069	0.419
MOD_Plk_4	63	69	PF00069	0.373
TRG_DiLeu_BaEn_1	167	172	PF01217	0.225
TRG_DiLeu_BaEn_1	210	215	PF01217	0.344
TRG_DiLeu_BaEn_1	373	378	PF01217	0.471
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.474
TRG_ENDOCYTIC_2	132	135	PF00928	0.326
TRG_ENDOCYTIC_2	143	146	PF00928	0.376
TRG_ENDOCYTIC_2	202	205	PF00928	0.433
TRG_ENDOCYTIC_2	309	312	PF00928	0.405
TRG_ENDOCYTIC_2	44	47	PF00928	0.457
TRG_ER_diArg_1	202	204	PF00400	0.371
TRG_ER_diArg_1	265	267	PF00400	0.476
TRG_ER_diArg_1	305	307	PF00400	0.575
TRG_ER_diArg_1	316	318	PF00400	0.371
TRG_NES_CRM1_1	87	101	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M6	Leptomonas seymouri	54%	100%
A0A3S7X6G6	Leishmania donovani	74%	99%
A4I8Q4	Leishmania infantum	74%	99%
E9B3L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q4J7	Leishmania major	76%	100%