Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL74_LEIBR

TriTrypDb:

LbrM.33.0380 , LBRM2903_330008800

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.564
CLV_NRD_NRD_1	119	121	PF00675	0.697
CLV_NRD_NRD_1	196	198	PF00675	0.646
CLV_NRD_NRD_1	230	232	PF00675	0.491
CLV_NRD_NRD_1	37	39	PF00675	0.452
CLV_NRD_NRD_1	40	42	PF00675	0.492
CLV_NRD_NRD_1	79	81	PF00675	0.643
CLV_PCSK_FUR_1	38	42	PF00082	0.385
CLV_PCSK_KEX2_1	119	121	PF00082	0.697
CLV_PCSK_KEX2_1	196	198	PF00082	0.646
CLV_PCSK_KEX2_1	230	232	PF00082	0.559
CLV_PCSK_KEX2_1	240	242	PF00082	0.543
CLV_PCSK_KEX2_1	355	357	PF00082	0.489
CLV_PCSK_KEX2_1	39	41	PF00082	0.487
CLV_PCSK_KEX2_1	79	81	PF00082	0.643
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.543
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.489
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.473
CLV_PCSK_SKI1_1	259	263	PF00082	0.426
CLV_PCSK_SKI1_1	278	282	PF00082	0.337
CLV_PCSK_SKI1_1	355	359	PF00082	0.500
DEG_ODPH_VHL_1	273	285	PF01847	0.513
DEG_SPOP_SBC_1	189	193	PF00917	0.553
DEG_SPOP_SBC_1	62	66	PF00917	0.707
DOC_CKS1_1	279	284	PF01111	0.314
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.557
DOC_MAPK_gen_1	38	48	PF00069	0.579
DOC_MAPK_MEF2A_6	29	37	PF00069	0.556
DOC_PP2B_LxvP_1	254	257	PF13499	0.478
DOC_PP4_FxxP_1	348	351	PF00568	0.363
DOC_USP7_MATH_1	128	132	PF00917	0.775
DOC_USP7_MATH_1	140	144	PF00917	0.567
DOC_USP7_MATH_1	160	164	PF00917	0.679
DOC_USP7_MATH_1	189	193	PF00917	0.620
DOC_USP7_MATH_1	248	252	PF00917	0.541
DOC_USP7_MATH_1	62	66	PF00917	0.774
DOC_USP7_UBL2_3	240	244	PF12436	0.542
DOC_WW_Pin1_4	141	146	PF00397	0.581
DOC_WW_Pin1_4	150	155	PF00397	0.707
DOC_WW_Pin1_4	173	178	PF00397	0.692
DOC_WW_Pin1_4	215	220	PF00397	0.604
DOC_WW_Pin1_4	278	283	PF00397	0.319
DOC_WW_Pin1_4	361	366	PF00397	0.623
DOC_WW_Pin1_4	71	76	PF00397	0.648
DOC_WW_Pin1_4	92	97	PF00397	0.730
LIG_14-3-3_CanoR_1	141	145	PF00244	0.643
LIG_14-3-3_CanoR_1	305	313	PF00244	0.374
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	145	149	PF00533	0.529
LIG_eIF4E_1	21	27	PF01652	0.468
LIG_FHA_1	279	285	PF00498	0.342
LIG_FHA_1	305	311	PF00498	0.398
LIG_FHA_1	62	68	PF00498	0.669
LIG_FHA_2	173	179	PF00498	0.565
LIG_FHA_2	26	32	PF00498	0.389
LIG_FHA_2	285	291	PF00498	0.405
LIG_LIR_Apic_2	347	351	PF02991	0.361
LIG_LIR_Gen_1	28	37	PF02991	0.448
LIG_LIR_Gen_1	332	343	PF02991	0.434
LIG_LIR_Gen_1	42	51	PF02991	0.485
LIG_LIR_Nem_3	20	24	PF02991	0.481
LIG_LIR_Nem_3	28	33	PF02991	0.496
LIG_LIR_Nem_3	332	338	PF02991	0.427
LIG_LIR_Nem_3	341	346	PF02991	0.363
LIG_LIR_Nem_3	42	48	PF02991	0.480
LIG_Pex14_2	348	352	PF04695	0.374
LIG_PTB_Apo_2	15	22	PF02174	0.428
LIG_PTB_Apo_2	337	344	PF02174	0.310
LIG_PTB_Phospho_1	15	21	PF10480	0.434
LIG_PTB_Phospho_1	337	343	PF10480	0.317
LIG_SH2_CRK	24	28	PF00017	0.466
LIG_SH2_CRK	270	274	PF00017	0.392
LIG_SH2_CRK	30	34	PF00017	0.422
LIG_SH2_GRB2like	16	19	PF00017	0.434
LIG_SH2_GRB2like	312	315	PF00017	0.384
LIG_SH2_NCK_1	223	227	PF00017	0.640
LIG_SH2_STAP1	223	227	PF00017	0.640
LIG_SH2_STAT5	21	24	PF00017	0.510
LIG_SH2_STAT5	295	298	PF00017	0.372
LIG_SH2_STAT5	343	346	PF00017	0.360
LIG_SH3_3	180	186	PF00018	0.688
LIG_SH3_3	216	222	PF00018	0.611
LIG_SH3_3	242	248	PF00018	0.535
LIG_SH3_3	276	282	PF00018	0.523
LIG_SH3_3	354	360	PF00018	0.487
LIG_SH3_3	69	75	PF00018	0.560
LIG_SUMO_SIM_par_1	281	287	PF11976	0.542
LIG_TYR_ITIM	22	27	PF00017	0.375
LIG_UBA3_1	309	318	PF00899	0.498
LIG_WRC_WIRS_1	345	350	PF05994	0.353
MOD_CDC14_SPxK_1	95	98	PF00782	0.639
MOD_CDK_SPxK_1	92	98	PF00069	0.648
MOD_CK1_1	143	149	PF00069	0.526
MOD_CK1_1	171	177	PF00069	0.826
MOD_CK1_1	249	255	PF00069	0.472
MOD_CK1_1	49	55	PF00069	0.630
MOD_CK1_1	92	98	PF00069	0.569
MOD_CK2_1	283	289	PF00069	0.413
MOD_DYRK1A_RPxSP_1	278	282	PF00069	0.326
MOD_GlcNHglycan	103	106	PF01048	0.762
MOD_GlcNHglycan	111	114	PF01048	0.763
MOD_GlcNHglycan	171	174	PF01048	0.785
MOD_GlcNHglycan	192	195	PF01048	0.648
MOD_GlcNHglycan	248	251	PF01048	0.544
MOD_GSK3_1	168	175	PF00069	0.665
MOD_GSK3_1	185	192	PF00069	0.578
MOD_GSK3_1	211	218	PF00069	0.656
MOD_GSK3_1	71	78	PF00069	0.602
MOD_GSK3_1	97	104	PF00069	0.643
MOD_N-GLC_1	313	318	PF02516	0.290
MOD_NEK2_1	161	166	PF00069	0.699
MOD_NEK2_1	190	195	PF00069	0.609
MOD_NEK2_1	236	241	PF00069	0.510
MOD_NEK2_1	269	274	PF00069	0.408
MOD_NEK2_1	313	318	PF00069	0.333
MOD_NEK2_1	326	331	PF00069	0.464
MOD_NEK2_1	61	66	PF00069	0.581
MOD_PIKK_1	152	158	PF00454	0.533
MOD_PIKK_1	203	209	PF00454	0.546
MOD_PIKK_1	46	52	PF00454	0.572
MOD_PK_1	119	125	PF00069	0.556
MOD_PKA_1	119	125	PF00069	0.556
MOD_PKA_2	119	125	PF00069	0.738
MOD_PKA_2	128	134	PF00069	0.550
MOD_PKA_2	140	146	PF00069	0.564
MOD_PKA_2	304	310	PF00069	0.315
MOD_PKA_2	97	103	PF00069	0.631
MOD_PKB_1	101	109	PF00069	0.564
MOD_Plk_1	313	319	PF00069	0.352
MOD_ProDKin_1	141	147	PF00069	0.583
MOD_ProDKin_1	150	156	PF00069	0.707
MOD_ProDKin_1	173	179	PF00069	0.693
MOD_ProDKin_1	215	221	PF00069	0.598
MOD_ProDKin_1	278	284	PF00069	0.313
MOD_ProDKin_1	361	367	PF00069	0.624
MOD_ProDKin_1	71	77	PF00069	0.651
MOD_ProDKin_1	92	98	PF00069	0.731
MOD_SUMO_rev_2	233	242	PF00179	0.508
TRG_ENDOCYTIC_2	10	13	PF00928	0.600
TRG_ENDOCYTIC_2	24	27	PF00928	0.387
TRG_ENDOCYTIC_2	270	273	PF00928	0.397
TRG_ENDOCYTIC_2	295	298	PF00928	0.372
TRG_ENDOCYTIC_2	30	33	PF00928	0.291
TRG_ER_diArg_1	195	197	PF00400	0.716
TRG_ER_diArg_1	37	40	PF00400	0.404
TRG_NLS_MonoExtN_4	351	358	PF00514	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P717	Leptomonas seymouri	50%	100%
A0A3Q8IJX1	Leishmania donovani	67%	100%
A4I8Q3	Leishmania infantum	67%	100%
E9B3L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q4G8	Leishmania major	65%	100%