Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL73_LEIBR

TriTrypDb:

LbrM.33.0370 , LBRM2903_330008700

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.487
CLV_NRD_NRD_1	96	98	PF00675	0.318
CLV_PCSK_FUR_1	94	98	PF00082	0.299
CLV_PCSK_KEX2_1	199	201	PF00082	0.439
CLV_PCSK_KEX2_1	96	98	PF00082	0.317
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.455
CLV_PCSK_SKI1_1	120	124	PF00082	0.492
CLV_PCSK_SKI1_1	188	192	PF00082	0.469
CLV_PCSK_SKI1_1	220	224	PF00082	0.527
CLV_PCSK_SKI1_1	268	272	PF00082	0.518
DEG_Nend_UBRbox_1	1	4	PF02207	0.416
DOC_CYCLIN_RxL_1	279	290	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.488
DOC_MAPK_DCC_7	4	14	PF00069	0.566
DOC_MAPK_MEF2A_6	128	136	PF00069	0.452
DOC_PP1_RVXF_1	248	254	PF00149	0.350
DOC_PP2B_LxvP_1	12	15	PF13499	0.564
DOC_PP2B_LxvP_1	159	162	PF13499	0.384
DOC_PP4_FxxP_1	253	256	PF00568	0.338
DOC_USP7_MATH_1	127	131	PF00917	0.421
DOC_USP7_UBL2_3	195	199	PF12436	0.430
DOC_WW_Pin1_4	138	143	PF00397	0.542
DOC_WW_Pin1_4	49	54	PF00397	0.622
LIG_14-3-3_CanoR_1	188	197	PF00244	0.447
LIG_14-3-3_CanoR_1	200	208	PF00244	0.367
LIG_14-3-3_CanoR_1	48	53	PF00244	0.618
LIG_14-3-3_CanoR_1	70	75	PF00244	0.493
LIG_BIR_III_2	215	219	PF00653	0.526
LIG_BRCT_BRCA1_1	100	104	PF00533	0.375
LIG_deltaCOP1_diTrp_1	258	266	PF00928	0.393
LIG_EVH1_1	159	163	PF00568	0.520
LIG_FHA_1	185	191	PF00498	0.591
LIG_FHA_1	225	231	PF00498	0.466
LIG_FHA_1	237	243	PF00498	0.504
LIG_FHA_1	71	77	PF00498	0.480
LIG_FHA_2	163	169	PF00498	0.402
LIG_FHA_2	200	206	PF00498	0.360
LIG_GBD_Chelix_1	243	251	PF00786	0.253
LIG_GBD_Chelix_1	280	288	PF00786	0.390
LIG_LIR_Apic_2	155	160	PF02991	0.428
LIG_LIR_Gen_1	168	177	PF02991	0.395
LIG_LIR_Gen_1	202	212	PF02991	0.384
LIG_LIR_Gen_1	258	267	PF02991	0.312
LIG_LIR_Gen_1	29	37	PF02991	0.528
LIG_LIR_Nem_3	16	21	PF02991	0.396
LIG_LIR_Nem_3	168	173	PF02991	0.400
LIG_LIR_Nem_3	202	207	PF02991	0.378
LIG_LIR_Nem_3	258	264	PF02991	0.383
LIG_LIR_Nem_3	29	33	PF02991	0.476
LIG_LIR_Nem_3	295	300	PF02991	0.456
LIG_Pex14_2	207	211	PF04695	0.348
LIG_REV1ctd_RIR_1	208	217	PF16727	0.394
LIG_SH2_CRK	157	161	PF00017	0.413
LIG_SH2_CRK	72	76	PF00017	0.479
LIG_SH2_GRB2like	30	33	PF00017	0.636
LIG_SH2_NCK_1	297	301	PF00017	0.552
LIG_SH2_PTP2	30	33	PF00017	0.550
LIG_SH2_SRC	30	33	PF00017	0.550
LIG_SH2_STAP1	45	49	PF00017	0.722
LIG_SH2_STAT5	151	154	PF00017	0.403
LIG_SH2_STAT5	287	290	PF00017	0.437
LIG_SH2_STAT5	30	33	PF00017	0.573
LIG_SH2_STAT5	72	75	PF00017	0.563
LIG_SH3_1	157	163	PF00018	0.535
LIG_SH3_2	218	223	PF14604	0.505
LIG_SH3_3	157	163	PF00018	0.484
LIG_SH3_3	215	221	PF00018	0.483
LIG_SH3_3	297	303	PF00018	0.505
LIG_SH3_3	3	9	PF00018	0.537
LIG_TRAF2_1	299	302	PF00917	0.393
LIG_WW_1	256	259	PF00397	0.357
MOD_CDK_SPK_2	138	143	PF00069	0.542
MOD_CK1_1	44	50	PF00069	0.613
MOD_CK2_1	162	168	PF00069	0.418
MOD_CK2_1	199	205	PF00069	0.370
MOD_GlcNHglycan	289	292	PF01048	0.412
MOD_GSK3_1	184	191	PF00069	0.454
MOD_GSK3_1	44	51	PF00069	0.582
MOD_GSK3_1	53	60	PF00069	0.606
MOD_N-GLC_1	184	189	PF02516	0.503
MOD_NEK2_1	286	291	PF00069	0.493
MOD_NEK2_1	99	104	PF00069	0.479
MOD_NEK2_2	259	264	PF00069	0.395
MOD_PIKK_1	199	205	PF00454	0.404
MOD_PIKK_1	224	230	PF00454	0.556
MOD_PKA_1	199	205	PF00069	0.404
MOD_PKA_2	199	205	PF00069	0.385
MOD_PKA_2	47	53	PF00069	0.588
MOD_Plk_1	184	190	PF00069	0.542
MOD_Plk_4	114	120	PF00069	0.408
MOD_Plk_4	272	278	PF00069	0.446
MOD_ProDKin_1	138	144	PF00069	0.534
MOD_ProDKin_1	49	55	PF00069	0.625
MOD_SUMO_rev_2	180	187	PF00179	0.503
TRG_AP2beta_CARGO_1	205	214	PF09066	0.352
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.468
TRG_ENDOCYTIC_2	260	263	PF00928	0.389
TRG_ENDOCYTIC_2	297	300	PF00928	0.504
TRG_ENDOCYTIC_2	30	33	PF00928	0.573
TRG_ER_diArg_1	1	4	PF00400	0.596
TRG_ER_diArg_1	132	135	PF00400	0.425
TRG_ER_diArg_1	94	97	PF00400	0.304
TRG_NLS_MonoCore_2	197	202	PF00514	0.537
TRG_NLS_MonoExtN_4	195	202	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I000	Leptomonas seymouri	75%	66%
A0A0S4IZ12	Bodo saltans	42%	84%
A0A1X0P257	Trypanosomatidae	46%	89%
A0A3Q8IGF0	Leishmania donovani	86%	95%
A0A3R7L0A9	Trypanosoma rangeli	48%	89%
A4I8Q2	Leishmania infantum	86%	95%
D0A4N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	91%
E9B3L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	71%
Q4Q4G9	Leishmania major	88%	100%
V5BFU1	Trypanosoma cruzi	48%	89%