Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HL72_LEIBR

TriTrypDb:

LbrM.33.0360 , LBRM2903_330008600

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005840	ribosome	5	4
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	4
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

A4HL72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL72

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	8
GO:0010604	positive regulation of macromolecule metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031396	regulation of protein ubiquitination	8	7
GO:0031398	positive regulation of protein ubiquitination	9	7
GO:0031399	regulation of protein modification process	6	7
GO:0031401	positive regulation of protein modification process	7	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0044093	positive regulation of molecular function	3	7
GO:0048518	positive regulation of biological process	3	8
GO:0050789	regulation of biological process	2	8
GO:0050790	regulation of catalytic activity	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051173	positive regulation of nitrogen compound metabolic process	5	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0051247	positive regulation of protein metabolic process	6	8
GO:0051338	regulation of transferase activity	4	7
GO:0051347	positive regulation of transferase activity	5	7
GO:0051438	regulation of ubiquitin-protein transferase activity	5	7
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	7
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0065009	regulation of molecular function	2	7
GO:0080090	regulation of primary metabolic process	4	8
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	7
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	7
GO:1904666	regulation of ubiquitin protein ligase activity	6	7
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	7
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045732	positive regulation of protein catabolic process	6	1
GO:0045862	positive regulation of proteolysis	7	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901800	positive regulation of proteasomal protein catabolic process	7	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	1
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	1
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008047	enzyme activator activity	3	8
GO:0010997	anaphase-promoting complex binding	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0044877	protein-containing complex binding	2	8
GO:0055106	ubiquitin-protein transferase regulator activity	3	8
GO:0097027	ubiquitin-protein transferase activator activity	4	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8
GO:1990757	ubiquitin ligase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.414
CLV_NRD_NRD_1	273	275	PF00675	0.781
CLV_NRD_NRD_1	37	39	PF00675	0.660
CLV_NRD_NRD_1	45	47	PF00675	0.669
CLV_NRD_NRD_1	535	537	PF00675	0.468
CLV_NRD_NRD_1	644	646	PF00675	0.422
CLV_NRD_NRD_1	711	713	PF00675	0.556
CLV_PCSK_KEX2_1	273	275	PF00082	0.781
CLV_PCSK_KEX2_1	37	39	PF00082	0.663
CLV_PCSK_KEX2_1	45	47	PF00082	0.669
CLV_PCSK_KEX2_1	535	537	PF00082	0.468
CLV_PCSK_KEX2_1	561	563	PF00082	0.406
CLV_PCSK_KEX2_1	583	585	PF00082	0.582
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.406
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.582
CLV_PCSK_PC7_1	41	47	PF00082	0.620
CLV_PCSK_SKI1_1	139	143	PF00082	0.633
CLV_PCSK_SKI1_1	225	229	PF00082	0.707
CLV_PCSK_SKI1_1	247	251	PF00082	0.703
CLV_PCSK_SKI1_1	308	312	PF00082	0.640
CLV_PCSK_SKI1_1	49	53	PF00082	0.639
CLV_PCSK_SKI1_1	493	497	PF00082	0.391
CLV_PCSK_SKI1_1	541	545	PF00082	0.398
CLV_PCSK_SKI1_1	564	568	PF00082	0.447
CLV_Separin_Metazoa	279	283	PF03568	0.562
DEG_Kelch_Keap1_1	403	408	PF01344	0.448
DEG_Nend_UBRbox_3	1	3	PF02207	0.676
DEG_SCF_FBW7_1	141	146	PF00400	0.504
DEG_SCF_FBW7_1	165	170	PF00400	0.636
DOC_CKS1_1	140	145	PF01111	0.501
DOC_CKS1_1	3	8	PF01111	0.539
DOC_MAPK_DCC_7	454	464	PF00069	0.307
DOC_MAPK_gen_1	454	464	PF00069	0.439
DOC_MAPK_gen_1	491	499	PF00069	0.334
DOC_MAPK_gen_1	637	644	PF00069	0.445
DOC_MAPK_MEF2A_6	429	437	PF00069	0.308
DOC_MAPK_MEF2A_6	457	464	PF00069	0.352
DOC_PP2B_LxvP_1	370	373	PF13499	0.390
DOC_USP7_MATH_1	108	112	PF00917	0.738
DOC_USP7_MATH_1	165	169	PF00917	0.493
DOC_USP7_MATH_1	171	175	PF00917	0.502
DOC_USP7_MATH_1	268	272	PF00917	0.619
DOC_USP7_MATH_1	475	479	PF00917	0.364
DOC_USP7_MATH_1	543	547	PF00917	0.381
DOC_USP7_MATH_2	301	307	PF00917	0.604
DOC_WW_Pin1_4	111	116	PF00397	0.586
DOC_WW_Pin1_4	139	144	PF00397	0.636
DOC_WW_Pin1_4	163	168	PF00397	0.642
DOC_WW_Pin1_4	2	7	PF00397	0.621
DOC_WW_Pin1_4	289	294	PF00397	0.691
DOC_WW_Pin1_4	297	302	PF00397	0.598
DOC_WW_Pin1_4	362	367	PF00397	0.455
DOC_WW_Pin1_4	536	541	PF00397	0.510
DOC_WW_Pin1_4	9	14	PF00397	0.612
LIG_14-3-3_CanoR_1	225	234	PF00244	0.546
LIG_14-3-3_CanoR_1	308	313	PF00244	0.637
LIG_14-3-3_CanoR_1	360	366	PF00244	0.455
LIG_14-3-3_CanoR_1	448	453	PF00244	0.449
LIG_14-3-3_CanoR_1	535	540	PF00244	0.525
LIG_14-3-3_CanoR_1	612	620	PF00244	0.362
LIG_14-3-3_CanoR_1	645	651	PF00244	0.437
LIG_14-3-3_CanoR_1	74	78	PF00244	0.681
LIG_APCC_ABBAyCdc20_2	712	718	PF00400	0.492
LIG_BRCT_BRCA1_1	168	172	PF00533	0.538
LIG_BRCT_BRCA1_1	562	566	PF00533	0.427
LIG_EH1_1	617	625	PF00400	0.417
LIG_eIF4E_1	618	624	PF01652	0.275
LIG_FHA_1	222	228	PF00498	0.603
LIG_FHA_1	302	308	PF00498	0.635
LIG_FHA_1	315	321	PF00498	0.622
LIG_FHA_1	378	384	PF00498	0.447
LIG_FHA_1	439	445	PF00498	0.392
LIG_FHA_1	605	611	PF00498	0.454
LIG_FHA_1	647	653	PF00498	0.434
LIG_FHA_2	285	291	PF00498	0.588
LIG_FHA_2	362	368	PF00498	0.391
LIG_FHA_2	38	44	PF00498	0.683
LIG_FHA_2	565	571	PF00498	0.424
LIG_FHA_2	588	594	PF00498	0.654
LIG_FHA_2	626	632	PF00498	0.310
LIG_IBAR_NPY_1	129	131	PF08397	0.603
LIG_Integrin_isoDGR_2	16	18	PF01839	0.555
LIG_LIR_Apic_2	137	143	PF02991	0.496
LIG_LIR_Gen_1	169	180	PF02991	0.769
LIG_LIR_Gen_1	188	199	PF02991	0.521
LIG_LIR_Gen_1	449	460	PF02991	0.556
LIG_LIR_Gen_1	648	658	PF02991	0.372
LIG_LIR_Gen_1	96	105	PF02991	0.650
LIG_LIR_Nem_3	169	175	PF02991	0.778
LIG_LIR_Nem_3	188	194	PF02991	0.532
LIG_LIR_Nem_3	449	455	PF02991	0.555
LIG_LIR_Nem_3	54	60	PF02991	0.494
LIG_LIR_Nem_3	648	653	PF02991	0.385
LIG_LIR_Nem_3	654	659	PF02991	0.375
LIG_LIR_Nem_3	685	691	PF02991	0.348
LIG_MAD2	368	376	PF02301	0.394
LIG_PCNA_yPIPBox_3	612	624	PF02747	0.430
LIG_Pex14_2	688	692	PF04695	0.358
LIG_RPA_C_Fungi	198	210	PF08784	0.499
LIG_RPA_C_Fungi	443	455	PF08784	0.394
LIG_SH2_NCK_1	159	163	PF00017	0.608
LIG_SH2_PTP2	140	143	PF00017	0.495
LIG_SH2_STAP1	159	163	PF00017	0.729
LIG_SH2_STAP1	223	227	PF00017	0.634
LIG_SH2_STAT5	131	134	PF00017	0.497
LIG_SH2_STAT5	140	143	PF00017	0.475
LIG_SH2_STAT5	223	226	PF00017	0.671
LIG_SH2_STAT5	347	350	PF00017	0.581
LIG_SH2_STAT5	512	515	PF00017	0.290
LIG_SH2_STAT5	519	522	PF00017	0.290
LIG_SH2_STAT5	609	612	PF00017	0.490
LIG_SH3_2	373	378	PF14604	0.482
LIG_SH3_3	109	115	PF00018	0.514
LIG_SH3_3	370	376	PF00018	0.437
LIG_SH3_3	453	459	PF00018	0.420
LIG_SH3_3	466	472	PF00018	0.351
LIG_SH3_3	50	56	PF00018	0.647
LIG_SH3_4	713	720	PF00018	0.492
LIG_SUMO_SIM_par_1	114	119	PF11976	0.492
LIG_SUMO_SIM_par_1	411	417	PF11976	0.433
LIG_SUMO_SIM_par_1	472	479	PF11976	0.371
LIG_SUMO_SIM_par_1	494	501	PF11976	0.245
LIG_TRAF2_1	592	595	PF00917	0.611
LIG_TRAF2_1	672	675	PF00917	0.422
LIG_WRC_WIRS_1	172	177	PF05994	0.638
LIG_WRC_WIRS_1	309	314	PF05994	0.500
LIG_WRC_WIRS_1	653	658	PF05994	0.412
LIG_WRC_WIRS_1	95	100	PF05994	0.625
MOD_CDK_SPK_2	289	294	PF00069	0.614
MOD_CDK_SPK_2	536	541	PF00069	0.474
MOD_CDK_SPxK_1	362	368	PF00069	0.450
MOD_CK1_1	111	117	PF00069	0.606
MOD_CK1_1	12	18	PF00069	0.626
MOD_CK1_1	149	155	PF00069	0.579
MOD_CK1_1	170	176	PF00069	0.611
MOD_CK1_1	178	184	PF00069	0.656
MOD_CK1_1	185	191	PF00069	0.674
MOD_CK1_1	20	26	PF00069	0.639
MOD_CK1_1	295	301	PF00069	0.527
MOD_CK1_1	323	329	PF00069	0.531
MOD_CK1_1	39	45	PF00069	0.642
MOD_CK1_1	398	404	PF00069	0.358
MOD_CK1_1	447	453	PF00069	0.416
MOD_CK1_1	525	531	PF00069	0.329
MOD_CK1_1	666	672	PF00069	0.376
MOD_CK2_1	171	177	PF00069	0.638
MOD_CK2_1	232	238	PF00069	0.657
MOD_CK2_1	284	290	PF00069	0.602
MOD_CK2_1	297	303	PF00069	0.574
MOD_CK2_1	361	367	PF00069	0.397
MOD_CK2_1	37	43	PF00069	0.719
MOD_CK2_1	5	11	PF00069	0.544
MOD_CK2_1	564	570	PF00069	0.413
MOD_CK2_1	625	631	PF00069	0.311
MOD_Cter_Amidation	710	713	PF01082	0.502
MOD_DYRK1A_RPxSP_1	536	540	PF00069	0.474
MOD_GlcNHglycan	169	172	PF01048	0.548
MOD_GlcNHglycan	19	22	PF01048	0.693
MOD_GlcNHglycan	229	232	PF01048	0.548
MOD_GlcNHglycan	263	266	PF01048	0.694
MOD_GlcNHglycan	270	273	PF01048	0.663
MOD_GlcNHglycan	312	315	PF01048	0.668
MOD_GlcNHglycan	335	338	PF01048	0.725
MOD_GlcNHglycan	348	351	PF01048	0.716
MOD_GlcNHglycan	402	405	PF01048	0.429
MOD_GlcNHglycan	620	623	PF01048	0.292
MOD_GlcNHglycan	75	78	PF01048	0.657
MOD_GSK3_1	107	114	PF00069	0.596
MOD_GSK3_1	135	142	PF00069	0.668
MOD_GSK3_1	143	150	PF00069	0.619
MOD_GSK3_1	163	170	PF00069	0.608
MOD_GSK3_1	171	178	PF00069	0.680
MOD_GSK3_1	181	188	PF00069	0.613
MOD_GSK3_1	232	239	PF00069	0.786
MOD_GSK3_1	247	254	PF00069	0.457
MOD_GSK3_1	257	264	PF00069	0.543
MOD_GSK3_1	28	35	PF00069	0.774
MOD_GSK3_1	295	302	PF00069	0.599
MOD_GSK3_1	310	317	PF00069	0.600
MOD_GSK3_1	321	328	PF00069	0.626
MOD_GSK3_1	342	349	PF00069	0.579
MOD_GSK3_1	444	451	PF00069	0.444
MOD_GSK3_1	5	12	PF00069	0.615
MOD_GSK3_1	560	567	PF00069	0.385
MOD_GSK3_1	604	611	PF00069	0.448
MOD_N-GLC_1	232	237	PF02516	0.573
MOD_N-GLC_1	362	367	PF02516	0.449
MOD_N-GLC_2	388	390	PF02516	0.409
MOD_NEK2_1	100	105	PF00069	0.569
MOD_NEK2_1	116	121	PF00069	0.528
MOD_NEK2_1	175	180	PF00069	0.631
MOD_NEK2_1	283	288	PF00069	0.574
MOD_NEK2_1	395	400	PF00069	0.394
MOD_NEK2_1	462	467	PF00069	0.410
MOD_NEK2_1	576	581	PF00069	0.427
MOD_NEK2_1	652	657	PF00069	0.457
MOD_NEK2_1	692	697	PF00069	0.481
MOD_NEK2_1	93	98	PF00069	0.571
MOD_NEK2_2	186	191	PF00069	0.534
MOD_NEK2_2	218	223	PF00069	0.498
MOD_NEK2_2	257	262	PF00069	0.511
MOD_NEK2_2	506	511	PF00069	0.224
MOD_NEK2_2	543	548	PF00069	0.514
MOD_NEK2_2	682	687	PF00069	0.421
MOD_OFUCOSY	661	667	PF10250	0.363
MOD_PIKK_1	377	383	PF00454	0.400
MOD_PIKK_1	604	610	PF00454	0.494
MOD_PIKK_1	613	619	PF00454	0.531
MOD_PKA_1	37	43	PF00069	0.685
MOD_PKA_1	45	51	PF00069	0.577
MOD_PKA_1	535	541	PF00069	0.476
MOD_PKA_1	645	651	PF00069	0.437
MOD_PKA_2	17	23	PF00069	0.616
MOD_PKA_2	33	39	PF00069	0.613
MOD_PKA_2	447	453	PF00069	0.447
MOD_PKA_2	45	51	PF00069	0.635
MOD_PKA_2	535	541	PF00069	0.480
MOD_PKA_2	73	79	PF00069	0.649
MOD_PKB_1	340	348	PF00069	0.591
MOD_PKB_1	562	570	PF00069	0.415
MOD_Plk_1	181	187	PF00069	0.541
MOD_Plk_1	232	238	PF00069	0.605
MOD_Plk_1	302	308	PF00069	0.628
MOD_Plk_1	661	667	PF00069	0.422
MOD_Plk_1	682	688	PF00069	0.408
MOD_Plk_1	91	97	PF00069	0.632
MOD_Plk_2-3	587	593	PF00069	0.487
MOD_Plk_4	175	181	PF00069	0.537
MOD_Plk_4	182	188	PF00069	0.496
MOD_Plk_4	218	224	PF00069	0.527
MOD_Plk_4	395	401	PF00069	0.385
MOD_Plk_4	448	454	PF00069	0.495
MOD_ProDKin_1	111	117	PF00069	0.586
MOD_ProDKin_1	139	145	PF00069	0.637
MOD_ProDKin_1	163	169	PF00069	0.641
MOD_ProDKin_1	2	8	PF00069	0.623
MOD_ProDKin_1	289	295	PF00069	0.692
MOD_ProDKin_1	297	303	PF00069	0.596
MOD_ProDKin_1	362	368	PF00069	0.456
MOD_ProDKin_1	536	542	PF00069	0.504
MOD_ProDKin_1	9	15	PF00069	0.609
TRG_ENDOCYTIC_2	191	194	PF00928	0.568
TRG_ER_diArg_1	339	342	PF00400	0.605
TRG_ER_diArg_1	562	565	PF00400	0.436
TRG_NLS_MonoExtN_4	559	565	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N4	Leptomonas seymouri	59%	98%
A0A1X0P1T2	Trypanosomatidae	40%	100%
A0A3Q8ILY5	Leishmania donovani	82%	100%
A4I8Q1	Leishmania infantum	82%	100%
E9B3L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4H0	Leishmania major	82%	100%