Heat shock protein 83-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 83-1

Species:

Leishmania braziliensis

UniProt:

A4HL71_LEIBR

TriTrypDb:

LbrM.33.0350 , LBRM2903_330008200

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL71

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017076	purine nucleotide binding	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0044183	protein folding chaperone	1	3
GO:0051082	unfolded protein binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:0140662	ATP-dependent protein folding chaperone	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.539
CLV_NRD_NRD_1	16	18	PF00675	0.530
CLV_NRD_NRD_1	162	164	PF00675	0.525
CLV_NRD_NRD_1	298	300	PF00675	0.539
CLV_NRD_NRD_1	62	64	PF00675	0.539
CLV_PCSK_KEX2_1	16	18	PF00082	0.386
CLV_PCSK_KEX2_1	162	164	PF00082	0.539
CLV_PCSK_KEX2_1	297	299	PF00082	0.539
CLV_PCSK_KEX2_1	7	9	PF00082	0.364
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.364
CLV_PCSK_SKI1_1	16	20	PF00082	0.530
CLV_PCSK_SKI1_1	223	227	PF00082	0.539
CLV_PCSK_SKI1_1	307	311	PF00082	0.539
CLV_PCSK_SKI1_1	340	344	PF00082	0.539
CLV_PCSK_SKI1_1	57	61	PF00082	0.539
CLV_PCSK_SKI1_1	93	97	PF00082	0.539
CLV_Separin_Metazoa	111	115	PF03568	0.539
DEG_APCC_DBOX_1	105	113	PF00400	0.539
DEG_APCC_DBOX_1	162	170	PF00400	0.526
DEG_Kelch_Keap1_1	117	122	PF01344	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.252
DEG_SPOP_SBC_1	370	374	PF00917	0.842
DOC_CYCLIN_RxL_1	63	76	PF00134	0.270
DOC_MAPK_gen_1	106	115	PF00069	0.539
DOC_MAPK_gen_1	160	170	PF00069	0.512
DOC_MAPK_gen_1	307	317	PF00069	0.539
DOC_MAPK_gen_1	337	346	PF00069	0.539
DOC_MAPK_gen_1	6	15	PF00069	0.530
DOC_MAPK_HePTP_8	238	250	PF00069	0.539
DOC_MAPK_MEF2A_6	162	170	PF00069	0.526
DOC_MAPK_MEF2A_6	241	250	PF00069	0.539
DOC_MAPK_MEF2A_6	310	317	PF00069	0.539
DOC_MAPK_MEF2A_6	337	346	PF00069	0.539
DOC_MAPK_MEF2A_6	6	15	PF00069	0.530
DOC_MAPK_NFAT4_5	8	16	PF00069	0.530
DOC_PP1_RVXF_1	308	315	PF00149	0.539
DOC_PP2B_PxIxI_1	245	251	PF00149	0.539
DOC_USP7_MATH_1	370	374	PF00917	0.842
DOC_USP7_UBL2_3	135	139	PF12436	0.539
DOC_USP7_UBL2_3	60	64	PF12436	0.539
DOC_USP7_UBL2_3	81	85	PF12436	0.539
DOC_WW_Pin1_4	152	157	PF00397	0.539
DOC_WW_Pin1_4	242	247	PF00397	0.539
LIG_14-3-3_CanoR_1	114	124	PF00244	0.539
LIG_14-3-3_CanoR_1	241	246	PF00244	0.539
LIG_Actin_WH2_2	256	272	PF00022	0.539
LIG_APCC_ABBA_1	71	76	PF00400	0.539
LIG_APCC_ABBA_1	97	102	PF00400	0.539
LIG_APCC_ABBAyCdc20_2	196	202	PF00400	0.539
LIG_APCC_ABBAyCdc20_2	96	102	PF00400	0.539
LIG_BRCT_BRCA1_1	153	157	PF00533	0.402
LIG_deltaCOP1_diTrp_1	30	34	PF00928	0.539
LIG_FHA_1	170	176	PF00498	0.539
LIG_FHA_1	281	287	PF00498	0.539
LIG_FHA_1	317	323	PF00498	0.539
LIG_FHA_2	124	130	PF00498	0.539
LIG_FHA_2	222	228	PF00498	0.539
LIG_FHA_2	235	241	PF00498	0.325
LIG_IRF3_LxIS_1	44	49	PF10401	0.539
LIG_LIR_Gen_1	188	199	PF02991	0.539
LIG_LIR_Gen_1	311	322	PF02991	0.539
LIG_LIR_Gen_1	72	78	PF02991	0.539
LIG_LIR_Nem_3	188	194	PF02991	0.539
LIG_LIR_Nem_3	30	34	PF02991	0.539
LIG_LIR_Nem_3	311	317	PF02991	0.539
LIG_LIR_Nem_3	82	87	PF02991	0.387
LIG_NRBOX	108	114	PF00104	0.539
LIG_NRBOX	311	317	PF00104	0.539
LIG_PCNA_yPIPBox_3	50	62	PF02747	0.539
LIG_Pex14_2	87	91	PF04695	0.539
LIG_Rb_pABgroove_1	311	319	PF01858	0.539
LIG_SH2_STAP1	334	338	PF00017	0.539
LIG_SH2_STAT3	178	181	PF00017	0.539
LIG_SH2_STAT5	130	133	PF00017	0.539
LIG_SH2_STAT5	14	17	PF00017	0.530
LIG_SH2_STAT5	143	146	PF00017	0.325
LIG_SH2_STAT5	178	181	PF00017	0.539
LIG_SH3_3	285	291	PF00018	0.539
LIG_SH3_4	135	142	PF00018	0.270
LIG_TRAF2_1	120	123	PF00917	0.539
LIG_TRAF2_1	204	207	PF00917	0.539
LIG_UBA3_1	58	64	PF00899	0.539
LIG_UBA3_1	73	81	PF00899	0.292
MOD_CK1_1	117	123	PF00069	0.539
MOD_CK1_1	280	286	PF00069	0.539
MOD_CK1_1	320	326	PF00069	0.539
MOD_CK2_1	117	123	PF00069	0.539
MOD_CK2_1	201	207	PF00069	0.539
MOD_CK2_1	221	227	PF00069	0.210
MOD_CK2_1	234	240	PF00069	0.325
MOD_CK2_1	344	350	PF00069	0.534
MOD_CK2_1	370	376	PF00069	0.760
MOD_GlcNHglycan	119	122	PF01048	0.539
MOD_GlcNHglycan	256	259	PF01048	0.539
MOD_GlcNHglycan	323	326	PF01048	0.539
MOD_GSK3_1	236	243	PF00069	0.539
MOD_GSK3_1	316	323	PF00069	0.539
MOD_GSK3_1	366	373	PF00069	0.790
MOD_N-GLC_1	46	51	PF02516	0.539
MOD_NEK2_1	221	226	PF00069	0.539
MOD_NEK2_1	254	259	PF00069	0.539
MOD_NEK2_1	269	274	PF00069	0.292
MOD_NEK2_1	316	321	PF00069	0.539
MOD_PKA_2	240	246	PF00069	0.539
MOD_PKA_2	269	275	PF00069	0.539
MOD_Plk_1	122	128	PF00069	0.539
MOD_Plk_1	270	276	PF00069	0.539
MOD_Plk_1	317	323	PF00069	0.539
MOD_Plk_2-3	123	129	PF00069	0.539
MOD_Plk_2-3	234	240	PF00069	0.402
MOD_Plk_4	137	143	PF00069	0.539
MOD_Plk_4	317	323	PF00069	0.539
MOD_ProDKin_1	152	158	PF00069	0.539
MOD_ProDKin_1	242	248	PF00069	0.539
MOD_SUMO_for_1	134	137	PF00179	0.402
MOD_SUMO_rev_2	185	192	PF00179	0.539
MOD_SUMO_rev_2	206	216	PF00179	0.525
MOD_SUMO_rev_2	79	87	PF00179	0.539
TRG_DiLeu_BaEn_2	152	158	PF01217	0.539
TRG_DiLeu_BaEn_4	122	128	PF01217	0.539
TRG_ENDOCYTIC_2	84	87	PF00928	0.539
TRG_ENDOCYTIC_2	88	91	PF00928	0.473
TRG_ER_diArg_1	15	17	PF00400	0.530
TRG_ER_diArg_1	296	299	PF00400	0.539
TRG_NES_CRM1_1	227	240	PF08389	0.539
TRG_NES_CRM1_1	336	352	PF08389	0.539
TRG_NLS_MonoExtC_3	105	111	PF00514	0.539
TRG_NLS_MonoExtN_4	4	10	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HL69	Leishmania braziliensis	99%	100%
P08712	Mesocricetus auratus	50%	95%
P27890	Leishmania donovani	91%	84%
P36182	Nicotiana tabacum	65%	76%
Q58FF3	Homo sapiens	43%	95%
Q58FF6	Homo sapiens	39%	75%