Heat shock protein 83-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 83-1

Species:

Leishmania braziliensis

UniProt:

A4HL69_LEIBR

TriTrypDb:

LbrM.33.0330 , LBRM2903_330008200

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL69

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017076	purine nucleotide binding	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0044183	protein folding chaperone	1	3
GO:0051082	unfolded protein binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:0140662	ATP-dependent protein folding chaperone	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.477
CLV_NRD_NRD_1	278	280	PF00675	0.387
CLV_NRD_NRD_1	42	44	PF00675	0.427
CLV_NRD_NRD_1	85	87	PF00675	0.558
CLV_PCSK_KEX2_1	142	144	PF00082	0.500
CLV_PCSK_KEX2_1	277	279	PF00082	0.383
CLV_PCSK_SKI1_1	203	207	PF00082	0.558
CLV_PCSK_SKI1_1	287	291	PF00082	0.558
CLV_PCSK_SKI1_1	320	324	PF00082	0.477
CLV_PCSK_SKI1_1	37	41	PF00082	0.558
CLV_PCSK_SKI1_1	73	77	PF00082	0.558
CLV_Separin_Metazoa	91	95	PF03568	0.558
DEG_APCC_DBOX_1	142	150	PF00400	0.558
DEG_APCC_DBOX_1	85	93	PF00400	0.558
DEG_Kelch_Keap1_1	97	102	PF01344	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.262
DEG_SPOP_SBC_1	350	354	PF00917	0.868
DOC_CYCLIN_RxL_1	43	56	PF00134	0.531
DOC_MAPK_gen_1	140	150	PF00069	0.477
DOC_MAPK_gen_1	287	297	PF00069	0.402
DOC_MAPK_gen_1	317	326	PF00069	0.558
DOC_MAPK_gen_1	86	95	PF00069	0.558
DOC_MAPK_HePTP_8	218	230	PF00069	0.558
DOC_MAPK_MEF2A_6	142	150	PF00069	0.558
DOC_MAPK_MEF2A_6	221	230	PF00069	0.558
DOC_MAPK_MEF2A_6	290	297	PF00069	0.558
DOC_MAPK_MEF2A_6	317	326	PF00069	0.558
DOC_PP1_RVXF_1	288	295	PF00149	0.558
DOC_PP2B_PxIxI_1	225	231	PF00149	0.558
DOC_USP7_MATH_1	350	354	PF00917	0.868
DOC_USP7_UBL2_3	115	119	PF12436	0.558
DOC_USP7_UBL2_3	40	44	PF12436	0.558
DOC_USP7_UBL2_3	61	65	PF12436	0.558
DOC_WW_Pin1_4	132	137	PF00397	0.558
DOC_WW_Pin1_4	222	227	PF00397	0.558
LIG_14-3-3_CanoR_1	221	226	PF00244	0.558
LIG_14-3-3_CanoR_1	94	104	PF00244	0.558
LIG_Actin_WH2_2	236	252	PF00022	0.558
LIG_APCC_ABBA_1	51	56	PF00400	0.558
LIG_APCC_ABBA_1	77	82	PF00400	0.558
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.558
LIG_APCC_ABBAyCdc20_2	76	82	PF00400	0.558
LIG_BRCT_BRCA1_1	133	137	PF00533	0.558
LIG_deltaCOP1_diTrp_1	10	14	PF00928	0.558
LIG_FHA_1	150	156	PF00498	0.558
LIG_FHA_1	261	267	PF00498	0.558
LIG_FHA_1	297	303	PF00498	0.558
LIG_FHA_2	104	110	PF00498	0.467
LIG_FHA_2	202	208	PF00498	0.558
LIG_FHA_2	215	221	PF00498	0.331
LIG_IRF3_LxIS_1	24	29	PF10401	0.558
LIG_LIR_Gen_1	168	179	PF02991	0.558
LIG_LIR_Gen_1	291	302	PF02991	0.526
LIG_LIR_Gen_1	52	58	PF02991	0.558
LIG_LIR_Nem_3	10	14	PF02991	0.558
LIG_LIR_Nem_3	168	174	PF02991	0.558
LIG_LIR_Nem_3	291	297	PF02991	0.526
LIG_LIR_Nem_3	62	67	PF02991	0.464
LIG_NRBOX	291	297	PF00104	0.558
LIG_NRBOX	88	94	PF00104	0.558
LIG_PCNA_yPIPBox_3	30	42	PF02747	0.558
LIG_Pex14_2	67	71	PF04695	0.558
LIG_Rb_pABgroove_1	291	299	PF01858	0.558
LIG_SH2_STAP1	314	318	PF00017	0.558
LIG_SH2_STAT3	158	161	PF00017	0.558
LIG_SH2_STAT5	110	113	PF00017	0.477
LIG_SH2_STAT5	123	126	PF00017	0.289
LIG_SH2_STAT5	158	161	PF00017	0.383
LIG_SH3_3	265	271	PF00018	0.558
LIG_SH3_4	115	122	PF00018	0.531
LIG_TRAF2_1	100	103	PF00917	0.558
LIG_TRAF2_1	184	187	PF00917	0.558
LIG_UBA3_1	38	44	PF00899	0.558
LIG_UBA3_1	53	61	PF00899	0.243
MOD_CK1_1	260	266	PF00069	0.558
MOD_CK1_1	300	306	PF00069	0.558
MOD_CK1_1	97	103	PF00069	0.558
MOD_CK2_1	181	187	PF00069	0.558
MOD_CK2_1	201	207	PF00069	0.208
MOD_CK2_1	214	220	PF00069	0.331
MOD_CK2_1	324	330	PF00069	0.558
MOD_CK2_1	350	356	PF00069	0.846
MOD_CK2_1	97	103	PF00069	0.392
MOD_GlcNHglycan	236	239	PF01048	0.558
MOD_GlcNHglycan	303	306	PF01048	0.558
MOD_GlcNHglycan	99	102	PF01048	0.558
MOD_GSK3_1	216	223	PF00069	0.558
MOD_GSK3_1	296	303	PF00069	0.558
MOD_GSK3_1	346	353	PF00069	0.856
MOD_N-GLC_1	26	31	PF02516	0.558
MOD_NEK2_1	201	206	PF00069	0.558
MOD_NEK2_1	234	239	PF00069	0.500
MOD_NEK2_1	249	254	PF00069	0.281
MOD_NEK2_1	296	301	PF00069	0.558
MOD_PKA_2	220	226	PF00069	0.558
MOD_PKA_2	249	255	PF00069	0.558
MOD_Plk_1	102	108	PF00069	0.558
MOD_Plk_1	250	256	PF00069	0.449
MOD_Plk_1	297	303	PF00069	0.558
MOD_Plk_2-3	103	109	PF00069	0.558
MOD_Plk_2-3	214	220	PF00069	0.558
MOD_Plk_4	117	123	PF00069	0.558
MOD_Plk_4	297	303	PF00069	0.558
MOD_ProDKin_1	132	138	PF00069	0.558
MOD_ProDKin_1	222	228	PF00069	0.558
MOD_SUMO_for_1	114	117	PF00179	0.558
MOD_SUMO_rev_2	165	172	PF00179	0.558
MOD_SUMO_rev_2	186	196	PF00179	0.557
MOD_SUMO_rev_2	59	67	PF00179	0.558
TRG_DiLeu_BaEn_2	132	138	PF01217	0.558
TRG_DiLeu_BaEn_4	102	108	PF01217	0.558
TRG_ENDOCYTIC_2	64	67	PF00928	0.402
TRG_ENDOCYTIC_2	68	71	PF00928	0.364
TRG_ER_diArg_1	276	279	PF00400	0.383
TRG_NES_CRM1_1	207	220	PF08389	0.402
TRG_NES_CRM1_1	316	332	PF08389	0.558
TRG_NLS_MonoExtC_3	85	91	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HL71	Leishmania braziliensis	99%	95%
P08712	Mesocricetus auratus	49%	90%
P27890	Leishmania donovani	91%	79%
P36182	Nicotiana tabacum	65%	72%
Q58FF3	Homo sapiens	41%	90%