Putative ATP-binding cassette protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette sub-family F member 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HL68_LEIBR

TriTrypDb:

LbrM.33.0320 , LBRM2903_330008100

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.393
CLV_C14_Caspase3-7	378	382	PF00656	0.401
CLV_NRD_NRD_1	17	19	PF00675	0.518
CLV_NRD_NRD_1	197	199	PF00675	0.259
CLV_NRD_NRD_1	20	22	PF00675	0.505
CLV_NRD_NRD_1	221	223	PF00675	0.247
CLV_NRD_NRD_1	364	366	PF00675	0.408
CLV_NRD_NRD_1	483	485	PF00675	0.263
CLV_NRD_NRD_1	605	607	PF00675	0.495
CLV_PCSK_FUR_1	195	199	PF00082	0.267
CLV_PCSK_KEX2_1	197	199	PF00082	0.259
CLV_PCSK_KEX2_1	223	225	PF00082	0.248
CLV_PCSK_KEX2_1	268	270	PF00082	0.418
CLV_PCSK_KEX2_1	334	336	PF00082	0.412
CLV_PCSK_KEX2_1	363	365	PF00082	0.411
CLV_PCSK_KEX2_1	483	485	PF00082	0.263
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.239
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.448
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.412
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.423
CLV_PCSK_SKI1_1	197	201	PF00082	0.239
CLV_PCSK_SKI1_1	224	228	PF00082	0.239
CLV_PCSK_SKI1_1	483	487	PF00082	0.336
CLV_PCSK_SKI1_1	510	514	PF00082	0.239
CLV_PCSK_SKI1_1	546	550	PF00082	0.358
CLV_PCSK_SKI1_1	607	611	PF00082	0.586
CLV_PCSK_SKI1_1	613	617	PF00082	0.512
CLV_PCSK_SKI1_1	658	662	PF00082	0.606
CLV_PCSK_SKI1_1	66	70	PF00082	0.472
CLV_PCSK_SKI1_1	80	84	PF00082	0.329
DEG_APCC_DBOX_1	196	204	PF00400	0.239
DEG_MDM2_SWIB_1	217	225	PF02201	0.251
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DOC_CYCLIN_RxL_1	480	488	PF00134	0.311
DOC_MAPK_FxFP_2	371	374	PF00069	0.448
DOC_MAPK_FxFP_2	392	395	PF00069	0.343
DOC_MAPK_gen_1	104	112	PF00069	0.251
DOC_MAPK_gen_1	195	205	PF00069	0.267
DOC_MAPK_gen_1	268	276	PF00069	0.355
DOC_MAPK_gen_1	363	371	PF00069	0.422
DOC_MAPK_gen_1	546	555	PF00069	0.317
DOC_MAPK_JIP1_4	269	275	PF00069	0.336
DOC_PP1_RVXF_1	174	180	PF00149	0.251
DOC_PP1_RVXF_1	195	202	PF00149	0.251
DOC_PP1_RVXF_1	508	514	PF00149	0.311
DOC_PP1_RVXF_1	64	71	PF00149	0.498
DOC_PP2B_LxvP_1	474	477	PF13499	0.416
DOC_PP4_FxxP_1	232	235	PF00568	0.267
DOC_PP4_FxxP_1	371	374	PF00568	0.347
DOC_PP4_FxxP_1	392	395	PF00568	0.427
DOC_PP4_FxxP_1	526	529	PF00568	0.247
DOC_USP7_MATH_1	119	123	PF00917	0.267
DOC_USP7_MATH_1	213	217	PF00917	0.251
DOC_USP7_MATH_1	226	230	PF00917	0.251
DOC_USP7_MATH_1	62	66	PF00917	0.510
DOC_USP7_MATH_1	8	12	PF00917	0.465
DOC_USP7_UBL2_3	19	23	PF12436	0.517
DOC_USP7_UBL2_3	654	658	PF12436	0.542
DOC_USP7_UBL2_3	80	84	PF12436	0.425
DOC_WW_Pin1_4	463	468	PF00397	0.311
DOC_WW_Pin1_4	517	522	PF00397	0.393
LIG_14-3-3_CanoR_1	104	113	PF00244	0.262
LIG_14-3-3_CanoR_1	212	218	PF00244	0.251
LIG_14-3-3_CanoR_1	269	274	PF00244	0.343
LIG_14-3-3_CanoR_1	413	417	PF00244	0.251
LIG_14-3-3_CanoR_1	66	71	PF00244	0.435
LIG_APCC_ABBA_1	523	528	PF00400	0.239
LIG_BRCT_BRCA1_1	228	232	PF00533	0.311
LIG_BRCT_BRCA1_1	519	523	PF00533	0.397
LIG_Clathr_ClatBox_1	126	130	PF01394	0.267
LIG_CtBP_PxDLS_1	376	380	PF00389	0.488
LIG_EH_1	49	53	PF12763	0.548
LIG_EVH1_1	373	377	PF00568	0.458
LIG_FHA_1	242	248	PF00498	0.239
LIG_FHA_1	270	276	PF00498	0.310
LIG_FHA_1	286	292	PF00498	0.281
LIG_FHA_1	430	436	PF00498	0.247
LIG_FHA_1	528	534	PF00498	0.239
LIG_FHA_1	56	62	PF00498	0.597
LIG_FHA_1	614	620	PF00498	0.417
LIG_FHA_1	85	91	PF00498	0.303
LIG_FHA_2	134	140	PF00498	0.393
LIG_FHA_2	15	21	PF00498	0.630
LIG_FHA_2	327	333	PF00498	0.432
LIG_FHA_2	464	470	PF00498	0.239
LIG_Integrin_isoDGR_2	102	104	PF01839	0.251
LIG_LIR_Apic_2	229	235	PF02991	0.286
LIG_LIR_Apic_2	368	374	PF02991	0.424
LIG_LIR_Apic_2	389	395	PF02991	0.324
LIG_LIR_Gen_1	320	330	PF02991	0.327
LIG_LIR_Gen_1	438	448	PF02991	0.393
LIG_LIR_Gen_1	520	529	PF02991	0.395
LIG_LIR_Gen_1	69	77	PF02991	0.514
LIG_LIR_Nem_3	304	308	PF02991	0.439
LIG_LIR_Nem_3	320	326	PF02991	0.317
LIG_LIR_Nem_3	438	444	PF02991	0.393
LIG_LIR_Nem_3	520	526	PF02991	0.395
LIG_LIR_Nem_3	585	590	PF02991	0.471
LIG_LIR_Nem_3	69	73	PF02991	0.527
LIG_MAD2	198	206	PF02301	0.267
LIG_NRBOX	123	129	PF00104	0.251
LIG_PCNA_yPIPBox_3	333	347	PF02747	0.304
LIG_Pex14_1	254	258	PF04695	0.290
LIG_Pex14_2	201	205	PF04695	0.251
LIG_Pex14_2	217	221	PF04695	0.251
LIG_SH2_CRK	587	591	PF00017	0.508
LIG_SH2_NCK_1	323	327	PF00017	0.413
LIG_SH2_PTP2	441	444	PF00017	0.393
LIG_SH2_STAP1	156	160	PF00017	0.224
LIG_SH2_STAP1	263	267	PF00017	0.450
LIG_SH2_STAP1	323	327	PF00017	0.520
LIG_SH2_STAP1	367	371	PF00017	0.436
LIG_SH2_STAT5	258	261	PF00017	0.330
LIG_SH2_STAT5	296	299	PF00017	0.316
LIG_SH2_STAT5	367	370	PF00017	0.409
LIG_SH2_STAT5	441	444	PF00017	0.395
LIG_SH3_3	366	372	PF00018	0.377
LIG_SH3_3	392	398	PF00018	0.451
LIG_SH3_3	431	437	PF00018	0.420
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.251
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.286
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.292
LIG_SUMO_SIM_par_1	125	130	PF11976	0.251
LIG_SUMO_SIM_par_1	236	242	PF11976	0.251
LIG_SUMO_SIM_par_1	271	277	PF11976	0.298
LIG_SUMO_SIM_par_1	551	556	PF11976	0.281
LIG_WRC_WIRS_1	486	491	PF05994	0.239
MOD_CK1_1	11	17	PF00069	0.667
MOD_CK1_1	138	144	PF00069	0.251
MOD_CK1_1	215	221	PF00069	0.345
MOD_CK1_1	257	263	PF00069	0.472
MOD_CK1_1	412	418	PF00069	0.257
MOD_CK1_1	517	523	PF00069	0.393
MOD_CK1_1	650	656	PF00069	0.414
MOD_CK1_1	91	97	PF00069	0.311
MOD_CK2_1	133	139	PF00069	0.343
MOD_CK2_1	14	20	PF00069	0.571
MOD_CK2_1	167	173	PF00069	0.283
MOD_CK2_1	463	469	PF00069	0.239
MOD_GlcNHglycan	13	16	PF01048	0.633
MOD_GlcNHglycan	139	143	PF01048	0.251
MOD_GlcNHglycan	168	172	PF01048	0.378
MOD_GlcNHglycan	217	220	PF01048	0.239
MOD_GlcNHglycan	228	231	PF01048	0.239
MOD_GlcNHglycan	305	308	PF01048	0.250
MOD_GlcNHglycan	352	355	PF01048	0.458
MOD_GlcNHglycan	395	398	PF01048	0.302
MOD_GlcNHglycan	503	506	PF01048	0.250
MOD_GlcNHglycan	516	519	PF01048	0.271
MOD_GlcNHglycan	621	624	PF01048	0.632
MOD_GlcNHglycan	649	652	PF01048	0.391
MOD_GlcNHglycan	90	93	PF01048	0.267
MOD_GSK3_1	211	218	PF00069	0.251
MOD_GSK3_1	257	264	PF00069	0.476
MOD_GSK3_1	322	329	PF00069	0.513
MOD_GSK3_1	62	69	PF00069	0.457
MOD_GSK3_1	84	91	PF00069	0.393
MOD_LATS_1	210	216	PF00433	0.311
MOD_N-GLC_1	11	16	PF02516	0.445
MOD_N-GLC_1	580	585	PF02516	0.412
MOD_N-GLC_1	66	71	PF02516	0.447
MOD_NEK2_1	485	490	PF00069	0.311
MOD_NEK2_1	619	624	PF00069	0.625
MOD_PIKK_1	204	210	PF00454	0.325
MOD_PK_1	322	328	PF00069	0.526
MOD_PKA_2	211	217	PF00069	0.251
MOD_PKA_2	301	307	PF00069	0.477
MOD_PKA_2	412	418	PF00069	0.251
MOD_Plk_1	11	17	PF00069	0.436
MOD_Plk_1	138	144	PF00069	0.267
MOD_Plk_1	365	371	PF00069	0.453
MOD_Plk_1	388	394	PF00069	0.234
MOD_Plk_1	66	72	PF00069	0.425
MOD_Plk_1	84	90	PF00069	0.286
MOD_Plk_2-3	534	540	PF00069	0.333
MOD_Plk_4	105	111	PF00069	0.247
MOD_Plk_4	254	260	PF00069	0.294
MOD_Plk_4	269	275	PF00069	0.324
MOD_Plk_4	423	429	PF00069	0.251
MOD_ProDKin_1	463	469	PF00069	0.311
MOD_ProDKin_1	517	523	PF00069	0.393
MOD_SUMO_for_1	165	168	PF00179	0.393
MOD_SUMO_for_1	660	663	PF00179	0.733
MOD_SUMO_rev_2	14	24	PF00179	0.609
MOD_SUMO_rev_2	158	163	PF00179	0.396
MOD_SUMO_rev_2	478	482	PF00179	0.311
MOD_SUMO_rev_2	583	590	PF00179	0.454
MOD_SUMO_rev_2	599	609	PF00179	0.492
TRG_DiLeu_BaEn_1	158	163	PF01217	0.402
TRG_DiLeu_BaEn_1	234	239	PF01217	0.251
TRG_DiLeu_BaEn_2	174	180	PF01217	0.311
TRG_DiLeu_BaEn_2	518	524	PF01217	0.251
TRG_DiLeu_BaEn_3	181	187	PF01217	0.345
TRG_DiLeu_BaEn_4	158	164	PF01217	0.340
TRG_DiLeu_BaEn_4	32	38	PF01217	0.541
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.251
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.393
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.318
TRG_ENDOCYTIC_2	305	308	PF00928	0.409
TRG_ENDOCYTIC_2	323	326	PF00928	0.305
TRG_ENDOCYTIC_2	441	444	PF00928	0.393
TRG_ENDOCYTIC_2	587	590	PF00928	0.513
TRG_ENDOCYTIC_2	96	99	PF00928	0.251
TRG_ER_diArg_1	195	198	PF00400	0.267
TRG_ER_diArg_1	221	224	PF00400	0.239
TRG_ER_diArg_1	483	485	PF00400	0.385
TRG_NLS_MonoCore_2	267	272	PF00514	0.414
TRG_NLS_MonoCore_2	654	659	PF00514	0.634
TRG_NLS_MonoExtC_3	653	658	PF00514	0.571
TRG_NLS_MonoExtN_4	654	659	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VBH0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	34%	100%
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
A0A0N0P4L2	Leptomonas seymouri	38%	92%
A0A0N1I593	Leptomonas seymouri	88%	99%
A0A0N1PAH6	Leptomonas seymouri	40%	100%
A0A0S4IYK6	Bodo saltans	49%	100%
A0A0S4JRN6	Bodo saltans	71%	98%
A0A0S4JUD9	Bodo saltans	33%	100%
A0A1X0P0L3	Trypanosomatidae	79%	99%
A0A1X0P688	Trypanosomatidae	39%	100%
A0A1X0P8V9	Trypanosomatidae	38%	92%
A0A3Q8IHB5	Leishmania donovani	94%	100%
A0A3R7LWT1	Trypanosoma rangeli	38%	100%
A0A3S5H525	Leishmania donovani	38%	92%
A0A3S7WVI6	Leishmania donovani	41%	100%
A0A422N7J4	Trypanosoma rangeli	37%	92%
A0A422NHP3	Trypanosoma rangeli	78%	99%
A4H3I8	Leishmania braziliensis	36%	100%
A4HA37	Leishmania braziliensis	40%	100%
A4HRS7	Leishmania infantum	38%	92%
A4HYA0	Leishmania infantum	40%	100%
A4I8P8	Leishmania infantum	94%	100%
D0A0N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A223	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
D0A4N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	97%
E9ACG3	Leishmania major	36%	100%
E9AJQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	92%
E9AS32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B3L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O05519	Bacillus subtilis (strain 168)	29%	100%
O06476	Bacillus subtilis (strain 168)	28%	100%
O31716	Bacillus subtilis (strain 168)	29%	100%
O34362	Bacillus subtilis (strain 168)	25%	100%
O34512	Bacillus subtilis (strain 168)	26%	100%
O42943	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O59672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	90%
P0A9U3	Escherichia coli (strain K12)	31%	100%
P0A9U4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
P0A9U5	Escherichia coli O157:H7	31%	100%
P0A9W3	Escherichia coli (strain K12)	27%	100%
P0A9W4	Escherichia coli O157:H7	27%	100%
P0A9W5	Shigella flexneri	27%	100%
P23212	Staphylococcus epidermidis	24%	100%
P25256	Streptomyces fradiae	27%	100%
P39115	Bacillus subtilis (strain 168)	25%	100%
P40024	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P43535	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	88%
P43672	Escherichia coli (strain K12)	29%	100%
P44808	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P63389	Escherichia coli (strain K12)	34%	100%
P63390	Escherichia coli O157:H7	34%	100%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q2KJA2	Bos taurus	37%	100%
Q4Q4I8	Leishmania major	94%	100%
Q4QDE1	Leishmania major	40%	100%
Q57242	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
Q58129	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5R9Z5	Pongo abelii	36%	94%
Q66H39	Rattus norvegicus	38%	94%
Q6MG08	Rattus norvegicus	45%	79%
Q6P542	Mus musculus	45%	79%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q767L0	Sus scrofa	45%	82%
Q7YR37	Pan troglodytes	44%	82%
Q8G838	Bifidobacterium longum (strain NCC 2705)	26%	85%
Q8H0V6	Arabidopsis thaliana	37%	93%
Q8K268	Mus musculus	36%	94%
Q8K9I3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	26%	100%
Q8NE71	Homo sapiens	45%	79%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8T6B7	Dictyostelium discoideum	36%	100%
Q8TQ05	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	25%	100%
Q99LE6	Mus musculus	36%	100%
Q9FIB4	Arabidopsis thaliana	29%	98%
Q9FJH6	Arabidopsis thaliana	37%	100%
Q9LV93	Arabidopsis thaliana	29%	96%
Q9M1H3	Arabidopsis thaliana	42%	92%
Q9NUQ8	Homo sapiens	36%	94%
Q9UG63	Homo sapiens	36%	100%
Q9USH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	81%
V5AVV7	Trypanosoma cruzi	76%	100%
V5BD93	Trypanosoma cruzi	36%	100%
V5DFD4	Trypanosoma cruzi	38%	100%