Putative autophagocytosis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagocytosis protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL66_LEIBR

TriTrypDb:

LbrM.33.0300 , LBRM2903_330007500

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000153	cytoplasmic ubiquitin ligase complex	4	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HL66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL66

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0000422	autophagy of mitochondrion	4	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007033	vacuole organization	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044804	autophagy of nucleus	4	1
GO:0061726	mitochondrion disassembly	6	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1903008	organelle disassembly	5	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0019776	Atg8 ligase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.421
CLV_NRD_NRD_1	4	6	PF00675	0.588
CLV_PCSK_KEX2_1	4	6	PF00082	0.483
CLV_PCSK_SKI1_1	119	123	PF00082	0.448
CLV_PCSK_SKI1_1	192	196	PF00082	0.421
DEG_Kelch_Keap1_1	127	132	PF01344	0.448
DEG_SPOP_SBC_1	21	25	PF00917	0.572
DOC_CKS1_1	158	163	PF01111	0.301
DOC_MAPK_FxFP_2	242	245	PF00069	0.301
DOC_PP1_RVXF_1	117	124	PF00149	0.301
DOC_PP2B_LxvP_1	202	205	PF13499	0.421
DOC_PP2B_PxIxI_1	204	210	PF00149	0.421
DOC_PP4_FxxP_1	242	245	PF00568	0.301
DOC_WW_Pin1_4	157	162	PF00397	0.301
DOC_WW_Pin1_4	171	176	PF00397	0.301
DOC_WW_Pin1_4	31	36	PF00397	0.384
DOC_WW_Pin1_4	88	93	PF00397	0.401
LIG_14-3-3_CanoR_1	4	8	PF00244	0.576
LIG_Actin_WH2_2	241	257	PF00022	0.301
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BRCT_BRCA1_1	268	272	PF00533	0.579
LIG_FHA_1	110	116	PF00498	0.271
LIG_FHA_1	191	197	PF00498	0.298
LIG_FHA_1	28	34	PF00498	0.395
LIG_FHA_2	111	117	PF00498	0.363
LIG_FHA_2	120	126	PF00498	0.421
LIG_FHA_2	136	142	PF00498	0.421
LIG_FHA_2	21	27	PF00498	0.502
LIG_FHA_2	32	38	PF00498	0.326
LIG_FHA_2	92	98	PF00498	0.243
LIG_LIR_Apic_2	155	161	PF02991	0.301
LIG_LIR_Apic_2	240	245	PF02991	0.336
LIG_LIR_Gen_1	269	275	PF02991	0.602
LIG_LIR_Nem_3	149	154	PF02991	0.302
LIG_LIR_Nem_3	269	275	PF02991	0.602
LIG_LIR_Nem_3	6	11	PF02991	0.450
LIG_NRBOX	247	253	PF00104	0.421
LIG_SH2_CRK	158	162	PF00017	0.317
LIG_SH2_STAP1	148	152	PF00017	0.301
LIG_SH2_STAP1	154	158	PF00017	0.301
LIG_SH2_STAT5	151	154	PF00017	0.421
LIG_SH2_STAT5	164	167	PF00017	0.421
LIG_SH2_STAT5	168	171	PF00017	0.421
LIG_SH2_STAT5	64	67	PF00017	0.361
LIG_SH3_3	105	111	PF00018	0.376
LIG_SUMO_SIM_par_1	174	179	PF11976	0.406
LIG_SUMO_SIM_par_1	192	197	PF11976	0.288
LIG_TRAF2_1	130	133	PF00917	0.436
LIG_UBA3_1	250	255	PF00899	0.317
MOD_CDK_SPK_2	157	162	PF00069	0.301
MOD_CDK_SPK_2	31	36	PF00069	0.483
MOD_CK1_1	88	94	PF00069	0.354
MOD_CK2_1	110	116	PF00069	0.353
MOD_CK2_1	119	125	PF00069	0.358
MOD_CK2_1	127	133	PF00069	0.400
MOD_CK2_1	3	9	PF00069	0.512
MOD_CK2_1	31	37	PF00069	0.401
MOD_CK2_1	91	97	PF00069	0.249
MOD_GlcNHglycan	127	132	PF01048	0.426
MOD_GlcNHglycan	269	272	PF01048	0.572
MOD_GlcNHglycan	88	91	PF01048	0.344
MOD_GSK3_1	167	174	PF00069	0.334
MOD_GSK3_1	22	29	PF00069	0.450
MOD_GSK3_1	256	263	PF00069	0.280
MOD_N-GLC_1	141	146	PF02516	0.195
MOD_NEK2_1	135	140	PF00069	0.176
MOD_NEK2_1	256	261	PF00069	0.301
MOD_NEK2_1	27	32	PF00069	0.413
MOD_NEK2_2	205	210	PF00069	0.301
MOD_PKA_2	3	9	PF00069	0.575
MOD_Plk_1	140	146	PF00069	0.370
MOD_Plk_4	110	116	PF00069	0.445
MOD_Plk_4	256	262	PF00069	0.322
MOD_ProDKin_1	157	163	PF00069	0.301
MOD_ProDKin_1	171	177	PF00069	0.301
MOD_ProDKin_1	31	37	PF00069	0.382
MOD_ProDKin_1	88	94	PF00069	0.401
MOD_SUMO_rev_2	116	121	PF00179	0.421
MOD_SUMO_rev_2	63	72	PF00179	0.421
TRG_DiLeu_BaEn_4	116	122	PF01217	0.421
TRG_ENDOCYTIC_2	8	11	PF00928	0.454
TRG_ER_diArg_1	3	5	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD5	Leptomonas seymouri	73%	99%
A0A0S4J5Z9	Bodo saltans	49%	100%
A0A1X0P139	Trypanosomatidae	49%	100%
A0A3Q8IHK8	Leishmania donovani	88%	100%
A0A422MV47	Trypanosoma rangeli	51%	100%
A1CAN8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	31%	77%
A1DF15	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	28%	78%
A3LX85	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	32%	86%
A4I8P6	Leishmania infantum	89%	100%
A5DN42	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	33%	94%
A6S8P6	Botryotinia fuckeliana (strain B05.10)	33%	79%
A6ZS81	Saccharomyces cerevisiae (strain YJM789)	32%	89%
A7F172	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	35%	76%
A7KAI2	Pichia angusta	33%	81%
A7KAL4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	28%	76%
A7TK16	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	31%	86%
C9ZIW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
E9B3K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F7VSU2	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	28%	79%
G2XNY3	Botryotinia fuckeliana (strain T4)	34%	76%
I1RX50	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	29%	79%
M7UQV4	Botryotinia fuckeliana (strain BcDW1)	34%	76%
O43035	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P0CM34	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	71%
P0CM35	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	71%
P40344	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	89%
Q0U388	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	35%	79%
Q0VCL3	Bos taurus	33%	88%
Q0WWQ1	Arabidopsis thaliana	32%	88%
Q2H427	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	81%
Q4Q4J0	Leishmania major	87%	100%
Q51LD2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	79%
Q5ABQ7	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	83%
Q5I0S6	Xenopus tropicalis	33%	88%
Q6AZ50	Rattus norvegicus	33%	88%
Q6BSC4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	85%
Q6C4Q9	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	75%
Q6CL19	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	91%
Q6FQJ2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	89%
Q6GQE7	Xenopus laevis	33%	88%
Q6PFS7	Danio rerio	33%	87%
Q755K1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	98%
Q7SDY2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	79%
Q9CPX6	Mus musculus	33%	88%
Q9NT62	Homo sapiens	33%	88%
V5DDG5	Trypanosoma cruzi	52%	100%
W0TEF9	Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)	35%	89%