LeishMANIAdb
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Putative glucose transporter/membrane transporter D2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glucose transporter/membrane transporter D2
Gene product:
glucose transporter/membrane transporter D2, putative
Species:
Leishmania braziliensis
UniProt:
A4HL65_LEIBR
TriTrypDb:
LbrM.33.0290 , LBRM2903_330007400 *
Length:
617

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

A4HL65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL65

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 17
GO:0008643 carbohydrate transport 5 17
GO:0051179 localization 1 17
GO:0051234 establishment of localization 2 17
GO:0071702 organic substance transport 4 17
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0022857 transmembrane transporter activity 2 40
GO:0015144 carbohydrate transmembrane transporter activity 3 14
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 450 456 PF00089 0.295
CLV_NRD_NRD_1 234 236 PF00675 0.226
CLV_NRD_NRD_1 380 382 PF00675 0.320
CLV_NRD_NRD_1 452 454 PF00675 0.251
CLV_PCSK_KEX2_1 230 232 PF00082 0.327
CLV_PCSK_KEX2_1 367 369 PF00082 0.326
CLV_PCSK_KEX2_1 452 454 PF00082 0.237
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.335
CLV_PCSK_PC1ET2_1 367 369 PF00082 0.137
CLV_PCSK_SKI1_1 236 240 PF00082 0.234
CLV_PCSK_SKI1_1 268 272 PF00082 0.277
CLV_PCSK_SKI1_1 381 385 PF00082 0.227
CLV_PCSK_SKI1_1 457 461 PF00082 0.253
DEG_SPOP_SBC_1 20 24 PF00917 0.709
DEG_SPOP_SBC_1 83 87 PF00917 0.594
DOC_CKS1_1 102 107 PF01111 0.166
DOC_CKS1_1 56 61 PF01111 0.558
DOC_MAPK_gen_1 235 243 PF00069 0.348
DOC_MAPK_gen_1 92 99 PF00069 0.437
DOC_MAPK_MEF2A_6 235 243 PF00069 0.472
DOC_MAPK_MEF2A_6 92 101 PF00069 0.539
DOC_PP2B_LxvP_1 353 356 PF13499 0.436
DOC_PP4_FxxP_1 114 117 PF00568 0.355
DOC_PP4_FxxP_1 588 591 PF00568 0.336
DOC_PP4_FxxP_1 80 83 PF00568 0.531
DOC_USP7_MATH_1 20 24 PF00917 0.702
DOC_USP7_MATH_1 527 531 PF00917 0.390
DOC_USP7_UBL2_3 382 386 PF12436 0.437
DOC_WW_Pin1_4 101 106 PF00397 0.418
DOC_WW_Pin1_4 24 29 PF00397 0.605
DOC_WW_Pin1_4 279 284 PF00397 0.261
DOC_WW_Pin1_4 51 56 PF00397 0.755
LIG_14-3-3_CanoR_1 235 239 PF00244 0.493
LIG_14-3-3_CanoR_1 330 336 PF00244 0.249
LIG_14-3-3_CanoR_1 381 390 PF00244 0.415
LIG_14-3-3_CanoR_1 452 457 PF00244 0.445
LIG_14-3-3_CanoR_1 62 66 PF00244 0.799
LIG_Actin_RPEL_3 228 247 PF02755 0.140
LIG_APCC_ABBA_1 518 523 PF00400 0.524
LIG_BIR_II_1 1 5 PF00653 0.528
LIG_BRCT_BRCA1_1 1 5 PF00533 0.528
LIG_BRCT_BRCA1_1 206 210 PF00533 0.270
LIG_BRCT_BRCA1_1 450 454 PF00533 0.407
LIG_BRCT_BRCA1_1 85 89 PF00533 0.557
LIG_DLG_GKlike_1 452 459 PF00625 0.374
LIG_EH1_1 237 245 PF00400 0.173
LIG_EH1_1 386 394 PF00400 0.374
LIG_eIF4E_1 234 240 PF01652 0.505
LIG_FHA_1 102 108 PF00498 0.296
LIG_FHA_1 168 174 PF00498 0.263
LIG_FHA_1 227 233 PF00498 0.315
LIG_FHA_1 442 448 PF00498 0.215
LIG_FHA_1 456 462 PF00498 0.364
LIG_FHA_1 531 537 PF00498 0.356
LIG_FHA_1 550 556 PF00498 0.257
LIG_FHA_1 611 617 PF00498 0.614
LIG_FHA_2 118 124 PF00498 0.147
LIG_FHA_2 156 162 PF00498 0.355
LIG_FHA_2 20 26 PF00498 0.581
LIG_FHA_2 482 488 PF00498 0.294
LIG_FHA_2 68 74 PF00498 0.735
LIG_LIR_Apic_2 585 591 PF02991 0.276
LIG_LIR_Apic_2 77 83 PF02991 0.541
LIG_LIR_Gen_1 237 246 PF02991 0.343
LIG_LIR_Gen_1 349 358 PF02991 0.371
LIG_LIR_Gen_1 384 395 PF02991 0.482
LIG_LIR_Gen_1 444 450 PF02991 0.324
LIG_LIR_Nem_3 157 162 PF02991 0.249
LIG_LIR_Nem_3 169 175 PF02991 0.243
LIG_LIR_Nem_3 237 241 PF02991 0.345
LIG_LIR_Nem_3 313 319 PF02991 0.283
LIG_LIR_Nem_3 349 354 PF02991 0.355
LIG_LIR_Nem_3 444 448 PF02991 0.321
LIG_LIR_Nem_3 523 528 PF02991 0.466
LIG_LIR_Nem_3 585 589 PF02991 0.281
LIG_LIR_Nem_3 601 606 PF02991 0.584
LIG_LYPXL_S_1 479 483 PF13949 0.315
LIG_LYPXL_yS_3 480 483 PF13949 0.257
LIG_MLH1_MIPbox_1 1 5 PF16413 0.528
LIG_PDZ_Class_3 612 617 PF00595 0.531
LIG_Pex14_2 273 277 PF04695 0.403
LIG_Pex14_2 311 315 PF04695 0.292
LIG_Pex14_2 521 525 PF04695 0.465
LIG_Pex14_2 588 592 PF04695 0.361
LIG_PTB_Apo_2 542 549 PF02174 0.303
LIG_PTB_Phospho_1 542 548 PF10480 0.346
LIG_REV1ctd_RIR_1 87 97 PF16727 0.600
LIG_SH2_CRK 118 122 PF00017 0.275
LIG_SH2_NCK_1 118 122 PF00017 0.225
LIG_SH2_SRC 122 125 PF00017 0.247
LIG_SH2_STAP1 118 122 PF00017 0.299
LIG_SH2_STAP1 175 179 PF00017 0.342
LIG_SH2_STAP1 285 289 PF00017 0.524
LIG_SH2_STAT3 79 82 PF00017 0.538
LIG_SH2_STAT5 153 156 PF00017 0.318
LIG_SH2_STAT5 227 230 PF00017 0.363
LIG_SH2_STAT5 285 288 PF00017 0.441
LIG_SH2_STAT5 387 390 PF00017 0.550
LIG_SH2_STAT5 4 7 PF00017 0.530
LIG_SH2_STAT5 514 517 PF00017 0.353
LIG_SH2_STAT5 586 589 PF00017 0.235
LIG_SH2_STAT5 79 82 PF00017 0.587
LIG_SH3_3 475 481 PF00018 0.292
LIG_SH3_3 63 69 PF00018 0.732
LIG_SH3_3 94 100 PF00018 0.361
LIG_SH3_4 36 43 PF00018 0.550
LIG_SUMO_SIM_par_1 12 18 PF11976 0.550
LIG_SUMO_SIM_par_1 514 519 PF11976 0.403
LIG_SUMO_SIM_par_1 99 104 PF11976 0.192
LIG_TRAF2_1 32 35 PF00917 0.577
LIG_TRFH_1 587 591 PF08558 0.336
LIG_TYR_ITIM 584 589 PF00017 0.289
LIG_TYR_ITSM 155 162 PF00017 0.192
LIG_UBA3_1 353 360 PF00899 0.224
LIG_WRC_WIRS_1 312 317 PF05994 0.261
LIG_WRC_WIRS_1 442 447 PF05994 0.409
MOD_CDC14_SPxK_1 27 30 PF00782 0.459
MOD_CDK_SPK_2 55 60 PF00069 0.434
MOD_CDK_SPxK_1 24 30 PF00069 0.460
MOD_CDK_SPxxK_3 55 62 PF00069 0.439
MOD_CK1_1 136 142 PF00069 0.284
MOD_CK1_1 151 157 PF00069 0.266
MOD_CK1_1 166 172 PF00069 0.306
MOD_CK1_1 18 24 PF00069 0.738
MOD_CK1_1 180 186 PF00069 0.278
MOD_CK1_1 190 196 PF00069 0.329
MOD_CK1_1 204 210 PF00069 0.342
MOD_CK1_1 279 285 PF00069 0.443
MOD_CK1_1 305 311 PF00069 0.452
MOD_CK1_1 455 461 PF00069 0.300
MOD_CK1_1 530 536 PF00069 0.231
MOD_CK2_1 117 123 PF00069 0.164
MOD_CK2_1 155 161 PF00069 0.378
MOD_CK2_1 61 67 PF00069 0.740
MOD_GlcNHglycan 206 209 PF01048 0.257
MOD_GlcNHglycan 490 493 PF01048 0.274
MOD_GlcNHglycan 555 558 PF01048 0.280
MOD_GlcNHglycan 559 562 PF01048 0.277
MOD_GlcNHglycan 63 66 PF01048 0.703
MOD_GSK3_1 136 143 PF00069 0.234
MOD_GSK3_1 15 22 PF00069 0.668
MOD_GSK3_1 151 158 PF00069 0.292
MOD_GSK3_1 163 170 PF00069 0.384
MOD_GSK3_1 173 180 PF00069 0.345
MOD_GSK3_1 190 197 PF00069 0.331
MOD_GSK3_1 200 207 PF00069 0.323
MOD_GSK3_1 249 256 PF00069 0.237
MOD_GSK3_1 279 286 PF00069 0.347
MOD_GSK3_1 342 349 PF00069 0.336
MOD_GSK3_1 377 384 PF00069 0.191
MOD_GSK3_1 448 455 PF00069 0.297
MOD_GSK3_1 51 58 PF00069 0.691
MOD_GSK3_1 549 556 PF00069 0.308
MOD_GSK3_1 78 85 PF00069 0.536
MOD_N-GLC_1 148 153 PF02516 0.367
MOD_N-GLC_1 155 160 PF02516 0.352
MOD_N-GLC_2 194 196 PF02516 0.403
MOD_N-GLC_2 545 547 PF02516 0.366
MOD_NEK2_1 140 145 PF00069 0.364
MOD_NEK2_1 148 153 PF00069 0.444
MOD_NEK2_1 182 187 PF00069 0.348
MOD_NEK2_1 210 215 PF00069 0.319
MOD_NEK2_1 302 307 PF00069 0.311
MOD_NEK2_1 311 316 PF00069 0.301
MOD_NEK2_1 320 325 PF00069 0.313
MOD_NEK2_1 441 446 PF00069 0.338
MOD_NEK2_1 465 470 PF00069 0.308
MOD_NEK2_1 88 93 PF00069 0.583
MOD_NEK2_2 117 122 PF00069 0.403
MOD_NEK2_2 84 89 PF00069 0.363
MOD_PIKK_1 78 84 PF00454 0.451
MOD_PKA_1 381 387 PF00069 0.140
MOD_PKA_1 452 458 PF00069 0.403
MOD_PKA_2 234 240 PF00069 0.379
MOD_PKA_2 452 458 PF00069 0.249
MOD_PKA_2 61 67 PF00069 0.788
MOD_Plk_1 148 154 PF00069 0.328
MOD_Plk_1 155 161 PF00069 0.292
MOD_Plk_1 177 183 PF00069 0.257
MOD_Plk_4 117 123 PF00069 0.329
MOD_Plk_4 210 216 PF00069 0.339
MOD_Plk_4 234 240 PF00069 0.278
MOD_Plk_4 297 303 PF00069 0.320
MOD_Plk_4 311 317 PF00069 0.356
MOD_Plk_4 343 349 PF00069 0.305
MOD_Plk_4 385 391 PF00069 0.214
MOD_Plk_4 417 423 PF00069 0.320
MOD_Plk_4 84 90 PF00069 0.409
MOD_ProDKin_1 101 107 PF00069 0.418
MOD_ProDKin_1 24 30 PF00069 0.518
MOD_ProDKin_1 279 285 PF00069 0.261
MOD_ProDKin_1 51 57 PF00069 0.727
TRG_DiLeu_BaLyEn_6 102 107 PF01217 0.192
TRG_DiLeu_BaLyEn_6 353 358 PF01217 0.192
TRG_DiLeu_LyEn_5 44 49 PF01217 0.419
TRG_ENDOCYTIC_2 118 121 PF00928 0.299
TRG_ENDOCYTIC_2 159 162 PF00928 0.395
TRG_ENDOCYTIC_2 261 264 PF00928 0.272
TRG_ENDOCYTIC_2 387 390 PF00928 0.353
TRG_ENDOCYTIC_2 480 483 PF00928 0.309
TRG_ENDOCYTIC_2 586 589 PF00928 0.259
TRG_ER_diArg_1 452 454 PF00400 0.295

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 23% 100%
A0A0N0P2E1 Leptomonas seymouri 41% 100%
A0A0N0P3Z7 Leptomonas seymouri 35% 81%
A0A0N0P4D8 Leptomonas seymouri 38% 84%
A0A0N1IG16 Leptomonas seymouri 42% 100%
A0A0N1P9H5 Leptomonas seymouri 61% 100%
A0A0S4J363 Bodo saltans 27% 100%
A0A0S4JDF9 Bodo saltans 38% 100%
A0A0S4JEY7 Bodo saltans 37% 100%
A0A0S4JH90 Bodo saltans 35% 100%
A0A0S4JS00 Bodo saltans 31% 100%
A0A1X0NLE0 Trypanosomatidae 42% 100%
A0A1X0NM05 Trypanosomatidae 42% 100%
A0A1X0NN62 Trypanosomatidae 44% 100%
A0A1X0P9L7 Trypanosomatidae 32% 100%
A0A381N054 Leishmania infantum 42% 100%
A0A3Q8IDK1 Leishmania donovani 84% 100%
A0A3Q8IK60 Leishmania donovani 42% 100%
A0A3Q8IWJ4 Leishmania donovani 40% 94%
A0A3R7KPU3 Trypanosoma rangeli 31% 100%
A0A3R7MGQ7 Trypanosoma rangeli 21% 100%
A0A3S7WY58 Leishmania donovani 23% 100%
A0A3S7XC27 Leishmania donovani 42% 100%
A0A422MNQ4 Trypanosoma rangeli 42% 100%
A4HDC6 Leishmania braziliensis 22% 100%
A4HQD6 Leishmania braziliensis 43% 100%
A4HQD7 Leishmania braziliensis 45% 100%
A4HQE7 Leishmania braziliensis 47% 100%
A4I0Q6 Leishmania infantum 23% 100%
A4I8N6 Leishmania infantum 84% 100%
A4IC83 Leishmania infantum 40% 94%
C0SPB2 Bacillus subtilis (strain 168) 24% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 98%
K0E3U9 Aspergillus rugulosus 23% 100%
O04249 Arabidopsis thaliana 24% 100%
O34718 Bacillus subtilis (strain 168) 23% 100%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
O74969 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
P0AGF4 Escherichia coli (strain K12) 23% 100%
P0AGF5 Escherichia coli O157:H7 23% 100%
P13865 Leishmania enriettii 42% 100%
P23585 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P46333 Bacillus subtilis (strain 168) 23% 100%
P78831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
P94493 Bacillus subtilis (strain 168) 24% 100%
Q01440 Leishmania donovani 23% 100%
Q01441 Leishmania donovani 86% 100%
Q06221 Trypanosoma brucei brucei 36% 100%
Q06222 Trypanosoma brucei brucei 37% 100%
Q09037 Trypanosoma brucei brucei 36% 100%
Q27115 Trypanosoma vivax 38% 100%
Q39228 Arabidopsis thaliana 23% 100%
Q3UDF0 Mus musculus 23% 100%
Q4Q0D0 Leishmania major 41% 100%
Q4Q0D1 Leishmania major 42% 100%
Q4Q0D2 Leishmania major 43% 100%
Q4Q4J1 Leishmania major 82% 100%
Q4QAR5 Leishmania major 23% 100%
Q5RET7 Pongo abelii 21% 100%
Q8VZ80 Arabidopsis thaliana 24% 100%
Q92253 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 23% 100%
Q94EC4 Oryza sativa subsp. japonica 24% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q9P3U7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q9SFG0 Arabidopsis thaliana 24% 100%
Q9SX48 Arabidopsis thaliana 24% 100%
Q9XIH6 Arabidopsis thaliana 24% 100%
Q9XIH7 Arabidopsis thaliana 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS