Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL64_LEIBR

TriTrypDb:

LbrM.33.0280 , LBRM2903_310011900

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0005848	mRNA cleavage stimulating factor complex	4	12
GO:0005849	mRNA cleavage factor complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4HL64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL64

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.538
CLV_NRD_NRD_1	113	115	PF00675	0.650
CLV_NRD_NRD_1	212	214	PF00675	0.416
CLV_NRD_NRD_1	409	411	PF00675	0.453
CLV_NRD_NRD_1	78	80	PF00675	0.671
CLV_NRD_NRD_1	8	10	PF00675	0.607
CLV_PCSK_KEX2_1	10	12	PF00082	0.600
CLV_PCSK_KEX2_1	113	115	PF00082	0.650
CLV_PCSK_KEX2_1	212	214	PF00082	0.416
CLV_PCSK_KEX2_1	409	411	PF00082	0.453
CLV_PCSK_KEX2_1	78	80	PF00082	0.696
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.600
CLV_PCSK_SKI1_1	253	257	PF00082	0.555
CLV_PCSK_SKI1_1	294	298	PF00082	0.514
CLV_PCSK_SKI1_1	438	442	PF00082	0.478
CLV_Separin_Metazoa	222	226	PF03568	0.495
DEG_SCF_FBW7_1	295	301	PF00400	0.640
DEG_SPOP_SBC_1	467	471	PF00917	0.309
DOC_CKS1_1	295	300	PF01111	0.541
DOC_CKS1_1	503	508	PF01111	0.451
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.576
DOC_MAPK_gen_1	9	18	PF00069	0.632
DOC_MAPK_MEF2A_6	98	105	PF00069	0.559
DOC_MAPK_NFAT4_5	98	106	PF00069	0.601
DOC_PP1_RVXF_1	130	137	PF00149	0.438
DOC_PP2B_LxvP_1	296	299	PF13499	0.634
DOC_PP2B_LxvP_1	99	102	PF13499	0.554
DOC_PP4_FxxP_1	426	429	PF00568	0.458
DOC_USP7_MATH_1	194	198	PF00917	0.705
DOC_USP7_MATH_1	315	319	PF00917	0.748
DOC_USP7_MATH_1	321	325	PF00917	0.650
DOC_USP7_MATH_1	332	336	PF00917	0.404
DOC_USP7_MATH_1	337	341	PF00917	0.466
DOC_USP7_MATH_1	381	385	PF00917	0.466
DOC_USP7_MATH_1	40	44	PF00917	0.507
DOC_USP7_MATH_1	443	447	PF00917	0.476
DOC_USP7_MATH_1	457	461	PF00917	0.300
DOC_WW_Pin1_4	134	139	PF00397	0.383
DOC_WW_Pin1_4	294	299	PF00397	0.522
DOC_WW_Pin1_4	341	346	PF00397	0.473
DOC_WW_Pin1_4	417	422	PF00397	0.610
DOC_WW_Pin1_4	483	488	PF00397	0.506
DOC_WW_Pin1_4	502	507	PF00397	0.430
LIG_14-3-3_CanoR_1	108	112	PF00244	0.612
LIG_14-3-3_CanoR_1	121	130	PF00244	0.349
LIG_14-3-3_CanoR_1	410	418	PF00244	0.606
LIG_14-3-3_CanoR_1	438	448	PF00244	0.441
LIG_14-3-3_CanoR_1	92	101	PF00244	0.576
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BIR_III_4	47	51	PF00653	0.486
LIG_BRCT_BRCA1_1	339	343	PF00533	0.538
LIG_CSL_BTD_1	503	506	PF09270	0.431
LIG_CSL_BTD_1	507	510	PF09270	0.516
LIG_CtBP_PxDLS_1	102	106	PF00389	0.661
LIG_FHA_1	146	152	PF00498	0.377
LIG_FHA_1	216	222	PF00498	0.405
LIG_FHA_1	227	233	PF00498	0.389
LIG_FHA_1	259	265	PF00498	0.448
LIG_FHA_1	290	296	PF00498	0.477
LIG_FHA_1	356	362	PF00498	0.528
LIG_FHA_1	381	387	PF00498	0.491
LIG_FHA_1	388	394	PF00498	0.466
LIG_FHA_1	400	406	PF00498	0.367
LIG_FHA_1	463	469	PF00498	0.523
LIG_FHA_1	47	53	PF00498	0.488
LIG_FHA_1	85	91	PF00498	0.607
LIG_FHA_2	157	163	PF00498	0.410
LIG_FHA_2	351	357	PF00498	0.538
LIG_FHA_2	428	434	PF00498	0.606
LIG_FHA_2	492	498	PF00498	0.478
LIG_LIR_Apic_2	415	421	PF02991	0.664
LIG_LIR_Apic_2	424	429	PF02991	0.461
LIG_LIR_Gen_1	24	33	PF02991	0.540
LIG_LIR_Gen_1	272	280	PF02991	0.465
LIG_LIR_Nem_3	24	29	PF02991	0.578
LIG_LIR_Nem_3	272	278	PF02991	0.382
LIG_LIR_Nem_3	356	362	PF02991	0.527
LIG_LIR_Nem_3	460	464	PF02991	0.430
LIG_LIR_Nem_3	97	103	PF02991	0.539
LIG_PTB_Apo_2	243	250	PF02174	0.505
LIG_PTB_Phospho_1	243	249	PF10480	0.489
LIG_SH2_CRK	100	104	PF00017	0.608
LIG_SH2_CRK	26	30	PF00017	0.489
LIG_SH2_CRK	362	366	PF00017	0.536
LIG_SH2_CRK	464	468	PF00017	0.439
LIG_SH2_PTP2	275	278	PF00017	0.513
LIG_SH2_SRC	247	250	PF00017	0.527
LIG_SH2_STAT5	142	145	PF00017	0.456
LIG_SH2_STAT5	243	246	PF00017	0.377
LIG_SH2_STAT5	275	278	PF00017	0.382
LIG_SH2_STAT5	461	464	PF00017	0.444
LIG_SH3_1	225	231	PF00018	0.494
LIG_SH3_3	225	231	PF00018	0.425
LIG_SH3_3	292	298	PF00018	0.559
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.494
LIG_SUMO_SIM_par_1	101	107	PF11976	0.661
LIG_SUMO_SIM_par_1	229	235	PF11976	0.401
LIG_SUMO_SIM_par_1	452	460	PF11976	0.520
LIG_TRAF2_1	80	83	PF00917	0.648
LIG_Vh1_VBS_1	38	56	PF01044	0.582
LIG_WRC_WIRS_1	423	428	PF05994	0.452
MOD_CDK_SPxxK_3	341	348	PF00069	0.473
MOD_CK1_1	104	110	PF00069	0.623
MOD_CK1_1	156	162	PF00069	0.385
MOD_CK1_1	470	476	PF00069	0.431
MOD_CK2_1	422	428	PF00069	0.452
MOD_CK2_1	439	445	PF00069	0.315
MOD_CK2_1	69	75	PF00069	0.675
MOD_Cter_Amidation	111	114	PF01082	0.662
MOD_GlcNHglycan	123	126	PF01048	0.486
MOD_GlcNHglycan	161	166	PF01048	0.535
MOD_GlcNHglycan	196	199	PF01048	0.613
MOD_GlcNHglycan	234	237	PF01048	0.474
MOD_GlcNHglycan	271	274	PF01048	0.445
MOD_GlcNHglycan	316	320	PF01048	0.699
MOD_GlcNHglycan	334	337	PF01048	0.121
MOD_GlcNHglycan	365	368	PF01048	0.529
MOD_GlcNHglycan	377	380	PF01048	0.297
MOD_GlcNHglycan	42	45	PF01048	0.494
MOD_GlcNHglycan	441	444	PF01048	0.511
MOD_GlcNHglycan	94	97	PF01048	0.578
MOD_GSK3_1	103	110	PF00069	0.513
MOD_GSK3_1	141	148	PF00069	0.267
MOD_GSK3_1	265	272	PF00069	0.491
MOD_GSK3_1	294	301	PF00069	0.563
MOD_GSK3_1	302	309	PF00069	0.604
MOD_GSK3_1	315	322	PF00069	0.628
MOD_GSK3_1	332	339	PF00069	0.310
MOD_GSK3_1	346	353	PF00069	0.423
MOD_GSK3_1	381	388	PF00069	0.470
MOD_GSK3_1	417	424	PF00069	0.569
MOD_GSK3_1	439	446	PF00069	0.424
MOD_GSK3_1	462	469	PF00069	0.462
MOD_GSK3_1	470	477	PF00069	0.465
MOD_N-GLC_1	443	448	PF02516	0.421
MOD_NEK2_1	103	108	PF00069	0.399
MOD_NEK2_1	123	128	PF00069	0.503
MOD_NEK2_1	350	355	PF00069	0.456
MOD_NEK2_1	399	404	PF00069	0.500
MOD_NEK2_1	411	416	PF00069	0.614
MOD_NEK2_1	84	89	PF00069	0.608
MOD_NEK2_1	94	99	PF00069	0.490
MOD_PIKK_1	215	221	PF00454	0.433
MOD_PIKK_1	471	477	PF00454	0.573
MOD_PIKK_1	84	90	PF00454	0.670
MOD_PKA_2	107	113	PF00069	0.607
MOD_PKA_2	325	331	PF00069	0.632
MOD_PKB_1	119	127	PF00069	0.421
MOD_Plk_1	132	138	PF00069	0.465
MOD_Plk_1	161	167	PF00069	0.541
MOD_Plk_1	265	271	PF00069	0.523
MOD_Plk_1	421	427	PF00069	0.570
MOD_Plk_1	443	449	PF00069	0.404
MOD_Plk_1	451	457	PF00069	0.375
MOD_Plk_1	496	502	PF00069	0.435
MOD_Plk_2-3	422	428	PF00069	0.469
MOD_Plk_4	355	361	PF00069	0.450
MOD_Plk_4	381	387	PF00069	0.562
MOD_Plk_4	451	457	PF00069	0.406
MOD_Plk_4	474	480	PF00069	0.503
MOD_ProDKin_1	134	140	PF00069	0.385
MOD_ProDKin_1	294	300	PF00069	0.529
MOD_ProDKin_1	341	347	PF00069	0.473
MOD_ProDKin_1	417	423	PF00069	0.605
MOD_ProDKin_1	483	489	PF00069	0.514
MOD_ProDKin_1	502	508	PF00069	0.443
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.409
TRG_ENDOCYTIC_2	100	103	PF00928	0.565
TRG_ENDOCYTIC_2	26	29	PF00928	0.455
TRG_ENDOCYTIC_2	275	278	PF00928	0.451
TRG_ENDOCYTIC_2	362	365	PF00928	0.533
TRG_ENDOCYTIC_2	464	467	PF00928	0.444
TRG_ER_diArg_1	116	119	PF00400	0.471
TRG_ER_diArg_1	211	213	PF00400	0.435
TRG_ER_diArg_1	408	410	PF00400	0.440
TRG_ER_diArg_1	500	503	PF00400	0.384
TRG_ER_diArg_1	9	12	PF00400	0.621
TRG_NES_CRM1_1	19	32	PF08389	0.615
TRG_NES_CRM1_1	61	77	PF08389	0.573
TRG_NLS_MonoCore_2	9	14	PF00514	0.632
TRG_NLS_MonoExtC_3	8	13	PF00514	0.618
TRG_NLS_MonoExtN_4	7	14	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHC2	Leptomonas seymouri	80%	94%
A0A0S4IHN1	Bodo saltans	39%	92%
A0A0S4JL38	Bodo saltans	24%	95%
A0A1X0P742	Trypanosomatidae	52%	100%
A0A3Q8ITT7	Leishmania donovani	94%	100%
A0A422NAT5	Trypanosoma rangeli	52%	97%
A4I8P5	Leishmania infantum	94%	100%
D0A0R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9B3K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q4J2	Leishmania major	94%	100%
Q8L4J2	Arabidopsis thaliana	24%	100%
V5BJ28	Trypanosoma cruzi	51%	94%