Mpv17/PMP22 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mpv17 / PMP22 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HL63_LEIBR

TriTrypDb:

LbrM.33.0270 , LBRM2903_310012000

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HL63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.473
CLV_C14_Caspase3-7	222	226	PF00656	0.392
CLV_C14_Caspase3-7	245	249	PF00656	0.359
CLV_C14_Caspase3-7	91	95	PF00656	0.585
CLV_NRD_NRD_1	119	121	PF00675	0.308
CLV_NRD_NRD_1	196	198	PF00675	0.636
CLV_NRD_NRD_1	281	283	PF00675	0.536
CLV_PCSK_KEX2_1	119	121	PF00082	0.308
CLV_PCSK_KEX2_1	154	156	PF00082	0.644
CLV_PCSK_KEX2_1	195	197	PF00082	0.631
CLV_PCSK_KEX2_1	281	283	PF00082	0.555
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.627
CLV_PCSK_PC7_1	192	198	PF00082	0.673
CLV_PCSK_SKI1_1	160	164	PF00082	0.562
CLV_PCSK_SKI1_1	2	6	PF00082	0.424
CLV_PCSK_SKI1_1	234	238	PF00082	0.735
CLV_PCSK_SKI1_1	293	297	PF00082	0.568
DEG_Nend_UBRbox_1	1	4	PF02207	0.637
DEG_SPOP_SBC_1	103	107	PF00917	0.688
DOC_AGCK_PIF_1	124	129	PF00069	0.406
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.397
DOC_MAPK_gen_1	192	201	PF00069	0.445
DOC_MAPK_MEF2A_6	195	203	PF00069	0.492
DOC_PP4_FxxP_1	131	134	PF00568	0.406
DOC_USP7_MATH_1	103	107	PF00917	0.750
DOC_USP7_MATH_1	226	230	PF00917	0.533
DOC_USP7_MATH_1	274	278	PF00917	0.281
DOC_USP7_MATH_1	317	321	PF00917	0.377
DOC_USP7_MATH_1	55	59	PF00917	0.661
DOC_USP7_MATH_1	88	92	PF00917	0.579
DOC_WW_Pin1_4	58	63	PF00397	0.641
DOC_WW_Pin1_4	66	71	PF00397	0.534
LIG_14-3-3_CanoR_1	119	123	PF00244	0.471
LIG_14-3-3_CanoR_1	241	247	PF00244	0.406
LIG_14-3-3_CanoR_1	315	325	PF00244	0.350
LIG_14-3-3_CanoR_1	85	93	PF00244	0.559
LIG_14-3-3_CterR_2	350	354	PF00244	0.633
LIG_APCC_ABBA_1	185	190	PF00400	0.434
LIG_BRCT_BRCA1_1	120	124	PF00533	0.471
LIG_BRCT_BRCA1_1	125	129	PF00533	0.314
LIG_EH_1	237	241	PF12763	0.379
LIG_eIF4E_1	165	171	PF01652	0.249
LIG_FHA_1	111	117	PF00498	0.608
LIG_FHA_1	17	23	PF00498	0.477
LIG_FHA_1	204	210	PF00498	0.494
LIG_FHA_1	242	248	PF00498	0.408
LIG_FHA_2	178	184	PF00498	0.340
LIG_FHA_2	241	247	PF00498	0.486
LIG_FHA_2	35	41	PF00498	0.594
LIG_FXI_DFP_1	285	289	PF00024	0.498
LIG_LIR_Apic_2	128	134	PF02991	0.406
LIG_LIR_Gen_1	121	131	PF02991	0.320
LIG_LIR_Gen_1	177	186	PF02991	0.260
LIG_LIR_Nem_3	121	127	PF02991	0.320
LIG_LIR_Nem_3	177	181	PF02991	0.342
LIG_LIR_Nem_3	183	188	PF02991	0.340
LIG_LIR_Nem_3	230	236	PF02991	0.535
LIG_LIR_Nem_3	287	291	PF02991	0.239
LIG_LIR_Nem_3	37	42	PF02991	0.523
LIG_Pex14_1	303	307	PF04695	0.271
LIG_Pex14_2	127	131	PF04695	0.350
LIG_Pex14_2	233	237	PF04695	0.536
LIG_PTB_Apo_2	169	176	PF02174	0.290
LIG_PTB_Apo_2	261	268	PF02174	0.446
LIG_PTB_Phospho_1	169	175	PF10480	0.293
LIG_REV1ctd_RIR_1	183	193	PF16727	0.436
LIG_SH2_CRK	294	298	PF00017	0.250
LIG_SH2_NCK_1	294	298	PF00017	0.330
LIG_SH2_PTP2	178	181	PF00017	0.246
LIG_SH2_SRC	309	312	PF00017	0.296
LIG_SH2_STAP1	294	298	PF00017	0.296
LIG_SH2_STAT5	11	14	PF00017	0.562
LIG_SH2_STAT5	135	138	PF00017	0.406
LIG_SH2_STAT5	165	168	PF00017	0.378
LIG_SH2_STAT5	175	178	PF00017	0.318
LIG_SH2_STAT5	272	275	PF00017	0.466
LIG_SH2_STAT5	3	6	PF00017	0.606
LIG_SH2_STAT5	309	312	PF00017	0.272
LIG_SH3_3	35	41	PF00018	0.465
LIG_SH3_3	64	70	PF00018	0.575
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.250
LIG_SUMO_SIM_par_1	63	69	PF11976	0.660
LIG_TYR_ITIM	176	181	PF00017	0.287
LIG_UBA3_1	4	13	PF00899	0.619
LIG_WRC_WIRS_1	124	129	PF05994	0.314
MOD_CK1_1	177	183	PF00069	0.250
MOD_CK1_1	58	64	PF00069	0.628
MOD_CK2_1	177	183	PF00069	0.266
MOD_CK2_1	240	246	PF00069	0.488
MOD_CK2_1	34	40	PF00069	0.594
MOD_CK2_1	83	89	PF00069	0.581
MOD_Cter_Amidation	193	196	PF01082	0.626
MOD_GlcNHglycan	106	109	PF01048	0.531
MOD_GlcNHglycan	155	158	PF01048	0.543
MOD_GlcNHglycan	218	224	PF01048	0.746
MOD_GlcNHglycan	319	322	PF01048	0.366
MOD_GlcNHglycan	326	329	PF01048	0.329
MOD_GSK3_1	324	331	PF00069	0.350
MOD_GSK3_1	83	90	PF00069	0.674
MOD_N-GLC_1	203	208	PF02516	0.575
MOD_N-GLC_1	241	246	PF02516	0.606
MOD_N-GLC_1	55	60	PF02516	0.480
MOD_NEK2_1	118	123	PF00069	0.516
MOD_NEK2_1	203	208	PF00069	0.417
MOD_NEK2_1	21	26	PF00069	0.580
MOD_NEK2_1	240	245	PF00069	0.496
MOD_NEK2_1	247	252	PF00069	0.474
MOD_NEK2_1	316	321	PF00069	0.504
MOD_NEK2_1	42	47	PF00069	0.524
MOD_NEK2_1	63	68	PF00069	0.616
MOD_PIKK_1	55	61	PF00454	0.640
MOD_PKA_2	118	124	PF00069	0.471
MOD_PKA_2	240	246	PF00069	0.464
MOD_PKA_2	84	90	PF00069	0.708
MOD_Plk_1	247	253	PF00069	0.456
MOD_Plk_1	88	94	PF00069	0.586
MOD_Plk_4	110	116	PF00069	0.576
MOD_Plk_4	161	167	PF00069	0.340
MOD_Plk_4	174	180	PF00069	0.320
MOD_Plk_4	34	40	PF00069	0.553
MOD_Plk_4	6	12	PF00069	0.593
MOD_Plk_4	88	94	PF00069	0.581
MOD_ProDKin_1	58	64	PF00069	0.633
MOD_ProDKin_1	66	72	PF00069	0.530
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.396
TRG_ENDOCYTIC_2	140	143	PF00928	0.315
TRG_ENDOCYTIC_2	178	181	PF00928	0.289
TRG_ENDOCYTIC_2	258	261	PF00928	0.442
TRG_ENDOCYTIC_2	294	297	PF00928	0.215
TRG_ENDOCYTIC_2	39	42	PF00928	0.490
TRG_ER_diArg_1	118	120	PF00400	0.539
TRG_ER_diArg_1	195	197	PF00400	0.463
TRG_ER_diArg_1	280	282	PF00400	0.355
TRG_ER_diArg_1	75	78	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA32	Leptomonas seymouri	68%	100%
A0A0S4JM85	Bodo saltans	30%	100%
A0A3Q8IGN8	Leishmania donovani	84%	100%
E9AHM7	Leishmania infantum	84%	100%
E9B3K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4J3	Leishmania major	82%	100%
V5BB92	Trypanosoma cruzi	33%	100%