Adenosine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

adenosine deaminase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HL61_LEIBR

TriTrypDb:

LbrM.31.0560 , LBRM2903_310012400 , LBRM2903_310012500

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL61

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004000	adenosine deaminase activity	4	2
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	2
GO:0019239	deaminase activity	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.808
CLV_NRD_NRD_1	124	126	PF00675	0.830
CLV_NRD_NRD_1	177	179	PF00675	0.769
CLV_NRD_NRD_1	19	21	PF00675	0.449
CLV_NRD_NRD_1	62	64	PF00675	0.723
CLV_PCSK_FUR_1	60	64	PF00082	0.699
CLV_PCSK_KEX2_1	126	128	PF00082	0.829
CLV_PCSK_KEX2_1	177	179	PF00082	0.769
CLV_PCSK_KEX2_1	18	20	PF00082	0.449
CLV_PCSK_KEX2_1	62	64	PF00082	0.723
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.829
CLV_PCSK_PC7_1	173	179	PF00082	0.772
CLV_PCSK_SKI1_1	92	96	PF00082	0.820
DEG_APCC_DBOX_1	19	27	PF00400	0.650
DEG_SCF_TRCP1_1	107	113	PF00400	0.798
DOC_MAPK_DCC_7	18	28	PF00069	0.650
DOC_MAPK_gen_1	6	15	PF00069	0.650
DOC_MAPK_MEF2A_6	200	207	PF00069	0.756
DOC_MAPK_NFAT4_5	200	208	PF00069	0.756
DOC_PP1_RVXF_1	266	272	PF00149	0.742
DOC_PP4_FxxP_1	24	27	PF00568	0.650
DOC_USP7_MATH_1	133	137	PF00917	0.830
DOC_USP7_MATH_1	223	227	PF00917	0.815
DOC_USP7_MATH_1	96	100	PF00917	0.839
LIG_14-3-3_CanoR_1	177	183	PF00244	0.776
LIG_14-3-3_CanoR_1	18	24	PF00244	0.650
LIG_14-3-3_CanoR_1	62	72	PF00244	0.755
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_Clathr_ClatBox_1	275	279	PF01394	0.762
LIG_deltaCOP1_diTrp_1	5	10	PF00928	0.650
LIG_EH1_1	198	206	PF00400	0.752
LIG_FHA_1	2	8	PF00498	0.650
LIG_FHA_1	209	215	PF00498	0.801
LIG_FHA_2	148	154	PF00498	0.790
LIG_FHA_2	179	185	PF00498	0.768
LIG_FHA_2	237	243	PF00498	0.808
LIG_FHA_2	260	266	PF00498	0.806
LIG_LIR_Apic_2	142	148	PF02991	0.770
LIG_LIR_Apic_2	22	27	PF02991	0.650
LIG_LIR_Gen_1	113	122	PF02991	0.772
LIG_LIR_Gen_1	38	46	PF02991	0.650
LIG_LIR_Gen_1	77	88	PF02991	0.707
LIG_LIR_Nem_3	113	118	PF02991	0.750
LIG_LIR_Nem_3	136	141	PF02991	0.811
LIG_LIR_Nem_3	234	240	PF02991	0.818
LIG_LIR_Nem_3	38	43	PF02991	0.650
LIG_LIR_Nem_3	77	83	PF02991	0.681
LIG_SH2_NCK_1	227	231	PF00017	0.818
LIG_SH2_SRC	227	230	PF00017	0.819
LIG_SH2_STAP1	233	237	PF00017	0.823
LIG_SH2_STAT3	255	258	PF00017	0.816
LIG_SH3_3	69	75	PF00018	0.752
LIG_SxIP_EBH_1	177	191	PF03271	0.759
LIG_UBA3_1	203	209	PF00899	0.763
MOD_CK1_1	105	111	PF00069	0.811
MOD_CK1_1	180	186	PF00069	0.766
MOD_CK1_1	217	223	PF00069	0.813
MOD_CK1_1	236	242	PF00069	0.481
MOD_CK1_1	81	87	PF00069	0.719
MOD_CK2_1	125	131	PF00069	0.834
MOD_CK2_1	178	184	PF00069	0.771
MOD_CK2_1	228	234	PF00069	0.817
MOD_CK2_1	63	69	PF00069	0.748
MOD_CK2_1	81	87	PF00069	0.403
MOD_Cter_Amidation	16	19	PF01082	0.449
MOD_GlcNHglycan	107	110	PF01048	0.806
MOD_GlcNHglycan	134	138	PF01048	0.831
MOD_GlcNHglycan	223	226	PF01048	0.813
MOD_GlcNHglycan	259	262	PF01048	0.817
MOD_GlcNHglycan	83	86	PF01048	0.722
MOD_GSK3_1	133	140	PF00069	0.823
MOD_GSK3_1	217	224	PF00069	0.813
MOD_GSK3_1	259	266	PF00069	0.810
MOD_GSK3_1	88	95	PF00069	0.793
MOD_N-GLC_1	105	110	PF02516	0.813
MOD_NEK2_1	116	121	PF00069	0.773
MOD_NEK2_1	246	251	PF00069	0.784
MOD_NEK2_1	257	262	PF00069	0.628
MOD_NEK2_1	270	275	PF00069	0.496
MOD_NEK2_1	36	41	PF00069	0.650
MOD_NEK2_1	88	93	PF00069	0.780
MOD_NEK2_2	78	83	PF00069	0.680
MOD_PIKK_1	246	252	PF00454	0.784
MOD_PK_1	29	35	PF00069	0.650
MOD_PKA_1	125	131	PF00069	0.834
MOD_PKA_1	177	183	PF00069	0.776
MOD_PKA_1	19	25	PF00069	0.650
MOD_PKA_2	177	183	PF00069	0.776
MOD_PKA_2	19	25	PF00069	0.650
MOD_Plk_1	133	139	PF00069	0.827
MOD_Plk_1	233	239	PF00069	0.819
MOD_Plk_1	244	250	PF00069	0.597
MOD_Plk_4	117	123	PF00069	0.787
MOD_Plk_4	154	160	PF00069	0.739
MOD_Plk_4	19	25	PF00069	0.650
MOD_Plk_4	228	234	PF00069	0.817
MOD_Plk_4	271	277	PF00069	0.733
MOD_SUMO_rev_2	119	128	PF00179	0.817
MOD_SUMO_rev_2	71	81	PF00179	0.712
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.764
TRG_ER_diArg_1	112	115	PF00400	0.770
TRG_ER_diArg_1	176	178	PF00400	0.785
TRG_ER_diArg_1	18	20	PF00400	0.650
TRG_ER_diArg_1	59	62	PF00400	0.691