LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HL58_LEIBR
TriTrypDb:
LbrM.33.0220 , LBRM2903_330007100 *
Length:
926

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HL58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL58

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 497 501 PF00656 0.610
CLV_C14_Caspase3-7 611 615 PF00656 0.575
CLV_C14_Caspase3-7 898 902 PF00656 0.621
CLV_NRD_NRD_1 181 183 PF00675 0.477
CLV_NRD_NRD_1 248 250 PF00675 0.413
CLV_NRD_NRD_1 271 273 PF00675 0.488
CLV_NRD_NRD_1 35 37 PF00675 0.549
CLV_NRD_NRD_1 758 760 PF00675 0.324
CLV_PCSK_KEX2_1 181 183 PF00082 0.477
CLV_PCSK_KEX2_1 271 273 PF00082 0.488
CLV_PCSK_KEX2_1 35 37 PF00082 0.549
CLV_PCSK_KEX2_1 758 760 PF00082 0.324
CLV_PCSK_SKI1_1 204 208 PF00082 0.422
CLV_PCSK_SKI1_1 346 350 PF00082 0.507
CLV_PCSK_SKI1_1 469 473 PF00082 0.603
CLV_PCSK_SKI1_1 540 544 PF00082 0.396
CLV_PCSK_SKI1_1 597 601 PF00082 0.326
CLV_PCSK_SKI1_1 909 913 PF00082 0.289
CLV_Separin_Metazoa 262 266 PF03568 0.610
DEG_APCC_DBOX_1 633 641 PF00400 0.528
DEG_ODPH_VHL_1 415 428 PF01847 0.233
DOC_CDC14_PxL_1 590 598 PF14671 0.590
DOC_CKS1_1 221 226 PF01111 0.645
DOC_CKS1_1 470 475 PF01111 0.709
DOC_CKS1_1 518 523 PF01111 0.630
DOC_CYCLIN_RxL_1 906 916 PF00134 0.491
DOC_CYCLIN_yCln2_LP_2 160 166 PF00134 0.683
DOC_CYCLIN_yCln2_LP_2 260 266 PF00134 0.613
DOC_MAPK_gen_1 564 572 PF00069 0.627
DOC_MAPK_MEF2A_6 684 692 PF00069 0.469
DOC_MAPK_RevD_3 168 182 PF00069 0.649
DOC_PP1_RVXF_1 34 41 PF00149 0.374
DOC_PP1_RVXF_1 69 75 PF00149 0.545
DOC_PP1_RVXF_1 738 745 PF00149 0.562
DOC_PP1_SILK_1 536 541 PF00149 0.601
DOC_PP2B_LxvP_1 160 163 PF13499 0.663
DOC_PP2B_LxvP_1 195 198 PF13499 0.662
DOC_PP2B_LxvP_1 264 267 PF13499 0.615
DOC_PP2B_LxvP_1 333 336 PF13499 0.368
DOC_PP4_FxxP_1 214 217 PF00568 0.635
DOC_PP4_FxxP_1 295 298 PF00568 0.244
DOC_PP4_FxxP_1 744 747 PF00568 0.553
DOC_USP7_MATH_1 174 178 PF00917 0.749
DOC_USP7_MATH_1 234 238 PF00917 0.654
DOC_USP7_MATH_1 274 278 PF00917 0.702
DOC_USP7_MATH_1 298 302 PF00917 0.342
DOC_USP7_MATH_1 682 686 PF00917 0.560
DOC_USP7_MATH_1 701 705 PF00917 0.557
DOC_USP7_MATH_1 722 726 PF00917 0.495
DOC_USP7_MATH_1 738 742 PF00917 0.521
DOC_USP7_MATH_1 892 896 PF00917 0.603
DOC_USP7_MATH_1 897 901 PF00917 0.657
DOC_USP7_MATH_2 228 234 PF00917 0.637
DOC_USP7_UBL2_3 703 707 PF12436 0.527
DOC_WW_Pin1_4 143 148 PF00397 0.671
DOC_WW_Pin1_4 193 198 PF00397 0.694
DOC_WW_Pin1_4 213 218 PF00397 0.628
DOC_WW_Pin1_4 220 225 PF00397 0.639
DOC_WW_Pin1_4 327 332 PF00397 0.383
DOC_WW_Pin1_4 402 407 PF00397 0.401
DOC_WW_Pin1_4 469 474 PF00397 0.759
DOC_WW_Pin1_4 517 522 PF00397 0.634
DOC_WW_Pin1_4 820 825 PF00397 0.662
LIG_14-3-3_CanoR_1 119 126 PF00244 0.646
LIG_14-3-3_CanoR_1 154 158 PF00244 0.733
LIG_14-3-3_CanoR_1 209 217 PF00244 0.633
LIG_14-3-3_CanoR_1 35 41 PF00244 0.313
LIG_14-3-3_CanoR_1 789 799 PF00244 0.536
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_BRCT_BRCA1_1 141 145 PF00533 0.627
LIG_BRCT_BRCA1_1 210 214 PF00533 0.635
LIG_BRCT_BRCA1_1 238 242 PF00533 0.626
LIG_BRCT_BRCA1_1 286 290 PF00533 0.556
LIG_BRCT_BRCA1_1 315 319 PF00533 0.305
LIG_BRCT_BRCA1_1 38 42 PF00533 0.298
LIG_BRCT_BRCA1_1 562 566 PF00533 0.737
LIG_BRCT_BRCA1_1 640 644 PF00533 0.634
LIG_BRCT_BRCA1_1 735 739 PF00533 0.587
LIG_BRCT_BRCA1_1 740 744 PF00533 0.464
LIG_Clathr_ClatBox_1 106 110 PF01394 0.606
LIG_Clathr_ClatBox_1 689 693 PF01394 0.504
LIG_DLG_GKlike_1 36 44 PF00625 0.301
LIG_EH_1 778 782 PF12763 0.728
LIG_EH1_1 41 49 PF00400 0.218
LIG_eIF4E_1 321 327 PF01652 0.343
LIG_eIF4E_1 414 420 PF01652 0.383
LIG_eIF4E_1 728 734 PF01652 0.475
LIG_EVH1_2 708 712 PF00568 0.648
LIG_FHA_1 112 118 PF00498 0.616
LIG_FHA_1 132 138 PF00498 0.698
LIG_FHA_1 190 196 PF00498 0.683
LIG_FHA_1 2 8 PF00498 0.546
LIG_FHA_1 303 309 PF00498 0.340
LIG_FHA_1 321 327 PF00498 0.417
LIG_FHA_1 366 372 PF00498 0.230
LIG_FHA_1 39 45 PF00498 0.329
LIG_FHA_1 465 471 PF00498 0.763
LIG_FHA_1 518 524 PF00498 0.631
LIG_FHA_1 62 68 PF00498 0.418
LIG_FHA_2 185 191 PF00498 0.638
LIG_FHA_2 435 441 PF00498 0.679
LIG_FHA_2 666 672 PF00498 0.590
LIG_FHA_2 83 89 PF00498 0.598
LIG_FHA_2 830 836 PF00498 0.646
LIG_GBD_Chelix_1 363 371 PF00786 0.218
LIG_GBD_Chelix_1 907 915 PF00786 0.385
LIG_KLC1_Yacidic_2 88 93 PF13176 0.584
LIG_LIR_Apic_2 211 217 PF02991 0.651
LIG_LIR_Apic_2 293 298 PF02991 0.418
LIG_LIR_Apic_2 391 397 PF02991 0.430
LIG_LIR_Apic_2 413 417 PF02991 0.282
LIG_LIR_Apic_2 741 747 PF02991 0.490
LIG_LIR_Gen_1 301 311 PF02991 0.322
LIG_LIR_Gen_1 368 378 PF02991 0.295
LIG_LIR_Gen_1 641 651 PF02991 0.538
LIG_LIR_Gen_1 725 734 PF02991 0.470
LIG_LIR_Gen_1 761 772 PF02991 0.495
LIG_LIR_Gen_1 778 786 PF02991 0.542
LIG_LIR_Gen_1 839 848 PF02991 0.601
LIG_LIR_Gen_1 84 92 PF02991 0.578
LIG_LIR_Gen_1 850 857 PF02991 0.596
LIG_LIR_LC3C_4 852 857 PF02991 0.587
LIG_LIR_Nem_3 301 306 PF02991 0.346
LIG_LIR_Nem_3 546 551 PF02991 0.604
LIG_LIR_Nem_3 600 606 PF02991 0.495
LIG_LIR_Nem_3 725 731 PF02991 0.468
LIG_LIR_Nem_3 736 742 PF02991 0.525
LIG_LIR_Nem_3 761 767 PF02991 0.473
LIG_LIR_Nem_3 778 784 PF02991 0.536
LIG_LIR_Nem_3 84 90 PF02991 0.575
LIG_LIR_Nem_3 850 856 PF02991 0.590
LIG_MAD2 469 477 PF02301 0.663
LIG_MLH1_MIPbox_1 287 291 PF16413 0.549
LIG_MYND_1 162 166 PF01753 0.617
LIG_MYND_1 217 221 PF01753 0.633
LIG_MYND_1 473 477 PF01753 0.612
LIG_MYND_1 521 525 PF01753 0.639
LIG_NBox_RRM_1 42 52 PF00076 0.217
LIG_Pex14_1 87 91 PF04695 0.581
LIG_Pex14_2 291 295 PF04695 0.533
LIG_Pex14_2 384 388 PF04695 0.236
LIG_Rb_LxCxE_1 913 926 PF01857 0.579
LIG_SH2_CRK 303 307 PF00017 0.320
LIG_SH2_CRK 728 732 PF00017 0.471
LIG_SH2_CRK 764 768 PF00017 0.484
LIG_SH2_NCK_1 728 732 PF00017 0.471
LIG_SH2_PTP2 414 417 PF00017 0.233
LIG_SH2_SRC 670 673 PF00017 0.574
LIG_SH2_SRC 91 94 PF00017 0.590
LIG_SH2_STAP1 670 674 PF00017 0.568
LIG_SH2_STAT5 24 27 PF00017 0.310
LIG_SH2_STAT5 414 417 PF00017 0.351
LIG_SH2_STAT5 603 606 PF00017 0.498
LIG_SH2_STAT5 665 668 PF00017 0.539
LIG_SH2_STAT5 764 767 PF00017 0.483
LIG_SH2_STAT5 869 872 PF00017 0.484
LIG_SH2_STAT5 91 94 PF00017 0.603
LIG_SH3_1 703 709 PF00018 0.523
LIG_SH3_3 156 162 PF00018 0.647
LIG_SH3_3 215 221 PF00018 0.737
LIG_SH3_3 390 396 PF00018 0.353
LIG_SH3_3 467 473 PF00018 0.770
LIG_SH3_3 515 521 PF00018 0.713
LIG_SH3_3 703 709 PF00018 0.586
LIG_SH3_3 721 727 PF00018 0.610
LIG_SH3_3 774 780 PF00018 0.652
LIG_SUMO_SIM_anti_2 309 316 PF11976 0.268
LIG_SUMO_SIM_anti_2 43 48 PF11976 0.235
LIG_SUMO_SIM_anti_2 506 511 PF11976 0.605
LIG_SUMO_SIM_par_1 131 139 PF11976 0.621
LIG_SUMO_SIM_par_1 304 309 PF11976 0.282
LIG_SUMO_SIM_par_1 372 377 PF11976 0.395
LIG_SUMO_SIM_par_1 63 68 PF11976 0.370
LIG_SUMO_SIM_par_1 688 693 PF11976 0.501
LIG_TRAF2_1 463 466 PF00917 0.618
LIG_TRAF2_1 832 835 PF00917 0.660
LIG_TRAF2_1 848 851 PF00917 0.595
LIG_TRFH_1 193 197 PF08558 0.622
LIG_TYR_ITIM 604 609 PF00017 0.515
LIG_UBA3_1 689 694 PF00899 0.502
MOD_CDK_SPK_2 402 407 PF00069 0.387
MOD_CK1_1 136 142 PF00069 0.737
MOD_CK1_1 153 159 PF00069 0.658
MOD_CK1_1 196 202 PF00069 0.805
MOD_CK1_1 377 383 PF00069 0.402
MOD_CK1_1 433 439 PF00069 0.584
MOD_CK1_1 513 519 PF00069 0.616
MOD_CK1_1 533 539 PF00069 0.765
MOD_CK1_1 574 580 PF00069 0.658
MOD_CK1_1 790 796 PF00069 0.675
MOD_CK1_1 895 901 PF00069 0.669
MOD_CK2_1 125 131 PF00069 0.690
MOD_CK2_1 184 190 PF00069 0.656
MOD_CK2_1 196 202 PF00069 0.701
MOD_CK2_1 223 229 PF00069 0.698
MOD_CK2_1 426 432 PF00069 0.486
MOD_CK2_1 434 440 PF00069 0.658
MOD_CK2_1 524 530 PF00069 0.733
MOD_CK2_1 665 671 PF00069 0.591
MOD_CK2_1 770 776 PF00069 0.662
MOD_CK2_1 829 835 PF00069 0.665
MOD_Cter_Amidation 247 250 PF01082 0.415
MOD_DYRK1A_RPxSP_1 469 473 PF00069 0.714
MOD_GlcNHglycan 198 201 PF01048 0.507
MOD_GlcNHglycan 210 213 PF01048 0.495
MOD_GlcNHglycan 232 235 PF01048 0.484
MOD_GlcNHglycan 238 241 PF01048 0.506
MOD_GlcNHglycan 275 279 PF01048 0.560
MOD_GlcNHglycan 437 440 PF01048 0.411
MOD_GlcNHglycan 443 446 PF01048 0.435
MOD_GlcNHglycan 500 503 PF01048 0.447
MOD_GlcNHglycan 512 515 PF01048 0.447
MOD_GlcNHglycan 540 543 PF01048 0.416
MOD_GlcNHglycan 545 548 PF01048 0.439
MOD_GlcNHglycan 658 661 PF01048 0.538
MOD_GlcNHglycan 724 727 PF01048 0.409
MOD_GlcNHglycan 735 738 PF01048 0.429
MOD_GlcNHglycan 881 885 PF01048 0.426
MOD_GlcNHglycan 894 897 PF01048 0.423
MOD_GlcNHglycan 93 97 PF01048 0.397
MOD_GSK3_1 125 132 PF00069 0.678
MOD_GSK3_1 139 146 PF00069 0.763
MOD_GSK3_1 149 156 PF00069 0.691
MOD_GSK3_1 189 196 PF00069 0.683
MOD_GSK3_1 208 215 PF00069 0.651
MOD_GSK3_1 219 226 PF00069 0.733
MOD_GSK3_1 230 237 PF00069 0.662
MOD_GSK3_1 238 245 PF00069 0.635
MOD_GSK3_1 274 281 PF00069 0.698
MOD_GSK3_1 298 305 PF00069 0.453
MOD_GSK3_1 309 316 PF00069 0.352
MOD_GSK3_1 36 43 PF00069 0.349
MOD_GSK3_1 426 433 PF00069 0.453
MOD_GSK3_1 465 472 PF00069 0.647
MOD_GSK3_1 494 501 PF00069 0.700
MOD_GSK3_1 510 517 PF00069 0.616
MOD_GSK3_1 530 537 PF00069 0.786
MOD_GSK3_1 570 577 PF00069 0.746
MOD_GSK3_1 581 588 PF00069 0.657
MOD_GSK3_1 61 68 PF00069 0.294
MOD_GSK3_1 612 619 PF00069 0.621
MOD_GSK3_1 626 633 PF00069 0.622
MOD_GSK3_1 722 729 PF00069 0.510
MOD_GSK3_1 766 773 PF00069 0.624
MOD_GSK3_1 787 794 PF00069 0.674
MOD_GSK3_1 82 89 PF00069 0.579
MOD_GSK3_1 825 832 PF00069 0.680
MOD_LATS_1 34 40 PF00433 0.315
MOD_N-GLC_1 111 116 PF02516 0.411
MOD_N-GLC_1 285 290 PF02516 0.355
MOD_N-GLC_1 350 355 PF02516 0.364
MOD_N-GLC_1 491 496 PF02516 0.433
MOD_N-GLC_1 552 557 PF02516 0.406
MOD_N-GLC_1 574 579 PF02516 0.490
MOD_N-GLC_1 825 830 PF02516 0.570
MOD_N-GLC_1 903 908 PF02516 0.331
MOD_NEK2_1 1 6 PF00069 0.547
MOD_NEK2_1 150 155 PF00069 0.674
MOD_NEK2_1 189 194 PF00069 0.747
MOD_NEK2_1 242 247 PF00069 0.619
MOD_NEK2_1 290 295 PF00069 0.581
MOD_NEK2_1 302 307 PF00069 0.500
MOD_NEK2_1 313 318 PF00069 0.295
MOD_NEK2_1 40 45 PF00069 0.382
MOD_NEK2_1 434 439 PF00069 0.596
MOD_NEK2_1 493 498 PF00069 0.682
MOD_NEK2_1 50 55 PF00069 0.274
MOD_NEK2_1 617 622 PF00069 0.647
MOD_NEK2_1 67 72 PF00069 0.610
MOD_NEK2_1 733 738 PF00069 0.696
MOD_NEK2_1 825 830 PF00069 0.645
MOD_NEK2_1 836 841 PF00069 0.462
MOD_NEK2_1 86 91 PF00069 0.550
MOD_NEK2_1 92 97 PF00069 0.579
MOD_NEK2_2 298 303 PF00069 0.310
MOD_NEK2_2 738 743 PF00069 0.555
MOD_PIKK_1 139 145 PF00454 0.639
MOD_PIKK_1 184 190 PF00454 0.643
MOD_PK_1 182 188 PF00069 0.653
MOD_PK_1 766 772 PF00069 0.568
MOD_PKA_1 758 764 PF00069 0.465
MOD_PKA_2 118 124 PF00069 0.647
MOD_PKA_2 129 135 PF00069 0.658
MOD_PKA_2 153 159 PF00069 0.765
MOD_PKA_2 208 214 PF00069 0.632
MOD_PKA_2 230 236 PF00069 0.634
MOD_PKA_2 758 764 PF00069 0.465
MOD_Plk_1 111 117 PF00069 0.660
MOD_Plk_1 130 136 PF00069 0.604
MOD_Plk_1 182 188 PF00069 0.653
MOD_Plk_1 189 195 PF00069 0.624
MOD_Plk_1 234 240 PF00069 0.627
MOD_Plk_1 242 248 PF00069 0.594
MOD_Plk_1 274 280 PF00069 0.661
MOD_Plk_1 465 471 PF00069 0.627
MOD_Plk_1 552 558 PF00069 0.608
MOD_Plk_1 613 619 PF00069 0.592
MOD_Plk_1 903 909 PF00069 0.537
MOD_Plk_4 145 151 PF00069 0.669
MOD_Plk_4 189 195 PF00069 0.740
MOD_Plk_4 298 304 PF00069 0.310
MOD_Plk_4 306 312 PF00069 0.283
MOD_Plk_4 313 319 PF00069 0.322
MOD_Plk_4 410 416 PF00069 0.311
MOD_Plk_4 50 56 PF00069 0.415
MOD_Plk_4 514 520 PF00069 0.665
MOD_Plk_4 534 540 PF00069 0.656
MOD_Plk_4 597 603 PF00069 0.496
MOD_Plk_4 61 67 PF00069 0.324
MOD_Plk_4 726 732 PF00069 0.525
MOD_Plk_4 82 88 PF00069 0.574
MOD_ProDKin_1 143 149 PF00069 0.670
MOD_ProDKin_1 193 199 PF00069 0.695
MOD_ProDKin_1 213 219 PF00069 0.632
MOD_ProDKin_1 220 226 PF00069 0.639
MOD_ProDKin_1 327 333 PF00069 0.383
MOD_ProDKin_1 402 408 PF00069 0.402
MOD_ProDKin_1 469 475 PF00069 0.758
MOD_ProDKin_1 517 523 PF00069 0.637
MOD_ProDKin_1 820 826 PF00069 0.663
MOD_SUMO_for_1 848 851 PF00179 0.548
MOD_SUMO_rev_2 808 818 PF00179 0.597
TRG_DiLeu_BaEn_1 715 720 PF01217 0.478
TRG_DiLeu_BaEn_1 851 856 PF01217 0.599
TRG_DiLeu_BaEn_4 190 196 PF01217 0.627
TRG_DiLeu_BaLyEn_6 547 552 PF01217 0.604
TRG_ENDOCYTIC_2 24 27 PF00928 0.310
TRG_ENDOCYTIC_2 261 264 PF00928 0.609
TRG_ENDOCYTIC_2 303 306 PF00928 0.320
TRG_ENDOCYTIC_2 606 609 PF00928 0.523
TRG_ENDOCYTIC_2 728 731 PF00928 0.474
TRG_ENDOCYTIC_2 764 767 PF00928 0.478
TRG_ENDOCYTIC_2 840 843 PF00928 0.545
TRG_ER_diArg_1 180 182 PF00400 0.686
TRG_ER_diArg_1 270 272 PF00400 0.672
TRG_ER_diArg_1 35 37 PF00400 0.331
TRG_ER_diArg_1 69 72 PF00400 0.541
TRG_ER_diArg_1 757 759 PF00400 0.524
TRG_NES_CRM1_1 595 608 PF08389 0.571
TRG_NES_CRM1_1 636 649 PF08389 0.498
TRG_Pf-PMV_PEXEL_1 607 611 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 909 913 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYR4 Leptomonas seymouri 38% 100%
A0A3S7X6B9 Leishmania donovani 57% 100%
A4I8N8 Leishmania infantum 57% 100%
E9B3J9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
Q4Q4K2 Leishmania major 54% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS