Glycos_transf_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL56_LEIBR

TriTrypDb:

LbrM.33.0200 , LBRM2903_330006900

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.624
CLV_C14_Caspase3-7	4	8	PF00656	0.630
CLV_NRD_NRD_1	131	133	PF00675	0.442
CLV_NRD_NRD_1	348	350	PF00675	0.585
CLV_NRD_NRD_1	359	361	PF00675	0.500
CLV_PCSK_KEX2_1	131	133	PF00082	0.442
CLV_PCSK_KEX2_1	188	190	PF00082	0.644
CLV_PCSK_KEX2_1	348	350	PF00082	0.585
CLV_PCSK_KEX2_1	361	363	PF00082	0.499
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.646
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.596
CLV_PCSK_PC7_1	357	363	PF00082	0.552
CLV_PCSK_SKI1_1	132	136	PF00082	0.497
CLV_PCSK_SKI1_1	162	166	PF00082	0.549
CLV_PCSK_SKI1_1	189	193	PF00082	0.468
CLV_PCSK_SKI1_1	268	272	PF00082	0.718
CLV_PCSK_SKI1_1	77	81	PF00082	0.583
DEG_APCC_DBOX_1	76	84	PF00400	0.598
DOC_AGCK_PIF_3	551	554	PF00069	0.716
DOC_CKS1_1	485	490	PF01111	0.710
DOC_MAPK_MEF2A_6	193	200	PF00069	0.380
DOC_MAPK_MEF2A_6	29	36	PF00069	0.602
DOC_MAPK_MEF2A_6	429	438	PF00069	0.514
DOC_PP2B_PxIxI_1	431	437	PF00149	0.608
DOC_USP7_MATH_1	479	483	PF00917	0.740
DOC_USP7_MATH_1	53	57	PF00917	0.697
DOC_USP7_MATH_1	68	72	PF00917	0.508
DOC_WW_Pin1_4	285	290	PF00397	0.661
DOC_WW_Pin1_4	379	384	PF00397	0.461
DOC_WW_Pin1_4	407	412	PF00397	0.690
DOC_WW_Pin1_4	462	467	PF00397	0.408
DOC_WW_Pin1_4	484	489	PF00397	0.725
DOC_WW_Pin1_4	499	504	PF00397	0.612
DOC_WW_Pin1_4	512	517	PF00397	0.741
LIG_14-3-3_CanoR_1	251	260	PF00244	0.678
LIG_14-3-3_CanoR_1	301	311	PF00244	0.525
LIG_14-3-3_CanoR_1	362	372	PF00244	0.578
LIG_14-3-3_CanoR_1	454	459	PF00244	0.654
LIG_14-3-3_CanoR_1	480	484	PF00244	0.531
LIG_14-3-3_CanoR_1	524	532	PF00244	0.747
LIG_Actin_WH2_2	263	280	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BRCT_BRCA1_1	364	368	PF00533	0.569
LIG_CORNRBOX	438	446	PF00104	0.449
LIG_DLG_GKlike_1	454	462	PF00625	0.668
LIG_eIF4E_1	42	48	PF01652	0.601
LIG_FHA_1	207	213	PF00498	0.472
LIG_FHA_1	29	35	PF00498	0.514
LIG_FHA_1	322	328	PF00498	0.649
LIG_FHA_1	365	371	PF00498	0.646
LIG_FHA_1	380	386	PF00498	0.454
LIG_FHA_1	431	437	PF00498	0.631
LIG_FHA_1	463	469	PF00498	0.450
LIG_FHA_1	523	529	PF00498	0.571
LIG_FHA_1	82	88	PF00498	0.580
LIG_FHA_2	161	167	PF00498	0.487
LIG_HP1_1	76	80	PF01393	0.594
LIG_LIR_Apic_2	482	488	PF02991	0.729
LIG_LIR_Gen_1	312	320	PF02991	0.528
LIG_LIR_Gen_1	329	339	PF02991	0.403
LIG_LIR_Gen_1	365	375	PF02991	0.528
LIG_LIR_Gen_1	449	458	PF02991	0.651
LIG_LIR_Gen_1	548	554	PF02991	0.608
LIG_LIR_Nem_3	106	112	PF02991	0.476
LIG_LIR_Nem_3	312	316	PF02991	0.583
LIG_LIR_Nem_3	365	371	PF02991	0.533
LIG_LIR_Nem_3	40	45	PF02991	0.561
LIG_LIR_Nem_3	449	453	PF02991	0.642
LIG_LIR_Nem_3	457	462	PF02991	0.431
LIG_LIR_Nem_3	548	554	PF02991	0.608
LIG_PDZ_Class_1	549	554	PF00595	0.604
LIG_SH2_CRK	239	243	PF00017	0.720
LIG_SH2_CRK	45	49	PF00017	0.600
LIG_SH2_NCK_1	45	49	PF00017	0.600
LIG_SH2_PTP2	313	316	PF00017	0.528
LIG_SH2_STAP1	45	49	PF00017	0.459
LIG_SH2_STAT3	49	52	PF00017	0.724
LIG_SH2_STAT5	313	316	PF00017	0.528
LIG_SH2_STAT5	42	45	PF00017	0.705
LIG_SH2_STAT5	531	534	PF00017	0.515
LIG_SH3_1	485	491	PF00018	0.498
LIG_SH3_2	488	493	PF14604	0.499
LIG_SH3_3	104	110	PF00018	0.397
LIG_SH3_3	13	19	PF00018	0.644
LIG_SH3_3	305	311	PF00018	0.555
LIG_SH3_3	469	475	PF00018	0.496
LIG_SH3_3	485	491	PF00018	0.590
LIG_SUMO_SIM_anti_2	365	373	PF11976	0.637
LIG_SUMO_SIM_par_1	213	219	PF11976	0.424
LIG_SUMO_SIM_par_1	365	373	PF11976	0.546
LIG_TYR_ITIM	43	48	PF00017	0.596
LIG_UBA3_1	135	142	PF00899	0.352
MOD_CDC14_SPxK_1	490	493	PF00782	0.490
MOD_CDK_SPxK_1	487	493	PF00069	0.499
MOD_CK1_1	222	228	PF00069	0.511
MOD_CK1_1	243	249	PF00069	0.627
MOD_CK1_1	25	31	PF00069	0.498
MOD_CK1_1	259	265	PF00069	0.566
MOD_CK1_1	321	327	PF00069	0.716
MOD_CK1_1	399	405	PF00069	0.560
MOD_CK1_1	499	505	PF00069	0.669
MOD_CK1_1	69	75	PF00069	0.485
MOD_CK2_1	160	166	PF00069	0.490
MOD_CK2_1	370	376	PF00069	0.543
MOD_Cter_Amidation	186	189	PF01082	0.670
MOD_GlcNHglycan	150	153	PF01048	0.467
MOD_GlcNHglycan	221	224	PF01048	0.590
MOD_GlcNHglycan	242	245	PF01048	0.711
MOD_GlcNHglycan	39	42	PF01048	0.696
MOD_GlcNHglycan	68	71	PF01048	0.516
MOD_GSK3_1	227	234	PF00069	0.695
MOD_GSK3_1	251	258	PF00069	0.585
MOD_GSK3_1	396	403	PF00069	0.531
MOD_GSK3_1	43	50	PF00069	0.454
MOD_GSK3_1	502	509	PF00069	0.633
MOD_GSK3_1	518	525	PF00069	0.740
MOD_GSK3_1	66	73	PF00069	0.544
MOD_N-GLC_1	302	307	PF02516	0.471
MOD_N-GLC_1	377	382	PF02516	0.545
MOD_N-GLC_1	81	86	PF02516	0.585
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	256	261	PF00069	0.573
MOD_NEK2_1	266	271	PF00069	0.469
MOD_NEK2_1	364	369	PF00069	0.665
MOD_NEK2_1	400	405	PF00069	0.609
MOD_NEK2_1	47	52	PF00069	0.501
MOD_NEK2_1	496	501	PF00069	0.678
MOD_NEK2_2	70	75	PF00069	0.485
MOD_PIKK_1	318	324	PF00454	0.777
MOD_PIKK_1	47	53	PF00454	0.498
MOD_PIKK_1	523	529	PF00454	0.786
MOD_PKA_2	250	256	PF00069	0.577
MOD_PKA_2	479	485	PF00069	0.512
MOD_PKA_2	511	517	PF00069	0.552
MOD_PKA_2	523	529	PF00069	0.724
MOD_PKB_1	276	284	PF00069	0.472
MOD_PKB_1	360	368	PF00069	0.704
MOD_Plk_1	2	8	PF00069	0.597
MOD_Plk_1	327	333	PF00069	0.485
MOD_Plk_1	377	383	PF00069	0.436
MOD_Plk_4	108	114	PF00069	0.525
MOD_Plk_4	231	237	PF00069	0.669
MOD_Plk_4	266	272	PF00069	0.647
MOD_Plk_4	327	333	PF00069	0.696
MOD_Plk_4	364	370	PF00069	0.660
MOD_Plk_4	43	49	PF00069	0.482
MOD_Plk_4	441	447	PF00069	0.551
MOD_Plk_4	454	460	PF00069	0.455
MOD_Plk_4	479	485	PF00069	0.758
MOD_Plk_4	502	508	PF00069	0.619
MOD_ProDKin_1	285	291	PF00069	0.663
MOD_ProDKin_1	379	385	PF00069	0.459
MOD_ProDKin_1	407	413	PF00069	0.692
MOD_ProDKin_1	462	468	PF00069	0.408
MOD_ProDKin_1	484	490	PF00069	0.716
MOD_ProDKin_1	499	505	PF00069	0.613
MOD_ProDKin_1	512	518	PF00069	0.743
MOD_SUMO_rev_2	199	205	PF00179	0.642
TRG_ENDOCYTIC_2	313	316	PF00928	0.570
TRG_ENDOCYTIC_2	45	48	PF00928	0.610
TRG_ER_diArg_1	130	132	PF00400	0.496
TRG_ER_diArg_1	275	278	PF00400	0.714
TRG_ER_diArg_1	347	349	PF00400	0.557
TRG_ER_diArg_1	74	77	PF00400	0.654
TRG_NES_CRM1_1	363	377	PF08389	0.663
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z6	Leptomonas seymouri	37%	100%
A0A3S5H7T7	Leishmania donovani	70%	82%
A4I8N5	Leishmania infantum	70%	100%
E9B3J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q4K4	Leishmania major	70%	100%