Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetraspanin family, putative

Species:

Leishmania braziliensis

UniProt:

A4HL54_LEIBR

TriTrypDb:

LbrM.33.0180 , LBRM2903_330006700

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HL54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.754
CLV_MEL_PAP_1	78	84	PF00089	0.233
CLV_NRD_NRD_1	126	128	PF00675	0.317
CLV_PCSK_KEX2_1	126	128	PF00082	0.370
CLV_PCSK_SKI1_1	270	274	PF00082	0.497
CLV_PCSK_SKI1_1	61	65	PF00082	0.297
CLV_PCSK_SKI1_1	8	12	PF00082	0.568
DEG_APCC_DBOX_1	60	68	PF00400	0.411
DOC_CDC14_PxL_1	42	50	PF14671	0.575
DOC_MAPK_gen_1	126	134	PF00069	0.522
DOC_MAPK_gen_1	265	274	PF00069	0.391
DOC_MAPK_gen_1	56	66	PF00069	0.650
DOC_MAPK_MEF2A_6	126	134	PF00069	0.411
DOC_USP7_MATH_1	18	22	PF00917	0.747
DOC_USP7_MATH_1	243	247	PF00917	0.211
DOC_USP7_MATH_1	289	293	PF00917	0.233
LIG_14-3-3_CanoR_1	126	131	PF00244	0.540
LIG_14-3-3_CanoR_1	244	252	PF00244	0.346
LIG_14-3-3_CanoR_1	8	16	PF00244	0.768
LIG_14-3-3_CanoR_1	81	90	PF00244	0.327
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	83	87	PF00533	0.382
LIG_EH1_1	73	81	PF00400	0.233
LIG_FHA_1	112	118	PF00498	0.412
LIG_FHA_1	223	229	PF00498	0.345
LIG_FHA_1	259	265	PF00498	0.353
LIG_FHA_1	275	281	PF00498	0.313
LIG_FHA_2	222	228	PF00498	0.312
LIG_LIR_Gen_1	131	141	PF02991	0.373
LIG_LIR_Gen_1	279	290	PF02991	0.471
LIG_LIR_Gen_1	84	95	PF02991	0.396
LIG_LIR_Nem_3	131	136	PF02991	0.371
LIG_LIR_Nem_3	279	285	PF02991	0.444
LIG_LIR_Nem_3	37	42	PF02991	0.635
LIG_LIR_Nem_3	84	90	PF02991	0.384
LIG_NRBOX	133	139	PF00104	0.257
LIG_NRBOX	259	265	PF00104	0.391
LIG_SH2_CRK	141	145	PF00017	0.452
LIG_SH2_CRK	39	43	PF00017	0.658
LIG_SH2_STAT5	217	220	PF00017	0.324
LIG_SH2_STAT5	302	305	PF00017	0.616
LIG_SH3_3	207	213	PF00018	0.351
LIG_SH3_3	231	237	PF00018	0.305
LIG_SH3_3	269	275	PF00018	0.211
LIG_Sin3_3	140	147	PF02671	0.389
LIG_SUMO_SIM_par_1	270	277	PF11976	0.297
LIG_TRAF2_1	230	233	PF00917	0.280
MOD_CK1_1	128	134	PF00069	0.411
MOD_CK1_1	259	265	PF00069	0.247
MOD_CK1_1	276	282	PF00069	0.456
MOD_CK1_1	88	94	PF00069	0.331
MOD_CK2_1	227	233	PF00069	0.383
MOD_GlcNHglycan	20	23	PF01048	0.573
MOD_GlcNHglycan	245	248	PF01048	0.508
MOD_GlcNHglycan	285	288	PF01048	0.424
MOD_GlcNHglycan	291	294	PF01048	0.530
MOD_GlcNHglycan	67	70	PF01048	0.444
MOD_GlcNHglycan	87	90	PF01048	0.567
MOD_GlcNHglycan	99	102	PF01048	0.480
MOD_GSK3_1	252	259	PF00069	0.379
MOD_GSK3_1	65	72	PF00069	0.403
MOD_GSK3_1	81	88	PF00069	0.243
MOD_GSK3_1	93	100	PF00069	0.358
MOD_N-GLC_1	221	226	PF02516	0.508
MOD_NEK2_1	147	152	PF00069	0.470
MOD_NEK2_1	190	195	PF00069	0.295
MOD_NEK2_1	283	288	PF00069	0.370
MOD_NEK2_1	93	98	PF00069	0.356
MOD_NEK2_2	69	74	PF00069	0.485
MOD_PIKK_1	190	196	PF00454	0.273
MOD_PKA_1	126	132	PF00069	0.494
MOD_PKA_2	125	131	PF00069	0.505
MOD_PKA_2	243	249	PF00069	0.383
MOD_PKA_2	80	86	PF00069	0.338
MOD_Plk_1	256	262	PF00069	0.211
MOD_Plk_4	128	134	PF00069	0.511
MOD_Plk_4	147	153	PF00069	0.386
MOD_Plk_4	166	172	PF00069	0.174
MOD_Plk_4	259	265	PF00069	0.367
MOD_Plk_4	276	282	PF00069	0.254
MOD_Plk_4	69	75	PF00069	0.384
MOD_Plk_4	88	94	PF00069	0.234
MOD_SUMO_for_1	250	253	PF00179	0.211
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.739
TRG_ENDOCYTIC_2	141	144	PF00928	0.434
TRG_ENDOCYTIC_2	39	42	PF00928	0.637
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P684	Leptomonas seymouri	40%	98%
A0A0S4JPS2	Bodo saltans	22%	100%
A0A3Q8IEM4	Leishmania donovani	73%	100%
A0A422NDS8	Trypanosoma rangeli	30%	100%
A4I8N3	Leishmania infantum	73%	100%
E9B3J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q4K6	Leishmania major	70%	100%
V5BBB3	Trypanosoma cruzi	28%	100%