Tetraspanin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tetraspanin

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HL53_LEIBR

TriTrypDb:

LbrM.33.0170 , LBRM2903_330006600

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HL53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.639
CLV_NRD_NRD_1	15	17	PF00675	0.448
CLV_NRD_NRD_1	200	202	PF00675	0.411
CLV_NRD_NRD_1	310	312	PF00675	0.687
CLV_NRD_NRD_1	44	46	PF00675	0.414
CLV_NRD_NRD_1	443	445	PF00675	0.511
CLV_NRD_NRD_1	47	49	PF00675	0.418
CLV_PCSK_KEX2_1	15	17	PF00082	0.453
CLV_PCSK_KEX2_1	199	201	PF00082	0.403
CLV_PCSK_KEX2_1	310	312	PF00082	0.631
CLV_PCSK_SKI1_1	177	181	PF00082	0.263
CLV_Separin_Metazoa	286	290	PF03568	0.360
DEG_MDM2_SWIB_1	90	98	PF02201	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.662
DEG_ODPH_VHL_1	180	193	PF01847	0.236
DEG_SCF_FBW7_1	359	365	PF00400	0.456
DEG_SCF_FBW7_1	416	423	PF00400	0.627
DOC_CDC14_PxL_1	130	138	PF14671	0.532
DOC_CKS1_1	359	364	PF01111	0.401
DOC_CKS1_1	417	422	PF01111	0.628
DOC_CYCLIN_RxL_1	236	246	PF00134	0.352
DOC_CYCLIN_RxL_1	289	301	PF00134	0.323
DOC_MAPK_gen_1	408	417	PF00069	0.693
DOC_MAPK_gen_1	45	53	PF00069	0.609
DOC_MAPK_JIP1_4	201	207	PF00069	0.545
DOC_MAPK_MEF2A_6	177	186	PF00069	0.263
DOC_PP1_RVXF_1	293	300	PF00149	0.309
DOC_PP4_FxxP_1	131	134	PF00568	0.448
DOC_USP7_MATH_1	352	356	PF00917	0.499
DOC_USP7_MATH_1	362	366	PF00917	0.429
DOC_USP7_MATH_1	409	413	PF00917	0.695
DOC_USP7_MATH_1	420	424	PF00917	0.655
DOC_WW_Pin1_4	23	28	PF00397	0.593
DOC_WW_Pin1_4	358	363	PF00397	0.496
DOC_WW_Pin1_4	39	44	PF00397	0.572
DOC_WW_Pin1_4	416	421	PF00397	0.707
DOC_WW_Pin1_4	6	11	PF00397	0.647
LIG_14-3-3_CanoR_1	150	157	PF00244	0.361
LIG_14-3-3_CanoR_1	408	417	PF00244	0.722
LIG_14-3-3_CanoR_1	86	91	PF00244	0.586
LIG_14-3-3_CterR_2	444	447	PF00244	0.716
LIG_Actin_WH2_2	162	179	PF00022	0.340
LIG_APCC_ABBA_1	241	246	PF00400	0.446
LIG_BRCT_BRCA1_1	225	229	PF00533	0.346
LIG_BRCT_BRCA1_1	295	299	PF00533	0.401
LIG_BRCT_BRCA1_1	74	78	PF00533	0.603
LIG_deltaCOP1_diTrp_1	292	299	PF00928	0.402
LIG_FHA_1	113	119	PF00498	0.280
LIG_FHA_1	135	141	PF00498	0.419
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	322	328	PF00498	0.356
LIG_FHA_1	395	401	PF00498	0.236
LIG_FHA_1	80	86	PF00498	0.587
LIG_FHA_2	334	340	PF00498	0.368
LIG_FHA_2	364	370	PF00498	0.473
LIG_FHA_2	7	13	PF00498	0.648
LIG_GBD_Chelix_1	140	148	PF00786	0.650
LIG_Integrin_RGD_1	57	59	PF01839	0.400
LIG_LIR_Apic_2	128	134	PF02991	0.551
LIG_LIR_Apic_2	404	409	PF02991	0.585
LIG_LIR_Gen_1	296	307	PF02991	0.341
LIG_LIR_Gen_1	318	327	PF02991	0.327
LIG_LIR_Nem_3	292	297	PF02991	0.371
LIG_LIR_Nem_3	318	323	PF02991	0.337
LIG_LIR_Nem_3	342	347	PF02991	0.464
LIG_LIR_Nem_3	412	417	PF02991	0.675
LIG_MLH1_MIPbox_1	225	229	PF16413	0.346
LIG_Pex14_1	236	240	PF04695	0.345
LIG_Pex14_1	260	264	PF04695	0.399
LIG_Pex14_2	224	228	PF04695	0.382
LIG_Pex14_2	240	244	PF04695	0.309
LIG_Pex14_2	299	303	PF04695	0.323
LIG_Pex14_2	372	376	PF04695	0.380
LIG_Pex14_2	90	94	PF04695	0.568
LIG_SH2_CRK	209	213	PF00017	0.371
LIG_SH2_CRK	406	410	PF00017	0.592
LIG_SH2_SRC	262	265	PF00017	0.449
LIG_SH2_STAT3	96	99	PF00017	0.559
LIG_SH2_STAT5	222	225	PF00017	0.506
LIG_SH2_STAT5	96	99	PF00017	0.559
LIG_SH3_3	176	182	PF00018	0.252
LIG_SH3_3	37	43	PF00018	0.611
LIG_SH3_3	414	420	PF00018	0.630
LIG_SH3_3	48	54	PF00018	0.616
LIG_SH3_5	340	344	PF00018	0.396
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.236
LIG_SUMO_SIM_anti_2	397	404	PF11976	0.236
LIG_SUMO_SIM_par_1	114	120	PF11976	0.223
LIG_SUMO_SIM_par_1	397	404	PF11976	0.291
LIG_SUMO_SIM_par_1	49	56	PF11976	0.604
LIG_TRAF2_1	10	13	PF00917	0.646
LIG_TRAF2_1	283	286	PF00917	0.430
LIG_TYR_ITIM	220	225	PF00017	0.371
LIG_UBA3_1	319	325	PF00899	0.320
LIG_WRC_WIRS_1	87	92	PF05994	0.572
MOD_CDC14_SPxK_1	42	45	PF00782	0.658
MOD_CDK_SPxK_1	39	45	PF00069	0.641
MOD_CDK_SPxxK_3	39	46	PF00069	0.603
MOD_CK1_1	135	141	PF00069	0.423
MOD_CK1_1	167	173	PF00069	0.334
MOD_CK1_1	20	26	PF00069	0.627
MOD_CK1_1	267	273	PF00069	0.444
MOD_CK1_1	278	284	PF00069	0.383
MOD_CK1_1	363	369	PF00069	0.380
MOD_CK1_1	394	400	PF00069	0.277
MOD_CK1_1	421	427	PF00069	0.693
MOD_CK2_1	101	107	PF00069	0.543
MOD_CK2_1	150	156	PF00069	0.501
MOD_CK2_1	280	286	PF00069	0.469
MOD_CK2_1	363	369	PF00069	0.477
MOD_CK2_1	420	426	PF00069	0.719
MOD_CK2_1	6	12	PF00069	0.648
MOD_GlcNHglycan	18	22	PF01048	0.438
MOD_GlcNHglycan	229	232	PF01048	0.634
MOD_GlcNHglycan	266	269	PF01048	0.587
MOD_GlcNHglycan	277	280	PF01048	0.600
MOD_GlcNHglycan	354	357	PF01048	0.617
MOD_GlcNHglycan	420	423	PF01048	0.458
MOD_GlcNHglycan	426	429	PF01048	0.437
MOD_GlcNHglycan	434	438	PF01048	0.416
MOD_GlcNHglycan	82	85	PF01048	0.396
MOD_GSK3_1	132	139	PF00069	0.421
MOD_GSK3_1	156	163	PF00069	0.462
MOD_GSK3_1	223	230	PF00069	0.418
MOD_GSK3_1	26	33	PF00069	0.610
MOD_GSK3_1	264	271	PF00069	0.410
MOD_GSK3_1	274	281	PF00069	0.425
MOD_GSK3_1	354	361	PF00069	0.496
MOD_GSK3_1	416	423	PF00069	0.685
MOD_N-GLC_1	275	280	PF02516	0.591
MOD_N-GLC_1	303	308	PF02516	0.513
MOD_N-GLC_1	424	429	PF02516	0.426
MOD_NEK2_1	101	106	PF00069	0.576
MOD_NEK2_1	112	117	PF00069	0.343
MOD_NEK2_1	119	124	PF00069	0.434
MOD_NEK2_1	136	141	PF00069	0.440
MOD_NEK2_1	223	228	PF00069	0.394
MOD_NEK2_1	346	351	PF00069	0.451
MOD_NEK2_1	376	381	PF00069	0.409
MOD_NEK2_1	388	393	PF00069	0.305
MOD_NEK2_1	61	66	PF00069	0.716
MOD_NEK2_2	125	130	PF00069	0.486
MOD_OFUCOSY	266	272	PF10250	0.640
MOD_PIKK_1	150	156	PF00454	0.368
MOD_PIKK_1	20	26	PF00454	0.593
MOD_PIKK_1	333	339	PF00454	0.447
MOD_PIKK_1	4	10	PF00454	0.650
MOD_PKA_2	409	415	PF00069	0.711
MOD_PKA_2	85	91	PF00069	0.587
MOD_Plk_1	275	281	PF00069	0.472
MOD_Plk_1	424	430	PF00069	0.625
MOD_Plk_4	112	118	PF00069	0.223
MOD_Plk_4	160	166	PF00069	0.414
MOD_Plk_4	167	173	PF00069	0.375
MOD_Plk_4	180	186	PF00069	0.286
MOD_Plk_4	223	229	PF00069	0.415
MOD_Plk_4	298	304	PF00069	0.323
MOD_Plk_4	391	397	PF00069	0.323
MOD_Plk_4	72	78	PF00069	0.604
MOD_ProDKin_1	23	29	PF00069	0.592
MOD_ProDKin_1	358	364	PF00069	0.496
MOD_ProDKin_1	39	45	PF00069	0.573
MOD_ProDKin_1	416	422	PF00069	0.706
MOD_ProDKin_1	6	12	PF00069	0.648
TRG_DiLeu_BaEn_2	315	321	PF01217	0.350
TRG_ENDOCYTIC_2	209	212	PF00928	0.371
TRG_ENDOCYTIC_2	222	225	PF00928	0.371
TRG_ER_diArg_1	199	201	PF00400	0.603
TRG_ER_diArg_1	310	313	PF00400	0.427
TRG_ER_diArg_1	408	411	PF00400	0.604
TRG_NLS_MonoExtC_3	44	49	PF00514	0.617
TRG_NLS_MonoExtN_4	43	49	PF00514	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK0	Leptomonas seymouri	35%	100%
A0A3Q8IHA4	Leishmania donovani	70%	100%
A4I8N2	Leishmania infantum	70%	100%
E9B3J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q4K7	Leishmania major	67%	100%