Iwr1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL52_LEIBR

TriTrypDb:

LbrM.33.0160 , LBRM2903_330006500

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.760
CLV_NRD_NRD_1	140	142	PF00675	0.660
CLV_NRD_NRD_1	175	177	PF00675	0.491
CLV_NRD_NRD_1	203	205	PF00675	0.346
CLV_NRD_NRD_1	21	23	PF00675	0.606
CLV_NRD_NRD_1	234	236	PF00675	0.647
CLV_NRD_NRD_1	246	248	PF00675	0.665
CLV_PCSK_KEX2_1	140	142	PF00082	0.543
CLV_PCSK_KEX2_1	175	177	PF00082	0.491
CLV_PCSK_KEX2_1	21	23	PF00082	0.606
CLV_PCSK_KEX2_1	234	236	PF00082	0.647
CLV_PCSK_KEX2_1	246	248	PF00082	0.670
CLV_PCSK_SKI1_1	17	21	PF00082	0.584
CLV_PCSK_SKI1_1	175	179	PF00082	0.514
CLV_PCSK_SKI1_1	33	37	PF00082	0.677
DOC_CKS1_1	1	6	PF01111	0.505
DOC_MAPK_gen_1	246	252	PF00069	0.627
DOC_PP4_FxxP_1	135	138	PF00568	0.746
DOC_USP7_MATH_1	11	15	PF00917	0.724
DOC_USP7_MATH_1	152	156	PF00917	0.699
DOC_USP7_MATH_1	158	162	PF00917	0.729
DOC_USP7_MATH_1	240	244	PF00917	0.754
DOC_USP7_MATH_1	28	32	PF00917	0.629
DOC_WW_Pin1_4	156	161	PF00397	0.745
LIG_14-3-3_CanoR_1	140	146	PF00244	0.732
LIG_14-3-3_CanoR_1	255	259	PF00244	0.686
LIG_14-3-3_CanoR_1	49	58	PF00244	0.679
LIG_14-3-3_CanoR_1	91	99	PF00244	0.443
LIG_Actin_WH2_2	105	123	PF00022	0.493
LIG_Clathr_ClatBox_1	85	89	PF01394	0.685
LIG_FHA_1	14	20	PF00498	0.605
LIG_FHA_1	140	146	PF00498	0.755
LIG_FHA_1	192	198	PF00498	0.706
LIG_FHA_1	255	261	PF00498	0.510
LIG_FHA_1	34	40	PF00498	0.567
LIG_FHA_1	80	86	PF00498	0.600
LIG_FHA_1	91	97	PF00498	0.373
LIG_FHA_2	148	154	PF00498	0.615
LIG_FHA_2	234	240	PF00498	0.567
LIG_LIR_Apic_2	196	201	PF02991	0.412
LIG_LIR_Gen_1	104	112	PF02991	0.559
LIG_LIR_Gen_1	180	189	PF02991	0.761
LIG_LIR_Nem_3	100	105	PF02991	0.591
LIG_LIR_Nem_3	161	166	PF02991	0.651
LIG_Rb_LxCxE_1	257	273	PF01857	0.496
LIG_SH2_STAP1	181	185	PF00017	0.663
LIG_SH2_STAP1	209	213	PF00017	0.448
LIG_SH2_STAT5	134	137	PF00017	0.621
LIG_SH2_STAT5	198	201	PF00017	0.546
LIG_SH2_STAT5	251	254	PF00017	0.520
LIG_TRAF2_1	236	239	PF00917	0.672
LIG_TRAF2_1	261	264	PF00917	0.499
LIG_TRFH_1	134	138	PF08558	0.746
MOD_CDC14_SPxK_1	159	162	PF00782	0.787
MOD_CDK_SPxK_1	156	162	PF00069	0.792
MOD_CK1_1	116	122	PF00069	0.534
MOD_CK1_1	13	19	PF00069	0.719
MOD_CK1_1	229	235	PF00069	0.796
MOD_CK1_1	241	247	PF00069	0.639
MOD_CK1_1	254	260	PF00069	0.677
MOD_CK1_1	267	273	PF00069	0.504
MOD_CK1_1	90	96	PF00069	0.715
MOD_CK2_1	147	153	PF00069	0.591
MOD_CK2_1	208	214	PF00069	0.546
MOD_CK2_1	233	239	PF00069	0.753
MOD_CK2_1	258	264	PF00069	0.572
MOD_CK2_1	50	56	PF00069	0.682
MOD_CK2_1	78	84	PF00069	0.483
MOD_GlcNHglycan	214	219	PF01048	0.355
MOD_GlcNHglycan	228	231	PF01048	0.651
MOD_GlcNHglycan	272	275	PF01048	0.632
MOD_GlcNHglycan	71	76	PF01048	0.748
MOD_GSK3_1	152	159	PF00069	0.685
MOD_GSK3_1	187	194	PF00069	0.653
MOD_GSK3_1	226	233	PF00069	0.678
MOD_GSK3_1	238	245	PF00069	0.777
MOD_GSK3_1	254	261	PF00069	0.676
MOD_GSK3_1	270	277	PF00069	0.668
MOD_GSK3_1	29	36	PF00069	0.626
MOD_GSK3_1	41	48	PF00069	0.802
MOD_N-GLC_1	241	246	PF02516	0.552
MOD_NEK2_1	139	144	PF00069	0.728
MOD_NEK2_1	50	55	PF00069	0.548
MOD_PIKK_1	113	119	PF00454	0.514
MOD_PIKK_1	50	56	PF00454	0.604
MOD_PK_1	141	147	PF00069	0.672
MOD_PKA_1	140	146	PF00069	0.656
MOD_PKA_2	139	145	PF00069	0.655
MOD_PKA_2	233	239	PF00069	0.570
MOD_PKA_2	254	260	PF00069	0.675
MOD_PKA_2	29	35	PF00069	0.488
MOD_PKA_2	48	54	PF00069	0.723
MOD_PKA_2	56	62	PF00069	0.572
MOD_PKA_2	90	96	PF00069	0.451
MOD_Plk_1	152	158	PF00069	0.537
MOD_Plk_1	267	273	PF00069	0.655
MOD_Plk_4	152	158	PF00069	0.664
MOD_ProDKin_1	156	162	PF00069	0.745
TRG_DiLeu_BaEn_4	126	132	PF01217	0.774
TRG_ENDOCYTIC_2	181	184	PF00928	0.670
TRG_ER_diArg_1	139	141	PF00400	0.652
TRG_ER_diArg_1	174	176	PF00400	0.486
TRG_ER_diArg_1	20	22	PF00400	0.542
TRG_ER_diArg_1	246	249	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U4	Leptomonas seymouri	44%	82%
A0A3S7X690	Leishmania donovani	69%	100%
A4I8N1	Leishmania infantum	69%	100%
E9B3J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q4K8	Leishmania major	68%	100%