ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HL51_LEIBR

TriTrypDb:

LbrM.33.0150 , LBRM2903_330006400

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.627
CLV_NRD_NRD_1	377	379	PF00675	0.549
CLV_NRD_NRD_1	384	386	PF00675	0.565
CLV_PCSK_FUR_1	59	63	PF00082	0.541
CLV_PCSK_KEX2_1	377	379	PF00082	0.544
CLV_PCSK_KEX2_1	384	386	PF00082	0.563
CLV_PCSK_KEX2_1	61	63	PF00082	0.660
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.548
CLV_PCSK_SKI1_1	21	25	PF00082	0.541
CLV_PCSK_SKI1_1	257	261	PF00082	0.427
DEG_APCC_DBOX_1	20	28	PF00400	0.523
DEG_APCC_DBOX_1	256	264	PF00400	0.369
DOC_CYCLIN_RxL_1	390	401	PF00134	0.431
DOC_MAPK_MEF2A_6	272	281	PF00069	0.381
DOC_PP2B_LxvP_1	193	196	PF13499	0.573
DOC_USP7_MATH_1	217	221	PF00917	0.386
DOC_USP7_MATH_1	334	338	PF00917	0.557
DOC_USP7_MATH_1	364	368	PF00917	0.616
DOC_USP7_UBL2_3	57	61	PF12436	0.485
DOC_WW_Pin1_4	128	133	PF00397	0.402
DOC_WW_Pin1_4	163	168	PF00397	0.480
DOC_WW_Pin1_4	270	275	PF00397	0.380
DOC_WW_Pin1_4	398	403	PF00397	0.540
DOC_WW_Pin1_4	45	50	PF00397	0.620
LIG_14-3-3_CanoR_1	176	180	PF00244	0.535
LIG_14-3-3_CanoR_1	207	215	PF00244	0.630
LIG_14-3-3_CanoR_1	237	245	PF00244	0.463
LIG_14-3-3_CanoR_1	306	316	PF00244	0.568
LIG_14-3-3_CanoR_1	377	382	PF00244	0.636
LIG_14-3-3_CanoR_1	384	388	PF00244	0.495
LIG_14-3-3_CanoR_1	62	68	PF00244	0.637
LIG_14-3-3_CterR_2	404	408	PF00244	0.728
LIG_Actin_WH2_2	241	259	PF00022	0.437
LIG_APCC_ABBA_1	195	200	PF00400	0.594
LIG_BIR_III_4	92	96	PF00653	0.513
LIG_BRCT_BRCA1_1	246	250	PF00533	0.681
LIG_EH_1	42	46	PF12763	0.601
LIG_FHA_1	125	131	PF00498	0.378
LIG_FHA_1	176	182	PF00498	0.550
LIG_FHA_1	27	33	PF00498	0.535
LIG_FHA_1	292	298	PF00498	0.626
LIG_FHA_1	308	314	PF00498	0.418
LIG_FHA_2	187	193	PF00498	0.326
LIG_FHA_2	208	214	PF00498	0.630
LIG_Integrin_RGD_1	40	42	PF01839	0.583
LIG_LIR_Nem_3	386	391	PF02991	0.516
LIG_NRBOX	226	232	PF00104	0.469
LIG_PCNA_yPIPBox_3	17	27	PF02747	0.667
LIG_PCNA_yPIPBox_3	187	199	PF02747	0.465
LIG_SH2_CRK	16	20	PF00017	0.740
LIG_SH2_STAP1	68	72	PF00017	0.496
LIG_SH2_STAT5	290	293	PF00017	0.494
LIG_SH2_STAT5	358	361	PF00017	0.586
LIG_SH2_STAT5	368	371	PF00017	0.492
LIG_SH2_STAT5	68	71	PF00017	0.690
LIG_SH2_STAT5	89	92	PF00017	0.445
LIG_SH3_3	152	158	PF00018	0.513
LIG_SH3_3	2	8	PF00018	0.720
LIG_SH3_3	79	85	PF00018	0.463
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.308
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.317
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.555
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.571
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.488
LIG_SUMO_SIM_par_1	244	249	PF11976	0.478
LIG_TRAF2_1	121	124	PF00917	0.261
MOD_CDC14_SPxK_1	401	404	PF00782	0.651
MOD_CDK_SPxK_1	398	404	PF00069	0.646
MOD_CK1_1	128	134	PF00069	0.513
MOD_CK1_1	270	276	PF00069	0.450
MOD_CK1_1	299	305	PF00069	0.544
MOD_CK1_1	94	100	PF00069	0.513
MOD_CK2_1	106	112	PF00069	0.290
MOD_CK2_1	186	192	PF00069	0.335
MOD_CK2_1	207	213	PF00069	0.641
MOD_CK2_1	217	223	PF00069	0.487
MOD_CK2_1	341	347	PF00069	0.594
MOD_CK2_1	364	370	PF00069	0.616
MOD_Cter_Amidation	375	378	PF01082	0.462
MOD_DYRK1A_RPxSP_1	272	276	PF00069	0.372
MOD_GlcNHglycan	127	130	PF01048	0.478
MOD_GlcNHglycan	210	213	PF01048	0.375
MOD_GlcNHglycan	219	222	PF01048	0.384
MOD_GlcNHglycan	240	243	PF01048	0.440
MOD_GlcNHglycan	298	301	PF01048	0.435
MOD_GlcNHglycan	337	340	PF01048	0.516
MOD_GlcNHglycan	92	96	PF01048	0.513
MOD_GSK3_1	124	131	PF00069	0.423
MOD_GSK3_1	263	270	PF00069	0.591
MOD_GSK3_1	292	299	PF00069	0.491
MOD_LATS_1	394	400	PF00433	0.393
MOD_N-GLC_1	125	130	PF02516	0.513
MOD_N-GLC_2	116	118	PF02516	0.261
MOD_NEK2_1	105	110	PF00069	0.411
MOD_NEK2_1	201	206	PF00069	0.472
MOD_NEK2_1	63	68	PF00069	0.498
MOD_NEK2_2	175	180	PF00069	0.454
MOD_PKA_1	377	383	PF00069	0.637
MOD_PKA_2	175	181	PF00069	0.536
MOD_PKA_2	236	242	PF00069	0.622
MOD_PKA_2	377	383	PF00069	0.635
MOD_Plk_1	292	298	PF00069	0.602
MOD_Plk_4	106	112	PF00069	0.255
MOD_Plk_4	175	181	PF00069	0.461
MOD_Plk_4	186	192	PF00069	0.427
MOD_Plk_4	225	231	PF00069	0.432
MOD_Plk_4	263	269	PF00069	0.578
MOD_Plk_4	292	298	PF00069	0.556
MOD_Plk_4	299	305	PF00069	0.477
MOD_Plk_4	31	37	PF00069	0.516
MOD_Plk_4	377	383	PF00069	0.584
MOD_Plk_4	63	69	PF00069	0.499
MOD_ProDKin_1	128	134	PF00069	0.402
MOD_ProDKin_1	163	169	PF00069	0.480
MOD_ProDKin_1	270	276	PF00069	0.378
MOD_ProDKin_1	398	404	PF00069	0.544
MOD_ProDKin_1	45	51	PF00069	0.619
MOD_SUMO_rev_2	220	227	PF00179	0.390
MOD_SUMO_rev_2	353	357	PF00179	0.569
TRG_DiLeu_BaEn_1	347	352	PF01217	0.475
TRG_ENDOCYTIC_2	198	201	PF00928	0.441
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF8	Leptomonas seymouri	51%	100%
A0A3Q8IHJ7	Leishmania donovani	75%	100%
A4I8N0	Leishmania infantum	75%	100%
E9B3J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q4K9	Leishmania major	74%	100%