Centrosomal protein of 19 kDa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CEP19-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL49_LEIBR

TriTrypDb:

LbrM.33.0130 , LBRM2903_330006200

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005814	centriole	5	12
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0000922	spindle pole	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HL49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL49

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006903	vesicle targeting	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0034453	microtubule anchoring	4	1
GO:0034454	microtubule anchoring at centrosome	6	1
GO:0048199	vesicle targeting, to, from or within Golgi	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072393	microtubule anchoring at microtubule organizing center	5	1
GO:0097712	vesicle targeting, trans-Golgi to periciliary membrane compartment	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.405
CLV_C14_Caspase3-7	312	316	PF00656	0.446
CLV_C14_Caspase3-7	82	86	PF00656	0.462
CLV_NRD_NRD_1	221	223	PF00675	0.304
CLV_NRD_NRD_1	25	27	PF00675	0.432
CLV_PCSK_KEX2_1	129	131	PF00082	0.508
CLV_PCSK_KEX2_1	221	223	PF00082	0.273
CLV_PCSK_KEX2_1	348	350	PF00082	0.268
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.481
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.257
CLV_PCSK_SKI1_1	158	162	PF00082	0.395
CLV_PCSK_SKI1_1	222	226	PF00082	0.346
DOC_MAPK_DCC_7	182	190	PF00069	0.467
DOC_MAPK_gen_1	242	252	PF00069	0.536
DOC_MAPK_gen_1	26	34	PF00069	0.495
DOC_MAPK_gen_1	291	299	PF00069	0.546
DOC_MAPK_MEF2A_6	182	190	PF00069	0.405
DOC_MAPK_RevD_3	115	130	PF00069	0.473
DOC_MAPK_RevD_3	334	349	PF00069	0.515
DOC_USP7_MATH_1	119	123	PF00917	0.292
DOC_USP7_MATH_1	196	200	PF00917	0.528
DOC_USP7_MATH_1	251	255	PF00917	0.532
DOC_USP7_MATH_1	271	275	PF00917	0.473
DOC_USP7_MATH_1	280	284	PF00917	0.456
DOC_USP7_MATH_1	287	291	PF00917	0.493
DOC_USP7_MATH_1	356	360	PF00917	0.538
DOC_USP7_UBL2_3	354	358	PF12436	0.385
DOC_WW_Pin1_4	158	163	PF00397	0.348
DOC_WW_Pin1_4	276	281	PF00397	0.538
LIG_14-3-3_CanoR_1	221	231	PF00244	0.466
LIG_14-3-3_CanoR_1	35	44	PF00244	0.409
LIG_14-3-3_CanoR_1	67	72	PF00244	0.492
LIG_APCC_ABBA_1	91	96	PF00400	0.412
LIG_deltaCOP1_diTrp_1	9	18	PF00928	0.486
LIG_FHA_1	185	191	PF00498	0.546
LIG_FHA_1	214	220	PF00498	0.457
LIG_FHA_2	223	229	PF00498	0.465
LIG_FHA_2	273	279	PF00498	0.474
LIG_FHA_2	318	324	PF00498	0.446
LIG_FHA_2	34	40	PF00498	0.524
LIG_LIR_Apic_2	191	195	PF02991	0.546
LIG_LIR_Gen_1	233	241	PF02991	0.546
LIG_LIR_Gen_1	58	69	PF02991	0.479
LIG_LIR_Gen_1	9	18	PF02991	0.381
LIG_LIR_Nem_3	187	192	PF02991	0.546
LIG_LIR_Nem_3	233	239	PF02991	0.471
LIG_LIR_Nem_3	323	327	PF02991	0.546
LIG_LIR_Nem_3	9	14	PF02991	0.379
LIG_MYND_1	115	119	PF01753	0.465
LIG_PTB_Apo_2	326	333	PF02174	0.546
LIG_RPA_C_Plants	76	87	PF08784	0.299
LIG_SH2_NCK_1	192	196	PF00017	0.546
LIG_SH2_STAP1	103	107	PF00017	0.348
LIG_SH2_STAP1	346	350	PF00017	0.457
LIG_SH2_STAT5	189	192	PF00017	0.481
LIG_SH2_STAT5	344	347	PF00017	0.489
LIG_SH3_3	209	215	PF00018	0.478
LIG_SH3_3	267	273	PF00018	0.509
LIG_SH3_3	333	339	PF00018	0.465
LIG_SH3_3	38	44	PF00018	0.606
LIG_SUMO_SIM_par_1	268	276	PF11976	0.385
LIG_TRAF2_1	320	323	PF00917	0.484
MOD_CDK_SPK_2	158	163	PF00069	0.381
MOD_CK1_1	101	107	PF00069	0.322
MOD_CK1_1	254	260	PF00069	0.472
MOD_CK1_1	283	289	PF00069	0.455
MOD_CK2_1	140	146	PF00069	0.403
MOD_CK2_1	222	228	PF00069	0.496
MOD_CK2_1	317	323	PF00069	0.459
MOD_CK2_1	33	39	PF00069	0.513
MOD_CK2_1	67	73	PF00069	0.525
MOD_CK2_1	96	102	PF00069	0.428
MOD_GlcNHglycan	253	256	PF01048	0.386
MOD_GlcNHglycan	282	285	PF01048	0.283
MOD_GSK3_1	180	187	PF00069	0.509
MOD_GSK3_1	250	257	PF00069	0.466
MOD_GSK3_1	272	279	PF00069	0.501
MOD_GSK3_1	283	290	PF00069	0.470
MOD_GSK3_1	35	42	PF00069	0.445
MOD_GSK3_1	63	70	PF00069	0.473
MOD_LATS_1	54	60	PF00433	0.297
MOD_NEK2_1	89	94	PF00069	0.442
MOD_PKA_2	174	180	PF00069	0.490
MOD_PKA_2	287	293	PF00069	0.536
MOD_Plk_1	317	323	PF00069	0.458
MOD_Plk_2-3	317	323	PF00069	0.446
MOD_Plk_2-3	39	45	PF00069	0.387
MOD_Plk_2-3	96	102	PF00069	0.306
MOD_Plk_4	184	190	PF00069	0.546
MOD_Plk_4	235	241	PF00069	0.492
MOD_Plk_4	265	271	PF00069	0.442
MOD_Plk_4	56	62	PF00069	0.455
MOD_Plk_4	67	73	PF00069	0.553
MOD_Plk_4	89	95	PF00069	0.442
MOD_ProDKin_1	158	164	PF00069	0.348
MOD_ProDKin_1	276	282	PF00069	0.538
MOD_SUMO_rev_2	317	327	PF00179	0.457
MOD_SUMO_rev_2	82	89	PF00179	0.286
TRG_DiLeu_BaEn_1	9	14	PF01217	0.379
TRG_ENDOCYTIC_2	61	64	PF00928	0.406
TRG_ER_diArg_1	221	223	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z2	Leptomonas seymouri	58%	95%
A0A0S4JKX9	Bodo saltans	39%	100%
A0A1X0P0L9	Trypanosomatidae	41%	94%
A0A3R7KC81	Trypanosoma rangeli	40%	96%
A0A3S7X6D1	Leishmania donovani	78%	100%
A4I8M8	Leishmania infantum	78%	100%
D0A4K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	96%
E9B3J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q4L1	Leishmania major	79%	100%
V5BKD3	Trypanosoma cruzi	41%	96%