Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HL48_LEIBR

TriTrypDb:

LbrM.33.0120 , LBRM2903_330006100

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.601
CLV_NRD_NRD_1	121	123	PF00675	0.790
CLV_NRD_NRD_1	127	129	PF00675	0.704
CLV_NRD_NRD_1	229	231	PF00675	0.743
CLV_NRD_NRD_1	285	287	PF00675	0.568
CLV_PCSK_FUR_1	283	287	PF00082	0.457
CLV_PCSK_KEX2_1	127	129	PF00082	0.683
CLV_PCSK_KEX2_1	188	190	PF00082	0.462
CLV_PCSK_KEX2_1	231	233	PF00082	0.661
CLV_PCSK_KEX2_1	285	287	PF00082	0.583
CLV_PCSK_KEX2_1	289	291	PF00082	0.539
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.460
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.645
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.412
CLV_PCSK_PC7_1	285	291	PF00082	0.506
CLV_PCSK_SKI1_1	188	192	PF00082	0.433
CLV_PCSK_SKI1_1	285	289	PF00082	0.565
CLV_PCSK_SKI1_1	41	45	PF00082	0.503
DEG_APCC_DBOX_1	40	48	PF00400	0.491
DOC_CYCLIN_RxL_1	185	195	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	270	273	PF00134	0.547
DOC_MAPK_gen_1	185	193	PF00069	0.548
DOC_MAPK_gen_1	30	39	PF00069	0.547
DOC_PP2B_LxvP_1	270	273	PF13499	0.547
DOC_USP7_MATH_1	173	177	PF00917	0.456
DOC_USP7_MATH_1	242	246	PF00917	0.605
DOC_WW_Pin1_4	127	132	PF00397	0.591
LIG_14-3-3_CanoR_1	110	120	PF00244	0.734
LIG_14-3-3_CanoR_1	28	33	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_FHA_2	17	23	PF00498	0.535
LIG_FHA_2	205	211	PF00498	0.519
LIG_LIR_Nem_3	156	161	PF02991	0.415
LIG_LIR_Nem_3	240	246	PF02991	0.611
LIG_PCNA_yPIPBox_3	197	209	PF02747	0.434
LIG_SH2_CRK	243	247	PF00017	0.570
LIG_SH2_STAP1	16	20	PF00017	0.530
LIG_SH2_STAT3	159	162	PF00017	0.521
LIG_SH2_STAT5	243	246	PF00017	0.569
LIG_SH2_STAT5	3	6	PF00017	0.626
LIG_SH3_3	36	42	PF00018	0.772
LIG_SH3_3	44	50	PF00018	0.641
LIG_SH3_3	54	60	PF00018	0.518
LIG_SH3_3	61	67	PF00018	0.507
LIG_TRAF2_1	160	163	PF00917	0.519
LIG_TRAF2_1	265	268	PF00917	0.558
LIG_TRAF2_1	291	294	PF00917	0.627
LIG_WW_2	64	67	PF00397	0.638
LIG_WW_3	119	123	PF00397	0.708
LIG_WW_3	130	134	PF00397	0.643
MOD_CDC14_SPxK_1	130	133	PF00782	0.664
MOD_CDK_SPxK_1	127	133	PF00069	0.625
MOD_CK1_1	101	107	PF00069	0.655
MOD_CK1_1	112	118	PF00069	0.538
MOD_CK1_1	31	37	PF00069	0.672
MOD_CK2_1	111	117	PF00069	0.543
MOD_CK2_1	147	153	PF00069	0.448
MOD_CK2_1	157	163	PF00069	0.524
MOD_CK2_1	262	268	PF00069	0.674
MOD_CK2_1	272	278	PF00069	0.651
MOD_CK2_1	32	38	PF00069	0.542
MOD_GlcNHglycan	103	106	PF01048	0.540
MOD_GlcNHglycan	149	152	PF01048	0.387
MOD_GlcNHglycan	22	26	PF01048	0.747
MOD_GlcNHglycan	225	228	PF01048	0.564
MOD_GlcNHglycan	239	242	PF01048	0.729
MOD_GlcNHglycan	251	254	PF01048	0.585
MOD_GlcNHglycan	264	267	PF01048	0.694
MOD_GSK3_1	12	19	PF00069	0.655
MOD_GSK3_1	153	160	PF00069	0.409
MOD_GSK3_1	237	244	PF00069	0.785
MOD_GSK3_1	272	279	PF00069	0.622
MOD_GSK3_1	28	35	PF00069	0.665
MOD_GSK3_1	95	102	PF00069	0.710
MOD_N-GLC_2	7	9	PF02516	0.519
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	109	114	PF00069	0.625
MOD_NEK2_1	157	162	PF00069	0.467
MOD_NEK2_1	20	25	PF00069	0.548
MOD_NEK2_1	204	209	PF00069	0.659
MOD_NEK2_1	32	37	PF00069	0.663
MOD_NEK2_2	173	178	PF00069	0.458
MOD_NEK2_2	242	247	PF00069	0.568
MOD_PK_1	33	39	PF00069	0.541
MOD_PKA_2	109	115	PF00069	0.671
MOD_PKA_2	32	38	PF00069	0.542
MOD_Plk_1	16	22	PF00069	0.636
MOD_Plk_1	276	282	PF00069	0.646
MOD_Plk_4	153	159	PF00069	0.416
MOD_ProDKin_1	127	133	PF00069	0.594
MOD_SUMO_rev_2	180	190	PF00179	0.408
TRG_ENDOCYTIC_2	187	190	PF00928	0.640
TRG_ENDOCYTIC_2	243	246	PF00928	0.696
TRG_ER_diArg_1	126	128	PF00400	0.730
TRG_ER_diArg_1	285	287	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5B4	Leptomonas seymouri	43%	100%
A0A3Q8ITS9	Leishmania donovani	64%	100%
A4I8M7	Leishmania infantum	65%	100%
E9B3I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%