Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL47_LEIBR

TriTrypDb:

LbrM.33.0110 , LBRM2903_330006000

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.523
CLV_NRD_NRD_1	12	14	PF00675	0.663
CLV_NRD_NRD_1	125	127	PF00675	0.545
CLV_NRD_NRD_1	267	269	PF00675	0.623
CLV_PCSK_FUR_1	140	144	PF00082	0.612
CLV_PCSK_KEX2_1	12	14	PF00082	0.630
CLV_PCSK_KEX2_1	125	127	PF00082	0.609
CLV_PCSK_KEX2_1	142	144	PF00082	0.387
CLV_PCSK_KEX2_1	23	25	PF00082	0.500
CLV_PCSK_KEX2_1	267	269	PF00082	0.667
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.512
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.583
CLV_PCSK_PC7_1	19	25	PF00082	0.562
CLV_PCSK_SKI1_1	220	224	PF00082	0.545
CLV_PCSK_SKI1_1	267	271	PF00082	0.644
CLV_PCSK_SKI1_1	301	305	PF00082	0.580
DOC_CKS1_1	151	156	PF01111	0.579
DOC_CKS1_1	311	316	PF01111	0.436
DOC_PP2B_LxvP_1	149	152	PF13499	0.658
DOC_USP7_MATH_1	240	244	PF00917	0.683
DOC_USP7_MATH_1	91	95	PF00917	0.713
DOC_USP7_MATH_2	207	213	PF00917	0.653
DOC_USP7_UBL2_3	172	176	PF12436	0.734
DOC_USP7_UBL2_3	216	220	PF12436	0.669
DOC_WW_Pin1_4	150	155	PF00397	0.632
DOC_WW_Pin1_4	161	166	PF00397	0.733
DOC_WW_Pin1_4	232	237	PF00397	0.621
DOC_WW_Pin1_4	310	315	PF00397	0.442
LIG_14-3-3_CanoR_1	12	17	PF00244	0.671
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_4	345	349	PF00653	0.471
LIG_eIF4E_1	198	204	PF01652	0.468
LIG_FHA_1	274	280	PF00498	0.588
LIG_FHA_1	311	317	PF00498	0.599
LIG_FHA_2	225	231	PF00498	0.638
LIG_FHA_2	38	44	PF00498	0.604
LIG_GSK3_LRP6_1	150	155	PF00069	0.435
LIG_LIR_Gen_1	177	183	PF02991	0.722
LIG_LIR_Nem_3	153	159	PF02991	0.585
LIG_LIR_Nem_3	177	182	PF02991	0.721
LIG_LIR_Nem_3	329	334	PF02991	0.645
LIG_SH2_NCK_1	198	202	PF00017	0.722
LIG_SH2_NCK_1	42	46	PF00017	0.660
LIG_SH2_PTP2	179	182	PF00017	0.474
LIG_SH2_SRC	198	201	PF00017	0.484
LIG_SH2_STAP1	42	46	PF00017	0.629
LIG_SH2_STAT5	179	182	PF00017	0.631
LIG_SH2_STAT5	238	241	PF00017	0.525
LIG_SH2_STAT5	82	85	PF00017	0.770
LIG_SH3_1	148	154	PF00018	0.676
LIG_SH3_3	148	154	PF00018	0.558
LIG_SH3_3	308	314	PF00018	0.574
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.730
MOD_CDK_SPK_2	232	237	PF00069	0.650
MOD_CDK_SPxxK_3	150	157	PF00069	0.442
MOD_CK1_1	15	21	PF00069	0.713
MOD_CK1_1	158	164	PF00069	0.623
MOD_CK1_1	273	279	PF00069	0.576
MOD_CK2_1	224	230	PF00069	0.637
MOD_CK2_1	87	93	PF00069	0.596
MOD_GlcNHglycan	113	116	PF01048	0.600
MOD_GlcNHglycan	58	61	PF01048	0.704
MOD_GlcNHglycan	89	92	PF01048	0.665
MOD_GSK3_1	11	18	PF00069	0.622
MOD_GSK3_1	216	223	PF00069	0.459
MOD_GSK3_1	26	33	PF00069	0.718
MOD_GSK3_1	288	295	PF00069	0.516
MOD_GSK3_1	326	333	PF00069	0.596
MOD_GSK3_1	34	41	PF00069	0.577
MOD_GSK3_1	87	94	PF00069	0.598
MOD_LATS_1	187	193	PF00433	0.471
MOD_N-GLC_1	255	260	PF02516	0.621
MOD_N-GLC_1	317	322	PF02516	0.630
MOD_NEK2_1	111	116	PF00069	0.524
MOD_NEK2_1	239	244	PF00069	0.580
MOD_NEK2_1	270	275	PF00069	0.642
MOD_NEK2_1	326	331	PF00069	0.556
MOD_PIKK_1	209	215	PF00454	0.589
MOD_PIKK_1	220	226	PF00454	0.566
MOD_PKA_1	12	18	PF00069	0.500
MOD_PKA_2	11	17	PF00069	0.684
MOD_Plk_1	183	189	PF00069	0.610
MOD_Plk_1	240	246	PF00069	0.669
MOD_Plk_1	255	261	PF00069	0.564
MOD_Plk_1	317	323	PF00069	0.580
MOD_Plk_1	38	44	PF00069	0.704
MOD_Plk_4	242	248	PF00069	0.678
MOD_Plk_4	326	332	PF00069	0.552
MOD_ProDKin_1	150	156	PF00069	0.634
MOD_ProDKin_1	161	167	PF00069	0.732
MOD_ProDKin_1	232	238	PF00069	0.616
MOD_ProDKin_1	310	316	PF00069	0.439
MOD_SUMO_for_1	188	191	PF00179	0.651
MOD_SUMO_rev_2	209	217	PF00179	0.673
TRG_ENDOCYTIC_2	179	182	PF00928	0.685
TRG_ENDOCYTIC_2	331	334	PF00928	0.644
TRG_ER_diArg_1	267	269	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS1	Leptomonas seymouri	55%	95%
A0A3Q8IGM9	Leishmania donovani	81%	100%
A0A422NYD6	Trypanosoma rangeli	38%	88%
A4I8M6	Leishmania infantum	81%	100%
C9ZPV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
E9B3I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4L2	Leishmania major	80%	100%
V5BJG4	Trypanosoma cruzi	40%	88%