Zinc transporter ZIP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ZIP Zinc transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HL46_LEIBR

TriTrypDb:

LbrM.33.0100 , LBRM2903_330005900

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HL46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL46

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006829	zinc ion transport	8	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005385	zinc ion transmembrane transporter activity	7	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.543
CLV_C14_Caspase3-7	77	81	PF00656	0.290
CLV_NRD_NRD_1	14	16	PF00675	0.425
CLV_PCSK_KEX2_1	14	16	PF00082	0.464
CLV_PCSK_SKI1_1	216	220	PF00082	0.291
DEG_APCC_DBOX_1	252	260	PF00400	0.398
DEG_APCC_DBOX_1	299	307	PF00400	0.482
DOC_CKS1_1	228	233	PF01111	0.403
DOC_CYCLIN_RxL_1	211	220	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.368
DOC_MAPK_MEF2A_6	171	180	PF00069	0.501
DOC_PP4_FxxP_1	219	222	PF00568	0.491
DOC_USP7_MATH_1	123	127	PF00917	0.756
DOC_USP7_MATH_1	205	209	PF00917	0.650
DOC_USP7_MATH_1	265	269	PF00917	0.567
DOC_USP7_MATH_1	284	288	PF00917	0.312
DOC_WW_Pin1_4	227	232	PF00397	0.363
DOC_WW_Pin1_4	271	276	PF00397	0.391
DOC_WW_Pin1_4	75	80	PF00397	0.412
LIG_14-3-3_CanoR_1	20	25	PF00244	0.663
LIG_14-3-3_CanoR_1	206	210	PF00244	0.599
LIG_14-3-3_CanoR_1	267	275	PF00244	0.352
LIG_14-3-3_CanoR_1	35	45	PF00244	0.660
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	286	290	PF00533	0.312
LIG_Clathr_ClatBox_1	150	154	PF01394	0.564
LIG_CSL_BTD_1	6	9	PF09270	0.569
LIG_CtBP_PxDLS_1	68	72	PF00389	0.256
LIG_FHA_1	144	150	PF00498	0.597
LIG_FHA_1	20	26	PF00498	0.773
LIG_FHA_1	317	323	PF00498	0.303
LIG_FHA_1	40	46	PF00498	0.623
LIG_FHA_2	112	118	PF00498	0.641
LIG_FHA_2	188	194	PF00498	0.537
LIG_FHA_2	75	81	PF00498	0.494
LIG_LIR_Gen_1	287	298	PF02991	0.416
LIG_LIR_Gen_1	43	53	PF02991	0.532
LIG_LIR_Nem_3	287	293	PF02991	0.328
LIG_LIR_Nem_3	43	49	PF02991	0.549
LIG_Pex14_1	215	219	PF04695	0.485
LIG_Pex14_1	7	11	PF04695	0.620
LIG_Pex14_2	8	12	PF04695	0.486
LIG_REV1ctd_RIR_1	9	15	PF16727	0.605
LIG_SH2_PTP2	292	295	PF00017	0.368
LIG_SH2_STAT5	292	295	PF00017	0.368
LIG_SH3_3	10	16	PF00018	0.586
LIG_SH3_3	258	264	PF00018	0.420
LIG_SH3_3	3	9	PF00018	0.547
LIG_SH3_3	89	95	PF00018	0.383
LIG_Sin3_3	157	164	PF02671	0.481
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.550
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.372
LIG_TRAF2_1	116	119	PF00917	0.598
LIG_TRAF2_1	190	193	PF00917	0.571
LIG_TRAF2_1	299	302	PF00917	0.474
MOD_CK1_1	126	132	PF00069	0.665
MOD_CK1_1	268	274	PF00069	0.430
MOD_CK1_1	40	46	PF00069	0.584
MOD_CK1_1	75	81	PF00069	0.461
MOD_CK2_1	111	117	PF00069	0.759
MOD_CK2_1	185	191	PF00069	0.577
MOD_CK2_1	296	302	PF00069	0.306
MOD_GlcNHglycan	125	128	PF01048	0.508
MOD_GlcNHglycan	130	133	PF01048	0.389
MOD_GlcNHglycan	161	164	PF01048	0.395
MOD_GlcNHglycan	286	289	PF01048	0.312
MOD_GlcNHglycan	326	329	PF01048	0.570
MOD_GlcNHglycan	39	42	PF01048	0.372
MOD_GlcNHglycan	53	56	PF01048	0.342
MOD_GlcNHglycan	74	77	PF01048	0.638
MOD_GSK3_1	126	133	PF00069	0.598
MOD_GSK3_1	19	26	PF00069	0.639
MOD_GSK3_1	33	40	PF00069	0.631
MOD_GSK3_1	74	81	PF00069	0.433
MOD_NEK2_1	323	328	PF00069	0.489
MOD_NEK2_1	33	38	PF00069	0.665
MOD_NEK2_1	45	50	PF00069	0.372
MOD_NEK2_1	98	103	PF00069	0.647
MOD_PKA_2	123	129	PF00069	0.600
MOD_PKA_2	19	25	PF00069	0.695
MOD_PKA_2	205	211	PF00069	0.642
MOD_PKA_2	266	272	PF00069	0.371
MOD_PKA_2	34	40	PF00069	0.632
MOD_Plk_1	98	104	PF00069	0.599
MOD_Plk_2-3	111	117	PF00069	0.594
MOD_Plk_4	20	26	PF00069	0.660
MOD_Plk_4	274	280	PF00069	0.437
MOD_Plk_4	286	292	PF00069	0.366
MOD_Plk_4	293	299	PF00069	0.331
MOD_ProDKin_1	227	233	PF00069	0.363
MOD_ProDKin_1	271	277	PF00069	0.382
MOD_ProDKin_1	75	81	PF00069	0.407
MOD_SUMO_rev_2	299	306	PF00179	0.511
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.558
TRG_ENDOCYTIC_2	292	295	PF00928	0.368
TRG_ER_diArg_1	13	15	PF00400	0.652
TRG_ER_diArg_1	211	214	PF00400	0.540
TRG_ER_diArg_1	30	33	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U6	Leptomonas seymouri	47%	95%
A0A1X0P3V2	Trypanosomatidae	29%	75%
A0A3R7MSD3	Trypanosoma rangeli	34%	100%
A0A3S7X6D4	Leishmania donovani	69%	100%
A4I8M5	Leishmania infantum	69%	100%
C9ZPV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	90%
E9B3I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q4L3	Leishmania major	68%	100%