Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL45_LEIBR

TriTrypDb:

LbrM.33.0090 , LBRM2903_330005800

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.330
CLV_NRD_NRD_1	219	221	PF00675	0.439
CLV_PCSK_KEX2_1	219	221	PF00082	0.439
CLV_PCSK_SKI1_1	101	105	PF00082	0.418
CLV_PCSK_SKI1_1	283	287	PF00082	0.392
CLV_PCSK_SKI1_1	381	385	PF00082	0.468
CLV_PCSK_SKI1_1	389	393	PF00082	0.457
CLV_PCSK_SKI1_1	482	486	PF00082	0.422
CLV_Separin_Metazoa	87	91	PF03568	0.300
DEG_APCC_DBOX_1	456	464	PF00400	0.398
DEG_SPOP_SBC_1	176	180	PF00917	0.450
DEG_SPOP_SBC_1	552	556	PF00917	0.527
DOC_ANK_TNKS_1	187	194	PF00023	0.552
DOC_CKS1_1	320	325	PF01111	0.382
DOC_CYCLIN_RxL_1	369	380	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	568	574	PF00134	0.542
DOC_MAPK_FxFP_2	489	492	PF00069	0.339
DOC_MAPK_gen_1	224	234	PF00069	0.343
DOC_MAPK_MEF2A_6	300	309	PF00069	0.452
DOC_MAPK_MEF2A_6	569	576	PF00069	0.470
DOC_MAPK_MEF2A_6	588	597	PF00069	0.289
DOC_PP1_RVXF_1	370	377	PF00149	0.439
DOC_PP2B_LxvP_1	183	186	PF13499	0.334
DOC_PP2B_LxvP_1	568	571	PF13499	0.557
DOC_PP4_FxxP_1	182	185	PF00568	0.413
DOC_PP4_FxxP_1	489	492	PF00568	0.339
DOC_USP7_MATH_1	131	135	PF00917	0.383
DOC_USP7_MATH_1	174	178	PF00917	0.554
DOC_USP7_MATH_1	200	204	PF00917	0.450
DOC_USP7_MATH_1	218	222	PF00917	0.412
DOC_USP7_MATH_1	354	358	PF00917	0.638
DOC_USP7_MATH_1	461	465	PF00917	0.318
DOC_USP7_MATH_1	492	496	PF00917	0.349
DOC_USP7_MATH_1	584	588	PF00917	0.375
DOC_USP7_MATH_1	69	73	PF00917	0.343
DOC_WW_Pin1_4	288	293	PF00397	0.337
DOC_WW_Pin1_4	319	324	PF00397	0.381
DOC_WW_Pin1_4	39	44	PF00397	0.404
DOC_WW_Pin1_4	511	516	PF00397	0.593
DOC_WW_Pin1_4	538	543	PF00397	0.589
DOC_WW_Pin1_4	548	553	PF00397	0.495
LIG_14-3-3_CanoR_1	123	132	PF00244	0.432
LIG_14-3-3_CanoR_1	219	223	PF00244	0.520
LIG_14-3-3_CanoR_1	227	233	PF00244	0.377
LIG_14-3-3_CanoR_1	252	257	PF00244	0.389
LIG_14-3-3_CanoR_1	300	307	PF00244	0.457
LIG_14-3-3_CanoR_1	372	377	PF00244	0.430
LIG_14-3-3_CanoR_1	482	487	PF00244	0.447
LIG_14-3-3_CanoR_1	488	492	PF00244	0.555
LIG_Actin_WH2_2	376	391	PF00022	0.416
LIG_BRCT_BRCA1_1	178	182	PF00533	0.397
LIG_CSL_BTD_1	8	11	PF09270	0.487
LIG_deltaCOP1_diTrp_1	251	256	PF00928	0.396
LIG_DLG_GKlike_1	372	379	PF00625	0.434
LIG_eIF4E_1	229	235	PF01652	0.328
LIG_EVH1_1	183	187	PF00568	0.350
LIG_EVH1_1	207	211	PF00568	0.404
LIG_FHA_1	163	169	PF00498	0.308
LIG_FHA_1	229	235	PF00498	0.328
LIG_FHA_1	279	285	PF00498	0.332
LIG_FHA_1	300	306	PF00498	0.460
LIG_FHA_1	313	319	PF00498	0.331
LIG_FHA_1	39	45	PF00498	0.328
LIG_FHA_1	511	517	PF00498	0.593
LIG_FHA_1	553	559	PF00498	0.682
LIG_FHA_1	95	101	PF00498	0.288
LIG_FHA_2	260	266	PF00498	0.415
LIG_FHA_2	363	369	PF00498	0.481
LIG_FHA_2	396	402	PF00498	0.430
LIG_FHA_2	544	550	PF00498	0.622
LIG_Integrin_RGD_1	399	401	PF01839	0.453
LIG_LIR_Apic_2	179	185	PF02991	0.483
LIG_LIR_Gen_1	432	441	PF02991	0.379
LIG_LIR_Gen_1	445	456	PF02991	0.364
LIG_LIR_Gen_1	609	618	PF02991	0.361
LIG_LIR_Gen_1	97	107	PF02991	0.299
LIG_LIR_Nem_3	251	256	PF02991	0.391
LIG_LIR_Nem_3	373	379	PF02991	0.498
LIG_LIR_Nem_3	432	437	PF02991	0.372
LIG_LIR_Nem_3	445	451	PF02991	0.352
LIG_LIR_Nem_3	490	494	PF02991	0.411
LIG_LIR_Nem_3	609	613	PF02991	0.329
LIG_LIR_Nem_3	97	102	PF02991	0.383
LIG_MAD2	123	131	PF02301	0.460
LIG_MYND_1	112	116	PF01753	0.330
LIG_MYND_1	187	191	PF01753	0.419
LIG_NRBOX	403	409	PF00104	0.359
LIG_NRBOX	465	471	PF00104	0.369
LIG_PCNA_PIPBox_1	222	231	PF02747	0.281
LIG_PDZ_Class_3	616	621	PF00595	0.437
LIG_Pex14_2	444	448	PF04695	0.420
LIG_PTB_Apo_2	88	95	PF02174	0.384
LIG_SH2_CRK	229	233	PF00017	0.329
LIG_SH2_SRC	459	462	PF00017	0.314
LIG_SH2_STAP1	170	174	PF00017	0.330
LIG_SH2_STAP1	229	233	PF00017	0.390
LIG_SH2_STAP1	301	305	PF00017	0.455
LIG_SH2_STAT5	301	304	PF00017	0.466
LIG_SH2_STAT5	459	462	PF00017	0.314
LIG_SH2_STAT5	502	505	PF00017	0.402
LIG_SH2_STAT5	84	87	PF00017	0.358
LIG_SH3_1	181	187	PF00018	0.345
LIG_SH3_2	208	213	PF14604	0.376
LIG_SH3_3	181	187	PF00018	0.474
LIG_SH3_3	205	211	PF00018	0.401
LIG_SH3_3	281	287	PF00018	0.305
LIG_SH3_3	5	11	PF00018	0.571
LIG_SH3_3	567	573	PF00018	0.441
LIG_Sin3_3	447	454	PF02671	0.277
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.335
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.301
LIG_SUMO_SIM_par_1	230	237	PF11976	0.396
LIG_SUMO_SIM_par_1	464	471	PF11976	0.382
LIG_SUMO_SIM_par_1	513	520	PF11976	0.572
LIG_SUMO_SIM_par_1	553	563	PF11976	0.432
LIG_UBA3_1	50	55	PF00899	0.428
LIG_WW_3	185	189	PF00397	0.380
MOD_CK1_1	177	183	PF00069	0.413
MOD_CK1_1	362	368	PF00069	0.551
MOD_CK1_1	38	44	PF00069	0.347
MOD_CK1_1	432	438	PF00069	0.410
MOD_CK1_1	553	559	PF00069	0.542
MOD_CK1_1	609	615	PF00069	0.426
MOD_CK1_1	72	78	PF00069	0.480
MOD_CK2_1	252	258	PF00069	0.423
MOD_CK2_1	259	265	PF00069	0.349
MOD_CK2_1	362	368	PF00069	0.483
MOD_CK2_1	411	417	PF00069	0.474
MOD_CK2_1	543	549	PF00069	0.582
MOD_CK2_1	72	78	PF00069	0.456
MOD_GlcNHglycan	127	130	PF01048	0.431
MOD_GlcNHglycan	267	270	PF01048	0.352
MOD_GlcNHglycan	355	359	PF01048	0.597
MOD_GlcNHglycan	47	50	PF01048	0.437
MOD_GlcNHglycan	527	530	PF01048	0.518
MOD_GlcNHglycan	57	60	PF01048	0.318
MOD_GlcNHglycan	71	74	PF01048	0.439
MOD_GSK3_1	17	24	PF00069	0.574
MOD_GSK3_1	330	337	PF00069	0.589
MOD_GSK3_1	35	42	PF00069	0.513
MOD_GSK3_1	359	366	PF00069	0.591
MOD_GSK3_1	368	375	PF00069	0.452
MOD_GSK3_1	407	414	PF00069	0.586
MOD_GSK3_1	418	425	PF00069	0.450
MOD_GSK3_1	429	436	PF00069	0.359
MOD_GSK3_1	506	513	PF00069	0.445
MOD_GSK3_1	548	555	PF00069	0.669
MOD_GSK3_1	72	79	PF00069	0.468
MOD_GSK3_1	90	97	PF00069	0.281
MOD_N-GLC_1	90	95	PF02516	0.434
MOD_NEK2_1	125	130	PF00069	0.548
MOD_NEK2_1	234	239	PF00069	0.476
MOD_NEK2_1	299	304	PF00069	0.405
MOD_NEK2_1	35	40	PF00069	0.302
MOD_NEK2_1	370	375	PF00069	0.464
MOD_NEK2_1	407	412	PF00069	0.414
MOD_NEK2_1	487	492	PF00069	0.558
MOD_NEK2_1	516	521	PF00069	0.558
MOD_NEK2_1	600	605	PF00069	0.377
MOD_NEK2_1	76	81	PF00069	0.418
MOD_PIKK_1	76	82	PF00454	0.361
MOD_PKA_2	155	161	PF00069	0.506
MOD_PKA_2	218	224	PF00069	0.511
MOD_PKA_2	299	305	PF00069	0.396
MOD_PKA_2	487	493	PF00069	0.456
MOD_Plk_1	305	311	PF00069	0.283
MOD_Plk_1	362	368	PF00069	0.528
MOD_Plk_1	400	406	PF00069	0.514
MOD_Plk_1	90	96	PF00069	0.449
MOD_Plk_2-3	363	369	PF00069	0.481
MOD_Plk_4	11	17	PF00069	0.496
MOD_Plk_4	137	143	PF00069	0.289
MOD_Plk_4	228	234	PF00069	0.345
MOD_Plk_4	294	300	PF00069	0.388
MOD_Plk_4	411	417	PF00069	0.587
MOD_Plk_4	418	424	PF00069	0.463
MOD_Plk_4	429	435	PF00069	0.342
MOD_Plk_4	461	467	PF00069	0.309
MOD_Plk_4	482	488	PF00069	0.471
MOD_Plk_4	494	500	PF00069	0.387
MOD_Plk_4	80	86	PF00069	0.570
MOD_Plk_4	90	96	PF00069	0.359
MOD_ProDKin_1	288	294	PF00069	0.338
MOD_ProDKin_1	319	325	PF00069	0.380
MOD_ProDKin_1	39	45	PF00069	0.402
MOD_ProDKin_1	511	517	PF00069	0.593
MOD_ProDKin_1	538	544	PF00069	0.593
MOD_ProDKin_1	548	554	PF00069	0.486
TRG_DiLeu_BaEn_1	164	169	PF01217	0.303
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.480
TRG_ENDOCYTIC_2	229	232	PF00928	0.328
TRG_ENDOCYTIC_2	591	594	PF00928	0.313
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P687	Leptomonas seymouri	42%	68%
A0A3S7X6C3	Leishmania donovani	72%	100%
A4I8M4	Leishmania infantum	72%	100%
E9B3I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q4L4	Leishmania major	73%	100%