Transposase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Transposase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL44_LEIBR

TriTrypDb:

LbrM.33.0080 , LBRM2903_330005700

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL44

PDB structure(s): 7aih_At , 7am2_At , 7ane_At

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.562
CLV_NRD_NRD_1	112	114	PF00675	0.455
CLV_NRD_NRD_1	132	134	PF00675	0.582
CLV_NRD_NRD_1	2	4	PF00675	0.561
CLV_NRD_NRD_1	60	62	PF00675	0.501
CLV_NRD_NRD_1	86	88	PF00675	0.495
CLV_PCSK_KEX2_1	112	114	PF00082	0.455
CLV_PCSK_KEX2_1	131	133	PF00082	0.403
CLV_PCSK_KEX2_1	16	18	PF00082	0.446
CLV_PCSK_KEX2_1	2	4	PF00082	0.564
CLV_PCSK_KEX2_1	60	62	PF00082	0.501
CLV_PCSK_KEX2_1	86	88	PF00082	0.515
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.517
CLV_PCSK_PC7_1	128	134	PF00082	0.588
CLV_PCSK_PC7_1	82	88	PF00082	0.513
CLV_PCSK_SKI1_1	60	64	PF00082	0.600
CLV_PCSK_SKI1_1	77	81	PF00082	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.571
DEG_SPOP_SBC_1	95	99	PF00917	0.473
DOC_MAPK_gen_1	2	8	PF00069	0.561
DOC_USP7_MATH_1	123	127	PF00917	0.637
DOC_USP7_MATH_1	62	66	PF00917	0.553
DOC_WW_Pin1_4	166	171	PF00397	0.527
LIG_14-3-3_CanoR_1	150	156	PF00244	0.517
LIG_14-3-3_CanoR_1	2	8	PF00244	0.573
LIG_14-3-3_CanoR_1	39	43	PF00244	0.458
LIG_14-3-3_CanoR_1	61	67	PF00244	0.580
LIG_FHA_1	158	164	PF00498	0.532
LIG_LIR_Gen_1	157	167	PF02991	0.617
LIG_LIR_Nem_3	157	162	PF02991	0.586
LIG_PDZ_Class_1	169	174	PF00595	0.580
LIG_SH2_CRK	159	163	PF00017	0.598
LIG_SH2_STAP1	159	163	PF00017	0.467
LIG_SH2_STAT5	159	162	PF00017	0.581
LIG_SH2_STAT5	35	38	PF00017	0.441
LIG_SH3_3	143	149	PF00018	0.462
LIG_SH3_3	164	170	PF00018	0.505
MOD_CDK_SPxxK_3	166	173	PF00069	0.538
MOD_CK1_1	154	160	PF00069	0.496
MOD_CK1_1	37	43	PF00069	0.579
MOD_GlcNHglycan	36	39	PF01048	0.487
MOD_GlcNHglycan	74	77	PF01048	0.485
MOD_GSK3_1	157	164	PF00069	0.509
MOD_GSK3_1	165	172	PF00069	0.479
MOD_GSK3_1	34	41	PF00069	0.442
MOD_GSK3_1	56	63	PF00069	0.367
MOD_N-GLC_1	157	162	PF02516	0.556
MOD_NEK2_1	151	156	PF00069	0.489
MOD_NEK2_1	72	77	PF00069	0.456
MOD_NEK2_1	96	101	PF00069	0.448
MOD_NEK2_2	38	43	PF00069	0.460
MOD_NEK2_2	9	14	PF00069	0.473
MOD_PIKK_1	123	129	PF00454	0.642
MOD_PIKK_1	157	163	PF00454	0.585
MOD_PIKK_1	60	66	PF00454	0.494
MOD_PKA_1	16	22	PF00069	0.424
MOD_PKA_1	60	66	PF00069	0.494
MOD_PKA_2	1	7	PF00069	0.601
MOD_PKA_2	16	22	PF00069	0.386
MOD_PKA_2	38	44	PF00069	0.455
MOD_PKA_2	53	59	PF00069	0.438
MOD_PKA_2	60	66	PF00069	0.505
MOD_Plk_1	157	163	PF00069	0.566
MOD_ProDKin_1	166	172	PF00069	0.529
TRG_ENDOCYTIC_2	159	162	PF00928	0.617
TRG_ENDOCYTIC_2	45	48	PF00928	0.411
TRG_ER_diArg_1	1	3	PF00400	0.547
TRG_ER_diArg_1	111	113	PF00400	0.453
TRG_ER_diArg_1	131	133	PF00400	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I402	Leptomonas seymouri	83%	100%
A0A0S4JQA3	Bodo saltans	57%	97%
A0A1X0P2R8	Trypanosomatidae	65%	97%
A0A3Q8IJU1	Leishmania donovani	91%	99%
A0A422NYD9	Trypanosoma rangeli	71%	92%
C9ZPU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	91%
E9AHM6	Leishmania infantum	92%	99%
E9B3I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	97%
Q4Q4L5	Leishmania major	94%	100%
V5DB04	Trypanosoma cruzi	70%	80%