TOG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL43_LEIBR

TriTrypDb:

LbrM.33.0070 , LBRM2903_330005600

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HL43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.438
CLV_NRD_NRD_1	185	187	PF00675	0.726
CLV_NRD_NRD_1	218	220	PF00675	0.445
CLV_NRD_NRD_1	265	267	PF00675	0.343
CLV_NRD_NRD_1	466	468	PF00675	0.383
CLV_NRD_NRD_1	523	525	PF00675	0.211
CLV_PCSK_FUR_1	216	220	PF00082	0.441
CLV_PCSK_KEX2_1	185	187	PF00082	0.700
CLV_PCSK_KEX2_1	218	220	PF00082	0.445
CLV_PCSK_KEX2_1	265	267	PF00082	0.330
CLV_PCSK_KEX2_1	466	468	PF00082	0.303
CLV_PCSK_KEX2_1	523	525	PF00082	0.211
CLV_PCSK_SKI1_1	102	106	PF00082	0.535
CLV_PCSK_SKI1_1	137	141	PF00082	0.364
CLV_PCSK_SKI1_1	292	296	PF00082	0.389
CLV_PCSK_SKI1_1	546	550	PF00082	0.329
CLV_PCSK_SKI1_1	635	639	PF00082	0.371
CLV_PCSK_SKI1_1	74	78	PF00082	0.432
CLV_PCSK_SKI1_1	82	86	PF00082	0.465
DEG_APCC_DBOX_1	289	297	PF00400	0.428
DEG_APCC_DBOX_1	606	614	PF00400	0.403
DEG_SCF_FBW7_1	234	241	PF00400	0.447
DOC_CKS1_1	179	184	PF01111	0.740
DOC_CYCLIN_RxL_1	134	141	PF00134	0.432
DOC_CYCLIN_RxL_1	632	640	PF00134	0.333
DOC_CYCLIN_RxL_1	658	671	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.343
DOC_MAPK_gen_1	102	111	PF00069	0.428
DOC_MAPK_gen_1	120	129	PF00069	0.391
DOC_MAPK_gen_1	265	273	PF00069	0.354
DOC_MAPK_gen_1	45	55	PF00069	0.482
DOC_MAPK_MEF2A_6	48	57	PF00069	0.458
DOC_MAPK_MEF2A_6	74	83	PF00069	0.354
DOC_PP1_RVXF_1	135	141	PF00149	0.422
DOC_PP1_RVXF_1	253	260	PF00149	0.499
DOC_PP1_RVXF_1	496	503	PF00149	0.211
DOC_PP1_RVXF_1	97	104	PF00149	0.506
DOC_PP2B_LxvP_1	35	38	PF13499	0.379
DOC_PP2B_LxvP_1	636	639	PF13499	0.449
DOC_PP4_FxxP_1	140	143	PF00568	0.450
DOC_PP4_FxxP_1	144	147	PF00568	0.487
DOC_SPAK_OSR1_1	457	461	PF12202	0.199
DOC_USP7_MATH_1	232	236	PF00917	0.698
DOC_USP7_MATH_1	250	254	PF00917	0.500
DOC_USP7_MATH_1	338	342	PF00917	0.436
DOC_USP7_MATH_1	364	368	PF00917	0.633
DOC_USP7_MATH_1	384	388	PF00917	0.666
DOC_USP7_MATH_1	527	531	PF00917	0.435
DOC_USP7_MATH_1	576	580	PF00917	0.438
DOC_USP7_UBL2_3	670	674	PF12436	0.524
DOC_USP7_UBL2_3	74	78	PF12436	0.436
DOC_WW_Pin1_4	178	183	PF00397	0.709
DOC_WW_Pin1_4	188	193	PF00397	0.614
DOC_WW_Pin1_4	234	239	PF00397	0.675
DOC_WW_Pin1_4	341	346	PF00397	0.515
DOC_WW_Pin1_4	46	51	PF00397	0.446
DOC_WW_Pin1_4	484	489	PF00397	0.416
LIG_14-3-3_CanoR_1	124	128	PF00244	0.454
LIG_14-3-3_CanoR_1	185	192	PF00244	0.759
LIG_14-3-3_CanoR_1	265	273	PF00244	0.475
LIG_14-3-3_CanoR_1	457	461	PF00244	0.469
LIG_14-3-3_CanoR_1	550	558	PF00244	0.442
LIG_14-3-3_CanoR_1	607	611	PF00244	0.467
LIG_14-3-3_CanoR_1	67	75	PF00244	0.324
LIG_Actin_WH2_2	250	267	PF00022	0.510
LIG_Actin_WH2_2	456	473	PF00022	0.429
LIG_AP2alpha_1	259	263	PF02296	0.471
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_BRCT_BRCA1_1	107	111	PF00533	0.416
LIG_BRCT_BRCA1_1	464	468	PF00533	0.396
LIG_Clathr_ClatBox_1	209	213	PF01394	0.549
LIG_deltaCOP1_diTrp_1	88	98	PF00928	0.531
LIG_eIF4E_1	134	140	PF01652	0.405
LIG_FHA_1	124	130	PF00498	0.392
LIG_FHA_1	239	245	PF00498	0.565
LIG_FHA_1	26	32	PF00498	0.372
LIG_FHA_1	273	279	PF00498	0.348
LIG_FHA_1	405	411	PF00498	0.365
LIG_FHA_1	450	456	PF00498	0.426
LIG_FHA_1	50	56	PF00498	0.457
LIG_FHA_1	563	569	PF00498	0.456
LIG_FHA_2	11	17	PF00498	0.478
LIG_FHA_2	394	400	PF00498	0.579
LIG_FHA_2	587	593	PF00498	0.539
LIG_FHA_2	75	81	PF00498	0.350
LIG_FHA_2	85	91	PF00498	0.423
LIG_GBD_Chelix_1	651	659	PF00786	0.434
LIG_HP1_1	232	236	PF01393	0.444
LIG_HP1_1	539	543	PF01393	0.423
LIG_Integrin_isoDGR_2	617	619	PF01839	0.317
LIG_LIR_Apic_2	141	147	PF02991	0.254
LIG_LIR_Apic_2	89	95	PF02991	0.542
LIG_LIR_Gen_1	132	143	PF02991	0.379
LIG_LIR_Gen_1	258	264	PF02991	0.516
LIG_LIR_Gen_1	609	615	PF02991	0.300
LIG_LIR_Nem_3	132	138	PF02991	0.369
LIG_LIR_Nem_3	258	262	PF02991	0.468
LIG_LIR_Nem_3	501	505	PF02991	0.378
LIG_LIR_Nem_3	609	614	PF02991	0.474
LIG_LIR_Nem_3	97	101	PF02991	0.375
LIG_MYND_1	207	211	PF01753	0.447
LIG_NRBOX	609	615	PF00104	0.285
LIG_NRBOX	632	638	PF00104	0.457
LIG_NRP_CendR_1	687	688	PF00754	0.416
LIG_PCNA_PIPBox_1	493	502	PF02747	0.204
LIG_PCNA_yPIPBox_3	326	337	PF02747	0.369
LIG_Pex14_2	140	144	PF04695	0.328
LIG_Pex14_2	259	263	PF04695	0.471
LIG_Pex14_2	446	450	PF04695	0.508
LIG_Pex14_2	464	468	PF04695	0.452
LIG_PTB_Apo_2	440	447	PF02174	0.393
LIG_PTB_Apo_2	510	517	PF02174	0.431
LIG_PTB_Apo_2	97	104	PF02174	0.423
LIG_Rb_pABgroove_1	134	142	PF01858	0.306
LIG_REV1ctd_RIR_1	260	270	PF16727	0.485
LIG_SH2_CRK	7	11	PF00017	0.447
LIG_SH2_STAP1	7	11	PF00017	0.447
LIG_SH2_STAT3	505	508	PF00017	0.417
LIG_SH2_STAT5	134	137	PF00017	0.316
LIG_SH2_STAT5	164	167	PF00017	0.368
LIG_SH2_STAT5	569	572	PF00017	0.448
LIG_SH3_3	14	20	PF00018	0.492
LIG_SH3_3	176	182	PF00018	0.587
LIG_SH3_3	205	211	PF00018	0.626
LIG_SH3_3	638	644	PF00018	0.421
LIG_SUMO_SIM_anti_2	291	298	PF11976	0.488
LIG_SUMO_SIM_anti_2	582	587	PF11976	0.464
LIG_SUMO_SIM_par_1	232	237	PF11976	0.444
LIG_SUMO_SIM_par_1	267	276	PF11976	0.298
LIG_SUMO_SIM_par_1	409	415	PF11976	0.429
LIG_SUMO_SIM_par_1	663	669	PF11976	0.397
LIG_SxIP_EBH_1	366	377	PF03271	0.456
LIG_SxIP_EBH_1	571	581	PF03271	0.237
LIG_TRAF2_1	403	406	PF00917	0.470
LIG_TYR_ITIM	5	10	PF00017	0.440
LIG_UBA3_1	664	670	PF00899	0.397
MOD_CDC14_SPxK_1	191	194	PF00782	0.470
MOD_CDK_SPxK_1	188	194	PF00069	0.492
MOD_CDK_SPxxK_3	178	185	PF00069	0.577
MOD_CK1_1	188	194	PF00069	0.611
MOD_CK1_1	239	245	PF00069	0.655
MOD_CK1_1	272	278	PF00069	0.497
MOD_CK1_1	341	347	PF00069	0.643
MOD_CK1_1	372	378	PF00069	0.595
MOD_CK1_1	579	585	PF00069	0.381
MOD_CK2_1	411	417	PF00069	0.300
MOD_CK2_1	586	592	PF00069	0.512
MOD_CK2_1	676	682	PF00069	0.324
MOD_CK2_1	74	80	PF00069	0.309
MOD_GlcNHglycan	160	164	PF01048	0.438
MOD_GlcNHglycan	187	190	PF01048	0.612
MOD_GlcNHglycan	202	205	PF01048	0.556
MOD_GlcNHglycan	246	249	PF01048	0.569
MOD_GlcNHglycan	42	45	PF01048	0.393
MOD_GlcNHglycan	533	536	PF01048	0.390
MOD_GlcNHglycan	623	626	PF01048	0.606
MOD_GSK3_1	110	117	PF00069	0.449
MOD_GSK3_1	155	162	PF00069	0.362
MOD_GSK3_1	180	187	PF00069	0.703
MOD_GSK3_1	232	239	PF00069	0.605
MOD_GSK3_1	337	344	PF00069	0.550
MOD_GSK3_1	346	353	PF00069	0.658
MOD_GSK3_1	36	43	PF00069	0.372
MOD_GSK3_1	364	371	PF00069	0.621
MOD_GSK3_1	393	400	PF00069	0.580
MOD_GSK3_1	411	418	PF00069	0.531
MOD_GSK3_1	426	433	PF00069	0.389
MOD_GSK3_1	527	534	PF00069	0.456
MOD_GSK3_1	571	578	PF00069	0.400
MOD_GSK3_1	592	599	PF00069	0.354
MOD_GSK3_1	676	683	PF00069	0.376
MOD_LATS_1	366	372	PF00433	0.456
MOD_N-GLC_1	223	228	PF02516	0.417
MOD_N-GLC_1	571	576	PF02516	0.477
MOD_NEK2_1	159	164	PF00069	0.364
MOD_NEK2_1	244	249	PF00069	0.569
MOD_NEK2_1	337	342	PF00069	0.487
MOD_NEK2_1	507	512	PF00069	0.391
MOD_NEK2_1	526	531	PF00069	0.410
MOD_NEK2_2	250	255	PF00069	0.444
MOD_NEK2_2	606	611	PF00069	0.288
MOD_PIKK_1	180	186	PF00454	0.576
MOD_PK_1	105	111	PF00069	0.487
MOD_PK_1	218	224	PF00069	0.451
MOD_PK_1	571	577	PF00069	0.258
MOD_PKA_1	185	191	PF00069	0.746
MOD_PKA_1	218	224	PF00069	0.437
MOD_PKA_2	123	129	PF00069	0.419
MOD_PKA_2	184	190	PF00069	0.737
MOD_PKA_2	218	224	PF00069	0.437
MOD_PKA_2	264	270	PF00069	0.459
MOD_PKA_2	456	462	PF00069	0.378
MOD_PKA_2	549	555	PF00069	0.430
MOD_PKA_2	606	612	PF00069	0.319
MOD_PKA_2	680	686	PF00069	0.583
MOD_PKB_1	216	224	PF00069	0.474
MOD_Plk_1	114	120	PF00069	0.431
MOD_Plk_1	411	417	PF00069	0.415
MOD_Plk_1	434	440	PF00069	0.419
MOD_Plk_1	571	577	PF00069	0.448
MOD_Plk_2-3	397	403	PF00069	0.457
MOD_Plk_2-3	412	418	PF00069	0.299
MOD_Plk_4	218	224	PF00069	0.437
MOD_Plk_4	226	232	PF00069	0.416
MOD_Plk_4	473	479	PF00069	0.334
MOD_Plk_4	49	55	PF00069	0.457
MOD_Plk_4	576	582	PF00069	0.442
MOD_Plk_4	606	612	PF00069	0.361
MOD_ProDKin_1	178	184	PF00069	0.711
MOD_ProDKin_1	188	194	PF00069	0.615
MOD_ProDKin_1	234	240	PF00069	0.675
MOD_ProDKin_1	341	347	PF00069	0.528
MOD_ProDKin_1	46	52	PF00069	0.437
MOD_ProDKin_1	484	490	PF00069	0.414
MOD_SUMO_for_1	129	132	PF00179	0.422
MOD_SUMO_for_1	273	276	PF00179	0.501
MOD_SUMO_rev_2	117	127	PF00179	0.455
MOD_SUMO_rev_2	70	76	PF00179	0.313
TRG_AP2beta_CARGO_1	132	142	PF09066	0.431
TRG_DiLeu_BaEn_1	406	411	PF01217	0.466
TRG_DiLeu_BaEn_4	268	274	PF01217	0.493
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.408
TRG_ENDOCYTIC_2	645	648	PF00928	0.244
TRG_ENDOCYTIC_2	7	10	PF00928	0.439
TRG_ER_diArg_1	216	219	PF00400	0.443
TRG_ER_diArg_1	264	266	PF00400	0.367
TRG_ER_diArg_1	466	468	PF00400	0.354
TRG_ER_diArg_1	522	524	PF00400	0.208
TRG_NES_CRM1_1	604	616	PF08389	0.414
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.220
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	57%	97%
A0A0N0P8K1	Leptomonas seymouri	26%	78%
A0A0S4ILQ6	Bodo saltans	24%	69%
A0A1X0P6E5	Trypanosomatidae	26%	81%
A0A3R7MW28	Trypanosoma rangeli	27%	81%
A0A3S7WVF9	Leishmania donovani	26%	79%
A0A3S7X6A2	Leishmania donovani	75%	99%
A4HY47	Leishmania infantum	26%	79%
A4I8M3	Leishmania infantum	75%	99%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	77%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	79%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
O60308	Homo sapiens	22%	74%
Q4Q4L6	Leishmania major	75%	100%
Q4QDJ6	Leishmania major	24%	100%
V5DTJ3	Trypanosoma cruzi	26%	81%