Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HL42_LEIBR

TriTrypDb:

LbrM.33.0060 , LBRM2903_330005500

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

A4HL42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.747
CLV_NRD_NRD_1	187	189	PF00675	0.420
CLV_NRD_NRD_1	410	412	PF00675	0.318
CLV_PCSK_KEX2_1	410	412	PF00082	0.318
CLV_PCSK_SKI1_1	252	256	PF00082	0.229
CLV_PCSK_SKI1_1	411	415	PF00082	0.315
DEG_APCC_DBOX_1	410	418	PF00400	0.445
DOC_MAPK_gen_1	107	115	PF00069	0.396
DOC_MAPK_gen_1	410	416	PF00069	0.303
DOC_PP1_RVXF_1	347	354	PF00149	0.473
DOC_PP4_FxxP_1	102	105	PF00568	0.450
DOC_USP7_MATH_1	170	174	PF00917	0.499
DOC_USP7_MATH_1	328	332	PF00917	0.458
DOC_USP7_MATH_1	383	387	PF00917	0.433
DOC_USP7_MATH_1	424	428	PF00917	0.320
DOC_USP7_UBL2_3	147	151	PF12436	0.283
DOC_WW_Pin1_4	160	165	PF00397	0.410
DOC_WW_Pin1_4	244	249	PF00397	0.441
DOC_WW_Pin1_4	278	283	PF00397	0.440
DOC_WW_Pin1_4	356	361	PF00397	0.459
LIG_14-3-3_CanoR_1	188	193	PF00244	0.434
LIG_14-3-3_CanoR_1	238	248	PF00244	0.484
LIG_14-3-3_CanoR_1	361	365	PF00244	0.405
LIG_14-3-3_CanoR_1	411	417	PF00244	0.274
LIG_Actin_WH2_2	134	149	PF00022	0.287
LIG_CSL_BTD_1	203	206	PF09270	0.291
LIG_CSL_BTD_1	245	248	PF09270	0.441
LIG_FHA_1	152	158	PF00498	0.446
LIG_FHA_1	259	265	PF00498	0.526
LIG_FHA_1	286	292	PF00498	0.302
LIG_FHA_1	304	310	PF00498	0.308
LIG_FHA_1	361	367	PF00498	0.425
LIG_FHA_2	138	144	PF00498	0.379
LIG_FHA_2	189	195	PF00498	0.387
LIG_FHA_2	342	348	PF00498	0.519
LIG_FHA_2	360	366	PF00498	0.316
LIG_FHA_2	424	430	PF00498	0.303
LIG_LIR_Apic_2	101	105	PF02991	0.505
LIG_LIR_Gen_1	19	30	PF02991	0.473
LIG_LIR_Gen_1	96	105	PF02991	0.517
LIG_LIR_Nem_3	19	25	PF02991	0.495
LIG_LIR_Nem_3	193	199	PF02991	0.377
LIG_LIR_Nem_3	271	276	PF02991	0.269
LIG_LIR_Nem_3	431	437	PF02991	0.339
LIG_LIR_Nem_3	96	102	PF02991	0.523
LIG_PCNA_yPIPBox_3	219	227	PF02747	0.292
LIG_PCNA_yPIPBox_3	278	291	PF02747	0.253
LIG_Pex14_2	437	441	PF04695	0.552
LIG_RPA_C_Fungi	405	417	PF08784	0.442
LIG_SH2_GRB2like	273	276	PF00017	0.264
LIG_SH2_STAT5	133	136	PF00017	0.351
LIG_SH2_STAT5	233	236	PF00017	0.254
LIG_SH2_STAT5	273	276	PF00017	0.326
LIG_SH3_3	138	144	PF00018	0.317
LIG_SH3_3	261	267	PF00018	0.289
LIG_SH3_3	396	402	PF00018	0.548
LIG_SUMO_SIM_anti_2	154	161	PF11976	0.291
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.511
LIG_SUMO_SIM_anti_2	337	345	PF11976	0.326
LIG_SUMO_SIM_par_1	133	140	PF11976	0.417
LIG_SUMO_SIM_par_1	154	161	PF11976	0.400
LIG_SUMO_SIM_par_1	337	345	PF11976	0.350
LIG_SUMO_SIM_par_1	362	369	PF11976	0.405
LIG_SUMO_SIM_par_1	412	420	PF11976	0.346
LIG_UBA3_1	134	142	PF00899	0.375
LIG_WRC_WIRS_1	159	164	PF05994	0.397
LIG_WRC_WIRS_1	99	104	PF05994	0.455
MOD_CDK_SPK_2	356	361	PF00069	0.459
MOD_CDK_SPxxK_3	244	251	PF00069	0.288
MOD_CK1_1	158	164	PF00069	0.397
MOD_CK1_1	173	179	PF00069	0.213
MOD_CK1_1	182	188	PF00069	0.310
MOD_CK1_1	258	264	PF00069	0.394
MOD_CK1_1	335	341	PF00069	0.203
MOD_CK1_1	359	365	PF00069	0.275
MOD_CK1_1	415	421	PF00069	0.446
MOD_CK2_1	137	143	PF00069	0.427
MOD_CK2_1	359	365	PF00069	0.397
MOD_CK2_1	383	389	PF00069	0.221
MOD_GlcNHglycan	125	128	PF01048	0.255
MOD_GlcNHglycan	170	173	PF01048	0.275
MOD_GlcNHglycan	34	38	PF01048	0.570
MOD_GlcNHglycan	396	399	PF01048	0.438
MOD_GlcNHglycan	419	422	PF01048	0.323
MOD_GSK3_1	151	158	PF00069	0.285
MOD_GSK3_1	170	177	PF00069	0.151
MOD_GSK3_1	254	261	PF00069	0.346
MOD_GSK3_1	274	281	PF00069	0.331
MOD_GSK3_1	328	335	PF00069	0.213
MOD_GSK3_1	356	363	PF00069	0.460
MOD_GSK3_1	412	419	PF00069	0.440
MOD_GSK3_1	424	431	PF00069	0.282
MOD_N-GLC_1	274	279	PF02516	0.311
MOD_N-GLC_2	119	121	PF02516	0.268
MOD_NEK2_1	137	142	PF00069	0.435
MOD_NEK2_1	146	151	PF00069	0.315
MOD_NEK2_1	174	179	PF00069	0.300
MOD_NEK2_1	226	231	PF00069	0.343
MOD_NEK2_1	33	38	PF00069	0.460
MOD_NEK2_1	340	345	PF00069	0.273
MOD_NEK2_1	412	417	PF00069	0.325
MOD_NEK2_1	437	442	PF00069	0.529
MOD_PIKK_1	49	55	PF00454	0.651
MOD_PKA_1	188	194	PF00069	0.396
MOD_PKA_2	360	366	PF00069	0.406
MOD_PKA_2	435	441	PF00069	0.329
MOD_Plk_1	174	180	PF00069	0.369
MOD_Plk_1	33	39	PF00069	0.538
MOD_Plk_4	155	161	PF00069	0.327
MOD_Plk_4	198	204	PF00069	0.288
MOD_Plk_4	205	211	PF00069	0.290
MOD_Plk_4	226	232	PF00069	0.446
MOD_Plk_4	335	341	PF00069	0.330
MOD_Plk_4	366	372	PF00069	0.340
MOD_Plk_4	412	418	PF00069	0.412
MOD_Plk_4	98	104	PF00069	0.507
MOD_ProDKin_1	160	166	PF00069	0.244
MOD_ProDKin_1	244	250	PF00069	0.288
MOD_ProDKin_1	278	284	PF00069	0.436
MOD_ProDKin_1	356	362	PF00069	0.453
MOD_SUMO_rev_2	182	191	PF00179	0.526
MOD_SUMO_rev_2	247	253	PF00179	0.288
TRG_DiLeu_BaEn_1	198	203	PF01217	0.291
TRG_DiLeu_BaEn_4	130	136	PF01217	0.459
TRG_ENDOCYTIC_2	196	199	PF00928	0.383
TRG_ENDOCYTIC_2	273	276	PF00928	0.264
TRG_ER_diArg_1	410	412	PF00400	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6C2	Leptomonas seymouri	22%	100%
A0A0N1IHN2	Leptomonas seymouri	24%	85%
A0A0N1PC28	Leptomonas seymouri	74%	100%
A0A0S4IWG1	Bodo saltans	21%	90%
A0A0S4JA64	Bodo saltans	24%	75%
A0A0S4JL38	Bodo saltans	28%	82%
A0A0S4JPK4	Bodo saltans	25%	74%
A0A0S4JQ88	Bodo saltans	49%	100%
A0A0S4JQ93	Bodo saltans	25%	80%
A0A0S4KJ87	Bodo saltans	23%	74%
A0A1X0NVZ7	Trypanosomatidae	23%	85%
A0A1X0P1V8	Trypanosomatidae	23%	95%
A0A1X0P2J6	Trypanosomatidae	37%	79%
A0A1X0P716	Trypanosomatidae	23%	75%
A0A3Q8IGC4	Leishmania donovani	25%	85%
A0A3Q8IGD2	Leishmania donovani	79%	100%
A0A3R7N6M9	Trypanosoma rangeli	24%	85%
A0A3S5ISA7	Trypanosoma rangeli	55%	100%
A0A3S7WR72	Leishmania donovani	23%	100%
A0CH87	Paramecium tetraurelia	21%	100%
A0DB19	Paramecium tetraurelia	21%	100%
A2RRU3	Rattus norvegicus	22%	84%
A4H4H1	Leishmania braziliensis	25%	66%
A4H666	Leishmania braziliensis	23%	100%
A4HDT7	Leishmania braziliensis	24%	85%
A4HUJ0	Leishmania infantum	23%	100%
A4I135	Leishmania infantum	25%	85%
A4I8M2	Leishmania infantum	79%	100%
A6ZYM0	Saccharomyces cerevisiae (strain YJM789)	27%	100%
A7RWD2	Nematostella vectensis	24%	100%
A7S338	Nematostella vectensis	24%	100%
A8NEG8	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	100%
A8X8C6	Caenorhabditis briggsae	23%	100%
A8XZJ9	Caenorhabditis briggsae	23%	100%
A9V790	Monosiga brevicollis	21%	100%
B0LSW3	Felis catus	24%	100%
B0XAF3	Culex quinquefasciatus	22%	100%
B3MC74	Drosophila ananassae	23%	100%
B3MJV8	Drosophila ananassae	24%	100%
B3NQR5	Drosophila erecta	23%	100%
B3S4I5	Trichoplax adhaerens	23%	100%
B4GDM7	Drosophila persimilis	23%	100%
B4GT01	Drosophila persimilis	24%	100%
B4HRQ6	Drosophila sechellia	23%	100%
B4JW81	Drosophila grimshawi	23%	100%
B4KKN1	Drosophila mojavensis	24%	100%
B4KTK4	Drosophila mojavensis	23%	100%
B4LJT7	Drosophila virilis	23%	100%
B4LS78	Drosophila virilis	23%	100%
B4MY77	Drosophila willistoni	23%	100%
B4P7Q3	Drosophila yakuba	23%	100%
B4QFZ8	Drosophila simulans	23%	100%
B5X3C4	Salmo salar	24%	100%
B5X3Z6	Salmo salar	23%	100%
B6Q4Z5	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	24%	67%
B7FNU7	Phaeodactylum tricornutum (strain CCAP 1055/1)	24%	100%
B7PS00	Ixodes scapularis	23%	100%
B8M7Q5	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	24%	66%
C3XVT5	Branchiostoma floridae	22%	100%
C4Q0P6	Schistosoma mansoni	24%	100%
C4YFX2	Candida albicans (strain WO-1)	23%	86%
C9ZPU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	86%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	97%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	75%
D0A4F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D3BUN1	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)	21%	100%
D3ZW91	Rattus norvegicus	22%	93%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	85%
E9B3I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
F1LTR1	Rattus norvegicus	27%	86%
F6ZT52	Xenopus tropicalis	23%	94%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	85%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	93%
O13982	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O14435	Cryphonectria parasitica	24%	100%
O18640	Drosophila melanogaster	22%	100%
O43660	Homo sapiens	22%	86%
O54929	Mus musculus	23%	100%
O60907	Homo sapiens	23%	77%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	88%
O75083	Homo sapiens	22%	73%
O76071	Homo sapiens	24%	100%
O76734	Dictyostelium discoideum	22%	76%
O80990	Arabidopsis thaliana	25%	100%
O88342	Mus musculus	23%	73%
O93277	Gallus gallus	23%	73%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	86%
P16520	Homo sapiens	24%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
P26308	Drosophila melanogaster	21%	100%
P43033	Bos taurus	24%	100%
P43034	Homo sapiens	24%	100%
P49027	Oryza sativa subsp. japonica	23%	100%
P61964	Homo sapiens	27%	100%
P61965	Mus musculus	27%	100%
P63004	Rattus norvegicus	24%	100%
P63005	Mus musculus	24%	100%
P73594	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	100%
P78706	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	73%
P87053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	73%
P93107	Chlamydomonas reinhardtii	24%	73%
Q05048	Homo sapiens	22%	100%
Q0P593	Bos taurus	26%	100%
Q0V8J1	Bos taurus	24%	100%
Q12417	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	98%
Q13685	Homo sapiens	24%	100%
Q17GR9	Aedes aegypti	21%	100%
Q1LV15	Danio rerio	24%	100%
Q28D01	Xenopus tropicalis	27%	72%
Q28DW0	Xenopus tropicalis	24%	100%
Q292E8	Drosophila pseudoobscura pseudoobscura	23%	100%
Q29KQ0	Drosophila pseudoobscura pseudoobscura	24%	100%
Q2KID6	Bos taurus	21%	86%
Q2KIG2	Bos taurus	27%	100%
Q2KJH4	Bos taurus	22%	73%
Q2TBP4	Bos taurus	25%	100%
Q32PJ6	Bos taurus	24%	100%
Q3SZK1	Bos taurus	24%	100%
Q498M4	Rattus norvegicus	27%	100%
Q4Q4L7	Leishmania major	80%	99%
Q4QAA4	Leishmania major	25%	85%
Q4QDZ5	Leishmania major	23%	71%
Q4QHD6	Leishmania major	23%	100%
Q4R8E7	Macaca fascicularis	27%	100%
Q4R8H1	Macaca fascicularis	23%	78%
Q4RJN5	Tetraodon nigroviridis	24%	100%
Q4V7Z1	Xenopus laevis	22%	94%
Q4V8C4	Rattus norvegicus	28%	100%
Q54KL5	Dictyostelium discoideum	25%	100%
Q55AR8	Dictyostelium discoideum	24%	100%
Q55DA2	Dictyostelium discoideum	23%	100%
Q58D20	Bos taurus	25%	91%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	98%
Q5BJQ6	Rattus norvegicus	22%	100%
Q5BK30	Rattus norvegicus	26%	100%
Q5FVN8	Rattus norvegicus	26%	93%
Q5IS43	Pan troglodytes	24%	100%
Q5M786	Xenopus tropicalis	25%	100%
Q5M7T1	Rattus norvegicus	24%	100%
Q5R8K2	Pongo abelii	22%	100%
Q5RCG7	Pongo abelii	24%	100%
Q5RD06	Pongo abelii	21%	98%
Q5RE95	Pongo abelii	28%	100%
Q5REG7	Pongo abelii	23%	100%
Q5RFF8	Pongo abelii	25%	91%
Q5RKI0	Rattus norvegicus	22%	73%
Q5SP67	Danio rerio	27%	77%
Q61011	Mus musculus	24%	100%
Q61FW2	Caenorhabditis briggsae	26%	75%
Q6CKX3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	98%
Q6DIF4	Xenopus tropicalis	21%	73%
Q6GPC6	Xenopus laevis	22%	85%
Q6NZH4	Xenopus tropicalis	23%	100%
Q6PAX7	Xenopus laevis	20%	73%
Q6PBY0	Danio rerio	24%	100%
Q6PE01	Mus musculus	26%	100%
Q6PH57	Danio rerio	24%	100%
Q7K0L4	Drosophila melanogaster	25%	70%
Q7K1Y4	Drosophila melanogaster	23%	100%
Q7PS24	Anopheles gambiae	22%	100%
Q7QJ33	Anopheles gambiae	21%	100%
Q7SZM9	Xenopus laevis	22%	85%
Q7T394	Danio rerio	24%	100%
Q7YR70	Canis lupus familiaris	24%	100%
Q7ZVF0	Danio rerio	25%	100%
Q7ZXK9	Xenopus laevis	23%	93%
Q803D2	Danio rerio	23%	100%
Q86TI4	Homo sapiens	23%	100%
Q86VZ2	Homo sapiens	29%	100%
Q8BHD1	Mus musculus	21%	93%
Q8BHJ5	Mus musculus	22%	86%
Q8C6G8	Mus musculus	27%	69%
Q8C7V3	Mus musculus	23%	84%
Q8HXX0	Macaca fascicularis	24%	100%
Q8I0F4	Dictyostelium discoideum	22%	100%
Q8JZX3	Mus musculus	25%	100%
Q8N136	Homo sapiens	27%	100%
Q8N9V3	Homo sapiens	26%	93%
Q8NAA4	Homo sapiens	24%	71%
Q8NBT0	Homo sapiens	26%	100%
Q8TC44	Homo sapiens	21%	92%
Q8TED0	Homo sapiens	22%	85%
Q8VEJ4	Mus musculus	24%	91%
Q90ZL4	Xenopus laevis	23%	100%
Q922V4	Mus musculus	22%	86%
Q93794	Caenorhabditis elegans	26%	75%
Q99KN2	Mus musculus	24%	100%
Q99LC2	Mus musculus	22%	100%
Q9BQ87	Homo sapiens	24%	85%
Q9BZK7	Homo sapiens	22%	86%
Q9CX97	Mus musculus	22%	100%
Q9D0I6	Mus musculus	25%	93%
Q9D7H2	Mus musculus	27%	100%
Q9FLX9	Arabidopsis thaliana	25%	93%
Q9FN19	Arabidopsis thaliana	24%	72%
Q9FNN2	Arabidopsis thaliana	26%	75%
Q9GL51	Sus scrofa	24%	100%
Q9H7D7	Homo sapiens	26%	67%
Q9NDC9	Caenorhabditis elegans	25%	100%
Q9NVX2	Homo sapiens	25%	91%
Q9NYS7	Homo sapiens	24%	100%
Q9PTR5	Gallus gallus	24%	100%
Q9QXE7	Mus musculus	23%	84%
Q9SXY1	Arabidopsis thaliana	22%	91%
Q9UT85	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	87%
Q9UTC7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	96%
Q9UUG8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	74%
Q9V3J8	Drosophila melanogaster	26%	100%
Q9VPR4	Drosophila melanogaster	24%	91%
Q9VU68	Drosophila melanogaster	22%	73%
Q9W7F2	Xenopus laevis	20%	73%
Q9WUC8	Rattus norvegicus	21%	86%
Q9ZU34	Arabidopsis thaliana	26%	72%
V5BEB2	Trypanosoma cruzi	22%	82%
V5BJG9	Trypanosoma cruzi	54%	99%