FOP_dimer domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL41_LEIBR

TriTrypDb:

LbrM.33.0050 , LBRM2903_330005400

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.523
CLV_PCSK_SKI1_1	114	118	PF00082	0.573
CLV_PCSK_SKI1_1	70	74	PF00082	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.649
DOC_ANK_TNKS_1	122	129	PF00023	0.592
DOC_CKS1_1	74	79	PF01111	0.313
DOC_CYCLIN_RxL_1	67	78	PF00134	0.509
DOC_PP1_RVXF_1	131	138	PF00149	0.338
DOC_PP4_FxxP_1	137	140	PF00568	0.382
DOC_PP4_FxxP_1	68	71	PF00568	0.609
DOC_USP7_MATH_1	147	151	PF00917	0.692
DOC_USP7_MATH_1	28	32	PF00917	0.559
DOC_WW_Pin1_4	154	159	PF00397	0.729
DOC_WW_Pin1_4	73	78	PF00397	0.403
LIG_14-3-3_CanoR_1	47	54	PF00244	0.567
LIG_14-3-3_CanoR_1	70	75	PF00244	0.602
LIG_14-3-3_CterR_2	229	232	PF00244	0.723
LIG_BRCT_BRCA1_1	207	211	PF00533	0.652
LIG_FHA_1	18	24	PF00498	0.343
LIG_FHA_1	185	191	PF00498	0.685
LIG_FHA_1	7	13	PF00498	0.695
LIG_FHA_1	95	101	PF00498	0.472
LIG_FHA_2	181	187	PF00498	0.702
LIG_FHA_2	8	14	PF00498	0.713
LIG_Integrin_RGD_1	55	57	PF01839	0.548
LIG_Rb_pABgroove_1	80	88	PF01858	0.321
LIG_SH2_CRK	86	90	PF00017	0.436
LIG_SH2_NCK_1	138	142	PF00017	0.408
LIG_SH2_SRC	138	141	PF00017	0.399
LIG_SH2_SRC	205	208	PF00017	0.544
LIG_SH2_STAP1	205	209	PF00017	0.564
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.578
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.421
LIG_SUMO_SIM_par_1	70	76	PF11976	0.541
LIG_SUMO_SIM_par_1	81	87	PF11976	0.387
LIG_SUMO_SIM_par_1	99	104	PF11976	0.332
LIG_TRAF2_1	182	185	PF00917	0.769
LIG_TYR_ITIM	84	89	PF00017	0.434
MOD_CDK_SPxK_1	154	160	PF00069	0.504
MOD_CDK_SPxK_1	73	79	PF00069	0.462
MOD_CK1_1	142	148	PF00069	0.672
MOD_CK1_1	18	24	PF00069	0.586
MOD_CK1_1	31	37	PF00069	0.548
MOD_CK2_1	126	132	PF00069	0.454
MOD_CK2_1	180	186	PF00069	0.685
MOD_CK2_1	209	215	PF00069	0.678
MOD_CK2_1	7	13	PF00069	0.740
MOD_GlcNHglycan	178	181	PF01048	0.661
MOD_GlcNHglycan	30	33	PF01048	0.549
MOD_GlcNHglycan	35	38	PF01048	0.516
MOD_GSK3_1	176	183	PF00069	0.651
MOD_GSK3_1	205	212	PF00069	0.536
MOD_GSK3_1	214	221	PF00069	0.570
MOD_GSK3_1	31	38	PF00069	0.541
MOD_N-GLC_1	15	20	PF02516	0.434
MOD_NEK2_1	175	180	PF00069	0.575
MOD_NEK2_1	33	38	PF00069	0.483
MOD_NEK2_1	46	51	PF00069	0.548
MOD_NEK2_1	94	99	PF00069	0.455
MOD_PIKK_1	139	145	PF00454	0.577
MOD_PKA_2	46	52	PF00069	0.552
MOD_Plk_1	112	118	PF00069	0.488
MOD_Plk_1	18	24	PF00069	0.427
MOD_Plk_1	205	211	PF00069	0.548
MOD_Plk_1	218	224	PF00069	0.592
MOD_Plk_2-3	7	13	PF00069	0.480
MOD_Plk_4	126	132	PF00069	0.505
MOD_Plk_4	18	24	PF00069	0.405
MOD_Plk_4	78	84	PF00069	0.478
MOD_ProDKin_1	154	160	PF00069	0.731
MOD_ProDKin_1	73	79	PF00069	0.395
TRG_DiLeu_BaEn_1	113	118	PF01217	0.504
TRG_DiLeu_BaEn_4	225	231	PF01217	0.615
TRG_ENDOCYTIC_2	86	89	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX52	Leptomonas seymouri	51%	100%
A0A0S4JQ70	Bodo saltans	35%	90%
A0A3Q8ILV2	Leishmania donovani	73%	100%
A0A3R7NRD8	Trypanosoma rangeli	36%	100%
A4I8M1	Leishmania infantum	73%	100%
C9ZPU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9B3I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q4L8	Leishmania major	72%	100%
V5BAE5	Trypanosoma cruzi	35%	100%