Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL40_LEIBR

TriTrypDb:

LbrM.33.0040 , LBRM2903_330005300

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.500
CLV_C14_Caspase3-7	447	451	PF00656	0.537
CLV_C14_Caspase3-7	516	520	PF00656	0.676
CLV_C14_Caspase3-7	68	72	PF00656	0.509
CLV_NRD_NRD_1	153	155	PF00675	0.531
CLV_NRD_NRD_1	2	4	PF00675	0.608
CLV_NRD_NRD_1	339	341	PF00675	0.673
CLV_NRD_NRD_1	412	414	PF00675	0.736
CLV_NRD_NRD_1	88	90	PF00675	0.572
CLV_PCSK_KEX2_1	2	4	PF00082	0.608
CLV_PCSK_KEX2_1	338	340	PF00082	0.682
CLV_PCSK_KEX2_1	412	414	PF00082	0.702
CLV_PCSK_KEX2_1	454	456	PF00082	0.511
CLV_PCSK_KEX2_1	88	90	PF00082	0.572
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.482
CLV_PCSK_SKI1_1	18	22	PF00082	0.483
CLV_PCSK_SKI1_1	217	221	PF00082	0.544
CLV_PCSK_SKI1_1	307	311	PF00082	0.654
CLV_PCSK_SKI1_1	89	93	PF00082	0.587
DEG_APCC_DBOX_1	17	25	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.723
DEG_SPOP_SBC_1	506	510	PF00917	0.427
DOC_CYCLIN_RxL_1	112	121	PF00134	0.426
DOC_CYCLIN_RxL_1	214	224	PF00134	0.538
DOC_MAPK_gen_1	214	222	PF00069	0.410
DOC_MAPK_MEF2A_6	214	222	PF00069	0.447
DOC_PP1_RVXF_1	114	121	PF00149	0.418
DOC_USP7_MATH_1	159	163	PF00917	0.549
DOC_USP7_MATH_1	260	264	PF00917	0.741
DOC_USP7_MATH_1	266	270	PF00917	0.726
DOC_USP7_MATH_1	478	482	PF00917	0.471
DOC_USP7_MATH_1	486	490	PF00917	0.452
DOC_USP7_MATH_1	506	510	PF00917	0.427
DOC_WW_Pin1_4	137	142	PF00397	0.702
DOC_WW_Pin1_4	360	365	PF00397	0.664
DOC_WW_Pin1_4	368	373	PF00397	0.532
DOC_WW_Pin1_4	390	395	PF00397	0.656
DOC_WW_Pin1_4	49	54	PF00397	0.429
LIG_14-3-3_CanoR_1	11	20	PF00244	0.510
LIG_14-3-3_CanoR_1	2	6	PF00244	0.666
LIG_14-3-3_CanoR_1	76	85	PF00244	0.495
LIG_14-3-3_CanoR_1	88	94	PF00244	0.573
LIG_BRCT_BRCA1_1	391	395	PF00533	0.537
LIG_BRCT_BRCA1_1	51	55	PF00533	0.482
LIG_EVH1_2	141	145	PF00568	0.471
LIG_FHA_1	108	114	PF00498	0.292
LIG_FHA_1	138	144	PF00498	0.566
LIG_FHA_1	148	154	PF00498	0.667
LIG_FHA_1	194	200	PF00498	0.453
LIG_FHA_1	30	36	PF00498	0.334
LIG_FHA_1	339	345	PF00498	0.701
LIG_FHA_1	444	450	PF00498	0.680
LIG_FHA_2	124	130	PF00498	0.659
LIG_FHA_2	300	306	PF00498	0.538
LIG_FHA_2	438	444	PF00498	0.634
LIG_FHA_2	483	489	PF00498	0.582
LIG_FHA_2	514	520	PF00498	0.631
LIG_FHA_2	55	61	PF00498	0.569
LIG_FHA_2	66	72	PF00498	0.371
LIG_HCF-1_HBM_1	200	203	PF13415	0.532
LIG_LIR_Apic_2	366	372	PF02991	0.494
LIG_LIR_Gen_1	117	125	PF02991	0.455
LIG_LIR_Gen_1	393	400	PF02991	0.533
LIG_LIR_Nem_3	14	20	PF02991	0.551
LIG_LIR_Nem_3	224	229	PF02991	0.417
LIG_LIR_Nem_3	393	399	PF02991	0.550
LIG_Pex14_2	51	55	PF04695	0.400
LIG_SH2_CRK	31	35	PF00017	0.537
LIG_SH2_SRC	448	451	PF00017	0.536
LIG_SH2_STAP1	31	35	PF00017	0.329
LIG_SH2_STAT3	144	147	PF00017	0.433
LIG_SH2_STAT3	203	206	PF00017	0.470
LIG_SH2_STAT5	144	147	PF00017	0.433
LIG_SH2_STAT5	245	248	PF00017	0.556
LIG_SH2_STAT5	31	34	PF00017	0.337
LIG_SH2_STAT5	448	451	PF00017	0.522
LIG_SH2_STAT5	483	486	PF00017	0.482
LIG_SH2_STAT5	77	80	PF00017	0.462
LIG_SH2_STAT5	85	88	PF00017	0.489
LIG_SH3_2	209	214	PF14604	0.465
LIG_SH3_3	206	212	PF00018	0.494
LIG_SH3_3	256	262	PF00018	0.692
LIG_SH3_3	33	39	PF00018	0.579
LIG_SH3_3	358	364	PF00018	0.508
LIG_SH3_3	417	423	PF00018	0.612
LIG_SH3_3	47	53	PF00018	0.551
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.613
LIG_TRAF2_1	371	374	PF00917	0.663
LIG_TYR_ITIM	29	34	PF00017	0.532
LIG_WW_1	141	144	PF00397	0.429
MOD_CDK_SPxxK_3	368	375	PF00069	0.448
MOD_CK1_1	134	140	PF00069	0.684
MOD_CK1_1	213	219	PF00069	0.317
MOD_CK1_1	318	324	PF00069	0.707
MOD_CK1_1	363	369	PF00069	0.616
MOD_CK1_1	481	487	PF00069	0.420
MOD_CK2_1	123	129	PF00069	0.631
MOD_CK2_1	251	257	PF00069	0.648
MOD_CK2_1	299	305	PF00069	0.600
MOD_CK2_1	368	374	PF00069	0.659
MOD_CK2_1	400	406	PF00069	0.661
MOD_CK2_1	437	443	PF00069	0.579
MOD_CK2_1	482	488	PF00069	0.554
MOD_GlcNHglycan	13	16	PF01048	0.431
MOD_GlcNHglycan	136	140	PF01048	0.699
MOD_GlcNHglycan	299	302	PF01048	0.518
MOD_GlcNHglycan	355	358	PF01048	0.687
MOD_GlcNHglycan	39	42	PF01048	0.582
MOD_GlcNHglycan	488	491	PF01048	0.462
MOD_GlcNHglycan	509	512	PF01048	0.579
MOD_GlcNHglycan	78	81	PF01048	0.506
MOD_GSK3_1	131	138	PF00069	0.684
MOD_GSK3_1	239	246	PF00069	0.502
MOD_GSK3_1	297	304	PF00069	0.667
MOD_GSK3_1	315	322	PF00069	0.485
MOD_GSK3_1	359	366	PF00069	0.724
MOD_GSK3_1	37	44	PF00069	0.568
MOD_GSK3_1	477	484	PF00069	0.519
MOD_GSK3_1	49	56	PF00069	0.371
MOD_GSK3_1	501	508	PF00069	0.425
MOD_GSK3_1	92	99	PF00069	0.489
MOD_LATS_1	9	15	PF00433	0.361
MOD_N-GLC_1	29	34	PF02516	0.342
MOD_N-GLC_1	89	94	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	299	304	PF00069	0.507
MOD_NEK2_1	319	324	PF00069	0.612
MOD_NEK2_1	43	48	PF00069	0.578
MOD_NEK2_1	460	465	PF00069	0.481
MOD_NEK2_1	505	510	PF00069	0.460
MOD_NEK2_1	54	59	PF00069	0.469
MOD_PIKK_1	177	183	PF00454	0.338
MOD_PIKK_1	400	406	PF00454	0.622
MOD_PIKK_1	54	60	PF00454	0.588
MOD_PKA_1	338	344	PF00069	0.707
MOD_PKA_2	1	7	PF00069	0.697
MOD_PKA_2	213	219	PF00069	0.413
MOD_PKA_2	338	344	PF00069	0.674
MOD_PKA_2	411	417	PF00069	0.702
MOD_PKA_2	481	487	PF00069	0.476
MOD_Plk_1	29	35	PF00069	0.338
MOD_Plk_1	291	297	PF00069	0.546
MOD_Plk_1	373	379	PF00069	0.557
MOD_Plk_1	460	466	PF00069	0.483
MOD_Plk_1	89	95	PF00069	0.335
MOD_Plk_4	291	297	PF00069	0.539
MOD_Plk_4	30	36	PF00069	0.593
MOD_Plk_4	315	321	PF00069	0.649
MOD_ProDKin_1	137	143	PF00069	0.698
MOD_ProDKin_1	360	366	PF00069	0.662
MOD_ProDKin_1	368	374	PF00069	0.530
MOD_ProDKin_1	390	396	PF00069	0.648
MOD_ProDKin_1	49	55	PF00069	0.428
MOD_SUMO_rev_2	300	309	PF00179	0.469
TRG_ENDOCYTIC_2	17	20	PF00928	0.508
TRG_ENDOCYTIC_2	31	34	PF00928	0.543
TRG_ENDOCYTIC_2	426	429	PF00928	0.667
TRG_ER_diArg_1	1	3	PF00400	0.616
TRG_ER_diArg_1	248	251	PF00400	0.666
TRG_ER_diArg_1	337	340	PF00400	0.645
TRG_ER_diArg_1	411	413	PF00400	0.736
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK4	Leptomonas seymouri	60%	99%
A0A0S4JPU3	Bodo saltans	33%	95%
A0A3S7X6B5	Leishmania donovani	79%	100%
A0A422NYF9	Trypanosoma rangeli	43%	100%
A4I8M0	Leishmania infantum	79%	100%
C9ZPU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9B3I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q4L9	Leishmania major	77%	100%
V5AUZ3	Trypanosoma cruzi	45%	100%