LysM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL37_LEIBR

TriTrypDb:

LbrM.33.0010 , LBRM2903_330005000

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL37

PDB structure(s): 7ane_e

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	586	590	PF00656	0.514
CLV_NRD_NRD_1	117	119	PF00675	0.534
CLV_NRD_NRD_1	2	4	PF00675	0.504
CLV_NRD_NRD_1	225	227	PF00675	0.364
CLV_NRD_NRD_1	397	399	PF00675	0.333
CLV_NRD_NRD_1	439	441	PF00675	0.362
CLV_NRD_NRD_1	530	532	PF00675	0.339
CLV_NRD_NRD_1	669	671	PF00675	0.381
CLV_PCSK_FUR_1	223	227	PF00082	0.384
CLV_PCSK_KEX2_1	2	4	PF00082	0.503
CLV_PCSK_KEX2_1	225	227	PF00082	0.400
CLV_PCSK_KEX2_1	439	441	PF00082	0.454
CLV_PCSK_KEX2_1	497	499	PF00082	0.350
CLV_PCSK_KEX2_1	530	532	PF00082	0.339
CLV_PCSK_KEX2_1	669	671	PF00082	0.381
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.350
CLV_PCSK_SKI1_1	131	135	PF00082	0.516
CLV_PCSK_SKI1_1	226	230	PF00082	0.439
CLV_PCSK_SKI1_1	245	249	PF00082	0.239
CLV_PCSK_SKI1_1	530	534	PF00082	0.382
CLV_PCSK_SKI1_1	669	673	PF00082	0.330
CLV_Separin_Metazoa	639	643	PF03568	0.193
DEG_APCC_DBOX_1	282	290	PF00400	0.519
DEG_APCC_DBOX_1	326	334	PF00400	0.388
DEG_Nend_UBRbox_1	1	4	PF02207	0.532
DEG_SCF_FBW7_2	772	779	PF00400	0.424
DOC_CDC14_PxL_1	698	706	PF14671	0.471
DOC_CKS1_1	723	728	PF01111	0.434
DOC_CYCLIN_yCln2_LP_2	599	605	PF00134	0.396
DOC_MAPK_gen_1	332	340	PF00069	0.258
DOC_MAPK_gen_1	398	408	PF00069	0.315
DOC_MAPK_MEF2A_6	399	408	PF00069	0.385
DOC_PP1_RVXF_1	813	820	PF00149	0.386
DOC_PP2B_LxvP_1	599	602	PF13499	0.353
DOC_PP4_FxxP_1	23	26	PF00568	0.469
DOC_PP4_FxxP_1	311	314	PF00568	0.474
DOC_PP4_FxxP_1	43	46	PF00568	0.432
DOC_PP4_FxxP_1	784	787	PF00568	0.339
DOC_USP7_MATH_1	125	129	PF00917	0.428
DOC_USP7_MATH_1	200	204	PF00917	0.439
DOC_USP7_MATH_1	206	210	PF00917	0.428
DOC_USP7_MATH_1	349	353	PF00917	0.475
DOC_USP7_MATH_1	357	361	PF00917	0.338
DOC_USP7_MATH_1	409	413	PF00917	0.335
DOC_USP7_MATH_1	537	541	PF00917	0.533
DOC_USP7_MATH_1	552	556	PF00917	0.512
DOC_USP7_MATH_1	584	588	PF00917	0.559
DOC_USP7_MATH_1	607	611	PF00917	0.484
DOC_USP7_MATH_1	652	656	PF00917	0.436
DOC_USP7_MATH_1	729	733	PF00917	0.396
DOC_USP7_UBL2_3	741	745	PF12436	0.448
DOC_WW_Pin1_4	121	126	PF00397	0.523
DOC_WW_Pin1_4	174	179	PF00397	0.393
DOC_WW_Pin1_4	454	459	PF00397	0.332
DOC_WW_Pin1_4	664	669	PF00397	0.402
DOC_WW_Pin1_4	722	727	PF00397	0.436
DOC_WW_Pin1_4	751	756	PF00397	0.389
DOC_WW_Pin1_4	772	777	PF00397	0.404
LIG_14-3-3_CanoR_1	2	7	PF00244	0.520
LIG_14-3-3_CanoR_1	202	206	PF00244	0.465
LIG_14-3-3_CanoR_1	208	217	PF00244	0.414
LIG_14-3-3_CanoR_1	283	287	PF00244	0.486
LIG_14-3-3_CanoR_1	428	434	PF00244	0.363
LIG_14-3-3_CanoR_1	465	470	PF00244	0.377
LIG_14-3-3_CanoR_1	498	506	PF00244	0.360
LIG_14-3-3_CanoR_1	530	536	PF00244	0.360
LIG_14-3-3_CanoR_1	632	641	PF00244	0.274
LIG_14-3-3_CanoR_1	87	94	PF00244	0.402
LIG_Actin_WH2_2	252	270	PF00022	0.323
LIG_APCC_ABBA_1	100	105	PF00400	0.396
LIG_BRCT_BRCA1_1	411	415	PF00533	0.326
LIG_BRCT_BRCA1_1	430	434	PF00533	0.431
LIG_BRCT_BRCA1_1	445	449	PF00533	0.458
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.356
LIG_FHA_1	149	155	PF00498	0.535
LIG_FHA_1	241	247	PF00498	0.314
LIG_FHA_1	317	323	PF00498	0.336
LIG_FHA_1	349	355	PF00498	0.555
LIG_FHA_1	527	533	PF00498	0.452
LIG_FHA_1	636	642	PF00498	0.402
LIG_FHA_1	680	686	PF00498	0.405
LIG_FHA_1	78	84	PF00498	0.398
LIG_FHA_2	326	332	PF00498	0.532
LIG_FHA_2	384	390	PF00498	0.377
LIG_FHA_2	411	417	PF00498	0.390
LIG_FHA_2	428	434	PF00498	0.278
LIG_FHA_2	449	455	PF00498	0.414
LIG_FHA_2	510	516	PF00498	0.529
LIG_FHA_2	593	599	PF00498	0.420
LIG_FHA_2	634	640	PF00498	0.233
LIG_FHA_2	687	693	PF00498	0.400
LIG_FHA_2	723	729	PF00498	0.353
LIG_FHA_2	773	779	PF00498	0.407
LIG_GBD_Chelix_1	322	330	PF00786	0.422
LIG_LIR_Apic_2	12	17	PF02991	0.410
LIG_LIR_Apic_2	40	46	PF02991	0.419
LIG_LIR_Apic_2	782	787	PF02991	0.332
LIG_LIR_Apic_2	816	822	PF02991	0.389
LIG_LIR_Gen_1	368	376	PF02991	0.355
LIG_LIR_Gen_1	382	393	PF02991	0.371
LIG_LIR_Gen_1	490	499	PF02991	0.255
LIG_LIR_Gen_1	612	621	PF02991	0.417
LIG_LIR_Gen_1	624	633	PF02991	0.256
LIG_LIR_LC3C_4	598	601	PF02991	0.446
LIG_LIR_Nem_3	211	217	PF02991	0.371
LIG_LIR_Nem_3	241	247	PF02991	0.315
LIG_LIR_Nem_3	360	364	PF02991	0.335
LIG_LIR_Nem_3	368	373	PF02991	0.358
LIG_LIR_Nem_3	382	388	PF02991	0.384
LIG_LIR_Nem_3	396	400	PF02991	0.423
LIG_LIR_Nem_3	490	495	PF02991	0.255
LIG_LIR_Nem_3	612	617	PF02991	0.364
LIG_LIR_Nem_3	624	629	PF02991	0.254
LIG_LIR_Nem_3	732	738	PF02991	0.382
LIG_MAD2	670	678	PF02301	0.305
LIG_MYND_1	674	678	PF01753	0.392
LIG_Pex14_2	397	401	PF04695	0.318
LIG_Pex14_2	469	473	PF04695	0.353
LIG_Pex14_2	617	621	PF04695	0.433
LIG_PTB_Apo_2	221	228	PF02174	0.361
LIG_Rb_LxCxE_1	494	515	PF01857	0.417
LIG_Rb_LxCxE_1	628	647	PF01857	0.334
LIG_SH2_CRK	14	18	PF00017	0.437
LIG_SH2_CRK	244	248	PF00017	0.300
LIG_SH2_SRC	113	116	PF00017	0.382
LIG_SH2_SRC	69	72	PF00017	0.352
LIG_SH2_STAP1	215	219	PF00017	0.360
LIG_SH2_STAP1	603	607	PF00017	0.302
LIG_SH2_STAP1	738	742	PF00017	0.360
LIG_SH2_STAT3	123	126	PF00017	0.437
LIG_SH2_STAT3	363	366	PF00017	0.313
LIG_SH2_STAT5	113	116	PF00017	0.378
LIG_SH2_STAT5	123	126	PF00017	0.403
LIG_SH2_STAT5	142	145	PF00017	0.272
LIG_SH2_STAT5	363	366	PF00017	0.286
LIG_SH2_STAT5	400	403	PF00017	0.318
LIG_SH2_STAT5	480	483	PF00017	0.435
LIG_SH2_STAT5	581	584	PF00017	0.437
LIG_SH2_STAT5	603	606	PF00017	0.405
LIG_SH2_STAT5	69	72	PF00017	0.392
LIG_SH2_STAT5	738	741	PF00017	0.355
LIG_SH2_STAT5	74	77	PF00017	0.436
LIG_SH2_STAT5	742	745	PF00017	0.392
LIG_SH3_3	172	178	PF00018	0.455
LIG_SH3_3	26	32	PF00018	0.481
LIG_SH3_3	343	349	PF00018	0.378
LIG_SH3_3	356	362	PF00018	0.353
LIG_SH3_3	403	409	PF00018	0.403
LIG_SH3_3	519	525	PF00018	0.517
LIG_SH3_3	540	546	PF00018	0.431
LIG_SH3_3	59	65	PF00018	0.384
LIG_SH3_3	643	649	PF00018	0.368
LIG_SH3_3	656	662	PF00018	0.358
LIG_SH3_3	699	705	PF00018	0.450
LIG_SH3_3	720	726	PF00018	0.431
LIG_TRAF2_1	512	515	PF00917	0.602
LIG_TRAF2_1	566	569	PF00917	0.399
LIG_TRAF2_1	725	728	PF00917	0.353
LIG_TRAF2_1	776	779	PF00917	0.411
LIG_TRAF2_2	543	548	PF00917	0.584
LIG_TYR_ITIM	242	247	PF00017	0.305
LIG_TYR_ITIM	478	483	PF00017	0.431
LIG_WRC_WIRS_1	466	471	PF05994	0.371
LIG_WRC_WIRS_1	532	537	PF05994	0.407
LIG_WRPW_2	100	103	PF00400	0.396
LIG_WRPW_2	86	89	PF00400	0.385
MOD_CDK_SPK_2	664	669	PF00069	0.402
MOD_CDK_SPxK_1	664	670	PF00069	0.400
MOD_CK1_1	121	127	PF00069	0.413
MOD_CK1_1	285	291	PF00069	0.579
MOD_CK1_1	37	43	PF00069	0.466
MOD_CK1_1	380	386	PF00069	0.387
MOD_CK1_1	491	497	PF00069	0.362
MOD_CK1_1	609	615	PF00069	0.426
MOD_CK1_1	628	634	PF00069	0.172
MOD_CK1_1	654	660	PF00069	0.533
MOD_CK1_1	664	670	PF00069	0.299
MOD_CK2_1	206	212	PF00069	0.298
MOD_CK2_1	235	241	PF00069	0.373
MOD_CK2_1	325	331	PF00069	0.466
MOD_CK2_1	381	387	PF00069	0.395
MOD_CK2_1	410	416	PF00069	0.360
MOD_CK2_1	427	433	PF00069	0.300
MOD_CK2_1	499	505	PF00069	0.398
MOD_CK2_1	509	515	PF00069	0.469
MOD_CK2_1	563	569	PF00069	0.403
MOD_CK2_1	592	598	PF00069	0.354
MOD_CK2_1	633	639	PF00069	0.267
MOD_CK2_1	686	692	PF00069	0.406
MOD_CK2_1	700	706	PF00069	0.435
MOD_CK2_1	722	728	PF00069	0.354
MOD_CK2_1	772	778	PF00069	0.409
MOD_DYRK1A_RPxSP_1	174	178	PF00069	0.448
MOD_GlcNHglycan	236	240	PF01048	0.368
MOD_GlcNHglycan	290	293	PF01048	0.500
MOD_GlcNHglycan	445	448	PF01048	0.489
MOD_GlcNHglycan	474	477	PF01048	0.389
MOD_GlcNHglycan	526	529	PF01048	0.589
MOD_GlcNHglycan	535	538	PF01048	0.556
MOD_GlcNHglycan	586	589	PF01048	0.630
MOD_GlcNHglycan	609	612	PF01048	0.425
MOD_GlcNHglycan	663	666	PF01048	0.497
MOD_GlcNHglycan	89	92	PF01048	0.441
MOD_GSK3_1	121	128	PF00069	0.519
MOD_GSK3_1	141	148	PF00069	0.413
MOD_GSK3_1	278	285	PF00069	0.554
MOD_GSK3_1	376	383	PF00069	0.378
MOD_GSK3_1	526	533	PF00069	0.347
MOD_GSK3_1	603	610	PF00069	0.451
MOD_GSK3_1	813	820	PF00069	0.402
MOD_LATS_1	116	122	PF00433	0.403
MOD_LATS_1	463	469	PF00433	0.381
MOD_N-GLC_1	303	308	PF02516	0.543
MOD_N-GLC_1	341	346	PF02516	0.474
MOD_N-GLC_1	35	40	PF02516	0.481
MOD_N-GLC_1	357	362	PF02516	0.526
MOD_N-GLC_1	509	514	PF02516	0.502
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	229	234	PF00069	0.437
MOD_NEK2_1	303	308	PF00069	0.558
MOD_NEK2_1	35	40	PF00069	0.477
MOD_NEK2_1	376	381	PF00069	0.378
MOD_NEK2_1	388	393	PF00069	0.333
MOD_NEK2_1	434	439	PF00069	0.493
MOD_NEK2_1	686	691	PF00069	0.434
MOD_NEK2_1	817	822	PF00069	0.433
MOD_PIKK_1	15	21	PF00454	0.434
MOD_PK_1	278	284	PF00069	0.460
MOD_PKA_1	118	124	PF00069	0.477
MOD_PKA_1	2	8	PF00069	0.608
MOD_PKA_1	530	536	PF00069	0.356
MOD_PKA_2	1	7	PF00069	0.495
MOD_PKA_2	157	163	PF00069	0.589
MOD_PKA_2	201	207	PF00069	0.518
MOD_PKA_2	282	288	PF00069	0.423
MOD_PKA_2	427	433	PF00069	0.348
MOD_PKA_2	530	536	PF00069	0.370
MOD_PKB_1	13	21	PF00069	0.446
MOD_Plk_1	149	155	PF00069	0.378
MOD_Plk_1	200	206	PF00069	0.391
MOD_Plk_1	240	246	PF00069	0.322
MOD_Plk_1	303	309	PF00069	0.536
MOD_Plk_1	357	363	PF00069	0.498
MOD_Plk_1	381	387	PF00069	0.383
MOD_Plk_1	509	515	PF00069	0.527
MOD_Plk_1	563	569	PF00069	0.322
MOD_Plk_1	779	785	PF00069	0.419
MOD_Plk_2-3	700	706	PF00069	0.542
MOD_Plk_4	157	163	PF00069	0.431
MOD_Plk_4	2	8	PF00069	0.490
MOD_Plk_4	537	543	PF00069	0.483
MOD_Plk_4	577	583	PF00069	0.548
MOD_Plk_4	69	75	PF00069	0.373
MOD_Plk_4	779	785	PF00069	0.419
MOD_ProDKin_1	121	127	PF00069	0.523
MOD_ProDKin_1	174	180	PF00069	0.389
MOD_ProDKin_1	454	460	PF00069	0.327
MOD_ProDKin_1	664	670	PF00069	0.400
MOD_ProDKin_1	722	728	PF00069	0.435
MOD_ProDKin_1	751	757	PF00069	0.391
MOD_ProDKin_1	772	778	PF00069	0.409
MOD_SUMO_rev_2	42	52	PF00179	0.417
TRG_DiLeu_BaEn_3	320	326	PF01217	0.363
TRG_ENDOCYTIC_2	103	106	PF00928	0.432
TRG_ENDOCYTIC_2	244	247	PF00928	0.307
TRG_ENDOCYTIC_2	400	403	PF00928	0.318
TRG_ENDOCYTIC_2	480	483	PF00928	0.435
TRG_ER_diArg_1	1	3	PF00400	0.525
TRG_ER_diArg_1	222	225	PF00400	0.347
TRG_ER_diArg_1	438	440	PF00400	0.423
TRG_ER_diArg_1	530	532	PF00400	0.355
TRG_ER_diArg_1	668	670	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	670	675	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z7	Leptomonas seymouri	81%	100%
A0A0S4JL67	Bodo saltans	59%	100%
A0A1X0P2Q6	Trypanosomatidae	65%	94%
A0A3Q8IH97	Leishmania donovani	88%	100%
A0A3R7M7H0	Trypanosoma rangeli	68%	100%
A4I8L7	Leishmania infantum	88%	100%
C9ZPU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B3H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4M2	Leishmania major	88%	100%
V5BJH2	Trypanosoma cruzi	70%	100%