H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gar1/Naf1 RNA binding region, putative

Species:

Leishmania braziliensis

UniProt:

A4HL35_LEIBR

TriTrypDb:

LbrM.32.4220 , LBRM2903_320052300

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	7
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A4HL35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL35

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	7
GO:0000493	box H/ACA snoRNP assembly	8	7
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0022607	cellular component assembly	4	7
GO:0022618	ribonucleoprotein complex assembly	6	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0071826	ribonucleoprotein complex subunit organization	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042254	ribosome biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	147	151	PF00082	0.623
CLV_PCSK_KEX2_1	146	148	PF00082	0.609
CLV_PCSK_KEX2_1	149	151	PF00082	0.632
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.609
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.632
CLV_PCSK_SKI1_1	67	71	PF00082	0.410
DEG_SPOP_SBC_1	20	24	PF00917	0.362
DOC_PP2B_LxvP_1	6	9	PF13499	0.591
DOC_USP7_MATH_1	19	23	PF00917	0.476
LIG_14-3-3_CanoR_1	47	56	PF00244	0.408
LIG_AP2alpha_2	107	109	PF02296	0.564
LIG_APCC_ABBA_1	93	98	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BIR_III_3	1	5	PF00653	0.699
LIG_BRCT_BRCA1_1	59	63	PF00533	0.258
LIG_FHA_1	22	28	PF00498	0.258
LIG_FHA_1	39	45	PF00498	0.258
LIG_FHA_2	74	80	PF00498	0.515
LIG_LIR_Gen_1	167	175	PF02991	0.655
LIG_LIR_Gen_1	78	86	PF02991	0.397
LIG_LIR_Nem_3	103	109	PF02991	0.418
LIG_LIR_Nem_3	167	173	PF02991	0.654
LIG_LIR_Nem_3	60	66	PF02991	0.375
LIG_LIR_Nem_3	78	83	PF02991	0.397
LIG_SH2_CRK	97	101	PF00017	0.501
LIG_SH2_GRB2like	122	125	PF00017	0.635
LIG_SH2_STAT5	122	125	PF00017	0.635
LIG_SH2_STAT5	58	61	PF00017	0.508
LIG_SH2_STAT5	71	74	PF00017	0.403
LIG_SH3_3	184	190	PF00018	0.679
LIG_SH3_3	59	65	PF00018	0.356
LIG_SUMO_SIM_par_1	14	25	PF11976	0.578
LIG_TRAF2_1	164	167	PF00917	0.553
LIG_TYR_ITIM	95	100	PF00017	0.317
MOD_CK1_1	11	17	PF00069	0.339
MOD_CK1_1	158	164	PF00069	0.683
MOD_CK1_1	22	28	PF00069	0.399
MOD_CK2_1	134	140	PF00069	0.621
MOD_CK2_1	157	163	PF00069	0.657
MOD_CK2_1	72	78	PF00069	0.288
MOD_GlcNHglycan	194	197	PF01048	0.632
MOD_GlcNHglycan	24	27	PF01048	0.328
MOD_GSK3_1	157	164	PF00069	0.601
MOD_GSK3_1	21	28	PF00069	0.286
MOD_N-GLC_1	155	160	PF02516	0.683
MOD_NEK2_2	58	63	PF00069	0.258
MOD_PIKK_1	8	14	PF00454	0.328
MOD_Plk_1	118	124	PF00069	0.632
MOD_Plk_1	155	161	PF00069	0.683
MOD_Plk_2-3	38	44	PF00069	0.258
MOD_Plk_4	118	124	PF00069	0.632
MOD_Plk_4	51	57	PF00069	0.346
MOD_Plk_4	58	64	PF00069	0.342
MOD_SUMO_rev_2	135	143	PF00179	0.613
TRG_ENDOCYTIC_2	106	109	PF00928	0.553
TRG_ENDOCYTIC_2	97	100	PF00928	0.473
TRG_NES_CRM1_1	38	52	PF08389	0.508
TRG_NLS_MonoExtC_3	145	150	PF00514	0.609
TRG_NLS_MonoExtN_4	146	153	PF00514	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P446	Leptomonas seymouri	69%	72%
A0A3S7X6B4	Leishmania donovani	81%	100%
A4I8L6	Leishmania infantum	81%	100%
E9B3H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4M4	Leishmania major	83%	100%