Cyclic nucleotide-binding protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP response protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HL34_LEIBR

TriTrypDb:

LbrM.32.4210 , LBRM2903_320052100

Length:

699

Annotations

LeishMANIAdb annotations

A protein related to animal PKA regulatory subunits. Likely binds cAMP.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL34

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0017076	purine nucleotide binding	4	1
GO:0030551	cyclic nucleotide binding	4	1
GO:0030552	cAMP binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.413
CLV_NRD_NRD_1	136	138	PF00675	0.495
CLV_NRD_NRD_1	152	154	PF00675	0.448
CLV_NRD_NRD_1	180	182	PF00675	0.398
CLV_NRD_NRD_1	198	200	PF00675	0.355
CLV_NRD_NRD_1	207	209	PF00675	0.456
CLV_NRD_NRD_1	257	259	PF00675	0.362
CLV_NRD_NRD_1	285	287	PF00675	0.387
CLV_NRD_NRD_1	293	295	PF00675	0.330
CLV_NRD_NRD_1	3	5	PF00675	0.585
CLV_NRD_NRD_1	365	367	PF00675	0.453
CLV_NRD_NRD_1	439	441	PF00675	0.413
CLV_NRD_NRD_1	517	519	PF00675	0.468
CLV_NRD_NRD_1	697	699	PF00675	0.655
CLV_NRD_NRD_1	94	96	PF00675	0.425
CLV_PCSK_FUR_1	204	208	PF00082	0.584
CLV_PCSK_KEX2_1	100	102	PF00082	0.421
CLV_PCSK_KEX2_1	136	138	PF00082	0.489
CLV_PCSK_KEX2_1	151	153	PF00082	0.419
CLV_PCSK_KEX2_1	180	182	PF00082	0.501
CLV_PCSK_KEX2_1	198	200	PF00082	0.358
CLV_PCSK_KEX2_1	206	208	PF00082	0.483
CLV_PCSK_KEX2_1	292	294	PF00082	0.335
CLV_PCSK_KEX2_1	364	366	PF00082	0.451
CLV_PCSK_KEX2_1	461	463	PF00082	0.329
CLV_PCSK_KEX2_1	500	502	PF00082	0.595
CLV_PCSK_KEX2_1	94	96	PF00082	0.410
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.416
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.555
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.335
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.344
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.595
CLV_PCSK_PC7_1	496	502	PF00082	0.316
CLV_PCSK_SKI1_1	109	113	PF00082	0.476
CLV_PCSK_SKI1_1	138	142	PF00082	0.379
CLV_PCSK_SKI1_1	198	202	PF00082	0.537
CLV_PCSK_SKI1_1	358	362	PF00082	0.480
CLV_PCSK_SKI1_1	440	444	PF00082	0.475
CLV_PCSK_SKI1_1	45	49	PF00082	0.481
CLV_PCSK_SKI1_1	511	515	PF00082	0.563
CLV_PCSK_SKI1_1	549	553	PF00082	0.522
DEG_APCC_DBOX_1	214	222	PF00400	0.475
DEG_APCC_DBOX_1	477	485	PF00400	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DOC_CYCLIN_yClb1_LxF_4	186	192	PF00134	0.344
DOC_MAPK_DCC_7	396	406	PF00069	0.324
DOC_MAPK_FxFP_2	223	226	PF00069	0.551
DOC_MAPK_gen_1	159	168	PF00069	0.473
DOC_MAPK_gen_1	292	302	PF00069	0.223
DOC_MAPK_gen_1	4	11	PF00069	0.687
DOC_MAPK_gen_1	440	450	PF00069	0.475
DOC_MAPK_gen_1	461	468	PF00069	0.399
DOC_MAPK_gen_1	475	484	PF00069	0.240
DOC_MAPK_gen_1	509	516	PF00069	0.489
DOC_MAPK_gen_1	518	525	PF00069	0.413
DOC_MAPK_HePTP_8	552	564	PF00069	0.540
DOC_MAPK_MEF2A_6	371	379	PF00069	0.453
DOC_MAPK_MEF2A_6	475	484	PF00069	0.339
DOC_MAPK_MEF2A_6	509	516	PF00069	0.389
DOC_MAPK_MEF2A_6	555	564	PF00069	0.533
DOC_PP1_RVXF_1	157	164	PF00149	0.503
DOC_PP2B_LxvP_1	192	195	PF13499	0.551
DOC_PP2B_PxIxI_1	479	485	PF00149	0.223
DOC_PP4_FxxP_1	223	226	PF00568	0.419
DOC_PP4_FxxP_1	34	37	PF00568	0.622
DOC_PP4_FxxP_1	38	41	PF00568	0.593
DOC_PP4_FxxP_1	525	528	PF00568	0.448
DOC_USP7_MATH_1	352	356	PF00917	0.567
DOC_USP7_MATH_1	460	464	PF00917	0.448
DOC_USP7_MATH_1	521	525	PF00917	0.520
DOC_USP7_UBL2_3	247	251	PF12436	0.515
DOC_USP7_UBL2_3	288	292	PF12436	0.346
DOC_WW_Pin1_4	335	340	PF00397	0.367
DOC_WW_Pin1_4	347	352	PF00397	0.435
DOC_WW_Pin1_4	537	542	PF00397	0.522
LIG_14-3-3_CanoR_1	162	168	PF00244	0.458
LIG_14-3-3_CanoR_1	215	225	PF00244	0.465
LIG_14-3-3_CanoR_1	4	10	PF00244	0.679
LIG_14-3-3_CanoR_1	45	55	PF00244	0.627
LIG_14-3-3_CanoR_1	596	601	PF00244	0.694
LIG_14-3-3_CanoR_1	67	73	PF00244	0.588
LIG_Actin_WH2_2	242	260	PF00022	0.519
LIG_Actin_WH2_2	677	693	PF00022	0.458
LIG_APCC_ABBA_1	684	689	PF00400	0.315
LIG_BRCT_BRCA1_1	12	16	PF00533	0.721
LIG_BRCT_BRCA1_1	232	236	PF00533	0.447
LIG_BRCT_BRCA1_1	30	34	PF00533	0.500
LIG_BRCT_BRCA1_1	420	424	PF00533	0.344
LIG_BRCT_BRCA1_1	598	602	PF00533	0.676
LIG_DLG_GKlike_1	153	161	PF00625	0.326
LIG_DLG_GKlike_1	51	58	PF00625	0.531
LIG_eIF4E_1	142	148	PF01652	0.576
LIG_eIF4E_1	52	58	PF01652	0.492
LIG_FHA_1	10	16	PF00498	0.702
LIG_FHA_1	126	132	PF00498	0.341
LIG_FHA_1	163	169	PF00498	0.380
LIG_FHA_1	208	214	PF00498	0.530
LIG_FHA_1	420	426	PF00498	0.475
LIG_FHA_1	538	544	PF00498	0.447
LIG_FHA_1	578	584	PF00498	0.546
LIG_FHA_2	22	28	PF00498	0.620
LIG_FHA_2	233	239	PF00498	0.507
LIG_Integrin_isoDGR_2	103	105	PF01839	0.383
LIG_LIR_Apic_2	220	226	PF02991	0.531
LIG_LIR_Apic_2	31	37	PF02991	0.577
LIG_LIR_Apic_2	524	528	PF02991	0.531
LIG_LIR_Gen_1	127	135	PF02991	0.330
LIG_LIR_Gen_1	313	321	PF02991	0.328
LIG_LIR_Gen_1	340	349	PF02991	0.363
LIG_LIR_Gen_1	467	476	PF02991	0.344
LIG_LIR_Gen_1	49	59	PF02991	0.613
LIG_LIR_Gen_1	520	528	PF02991	0.370
LIG_LIR_Gen_1	682	690	PF02991	0.477
LIG_LIR_Nem_3	127	133	PF02991	0.527
LIG_LIR_Nem_3	238	243	PF02991	0.395
LIG_LIR_Nem_3	313	317	PF02991	0.328
LIG_LIR_Nem_3	331	337	PF02991	0.328
LIG_LIR_Nem_3	340	345	PF02991	0.300
LIG_LIR_Nem_3	467	473	PF02991	0.344
LIG_LIR_Nem_3	49	55	PF02991	0.682
LIG_LIR_Nem_3	520	525	PF02991	0.372
LIG_LIR_Nem_3	599	605	PF02991	0.553
LIG_LIR_Nem_3	682	686	PF02991	0.486
LIG_LYPXL_yS_3	225	228	PF13949	0.308
LIG_MLH1_MIPbox_1	420	424	PF16413	0.344
LIG_Pex14_2	236	240	PF04695	0.398
LIG_Pex14_2	34	38	PF04695	0.686
LIG_Pex14_2	379	383	PF04695	0.442
LIG_PTB_Apo_2	379	386	PF02174	0.527
LIG_PTB_Phospho_1	379	385	PF10480	0.532
LIG_Rb_LxCxE_1	313	331	PF01857	0.328
LIG_REV1ctd_RIR_1	514	520	PF16727	0.301
LIG_RPA_C_Fungi	46	58	PF08784	0.488
LIG_SH2_PTP2	52	55	PF00017	0.718
LIG_SH2_SRC	342	345	PF00017	0.363
LIG_SH2_STAP1	342	346	PF00017	0.363
LIG_SH2_STAT3	142	145	PF00017	0.465
LIG_SH2_STAT3	385	388	PF00017	0.501
LIG_SH2_STAT3	423	426	PF00017	0.344
LIG_SH2_STAT5	256	259	PF00017	0.369
LIG_SH2_STAT5	262	265	PF00017	0.354
LIG_SH2_STAT5	348	351	PF00017	0.582
LIG_SH2_STAT5	385	388	PF00017	0.395
LIG_SH2_STAT5	411	414	PF00017	0.402
LIG_SH2_STAT5	423	426	PF00017	0.252
LIG_SH2_STAT5	470	473	PF00017	0.363
LIG_SH2_STAT5	52	55	PF00017	0.683
LIG_SH2_STAT5	621	624	PF00017	0.315
LIG_SH3_3	38	44	PF00018	0.589
LIG_SH3_3	454	460	PF00018	0.358
LIG_SUMO_SIM_anti_2	427	434	PF11976	0.228
LIG_SUMO_SIM_anti_2	548	554	PF11976	0.526
LIG_SUMO_SIM_par_1	402	408	PF11976	0.363
LIG_SUMO_SIM_par_1	463	469	PF11976	0.259
LIG_SUMO_SIM_par_1	565	571	PF11976	0.519
LIG_SxIP_EBH_1	215	227	PF03271	0.326
LIG_TRAF2_1	24	27	PF00917	0.639
LIG_TYR_ITIM	332	337	PF00017	0.449
LIG_TYR_ITIM	468	473	PF00017	0.449
LIG_UBA3_1	244	253	PF00899	0.408
LIG_UBA3_1	77	83	PF00899	0.573
LIG_WRC_WIRS_1	522	527	PF05994	0.451
MOD_CK1_1	216	222	PF00069	0.333
MOD_CK1_1	390	396	PF00069	0.540
MOD_CK1_1	46	52	PF00069	0.531
MOD_CK1_1	464	470	PF00069	0.381
MOD_CK1_1	539	545	PF00069	0.494
MOD_CK1_1	591	597	PF00069	0.607
MOD_CK1_1	60	66	PF00069	0.699
MOD_CK1_1	616	622	PF00069	0.420
MOD_CK2_1	21	27	PF00069	0.740
MOD_CK2_1	232	238	PF00069	0.506
MOD_CK2_1	655	661	PF00069	0.498
MOD_GlcNHglycan	232	235	PF01048	0.317
MOD_GlcNHglycan	322	325	PF01048	0.328
MOD_GlcNHglycan	496	499	PF01048	0.345
MOD_GlcNHglycan	564	567	PF01048	0.452
MOD_GlcNHglycan	59	62	PF01048	0.712
MOD_GlcNHglycan	596	599	PF01048	0.630
MOD_GSK3_1	207	214	PF00069	0.588
MOD_GSK3_1	228	235	PF00069	0.454
MOD_GSK3_1	292	299	PF00069	0.475
MOD_GSK3_1	460	467	PF00069	0.411
MOD_GSK3_1	5	12	PF00069	0.707
MOD_GSK3_1	558	565	PF00069	0.487
MOD_GSK3_1	624	631	PF00069	0.398
MOD_N-GLC_1	418	423	PF02516	0.223
MOD_N-GLC_1	5	10	PF02516	0.710
MOD_N-GLC_1	591	596	PF02516	0.726
MOD_NEK2_1	10	15	PF00069	0.675
MOD_NEK2_1	213	218	PF00069	0.470
MOD_NEK2_1	232	237	PF00069	0.414
MOD_NEK2_1	418	423	PF00069	0.274
MOD_NEK2_1	443	448	PF00069	0.475
MOD_NEK2_1	451	456	PF00069	0.343
MOD_NEK2_1	536	541	PF00069	0.488
MOD_NEK2_1	553	558	PF00069	0.402
MOD_NEK2_1	568	573	PF00069	0.312
MOD_NEK2_1	614	619	PF00069	0.505
MOD_NEK2_1	96	101	PF00069	0.561
MOD_PIKK_1	21	27	PF00454	0.509
MOD_PIKK_1	435	441	PF00454	0.223
MOD_PIKK_1	616	622	PF00454	0.455
MOD_PK_1	28	34	PF00069	0.502
MOD_PK_1	296	302	PF00069	0.223
MOD_PK_1	322	328	PF00069	0.328
MOD_PK_1	461	467	PF00069	0.413
MOD_PK_1	5	11	PF00069	0.698
MOD_PKA_1	207	213	PF00069	0.533
MOD_PKA_1	258	264	PF00069	0.358
MOD_PKA_1	292	298	PF00069	0.363
MOD_PKA_1	4	10	PF00069	0.582
MOD_PKA_1	461	467	PF00069	0.344
MOD_PKA_1	94	100	PF00069	0.435
MOD_PKA_2	125	131	PF00069	0.489
MOD_PKA_2	161	167	PF00069	0.459
MOD_PKA_2	207	213	PF00069	0.533
MOD_PKA_2	292	298	PF00069	0.437
MOD_PKA_2	461	467	PF00069	0.361
MOD_PKA_2	474	480	PF00069	0.308
MOD_PKA_2	502	508	PF00069	0.468
MOD_PKA_2	94	100	PF00069	0.537
MOD_Plk_1	153	159	PF00069	0.572
MOD_Plk_1	28	34	PF00069	0.502
MOD_Plk_1	296	302	PF00069	0.223
MOD_Plk_1	390	396	PF00069	0.540
MOD_Plk_1	418	424	PF00069	0.363
MOD_Plk_1	5	11	PF00069	0.710
MOD_Plk_1	568	574	PF00069	0.436
MOD_Plk_1	576	582	PF00069	0.503
MOD_Plk_1	591	597	PF00069	0.663
MOD_Plk_4	162	168	PF00069	0.330
MOD_Plk_4	187	193	PF00069	0.573
MOD_Plk_4	232	238	PF00069	0.438
MOD_Plk_4	239	245	PF00069	0.442
MOD_Plk_4	258	264	PF00069	0.152
MOD_Plk_4	279	285	PF00069	0.363
MOD_Plk_4	322	328	PF00069	0.378
MOD_Plk_4	390	396	PF00069	0.287
MOD_Plk_4	419	425	PF00069	0.475
MOD_Plk_4	461	467	PF00069	0.337
MOD_Plk_4	5	11	PF00069	0.705
MOD_Plk_4	539	545	PF00069	0.465
MOD_Plk_4	558	564	PF00069	0.252
MOD_Plk_4	679	685	PF00069	0.431
MOD_ProDKin_1	335	341	PF00069	0.367
MOD_ProDKin_1	347	353	PF00069	0.429
MOD_ProDKin_1	537	543	PF00069	0.517
MOD_SUMO_rev_2	113	121	PF00179	0.395
MOD_SUMO_rev_2	454	463	PF00179	0.437
MOD_SUMO_rev_2	637	646	PF00179	0.457
TRG_DiLeu_BaEn_1	488	493	PF01217	0.498
TRG_DiLeu_BaEn_1	548	553	PF01217	0.522
TRG_DiLeu_BaEn_1	670	675	PF01217	0.572
TRG_DiLeu_BaEn_2	678	684	PF01217	0.305
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.270
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.223
TRG_ENDOCYTIC_2	225	228	PF00928	0.392
TRG_ENDOCYTIC_2	334	337	PF00928	0.391
TRG_ENDOCYTIC_2	342	345	PF00928	0.328
TRG_ENDOCYTIC_2	470	473	PF00928	0.350
TRG_ENDOCYTIC_2	52	55	PF00928	0.613
TRG_ENDOCYTIC_2	522	525	PF00928	0.385
TRG_ENDOCYTIC_2	687	690	PF00928	0.522
TRG_ER_diArg_1	180	182	PF00400	0.492
TRG_ER_diArg_1	197	199	PF00400	0.358
TRG_ER_diArg_1	203	206	PF00400	0.493
TRG_ER_diArg_1	363	366	PF00400	0.459
TRG_ER_diArg_1	94	96	PF00400	0.412
TRG_NLS_MonoExtC_3	285	290	PF00514	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAZ4	Leptomonas seymouri	62%	100%
A0A0S4JPP7	Bodo saltans	34%	69%
A0A1X0NTP9	Trypanosomatidae	48%	98%
A0A3Q8IDJ1	Leishmania donovani	80%	100%
A0A422NHV4	Trypanosoma rangeli	47%	99%
A4I8L5	Leishmania infantum	80%	100%
D0AAJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9B3H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4M5	Leishmania major	80%	100%
V5BDD3	Trypanosoma cruzi	47%	99%