Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL33_LEIBR

TriTrypDb:

LbrM.32.4200 , LBRM2903_320052000

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.699
CLV_NRD_NRD_1	134	136	PF00675	0.586
CLV_NRD_NRD_1	164	166	PF00675	0.687
CLV_NRD_NRD_1	175	177	PF00675	0.565
CLV_NRD_NRD_1	39	41	PF00675	0.571
CLV_NRD_NRD_1	46	48	PF00675	0.545
CLV_NRD_NRD_1	7	9	PF00675	0.474
CLV_PCSK_KEX2_1	134	136	PF00082	0.586
CLV_PCSK_KEX2_1	175	177	PF00082	0.584
CLV_PCSK_KEX2_1	39	41	PF00082	0.520
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.584
CLV_PCSK_PC7_1	171	177	PF00082	0.736
CLV_PCSK_SKI1_1	176	180	PF00082	0.619
CLV_PCSK_SKI1_1	39	43	PF00082	0.575
DEG_APCC_DBOX_1	92	100	PF00400	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DOC_MAPK_gen_1	39	46	PF00069	0.580
DOC_MAPK_gen_1	8	15	PF00069	0.532
DOC_MAPK_MEF2A_6	39	46	PF00069	0.560
DOC_MAPK_MEF2A_6	8	15	PF00069	0.682
DOC_MAPK_NFAT4_5	39	47	PF00069	0.562
DOC_MAPK_RevD_3	27	40	PF00069	0.607
DOC_USP7_MATH_1	18	22	PF00917	0.613
DOC_USP7_UBL2_3	173	177	PF12436	0.594
DOC_WW_Pin1_4	14	19	PF00397	0.585
LIG_FHA_1	103	109	PF00498	0.414
LIG_FHA_1	51	57	PF00498	0.631
LIG_FHA_2	157	163	PF00498	0.650
LIG_FHA_2	179	185	PF00498	0.597
LIG_FHA_2	61	67	PF00498	0.573
LIG_LIR_Nem_3	35	41	PF02991	0.553
LIG_Pex14_2	132	136	PF04695	0.694
LIG_PTAP_UEV_1	19	24	PF05743	0.668
LIG_SH2_CRK	38	42	PF00017	0.566
LIG_SH2_GRB2like	100	103	PF00017	0.643
LIG_SH2_STAP1	65	69	PF00017	0.649
LIG_SH2_STAT5	45	48	PF00017	0.552
LIG_SH3_3	17	23	PF00018	0.584
LIG_TRAF2_1	128	131	PF00917	0.650
LIG_TRAF2_1	74	77	PF00917	0.689
LIG_TRAF2_2	23	28	PF00917	0.725
LIG_TRFH_1	27	31	PF08558	0.684
LIG_TYR_ITIM	36	41	PF00017	0.565
LIG_UBA3_1	41	48	PF00899	0.558
LIG_UBA3_1	80	84	PF00899	0.658
MOD_CK2_1	125	131	PF00069	0.647
MOD_CK2_1	60	66	PF00069	0.572
MOD_CK2_1	71	77	PF00069	0.591
MOD_GlcNHglycan	127	130	PF01048	0.687
MOD_GlcNHglycan	20	23	PF01048	0.619
MOD_GSK3_1	14	21	PF00069	0.651
MOD_GSK3_1	48	55	PF00069	0.537
MOD_LATS_1	137	143	PF00433	0.672
MOD_N-GLC_1	71	76	PF02516	0.586
MOD_PKA_2	156	162	PF00069	0.651
MOD_Plk_4	32	38	PF00069	0.581
MOD_Plk_4	52	58	PF00069	0.353
MOD_ProDKin_1	14	20	PF00069	0.585
MOD_SUMO_for_1	11	14	PF00179	0.614
TRG_DiLeu_BaEn_1	76	81	PF01217	0.659
TRG_DiLeu_BaEn_4	76	82	PF01217	0.697
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.517
TRG_ENDOCYTIC_2	38	41	PF00928	0.566
TRG_ER_diArg_1	133	135	PF00400	0.576
TRG_ER_diArg_1	38	40	PF00400	0.525
TRG_NLS_Bipartite_1	165	180	PF00514	0.695
TRG_NLS_MonoExtC_3	174	179	PF00514	0.597
TRG_NLS_MonoExtN_4	173	180	PF00514	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q7	Leptomonas seymouri	85%	100%
A0A0S4INC1	Bodo saltans	54%	86%
A0A1X0NTH6	Trypanosomatidae	67%	99%
A0A3S7X692	Leishmania donovani	94%	100%
A0A422NHV0	Trypanosoma rangeli	63%	100%
A4I8L4	Leishmania infantum	93%	100%
D0AAK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9B3H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4M6	Leishmania major	91%	100%