Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL32_LEIBR

TriTrypDb:

LbrM.32.4190 , LBRM2903_320051800 , LBRM2903_320051900

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HL32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL32

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	891	895	PF00656	0.545
CLV_C14_Caspase3-7	938	942	PF00656	0.605
CLV_NRD_NRD_1	315	317	PF00675	0.514
CLV_NRD_NRD_1	345	347	PF00675	0.361
CLV_NRD_NRD_1	348	350	PF00675	0.332
CLV_NRD_NRD_1	51	53	PF00675	0.408
CLV_NRD_NRD_1	644	646	PF00675	0.341
CLV_NRD_NRD_1	881	883	PF00675	0.686
CLV_NRD_NRD_1	9	11	PF00675	0.526
CLV_PCSK_KEX2_1	315	317	PF00082	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTN3	Leptomonas seymouri	62%	99%
A0A1X0NSF8	Trypanosomatidae	32%	100%
A0A3Q8ITR9	Leishmania donovani	83%	100%
A0A422NHV7	Trypanosoma rangeli	33%	100%
A4I8L3	Leishmania infantum	83%	100%
D0AAK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4M7	Leishmania major	81%	100%
V5AXZ4	Trypanosoma cruzi	36%	100%

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