PINc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL31_LEIBR

TriTrypDb:

LbrM.32.4180 , LBRM2903_320051700

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.355
CLV_NRD_NRD_1	100	102	PF00675	0.516
CLV_NRD_NRD_1	148	150	PF00675	0.504
CLV_NRD_NRD_1	418	420	PF00675	0.547
CLV_NRD_NRD_1	516	518	PF00675	0.364
CLV_PCSK_KEX2_1	100	102	PF00082	0.423
CLV_PCSK_KEX2_1	148	150	PF00082	0.472
CLV_PCSK_KEX2_1	516	518	PF00082	0.376
CLV_PCSK_KEX2_1	537	539	PF00082	0.428
CLV_PCSK_KEX2_1	88	90	PF00082	0.434
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.430
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.367
CLV_PCSK_SKI1_1	118	122	PF00082	0.418
CLV_PCSK_SKI1_1	149	153	PF00082	0.498
CLV_PCSK_SKI1_1	162	166	PF00082	0.515
CLV_PCSK_SKI1_1	195	199	PF00082	0.539
CLV_PCSK_SKI1_1	294	298	PF00082	0.639
CLV_PCSK_SKI1_1	419	423	PF00082	0.397
CLV_PCSK_SKI1_1	488	492	PF00082	0.461
CLV_PCSK_SKI1_1	520	524	PF00082	0.464
CLV_PCSK_SKI1_1	529	533	PF00082	0.422
DEG_APCC_DBOX_1	148	156	PF00400	0.487
DEG_APCC_DBOX_1	161	169	PF00400	0.509
DEG_APCC_DBOX_1	528	536	PF00400	0.470
DEG_APCC_KENBOX_2	347	351	PF00400	0.296
DEG_SCF_FBW7_1	68	75	PF00400	0.516
DEG_SCF_FBW7_1	76	81	PF00400	0.554
DEG_SPOP_SBC_1	107	111	PF00917	0.424
DEG_SPOP_SBC_1	58	62	PF00917	0.455
DOC_CDC14_PxL_1	449	457	PF14671	0.506
DOC_CKS1_1	69	74	PF01111	0.527
DOC_CYCLIN_RxL_1	363	372	PF00134	0.472
DOC_MAPK_DCC_7	173	181	PF00069	0.543
DOC_MAPK_MEF2A_6	348	356	PF00069	0.339
DOC_MAPK_RevD_3	405	420	PF00069	0.469
DOC_PP1_RVXF_1	417	424	PF00149	0.424
DOC_USP7_MATH_1	120	124	PF00917	0.536
DOC_USP7_MATH_1	206	210	PF00917	0.559
DOC_USP7_MATH_1	287	291	PF00917	0.441
DOC_USP7_MATH_1	445	449	PF00917	0.495
DOC_USP7_MATH_1	72	76	PF00917	0.619
DOC_USP7_MATH_1	78	82	PF00917	0.546
DOC_WW_Pin1_4	303	308	PF00397	0.544
DOC_WW_Pin1_4	41	46	PF00397	0.553
DOC_WW_Pin1_4	68	73	PF00397	0.560
DOC_WW_Pin1_4	74	79	PF00397	0.593
LIG_14-3-3_CanoR_1	19	24	PF00244	0.532
LIG_14-3-3_CanoR_1	199	205	PF00244	0.525
LIG_14-3-3_CanoR_1	286	295	PF00244	0.642
LIG_14-3-3_CanoR_1	4	10	PF00244	0.515
LIG_14-3-3_CanoR_1	425	430	PF00244	0.434
LIG_14-3-3_CanoR_1	475	480	PF00244	0.365
LIG_14-3-3_CanoR_1	517	523	PF00244	0.474
LIG_14-3-3_CanoR_1	59	64	PF00244	0.298
LIG_Actin_WH2_2	184	201	PF00022	0.510
LIG_Actin_WH2_2	33	51	PF00022	0.418
LIG_CaM_NSCaTE_8	229	236	PF13499	0.447
LIG_Clathr_ClatBox_1	353	357	PF01394	0.375
LIG_FHA_1	122	128	PF00498	0.559
LIG_FHA_1	349	355	PF00498	0.370
LIG_FHA_1	356	362	PF00498	0.344
LIG_FHA_1	390	396	PF00498	0.456
LIG_FHA_1	491	497	PF00498	0.486
LIG_FHA_2	243	249	PF00498	0.497
LIG_FHA_2	397	403	PF00498	0.383
LIG_FHA_2	42	48	PF00498	0.456
LIG_FHA_2	457	463	PF00498	0.334
LIG_HCF-1_HBM_1	372	375	PF13415	0.509
LIG_LIR_Gen_1	22	30	PF02991	0.425
LIG_LIR_Gen_1	254	264	PF02991	0.433
LIG_LIR_Gen_1	267	277	PF02991	0.461
LIG_LIR_Gen_1	309	319	PF02991	0.468
LIG_LIR_Gen_1	372	383	PF02991	0.474
LIG_LIR_Gen_1	389	397	PF02991	0.298
LIG_LIR_Gen_1	401	410	PF02991	0.277
LIG_LIR_Nem_3	22	26	PF02991	0.432
LIG_LIR_Nem_3	254	259	PF02991	0.428
LIG_LIR_Nem_3	267	272	PF02991	0.414
LIG_LIR_Nem_3	309	314	PF02991	0.439
LIG_LIR_Nem_3	372	377	PF02991	0.438
LIG_LIR_Nem_3	389	393	PF02991	0.304
LIG_LIR_Nem_3	401	407	PF02991	0.244
LIG_LIR_Nem_3	62	68	PF02991	0.438
LIG_LYPXL_S_1	381	385	PF13949	0.452
LIG_LYPXL_yS_3	382	385	PF13949	0.391
LIG_MYND_1	552	556	PF01753	0.595
LIG_NRBOX	131	137	PF00104	0.537
LIG_NRBOX	506	512	PF00104	0.484
LIG_PCNA_PIPBox_1	368	377	PF02747	0.544
LIG_PCNA_yPIPBox_3	250	264	PF02747	0.456
LIG_PCNA_yPIPBox_3	367	375	PF02747	0.425
LIG_Pex14_2	551	555	PF04695	0.302
LIG_SH2_CRK	256	260	PF00017	0.413
LIG_SH2_CRK	66	70	PF00017	0.433
LIG_SH2_SRC	36	39	PF00017	0.409
LIG_SH2_SRC	404	407	PF00017	0.407
LIG_SH2_STAP1	264	268	PF00017	0.486
LIG_SH2_STAP1	325	329	PF00017	0.452
LIG_SH2_STAP1	335	339	PF00017	0.488
LIG_SH2_STAP1	404	408	PF00017	0.411
LIG_SH2_STAT3	377	380	PF00017	0.543
LIG_SH2_STAT5	36	39	PF00017	0.596
LIG_SH2_STAT5	406	409	PF00017	0.361
LIG_SH2_STAT5	436	439	PF00017	0.494
LIG_SH2_STAT5	486	489	PF00017	0.400
LIG_SH2_STAT5	518	521	PF00017	0.529
LIG_SH3_3	37	43	PF00018	0.506
LIG_SH3_3	390	396	PF00018	0.442
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.511
LIG_SUMO_SIM_anti_2	351	358	PF11976	0.344
LIG_SUMO_SIM_par_1	351	358	PF11976	0.344
LIG_TRAF2_1	235	238	PF00917	0.461
LIG_TRAF2_1	289	292	PF00917	0.450
LIG_TYR_ITIM	63	68	PF00017	0.405
LIG_UBA3_1	219	228	PF00899	0.487
LIG_UBA3_1	361	367	PF00899	0.490
LIG_UBA3_1	507	512	PF00899	0.378
LIG_UBA3_1	531	537	PF00899	0.401
MOD_CAAXbox	553	556	PF01239	0.359
MOD_CDK_SPxK_1	74	80	PF00069	0.624
MOD_CK1_1	290	296	PF00069	0.535
MOD_CK1_1	389	395	PF00069	0.421
MOD_CK2_1	107	113	PF00069	0.382
MOD_CK2_1	242	248	PF00069	0.476
MOD_CK2_1	303	309	PF00069	0.330
MOD_CK2_1	396	402	PF00069	0.382
MOD_CK2_1	41	47	PF00069	0.477
MOD_GlcNHglycan	152	155	PF01048	0.369
MOD_GlcNHglycan	195	198	PF01048	0.491
MOD_GlcNHglycan	216	219	PF01048	0.375
MOD_GlcNHglycan	242	245	PF01048	0.551
MOD_GlcNHglycan	339	342	PF01048	0.451
MOD_GlcNHglycan	344	347	PF01048	0.513
MOD_GlcNHglycan	7	10	PF01048	0.520
MOD_GSK3_1	15	22	PF00069	0.411
MOD_GSK3_1	219	226	PF00069	0.430
MOD_GSK3_1	290	297	PF00069	0.548
MOD_GSK3_1	319	326	PF00069	0.428
MOD_GSK3_1	333	340	PF00069	0.469
MOD_GSK3_1	421	428	PF00069	0.395
MOD_GSK3_1	68	75	PF00069	0.476
MOD_N-GLC_1	107	112	PF02516	0.347
MOD_N-GLC_1	251	256	PF02516	0.554
MOD_NEK2_1	121	126	PF00069	0.553
MOD_NEK2_1	141	146	PF00069	0.229
MOD_NEK2_1	15	20	PF00069	0.435
MOD_NEK2_1	198	203	PF00069	0.484
MOD_NEK2_1	223	228	PF00069	0.467
MOD_NEK2_1	242	247	PF00069	0.243
MOD_NEK2_1	319	324	PF00069	0.428
MOD_NEK2_1	421	426	PF00069	0.353
MOD_NEK2_1	496	501	PF00069	0.560
MOD_NEK2_1	5	10	PF00069	0.541
MOD_NEK2_2	518	523	PF00069	0.531
MOD_PK_1	475	481	PF00069	0.469
MOD_PKA_1	537	543	PF00069	0.393
MOD_PKA_2	198	204	PF00069	0.550
MOD_PKA_2	287	293	PF00069	0.661
MOD_PKA_2	3	9	PF00069	0.529
MOD_PKA_2	537	543	PF00069	0.393
MOD_PKA_2	58	64	PF00069	0.298
MOD_Plk_1	107	113	PF00069	0.488
MOD_Plk_1	251	257	PF00069	0.551
MOD_Plk_1	290	296	PF00069	0.567
MOD_Plk_1	348	354	PF00069	0.462
MOD_Plk_1	78	84	PF00069	0.546
MOD_Plk_4	131	137	PF00069	0.498
MOD_Plk_4	19	25	PF00069	0.476
MOD_Plk_4	251	257	PF00069	0.521
MOD_Plk_4	313	319	PF00069	0.466
MOD_Plk_4	348	354	PF00069	0.354
MOD_Plk_4	389	395	PF00069	0.489
MOD_Plk_4	425	431	PF00069	0.385
MOD_Plk_4	50	56	PF00069	0.507
MOD_Plk_4	59	65	PF00069	0.330
MOD_Plk_4	78	84	PF00069	0.441
MOD_ProDKin_1	303	309	PF00069	0.543
MOD_ProDKin_1	41	47	PF00069	0.546
MOD_ProDKin_1	68	74	PF00069	0.573
TRG_DiLeu_BaEn_1	349	354	PF01217	0.492
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.459
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.470
TRG_ENDOCYTIC_2	256	259	PF00928	0.409
TRG_ENDOCYTIC_2	269	272	PF00928	0.377
TRG_ENDOCYTIC_2	375	378	PF00928	0.393
TRG_ENDOCYTIC_2	382	385	PF00928	0.378
TRG_ENDOCYTIC_2	404	407	PF00928	0.292
TRG_ENDOCYTIC_2	457	460	PF00928	0.398
TRG_ENDOCYTIC_2	486	489	PF00928	0.367
TRG_ENDOCYTIC_2	65	68	PF00928	0.420
TRG_ER_diArg_1	148	150	PF00400	0.508
TRG_ER_diArg_1	284	287	PF00400	0.605
TRG_ER_diArg_1	515	517	PF00400	0.363
TRG_ER_diArg_1	99	101	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II47	Leptomonas seymouri	57%	100%
A0A0S4JG92	Bodo saltans	23%	77%
A0A1X0NRZ6	Trypanosomatidae	39%	99%
A0A3Q8IGL6	Leishmania donovani	82%	100%
A0A422NHU1	Trypanosoma rangeli	40%	98%
A4I8L2	Leishmania infantum	82%	100%
D0AAK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
E9B3H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4M8	Leishmania major	82%	100%
V5BI03	Trypanosoma cruzi	41%	98%