DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

TFIIH basal transcription factor complex helicase XPB subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HL29_LEIBR

TriTrypDb:

LbrM.32.4160 , LBRM2903_320051400 , LBRM2903_320051500

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000112	nucleotide-excision repair factor 3 complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0097550	transcription preinitiation complex	3	1

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Expansion

Sequence features

A4HL29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL29

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	5
GO:0006281	DNA repair	5	5
GO:0006289	nucleotide-excision repair	6	5
GO:0006352	DNA-templated transcription initiation	6	6
GO:0006367	transcription initiation at RNA polymerase II promoter	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.386
CLV_C14_Caspase3-7	754	758	PF00656	0.563
CLV_NRD_NRD_1	112	114	PF00675	0.301
CLV_NRD_NRD_1	206	208	PF00675	0.525
CLV_NRD_NRD_1	220	222	PF00675	0.377
CLV_NRD_NRD_1	368	370	PF00675	0.262
CLV_NRD_NRD_1	475	477	PF00675	0.321
CLV_NRD_NRD_1	589	591	PF00675	0.242
CLV_NRD_NRD_1	710	712	PF00675	0.438
CLV_NRD_NRD_1	737	739	PF00675	0.546

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS9	Leptomonas seymouri	75%	99%
A0A0S4J760	Bodo saltans	46%	74%
A0A1X0NS07	Trypanosomatidae	58%	100%
A0A3R7MM80	Trypanosoma rangeli	58%	100%
A0A3S7X6B2	Leishmania donovani	84%	100%
A4I8L0	Leishmania infantum	84%	100%
A6WE36	Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)	32%	100%
A9CRJ7	Enterocytozoon bieneusi (strain H348)	34%	100%
C4V922	Nosema ceranae (strain BRL01)	35%	100%
D0AAK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%

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