DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

TFIIH basal transcription factor complex helicase XPB subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HL29_LEIBR

TriTrypDb:

LbrM.32.4160 , LBRM2903_320051400 , LBRM2903_320051500

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000112	nucleotide-excision repair factor 3 complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0097550	transcription preinitiation complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HL29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL29

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	5
GO:0006281	DNA repair	5	5
GO:0006289	nucleotide-excision repair	6	5
GO:0006352	DNA-templated transcription initiation	6	6
GO:0006367	transcription initiation at RNA polymerase II promoter	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009059	macromolecule biosynthetic process	4	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0032774	RNA biosynthetic process	5	6
GO:0033554	cellular response to stress	3	5
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0046483	heterocycle metabolic process	3	6
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0043138	3'-5' DNA helicase activity	4	1
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.386
CLV_C14_Caspase3-7	754	758	PF00656	0.563
CLV_NRD_NRD_1	112	114	PF00675	0.301
CLV_NRD_NRD_1	206	208	PF00675	0.525
CLV_NRD_NRD_1	220	222	PF00675	0.377
CLV_NRD_NRD_1	368	370	PF00675	0.262
CLV_NRD_NRD_1	475	477	PF00675	0.321
CLV_NRD_NRD_1	589	591	PF00675	0.242
CLV_NRD_NRD_1	710	712	PF00675	0.438
CLV_NRD_NRD_1	737	739	PF00675	0.546
CLV_NRD_NRD_1	741	743	PF00675	0.565
CLV_NRD_NRD_1	99	101	PF00675	0.301
CLV_PCSK_FUR_1	738	742	PF00082	0.521
CLV_PCSK_KEX2_1	112	114	PF00082	0.301
CLV_PCSK_KEX2_1	220	222	PF00082	0.386
CLV_PCSK_KEX2_1	370	372	PF00082	0.257
CLV_PCSK_KEX2_1	474	476	PF00082	0.312
CLV_PCSK_KEX2_1	589	591	PF00082	0.260
CLV_PCSK_KEX2_1	710	712	PF00082	0.497
CLV_PCSK_KEX2_1	739	741	PF00082	0.564
CLV_PCSK_KEX2_1	99	101	PF00082	0.301
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.260
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.591
CLV_PCSK_PC7_1	366	372	PF00082	0.301
CLV_PCSK_SKI1_1	14	18	PF00082	0.414
CLV_PCSK_SKI1_1	249	253	PF00082	0.386
CLV_PCSK_SKI1_1	43	47	PF00082	0.296
CLV_PCSK_SKI1_1	633	637	PF00082	0.299
DEG_APCC_DBOX_1	112	120	PF00400	0.246
DEG_APCC_DBOX_1	399	407	PF00400	0.386
DEG_APCC_DBOX_1	42	50	PF00400	0.336
DEG_APCC_KENBOX_2	371	375	PF00400	0.386
DOC_CKS1_1	458	463	PF01111	0.244
DOC_CYCLIN_RxL_1	40	48	PF00134	0.152
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.257
DOC_MAPK_gen_1	112	119	PF00069	0.256
DOC_MAPK_gen_1	207	213	PF00069	0.267
DOC_MAPK_gen_1	259	267	PF00069	0.243
DOC_MAPK_gen_1	668	678	PF00069	0.582
DOC_MAPK_MEF2A_6	112	121	PF00069	0.152
DOC_MAPK_MEF2A_6	249	256	PF00069	0.242
DOC_MAPK_MEF2A_6	259	267	PF00069	0.242
DOC_MAPK_MEF2A_6	482	489	PF00069	0.274
DOC_MAPK_MEF2A_6	565	573	PF00069	0.242
DOC_PP1_RVXF_1	499	506	PF00149	0.280
DOC_PP2B_LxvP_1	287	290	PF13499	0.361
DOC_PP2B_LxvP_1	379	382	PF13499	0.386
DOC_PP2B_LxvP_1	531	534	PF13499	0.283
DOC_USP7_MATH_1	168	172	PF00917	0.383
DOC_USP7_MATH_1	395	399	PF00917	0.386
DOC_USP7_MATH_1	443	447	PF00917	0.203
DOC_USP7_MATH_1	478	482	PF00917	0.265
DOC_USP7_MATH_1	651	655	PF00917	0.402
DOC_USP7_MATH_1	656	660	PF00917	0.598
DOC_USP7_MATH_1	698	702	PF00917	0.643
DOC_USP7_MATH_1	71	75	PF00917	0.259
DOC_USP7_MATH_1	94	98	PF00917	0.315
DOC_USP7_UBL2_3	372	376	PF12436	0.386
DOC_USP7_UBL2_3	664	668	PF12436	0.652
DOC_WW_Pin1_4	148	153	PF00397	0.405
DOC_WW_Pin1_4	457	462	PF00397	0.245
DOC_WW_Pin1_4	62	67	PF00397	0.257
LIG_14-3-3_CanoR_1	21	30	PF00244	0.295
LIG_14-3-3_CanoR_1	43	53	PF00244	0.347
LIG_14-3-3_CanoR_1	710	717	PF00244	0.404
LIG_14-3-3_CanoR_1	740	748	PF00244	0.540
LIG_14-3-3_CanoR_1	763	769	PF00244	0.584
LIG_14-3-3_CanoR_1	784	792	PF00244	0.664
LIG_APCC_ABBA_1	546	551	PF00400	0.242
LIG_APCC_ABBAyCdc20_2	545	551	PF00400	0.242
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BIR_III_4	407	411	PF00653	0.276
LIG_BIR_III_4	755	759	PF00653	0.451
LIG_BRCT_BRCA1_1	401	405	PF00533	0.336
LIG_Clathr_ClatBox_1	385	389	PF01394	0.242
LIG_Clathr_ClatBox_1	791	795	PF01394	0.548
LIG_EVH1_2	152	156	PF00568	0.268
LIG_FHA_1	262	268	PF00498	0.273
LIG_FHA_1	329	335	PF00498	0.242
LIG_FHA_1	481	487	PF00498	0.375
LIG_FHA_1	553	559	PF00498	0.242
LIG_FHA_1	632	638	PF00498	0.280
LIG_FHA_1	710	716	PF00498	0.511
LIG_FHA_1	81	87	PF00498	0.342
LIG_FHA_2	291	297	PF00498	0.162
LIG_FHA_2	354	360	PF00498	0.381
LIG_FHA_2	46	52	PF00498	0.276
LIG_FHA_2	741	747	PF00498	0.382
LIG_FHA_2	82	88	PF00498	0.152
LIG_FHA_2	93	99	PF00498	0.132
LIG_Integrin_isoDGR_2	608	610	PF01839	0.315
LIG_LIR_Gen_1	24	35	PF02991	0.273
LIG_LIR_Gen_1	283	292	PF02991	0.242
LIG_LIR_Gen_1	336	344	PF02991	0.242
LIG_LIR_Gen_1	38	46	PF02991	0.221
LIG_LIR_Gen_1	427	437	PF02991	0.311
LIG_LIR_Gen_1	502	512	PF02991	0.177
LIG_LIR_Gen_1	681	692	PF02991	0.629
LIG_LIR_Gen_1	767	774	PF02991	0.629
LIG_LIR_LC3C_4	264	267	PF02991	0.361
LIG_LIR_Nem_3	24	30	PF02991	0.346
LIG_LIR_Nem_3	283	287	PF02991	0.242
LIG_LIR_Nem_3	336	341	PF02991	0.242
LIG_LIR_Nem_3	377	383	PF02991	0.257
LIG_LIR_Nem_3	38	42	PF02991	0.221
LIG_LIR_Nem_3	427	432	PF02991	0.314
LIG_LIR_Nem_3	502	508	PF02991	0.177
LIG_LIR_Nem_3	526	530	PF02991	0.245
LIG_LIR_Nem_3	613	619	PF02991	0.242
LIG_LIR_Nem_3	648	652	PF02991	0.381
LIG_LIR_Nem_3	681	687	PF02991	0.606
LIG_LIR_Nem_3	767	771	PF02991	0.624
LIG_Pex14_1	729	733	PF04695	0.391
LIG_SH2_CRK	114	118	PF00017	0.152
LIG_SH2_CRK	338	342	PF00017	0.242
LIG_SH2_CRK	383	387	PF00017	0.257
LIG_SH2_CRK	617	621	PF00017	0.242
LIG_SH2_CRK	768	772	PF00017	0.628
LIG_SH2_NCK_1	617	621	PF00017	0.242
LIG_SH2_PTP2	27	30	PF00017	0.323
LIG_SH2_SRC	437	440	PF00017	0.384
LIG_SH2_SRC	89	92	PF00017	0.269
LIG_SH2_STAP1	338	342	PF00017	0.257
LIG_SH2_STAP1	437	441	PF00017	0.372
LIG_SH2_STAP1	642	646	PF00017	0.276
LIG_SH2_STAT5	27	30	PF00017	0.323
LIG_SH2_STAT5	418	421	PF00017	0.390
LIG_SH2_STAT5	449	452	PF00017	0.267
LIG_SH2_STAT5	649	652	PF00017	0.271
LIG_SH3_3	257	263	PF00018	0.257
LIG_SH3_3	455	461	PF00018	0.257
LIG_SH3_3	50	56	PF00018	0.200
LIG_SH3_3	568	574	PF00018	0.242
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.252
LIG_SUMO_SIM_anti_2	519	526	PF11976	0.242
LIG_SUMO_SIM_par_1	384	390	PF11976	0.386
LIG_TRFH_1	62	66	PF08558	0.386
LIG_TYR_ITIM	282	287	PF00017	0.336
LIG_UBA3_1	251	259	PF00899	0.268
LIG_UBA3_1	428	435	PF00899	0.315
LIG_UBA3_1	521	525	PF00899	0.260
LIG_WRC_WIRS_1	169	174	PF05994	0.447
MOD_CDK_SPxxK_3	457	464	PF00069	0.257
MOD_CK1_1	123	129	PF00069	0.160
MOD_CK1_1	212	218	PF00069	0.470
MOD_CK1_1	311	317	PF00069	0.349
MOD_CK1_1	38	44	PF00069	0.264
MOD_CK1_1	481	487	PF00069	0.416
MOD_CK1_1	54	60	PF00069	0.260
MOD_CK1_1	618	624	PF00069	0.251
MOD_CK1_1	655	661	PF00069	0.529
MOD_CK1_1	764	770	PF00069	0.610
MOD_CK2_1	158	164	PF00069	0.452
MOD_CK2_1	353	359	PF00069	0.290
MOD_CK2_1	45	51	PF00069	0.276
MOD_CK2_1	724	730	PF00069	0.385
MOD_CK2_1	740	746	PF00069	0.498
MOD_CK2_1	81	87	PF00069	0.225
MOD_CK2_1	92	98	PF00069	0.243
MOD_GlcNHglycan	237	240	PF01048	0.242
MOD_GlcNHglycan	310	313	PF01048	0.375
MOD_GlcNHglycan	653	657	PF01048	0.365
MOD_GlcNHglycan	699	703	PF01048	0.513
MOD_GlcNHglycan	777	780	PF01048	0.567
MOD_GSK3_1	144	151	PF00069	0.363
MOD_GSK3_1	17	24	PF00069	0.520
MOD_GSK3_1	173	180	PF00069	0.487
MOD_GSK3_1	31	38	PF00069	0.204
MOD_GSK3_1	336	343	PF00069	0.257
MOD_GSK3_1	395	402	PF00069	0.311
MOD_GSK3_1	477	484	PF00069	0.193
MOD_GSK3_1	547	554	PF00069	0.242
MOD_GSK3_1	581	588	PF00069	0.242
MOD_GSK3_1	651	658	PF00069	0.592
MOD_GSK3_1	683	690	PF00069	0.577
MOD_GSK3_1	709	716	PF00069	0.550
MOD_GSK3_1	720	727	PF00069	0.366
MOD_GSK3_1	757	764	PF00069	0.588
MOD_GSK3_1	77	84	PF00069	0.162
MOD_N-GLC_1	201	206	PF02516	0.407
MOD_N-GLC_1	656	661	PF02516	0.530
MOD_N-GLC_1	750	755	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	106	111	PF00069	0.246
MOD_NEK2_1	156	161	PF00069	0.513
MOD_NEK2_1	17	22	PF00069	0.388
MOD_NEK2_1	173	178	PF00069	0.396
MOD_NEK2_1	31	36	PF00069	0.180
MOD_NEK2_1	340	345	PF00069	0.257
MOD_NEK2_1	399	404	PF00069	0.326
MOD_NEK2_1	414	419	PF00069	0.197
MOD_NEK2_1	45	50	PF00069	0.237
MOD_NEK2_1	552	557	PF00069	0.242
MOD_NEK2_1	652	657	PF00069	0.538
MOD_NEK2_1	683	688	PF00069	0.504
MOD_NEK2_1	85	90	PF00069	0.336
MOD_NEK2_2	209	214	PF00069	0.495
MOD_NEK2_2	395	400	PF00069	0.386
MOD_PIKK_1	212	218	PF00454	0.381
MOD_PIKK_1	276	282	PF00454	0.315
MOD_PIKK_1	298	304	PF00454	0.152
MOD_PIKK_1	443	449	PF00454	0.410
MOD_PIKK_1	537	543	PF00454	0.386
MOD_PKA_1	261	267	PF00069	0.242
MOD_PKA_1	740	746	PF00069	0.614
MOD_PKA_2	35	41	PF00069	0.289
MOD_PKA_2	399	405	PF00069	0.336
MOD_PKA_2	54	60	PF00069	0.250
MOD_PKA_2	709	715	PF00069	0.576
MOD_PKA_2	740	746	PF00069	0.635
MOD_PKA_2	775	781	PF00069	0.426
MOD_PKA_2	783	789	PF00069	0.641
MOD_PKB_1	738	746	PF00069	0.530
MOD_Plk_1	123	129	PF00069	0.386
MOD_Plk_1	157	163	PF00069	0.447
MOD_Plk_1	201	207	PF00069	0.381
MOD_Plk_1	437	443	PF00069	0.320
MOD_Plk_1	567	573	PF00069	0.242
MOD_Plk_1	656	662	PF00069	0.389
MOD_Plk_1	80	86	PF00069	0.386
MOD_Plk_2-3	158	164	PF00069	0.459
MOD_Plk_2-3	283	289	PF00069	0.377
MOD_Plk_2-3	325	331	PF00069	0.242
MOD_Plk_2-3	750	756	PF00069	0.438
MOD_Plk_2-3	81	87	PF00069	0.252
MOD_Plk_4	168	174	PF00069	0.456
MOD_Plk_4	247	253	PF00069	0.242
MOD_Plk_4	261	267	PF00069	0.307
MOD_Plk_4	336	342	PF00069	0.242
MOD_Plk_4	414	420	PF00069	0.275
MOD_Plk_4	481	487	PF00069	0.277
MOD_Plk_4	54	60	PF00069	0.269
MOD_Plk_4	615	621	PF00069	0.242
MOD_Plk_4	688	694	PF00069	0.647
MOD_Plk_4	81	87	PF00069	0.205
MOD_ProDKin_1	148	154	PF00069	0.411
MOD_ProDKin_1	457	463	PF00069	0.245
MOD_ProDKin_1	62	68	PF00069	0.257
MOD_SUMO_for_1	667	670	PF00179	0.553
MOD_SUMO_for_1	678	681	PF00179	0.480
MOD_SUMO_for_1	771	774	PF00179	0.486
MOD_SUMO_rev_2	402	411	PF00179	0.279
MOD_SUMO_rev_2	421	426	PF00179	0.294
TRG_DiLeu_BaEn_1	526	531	PF01217	0.242
TRG_DiLeu_BaEn_2	12	18	PF01217	0.419
TRG_DiLeu_BaEn_2	80	86	PF01217	0.301
TRG_DiLeu_BaEn_3	133	139	PF01217	0.386
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.177
TRG_ENDOCYTIC_2	114	117	PF00928	0.152
TRG_ENDOCYTIC_2	169	172	PF00928	0.447
TRG_ENDOCYTIC_2	27	30	PF00928	0.323
TRG_ENDOCYTIC_2	284	287	PF00928	0.336
TRG_ENDOCYTIC_2	338	341	PF00928	0.242
TRG_ENDOCYTIC_2	383	386	PF00928	0.257
TRG_ENDOCYTIC_2	39	42	PF00928	0.276
TRG_ENDOCYTIC_2	527	530	PF00928	0.244
TRG_ENDOCYTIC_2	617	620	PF00928	0.242
TRG_ENDOCYTIC_2	649	652	PF00928	0.404
TRG_ENDOCYTIC_2	684	687	PF00928	0.517
TRG_ENDOCYTIC_2	768	771	PF00928	0.624
TRG_ENDOCYTIC_2	800	803	PF00928	0.517
TRG_ER_diArg_1	111	113	PF00400	0.179
TRG_ER_diArg_1	219	221	PF00400	0.304
TRG_ER_diArg_1	368	371	PF00400	0.264
TRG_ER_diArg_1	474	476	PF00400	0.312
TRG_ER_diArg_1	738	741	PF00400	0.516
TRG_ER_diArg_1	99	102	PF00400	0.200
TRG_NLS_MonoCore_2	737	742	PF00514	0.514
TRG_NLS_MonoExtC_3	737	742	PF00514	0.585
TRG_NLS_MonoExtN_4	738	743	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS9	Leptomonas seymouri	75%	99%
A0A0S4J760	Bodo saltans	46%	74%
A0A1X0NS07	Trypanosomatidae	58%	100%
A0A3R7MM80	Trypanosoma rangeli	58%	100%
A0A3S7X6B2	Leishmania donovani	84%	100%
A4I8L0	Leishmania infantum	84%	100%
A6WE36	Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)	32%	100%
A9CRJ7	Enterocytozoon bieneusi (strain H348)	34%	100%
C4V922	Nosema ceranae (strain BRL01)	35%	100%
D0AAK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B3H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O00835	Dictyostelium discoideum	34%	100%
O13768	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O53873	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
P19447	Homo sapiens	35%	100%
Q00578	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
Q1RMT1	Bos taurus	35%	100%
Q381F9	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	54%	100%
Q38861	Arabidopsis thaliana	33%	100%
Q4G005	Rattus norvegicus	34%	100%
Q4Q4N0	Leishmania major	83%	100%
Q5RA62	Pongo abelii	35%	100%
Q5ZKK7	Gallus gallus	34%	100%
Q60HG1	Macaca fascicularis	35%	100%
Q6E6J3	Antonospora locustae	36%	100%
Q7ZVV1	Danio rerio	34%	100%
Q8SSK1	Encephalitozoon cuniculi (strain GB-M1)	36%	100%
Q9FUG4	Arabidopsis thaliana	34%	100%
V5BDD7	Trypanosoma cruzi	57%	100%