Endoplasmic reticulum-Golgi intermediate compartment protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HL28_LEIBR

TriTrypDb:

LbrM.32.4150 , LBRM2903_320051300

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HL28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	302	304	PF00675	0.295
CLV_PCSK_KEX2_1	302	304	PF00082	0.295
CLV_PCSK_SKI1_1	18	22	PF00082	0.300
CLV_PCSK_SKI1_1	302	306	PF00082	0.335
DOC_CDC14_PxL_1	58	66	PF14671	0.165
DOC_MAPK_MEF2A_6	71	78	PF00069	0.241
DOC_USP7_MATH_1	169	173	PF00917	0.165
DOC_USP7_MATH_1	239	243	PF00917	0.165
DOC_USP7_MATH_1	264	268	PF00917	0.245
DOC_USP7_MATH_1	3	7	PF00917	0.491
DOC_USP7_UBL2_3	184	188	PF12436	0.245
DOC_WW_Pin1_4	235	240	PF00397	0.242
DOC_WW_Pin1_4	252	257	PF00397	0.164
DOC_WW_Pin1_4	48	53	PF00397	0.164
LIG_14-3-3_CanoR_1	260	268	PF00244	0.214
LIG_14-3-3_CanoR_1	291	300	PF00244	0.482
LIG_14-3-3_CanoR_1	53	62	PF00244	0.207
LIG_BRCT_BRCA1_1	122	126	PF00533	0.227
LIG_EH1_1	282	290	PF00400	0.232
LIG_eIF4E_1	283	289	PF01652	0.260
LIG_FHA_1	178	184	PF00498	0.362
LIG_FHA_1	267	273	PF00498	0.211
LIG_FHA_1	34	40	PF00498	0.173
LIG_FHA_1	65	71	PF00498	0.246
LIG_FHA_1	85	91	PF00498	0.229
LIG_FHA_2	106	112	PF00498	0.327
LIG_FHA_2	165	171	PF00498	0.165
LIG_FHA_2	215	221	PF00498	0.245
LIG_LIR_Apic_2	48	52	PF02991	0.193
LIG_LIR_Gen_1	136	145	PF02991	0.202
LIG_LIR_Nem_3	10	16	PF02991	0.408
LIG_LIR_Nem_3	136	141	PF02991	0.251
LIG_LIR_Nem_3	177	181	PF02991	0.218
LIG_LIR_Nem_3	269	274	PF02991	0.215
LIG_PCNA_PIPBox_1	156	165	PF02747	0.227
LIG_PTB_Apo_2	93	100	PF02174	0.245
LIG_REV1ctd_RIR_1	10	16	PF16727	0.445
LIG_SH2_NCK_1	283	287	PF00017	0.260
LIG_SH2_PTP2	138	141	PF00017	0.227
LIG_SH2_PTP2	49	52	PF00017	0.245
LIG_SH2_STAP1	219	223	PF00017	0.294
LIG_SH2_STAT5	138	141	PF00017	0.227
LIG_SH2_STAT5	210	213	PF00017	0.209
LIG_SH2_STAT5	274	277	PF00017	0.232
LIG_SH2_STAT5	283	286	PF00017	0.232
LIG_SH2_STAT5	49	52	PF00017	0.207
LIG_SH3_3	76	82	PF00018	0.227
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.173
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.210
LIG_SUMO_SIM_par_1	56	63	PF11976	0.165
LIG_SUMO_SIM_par_1	84	89	PF11976	0.245
MOD_CDK_SPK_2	48	53	PF00069	0.164
MOD_CK1_1	177	183	PF00069	0.317
MOD_CK1_1	221	227	PF00069	0.227
MOD_CK1_1	23	29	PF00069	0.238
MOD_CK1_1	235	241	PF00069	0.162
MOD_CK1_1	255	261	PF00069	0.146
MOD_CK1_1	48	54	PF00069	0.164
MOD_CK2_1	125	131	PF00069	0.245
MOD_CK2_1	164	170	PF00069	0.165
MOD_CK2_1	214	220	PF00069	0.245
MOD_GlcNHglycan	127	130	PF01048	0.365
MOD_GlcNHglycan	25	28	PF01048	0.173
MOD_GlcNHglycan	262	265	PF01048	0.381
MOD_GlcNHglycan	295	298	PF01048	0.292
MOD_GSK3_1	115	122	PF00069	0.424
MOD_GSK3_1	18	25	PF00069	0.429
MOD_GSK3_1	214	221	PF00069	0.271
MOD_GSK3_1	225	232	PF00069	0.213
MOD_GSK3_1	235	242	PF00069	0.287
MOD_GSK3_1	255	262	PF00069	0.196
MOD_GSK3_1	266	273	PF00069	0.207
MOD_GSK3_1	3	10	PF00069	0.489
MOD_GSK3_1	66	73	PF00069	0.245
MOD_N-GLC_1	164	169	PF02516	0.365
MOD_NEK2_1	125	130	PF00069	0.179
MOD_NEK2_1	148	153	PF00069	0.207
MOD_NEK2_1	158	163	PF00069	0.207
MOD_NEK2_1	20	25	PF00069	0.399
MOD_NEK2_1	231	236	PF00069	0.245
MOD_NEK2_1	292	297	PF00069	0.489
MOD_NEK2_1	64	69	PF00069	0.218
MOD_NEK2_1	74	79	PF00069	0.202
MOD_NEK2_2	169	174	PF00069	0.165
MOD_PIKK_1	240	246	PF00454	0.165
MOD_PKA_2	259	265	PF00069	0.214
MOD_Plk_1	169	175	PF00069	0.245
MOD_Plk_1	219	225	PF00069	0.227
MOD_Plk_1	65	71	PF00069	0.216
MOD_Plk_1	74	80	PF00069	0.202
MOD_Plk_4	214	220	PF00069	0.207
MOD_Plk_4	270	276	PF00069	0.243
MOD_Plk_4	33	39	PF00069	0.382
MOD_ProDKin_1	235	241	PF00069	0.242
MOD_ProDKin_1	252	258	PF00069	0.164
MOD_ProDKin_1	48	54	PF00069	0.164
MOD_SUMO_rev_2	177	186	PF00179	0.245
TRG_ENDOCYTIC_2	138	141	PF00928	0.227
TRG_ENDOCYTIC_2	208	211	PF00928	0.211
TRG_ER_diArg_1	107	110	PF00400	0.444
TRG_ER_diArg_1	302	304	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.245

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	23%	78%
A0A0N0P4A5	Leptomonas seymouri	25%	76%
A0A0N0P8T7	Leptomonas seymouri	26%	92%
A0A0N1I377	Leptomonas seymouri	74%	100%
A0A0S4J3I3	Bodo saltans	47%	98%
A0A0S4JE72	Bodo saltans	31%	77%
A0A1X0NIB7	Trypanosomatidae	29%	79%
A0A3Q8IGC2	Leishmania donovani	86%	100%
A0A3Q8IGE1	Leishmania donovani	27%	66%
A0A3S5H6H6	Leishmania donovani	22%	84%
A0A3S7X427	Leishmania donovani	27%	91%
A4HJ02	Leishmania braziliensis	26%	100%
A4HUR4	Leishmania infantum	22%	84%
A4I6C1	Leishmania infantum	27%	91%
A4I779	Leishmania infantum	27%	66%
A4I8K9	Leishmania infantum	87%	100%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	84%
E9B1H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	76%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O94283	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
P39727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	74%
Q4Q4N1	Leishmania major	85%	100%
Q4Q5Y6	Leishmania major	28%	66%
Q4Q6N5	Leishmania major	28%	100%
Q4QH78	Leishmania major	23%	100%
Q4R5C3	Macaca fascicularis	26%	82%
Q4R8X1	Macaca fascicularis	27%	81%
Q4V8Y6	Danio rerio	32%	100%
Q54DW2	Dictyostelium discoideum	36%	81%
Q5EAE0	Bos taurus	27%	81%
Q5R8G3	Pongo abelii	27%	81%
Q66KH2	Xenopus laevis	26%	79%
Q6NS19	Xenopus laevis	34%	100%
Q6NVS2	Xenopus tropicalis	27%	80%
Q7T2D4	Danio rerio	27%	82%
Q969X5	Homo sapiens	34%	100%
Q96RQ1	Homo sapiens	27%	82%
Q9CR89	Mus musculus	26%	82%
Q9DC16	Mus musculus	34%	100%
Q9Y282	Homo sapiens	27%	81%
V5AS26	Trypanosoma cruzi	27%	76%
V5BGJ7	Trypanosoma cruzi	24%	79%