WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL25_LEIBR

TriTrypDb:

LbrM.32.4120 , LBRM2903_320051000

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.507
CLV_C14_Caspase3-7	200	204	PF00656	0.530
CLV_NRD_NRD_1	42	44	PF00675	0.402
CLV_NRD_NRD_1	84	86	PF00675	0.439
CLV_PCSK_KEX2_1	42	44	PF00082	0.403
CLV_PCSK_SKI1_1	182	186	PF00082	0.445
CLV_PCSK_SKI1_1	206	210	PF00082	0.452
CLV_PCSK_SKI1_1	344	348	PF00082	0.334
DEG_Nend_UBRbox_2	1	3	PF02207	0.375
DEG_SPOP_SBC_1	110	114	PF00917	0.430
DEG_SPOP_SBC_1	19	23	PF00917	0.395
DOC_MAPK_gen_1	39	48	PF00069	0.496
DOC_PP1_RVXF_1	180	186	PF00149	0.404
DOC_PP1_RVXF_1	204	210	PF00149	0.455
DOC_USP7_MATH_1	109	113	PF00917	0.336
DOC_USP7_MATH_1	15	19	PF00917	0.397
DOC_USP7_UBL2_3	53	57	PF12436	0.308
DOC_WW_Pin1_4	146	151	PF00397	0.563
DOC_WW_Pin1_4	212	217	PF00397	0.569
DOC_WW_Pin1_4	261	266	PF00397	0.487
DOC_WW_Pin1_4	276	281	PF00397	0.322
LIG_14-3-3_CanoR_1	255	265	PF00244	0.296
LIG_14-3-3_CanoR_1	43	49	PF00244	0.305
LIG_14-3-3_CanoR_1	85	94	PF00244	0.444
LIG_FHA_1	111	117	PF00498	0.372
LIG_FHA_1	179	185	PF00498	0.550
LIG_FHA_1	283	289	PF00498	0.297
LIG_FHA_1	76	82	PF00498	0.411
LIG_FHA_2	32	38	PF00498	0.265
LIG_LIR_Gen_1	21	32	PF02991	0.258
LIG_LIR_Gen_1	245	253	PF02991	0.297
LIG_LIR_Nem_3	154	160	PF02991	0.376
LIG_LIR_Nem_3	21	27	PF02991	0.320
LIG_LIR_Nem_3	245	251	PF02991	0.377
LIG_PDZ_Class_2	356	361	PF00595	0.470
LIG_SH2_CRK	45	49	PF00017	0.337
LIG_SH2_GRB2like	274	277	PF00017	0.216
LIG_SH2_SRC	137	140	PF00017	0.348
LIG_SH2_STAT5	137	140	PF00017	0.385
LIG_SH2_STAT5	141	144	PF00017	0.360
LIG_SH2_STAT5	163	166	PF00017	0.326
LIG_SH2_STAT5	274	277	PF00017	0.427
LIG_SH2_STAT5	345	348	PF00017	0.416
LIG_SH2_STAT5	64	67	PF00017	0.460
LIG_SH3_3	221	227	PF00018	0.493
LIG_SH3_3	35	41	PF00018	0.435
LIG_TRAF2_1	305	308	PF00917	0.660
MOD_CDK_SPK_2	212	217	PF00069	0.410
MOD_CK1_1	112	118	PF00069	0.407
MOD_CK1_1	17	23	PF00069	0.402
MOD_CK1_1	178	184	PF00069	0.367
MOD_CK1_1	212	218	PF00069	0.418
MOD_CK1_1	256	262	PF00069	0.292
MOD_CK1_1	89	95	PF00069	0.507
MOD_CK2_1	246	252	PF00069	0.508
MOD_CK2_1	302	308	PF00069	0.672
MOD_CK2_1	93	99	PF00069	0.515
MOD_GlcNHglycan	164	167	PF01048	0.425
MOD_GlcNHglycan	17	20	PF01048	0.472
MOD_GlcNHglycan	196	199	PF01048	0.517
MOD_GlcNHglycan	203	206	PF01048	0.488
MOD_GlcNHglycan	217	220	PF01048	0.550
MOD_GlcNHglycan	254	258	PF01048	0.405
MOD_GlcNHglycan	304	307	PF01048	0.689
MOD_GlcNHglycan	7	10	PF01048	0.467
MOD_GlcNHglycan	95	98	PF01048	0.349
MOD_GSK3_1	10	17	PF00069	0.353
MOD_GSK3_1	158	165	PF00069	0.536
MOD_GSK3_1	19	26	PF00069	0.343
MOD_GSK3_1	89	96	PF00069	0.473
MOD_N-GLC_1	110	115	PF02516	0.301
MOD_N-GLC_1	229	234	PF02516	0.447
MOD_N-GLC_2	162	164	PF02516	0.325
MOD_NEK2_1	283	288	PF00069	0.319
MOD_NEK2_1	347	352	PF00069	0.273
MOD_NEK2_1	81	86	PF00069	0.441
MOD_NEK2_2	246	251	PF00069	0.383
MOD_PIKK_1	209	215	PF00454	0.354
MOD_PKA_2	158	164	PF00069	0.343
MOD_PKA_2	5	11	PF00069	0.269
MOD_Plk_1	229	235	PF00069	0.449
MOD_Plk_4	112	118	PF00069	0.342
MOD_Plk_4	246	252	PF00069	0.432
MOD_Plk_4	31	37	PF00069	0.320
MOD_ProDKin_1	146	152	PF00069	0.563
MOD_ProDKin_1	212	218	PF00069	0.577
MOD_ProDKin_1	261	267	PF00069	0.484
MOD_ProDKin_1	276	282	PF00069	0.320
MOD_SUMO_for_1	104	107	PF00179	0.313
TRG_DiLeu_BaEn_2	98	104	PF01217	0.324
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.496
TRG_ENDOCYTIC_2	248	251	PF00928	0.294
TRG_ENDOCYTIC_2	45	48	PF00928	0.363
TRG_ER_diArg_1	41	43	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G5	Leptomonas seymouri	59%	99%
A0A1X0NS90	Trypanosomatidae	34%	98%
A0A3S5IR82	Trypanosoma rangeli	35%	100%
A0A3S7X6A3	Leishmania donovani	83%	100%
A4I8K6	Leishmania infantum	82%	100%
D0AAK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B3G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4N4	Leishmania major	83%	99%
V5DE80	Trypanosoma cruzi	34%	100%