Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HL22_LEIBR

TriTrypDb:

LbrM.32.4090 , LBRM2903_320050600

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.376
CLV_C14_Caspase3-7	34	38	PF00656	0.488
CLV_C14_Caspase3-7	6	10	PF00656	0.583
CLV_NRD_NRD_1	82	84	PF00675	0.560
CLV_PCSK_FUR_1	80	84	PF00082	0.557
CLV_PCSK_KEX2_1	280	282	PF00082	0.570
CLV_PCSK_KEX2_1	82	84	PF00082	0.560
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.588
CLV_PCSK_SKI1_1	121	125	PF00082	0.562
CLV_PCSK_SKI1_1	48	52	PF00082	0.525
CLV_PCSK_SKI1_1	83	87	PF00082	0.555
CLV_Separin_Metazoa	177	181	PF03568	0.471
DEG_APCC_DBOX_1	147	155	PF00400	0.598
DEG_Nend_UBRbox_1	1	4	PF02207	0.659
DEG_SCF_FBW7_1	51	56	PF00400	0.492
DEG_SPOP_SBC_1	4	8	PF00917	0.534
DOC_CKS1_1	16	21	PF01111	0.522
DOC_MAPK_gen_1	180	187	PF00069	0.451
DOC_MAPK_MEF2A_6	17	26	PF00069	0.496
DOC_USP7_MATH_1	133	137	PF00917	0.518
DOC_USP7_MATH_1	144	148	PF00917	0.516
DOC_USP7_MATH_1	20	24	PF00917	0.473
DOC_USP7_MATH_1	259	263	PF00917	0.522
DOC_USP7_MATH_1	266	270	PF00917	0.491
DOC_USP7_MATH_1	3	7	PF00917	0.617
DOC_USP7_MATH_1	31	35	PF00917	0.533
DOC_USP7_MATH_1	53	57	PF00917	0.526
DOC_WW_Pin1_4	15	20	PF00397	0.529
DOC_WW_Pin1_4	154	159	PF00397	0.521
DOC_WW_Pin1_4	49	54	PF00397	0.516
LIG_14-3-3_CanoR_1	148	152	PF00244	0.540
LIG_14-3-3_CanoR_1	180	186	PF00244	0.377
LIG_14-3-3_CanoR_1	2	11	PF00244	0.555
LIG_14-3-3_CanoR_1	229	237	PF00244	0.402
LIG_14-3-3_CanoR_1	251	259	PF00244	0.490
LIG_14-3-3_CanoR_1	281	286	PF00244	0.451
LIG_Actin_WH2_2	167	184	PF00022	0.408
LIG_Actin_WH2_2	71	89	PF00022	0.554
LIG_EVH1_1	138	142	PF00568	0.533
LIG_FHA_1	187	193	PF00498	0.524
LIG_FHA_2	23	29	PF00498	0.620
LIG_FHA_2	262	268	PF00498	0.520
LIG_FHA_2	71	77	PF00498	0.392
LIG_Integrin_RGD_1	35	37	PF01839	0.490
LIG_LIR_Gen_1	267	278	PF02991	0.565
LIG_LIR_Nem_3	246	250	PF02991	0.538
LIG_LIR_Nem_3	267	273	PF02991	0.583
LIG_PCNA_yPIPBox_3	115	124	PF02747	0.387
LIG_PCNA_yPIPBox_3	125	138	PF02747	0.462
LIG_PDZ_Class_3	283	288	PF00595	0.468
LIG_SH2_NCK_1	263	267	PF00017	0.546
LIG_SH2_STAT5	205	208	PF00017	0.525
LIG_SH2_STAT5	263	266	PF00017	0.541
LIG_SH2_STAT5	278	281	PF00017	0.398
LIG_SH3_3	136	142	PF00018	0.675
LIG_SH3_3	155	161	PF00018	0.581
LIG_SH3_3	234	240	PF00018	0.406
LIG_TRAF2_1	274	277	PF00917	0.451
LIG_WRC_WIRS_1	244	249	PF05994	0.574
MOD_CDK_SPxK_1	49	55	PF00069	0.510
MOD_CK1_1	147	153	PF00069	0.541
MOD_CK1_1	224	230	PF00069	0.399
MOD_CK1_1	246	252	PF00069	0.617
MOD_CK1_1	262	268	PF00069	0.513
MOD_CK1_1	269	275	PF00069	0.497
MOD_CK2_1	153	159	PF00069	0.613
MOD_CK2_1	261	267	PF00069	0.521
MOD_CK2_1	271	277	PF00069	0.435
MOD_CK2_1	53	59	PF00069	0.612
MOD_CK2_1	70	76	PF00069	0.390
MOD_GlcNHglycan	169	174	PF01048	0.427
MOD_GlcNHglycan	226	229	PF01048	0.443
MOD_GlcNHglycan	255	258	PF01048	0.577
MOD_GlcNHglycan	87	90	PF01048	0.554
MOD_GSK3_1	123	130	PF00069	0.437
MOD_GSK3_1	142	149	PF00069	0.493
MOD_GSK3_1	150	157	PF00069	0.500
MOD_GSK3_1	224	231	PF00069	0.400
MOD_GSK3_1	253	260	PF00069	0.624
MOD_GSK3_1	261	268	PF00069	0.626
MOD_GSK3_1	49	56	PF00069	0.610
MOD_GSK3_1	5	12	PF00069	0.540
MOD_GSK3_1	59	66	PF00069	0.411
MOD_N-GLC_1	70	75	PF02516	0.390
MOD_NEK2_1	181	186	PF00069	0.378
MOD_NEK2_1	85	90	PF00069	0.607
MOD_NEK2_1	95	100	PF00069	0.547
MOD_PIKK_1	123	129	PF00454	0.432
MOD_PIKK_1	186	192	PF00454	0.544
MOD_PK_1	281	287	PF00069	0.452
MOD_PKA_2	147	153	PF00069	0.602
MOD_PKA_2	181	187	PF00069	0.379
MOD_PKA_2	228	234	PF00069	0.558
MOD_PKA_2	252	258	PF00069	0.490
MOD_PKB_1	251	259	PF00069	0.490
MOD_Plk_1	105	111	PF00069	0.377
MOD_Plk_1	169	175	PF00069	0.434
MOD_Plk_1	266	272	PF00069	0.500
MOD_Plk_1	70	76	PF00069	0.390
MOD_Plk_2-3	59	65	PF00069	0.406
MOD_Plk_2-3	70	76	PF00069	0.354
MOD_Plk_4	133	139	PF00069	0.523
MOD_Plk_4	243	249	PF00069	0.603
MOD_Plk_4	59	65	PF00069	0.496
MOD_ProDKin_1	15	21	PF00069	0.524
MOD_ProDKin_1	154	160	PF00069	0.515
MOD_ProDKin_1	49	55	PF00069	0.510
MOD_SUMO_rev_2	157	167	PF00179	0.507
TRG_ER_diArg_1	179	182	PF00400	0.479
TRG_ER_diArg_1	250	253	PF00400	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEK8	Leishmania donovani	57%	99%
A4I8K3	Leishmania infantum	57%	99%
E9B3G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	99%
Q4Q4N7	Leishmania major	59%	100%