Cornichon family AMPA receptor auxiliary protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cornichon protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL21_LEIBR

TriTrypDb:

LbrM.32.4080 , LBRM2903_320050500

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HL21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL21

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	19
GO:0016192	vesicle-mediated transport	4	19
GO:0051179	localization	1	19
GO:0051234	establishment of localization	2	19

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.374
CLV_PCSK_KEX2_1	34	36	PF00082	0.351
CLV_PCSK_KEX2_1	5	7	PF00082	0.431
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.374
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.431
CLV_PCSK_SKI1_1	143	147	PF00082	0.486
CLV_PCSK_SKI1_1	35	39	PF00082	0.273
CLV_PCSK_SKI1_1	5	9	PF00082	0.395
DEG_APCC_DBOX_1	120	128	PF00400	0.194
DEG_APCC_DBOX_1	34	42	PF00400	0.557
DOC_CDC14_PxL_1	15	23	PF14671	0.639
DOC_CYCLIN_RxL_1	140	150	PF00134	0.322
DOC_CYCLIN_RxL_1	88	96	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.194
DOC_MAPK_gen_1	33	39	PF00069	0.586
DOC_PP1_RVXF_1	10	16	PF00149	0.615
DOC_PP1_RVXF_1	33	40	PF00149	0.440
DOC_PP2B_LxvP_1	172	175	PF13499	0.194
DOC_USP7_MATH_1	105	109	PF00917	0.490
LIG_14-3-3_CanoR_1	33	38	PF00244	0.499
LIG_14-3-3_CanoR_1	6	13	PF00244	0.684
LIG_14-3-3_CanoR_1	88	94	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	35	39	PF00533	0.480
LIG_FHA_1	2	8	PF00498	0.577
LIG_FHA_1	43	49	PF00498	0.304
LIG_FHA_2	27	33	PF00498	0.589
LIG_FHA_2	78	84	PF00498	0.194
LIG_LIR_Gen_1	120	131	PF02991	0.418
LIG_LIR_Gen_1	36	47	PF02991	0.471
LIG_LIR_Nem_3	120	126	PF02991	0.398
LIG_LIR_Nem_3	132	138	PF02991	0.338
LIG_LIR_Nem_3	150	156	PF02991	0.284
LIG_LIR_Nem_3	36	42	PF02991	0.495
LIG_LIR_Nem_3	45	49	PF02991	0.336
LIG_OCRL_FandH_1	38	50	PF00620	0.438
LIG_Pex14_1	61	65	PF04695	0.357
LIG_Pex14_2	11	15	PF04695	0.550
LIG_SH2_CRK	169	173	PF00017	0.360
LIG_SH2_STAP1	135	139	PF00017	0.355
LIG_SH2_STAP1	85	89	PF00017	0.515
LIG_SH2_STAT3	138	141	PF00017	0.302
LIG_SH2_STAT5	138	141	PF00017	0.341
LIG_SH2_STAT5	180	183	PF00017	0.359
LIG_SH3_3	95	101	PF00018	0.480
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.237
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.320
LIG_SUMO_SIM_par_1	100	106	PF11976	0.494
LIG_SUMO_SIM_par_1	18	24	PF11976	0.614
LIG_TYR_ITIM	167	172	PF00017	0.256
MOD_CK1_1	26	32	PF00069	0.596
MOD_CK2_1	26	32	PF00069	0.563
MOD_CK2_1	77	83	PF00069	0.458
MOD_GlcNHglycan	29	32	PF01048	0.410
MOD_GSK3_1	1	8	PF00069	0.569
MOD_GSK3_1	181	188	PF00069	0.429
MOD_GSK3_1	23	30	PF00069	0.565
MOD_N-GLC_1	89	94	PF02516	0.183
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	119	124	PF00069	0.358
MOD_NEK2_1	181	186	PF00069	0.365
MOD_NEK2_1	42	47	PF00069	0.325
MOD_NEK2_1	77	82	PF00069	0.399
MOD_NEK2_2	105	110	PF00069	0.418
MOD_PK_1	33	39	PF00069	0.443
MOD_PKA_1	33	39	PF00069	0.577
MOD_PKA_1	5	11	PF00069	0.505
MOD_PKA_2	5	11	PF00069	0.680
MOD_Plk_1	105	111	PF00069	0.385
MOD_Plk_1	89	95	PF00069	0.514
MOD_Plk_4	148	154	PF00069	0.276
MOD_Plk_4	42	48	PF00069	0.365
MOD_Plk_4	57	63	PF00069	0.270
MOD_Plk_4	77	83	PF00069	0.297
MOD_SUMO_rev_2	26	36	PF00179	0.600
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.537
TRG_ENDOCYTIC_2	169	172	PF00928	0.287
TRG_ENDOCYTIC_2	180	183	PF00928	0.303
TRG_ER_diArg_1	164	167	PF00400	0.238
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	62%	99%
A0A0N1HVI2	Leptomonas seymouri	27%	100%
A0A0S4IRN3	Bodo saltans	23%	86%
A0A1X0P478	Trypanosomatidae	43%	99%
A0A3Q8IH86	Leishmania donovani	70%	100%
A0A3Q8IHH3	Leishmania donovani	25%	100%
A0A3R7KL43	Trypanosoma rangeli	44%	99%
A0A3R7KRD8	Trypanosoma rangeli	23%	100%
A4HL20	Leishmania braziliensis	26%	100%
A4I8K1	Leishmania infantum	25%	100%
A4I8K2	Leishmania infantum	70%	100%
D0AAL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B3G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q4N8	Leishmania major	68%	100%
Q4Q4N9	Leishmania major	25%	100%
V5BLE0	Trypanosoma cruzi	23%	100%